| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Adagrasib perturbation in SW 900 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Adagrasib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| VEGFA | vascular endothelial growth factor A | 0.126747 |
| SFTPA2 | surfactant protein A2 | 0.0986938 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0938526 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0871269 |
| TMSB4X | thymosin beta 4, X-linked | 0.0745887 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0741277 |
| ASPH | aspartate beta-hydroxylase | 0.0652408 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0648938 |
| B2M | beta-2-microglobulin | 0.0578372 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0555847 |
| RPS12 | ribosomal protein S12 | 0.0552113 |
| STC2 | stanniocalcin 2 | 0.0530161 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0519373 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0481078 |
| CALR | calreticulin | 0.0443205 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0438909 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0435673 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.0435047 |
| NTN4 | netrin 4 | 0.0424868 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0412582 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0396317 |
| SEPTIN9 | septin 9 | 0.0390431 |
| HDGF | hepatoma-derived growth factor | 0.0381263 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0378952 |
| VCL | vinculin | 0.0375191 |
| TMEM156 | transmembrane protein 156 | 0.0367417 |
| ENO1 | enolase 1, (alpha) | 0.0365942 |
| HMGB3 | high mobility group box 3 | 0.0364353 |
| RPL37 | ribosomal protein L37 | 0.0347579 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0321148 |
| FTL | ferritin, light polypeptide | 0.0313145 |
| AHNAK | AHNAK nucleoprotein | 0.0310955 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | 0.0309073 |
| RACK1 | receptor for activated C kinase 1 | 0.0308948 |
| LDHA | lactate dehydrogenase A | 0.0308489 |
| RPL13A | ribosomal protein L13a | 0.0302139 |
| MCFD2 | multiple coagulation factor deficiency 2 | 0.0300791 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0296199 |
| SRRM1 | serine/arginine repetitive matrix 1 | 0.029591 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0293294 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0283338 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0281952 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0280936 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0276996 |
| TPM3 | tropomyosin 3 | 0.0276751 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0275509 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0274006 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0270471 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0270199 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0269721 |
| RASAL2 | RAS protein activator like 2 | 0.0267159 |
| TPI1 | triosephosphate isomerase 1 | 0.0265361 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0258916 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0256893 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | 0.025591 |
| RPS3 | ribosomal protein S3 | 0.0250834 |
| CLIP2 | CAP-GLY domain containing linker protein 2 | 0.0250686 |
| MKI67 | marker of proliferation Ki-67 | 0.0248645 |
| DST | dystonin | 0.024668 |
| MAPKAPK2 | mitogen-activated protein kinase-activated protein kinase 2 | 0.0242388 |
| GALNT2 | polypeptide N-acetylgalactosaminyltransferase 2 | 0.0240315 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | 0.0236537 |
| HLA-A | major histocompatibility complex, class I, A | 0.0235755 |
| HIPK2 | homeodomain interacting protein kinase 2 | 0.0235413 |
| PNN | pinin, desmosome associated protein | 0.023388 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0233709 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0230624 |
| RPL26 | ribosomal protein L26 | 0.0226526 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0226094 |
| NPAS2 | neuronal PAS domain protein 2 | 0.0225177 |
| RPL37A | ribosomal protein L37a | 0.0223941 |
| GPX4 | glutathione peroxidase 4 | 0.0220844 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0219691 |
| DUSP6 | dual specificity phosphatase 6 | 0.0219561 |
| RPL3 | ribosomal protein L3 | 0.0213918 |
| PALLD | palladin, cytoskeletal associated protein | 0.0212142 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0212136 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0210917 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0210013 |
| ATF4 | activating transcription factor 4 | 0.0208001 |
| TMF1 | TATA element modulatory factor 1 | 0.0207267 |
| RAB10 | RAB10, member RAS oncogene family | 0.0205963 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0205751 |
| SDC4 | syndecan 4 | 0.0204003 |
| ENAH | enabled homolog (Drosophila) | 0.0202124 |
| RPL4 | ribosomal protein L4 | 0.020126 |
| NXN | nucleoredoxin | 0.0200987 |
| S100A9 | S100 calcium binding protein A9 | 0.0200553 |
| CNBP | CCHC-type zinc finger, nucleic acid binding protein | 0.0197829 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0195006 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0193055 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | 0.0192962 |
| RPS17 | ribosomal protein S17 | 0.0189629 |
| RPL8 | ribosomal protein L8 | 0.0189082 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0188581 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | 0.0188426 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0188407 |
| WDR33 | WD repeat domain 33 | 0.0188078 |
| INSIG2 | insulin induced gene 2 | 0.0187275 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0186691 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.185922 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.143598 |
| FN1 | fibronectin 1 | -0.109663 |
| NDRG1 | N-myc downstream regulated 1 | -0.108399 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.10277 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0953459 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.0874849 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0697817 |
| RPL35A | ribosomal protein L35a | -0.0690448 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0669887 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0621424 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0596191 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0556209 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0511471 |
| SPAG9 | sperm associated antigen 9 | -0.05004 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0472934 |
| GNAS | GNAS complex locus | -0.0460474 |
| EGR1 | early growth response 1 | -0.0417505 |
| NRG1 | neuregulin 1 | -0.0404868 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0403126 |
| SYT1 | synaptotagmin I | -0.0395979 |
| TMSB10 | thymosin beta 10 | -0.0393703 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0387996 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0362762 |
| LCORL | ligand dependent nuclear receptor corepressor-like | -0.0343073 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0335877 |
| S100A6 | S100 calcium binding protein A6 | -0.0324891 |
| ITGA1 | integrin, alpha 1 | -0.0324218 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0318941 |
| HMGA1 | high mobility group AT-hook 1 | -0.0310617 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0306336 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0305147 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0292011 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0286969 |
| FBXW11 | F-box and WD repeat domain containing 11 | -0.0283419 |
| FNBP1 | formin binding protein 1 | -0.0281086 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0280965 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.028052 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0280127 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0278943 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0276695 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0274134 |
| MAP3K2 | mitogen-activated protein kinase kinase kinase 2 | -0.0272423 |
| IER3 | immediate early response 3 | -0.0271227 |
| COG5 | component of oligomeric golgi complex 5 | -0.0267329 |
| CPEB4 | cytoplasmic polyadenylation element binding protein 4 | -0.026525 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0265125 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0263634 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0261072 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0258485 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0254343 |
| RPLP1 | ribosomal protein, large, P1 | -0.0254083 |
| DNM1L | dynamin 1-like | -0.0253753 |
| HPCAL1 | hippocalcin-like 1 | -0.0253539 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0253211 |
| IBTK | inhibitor of Bruton agammaglobulinemia tyrosine kinase | -0.0247635 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0245211 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0237554 |
| RTN4 | reticulon 4 | -0.0235696 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0233773 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0232204 |
| SRP54 | signal recognition particle 54kDa | -0.0230485 |
| WDR45B | WD repeat domain 45B | -0.0229724 |
| NOP58 | NOP58 ribonucleoprotein | -0.0229636 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0229036 |
| PIM3 | Pim-3 proto-oncogene, serine/threonine kinase | -0.0228971 |
| HDLBP | high density lipoprotein binding protein | -0.0226652 |
| MORF4L2 | mortality factor 4 like 2 | -0.0226388 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0225752 |
| SDCBP | syndecan binding protein (syntenin) | -0.0225107 |
| ZNF207 | zinc finger protein 207 | -0.0224632 |
| FAM3C | family with sequence similarity 3, member C | -0.0222519 |
| RPS20 | ribosomal protein S20 | -0.0221103 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0221014 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0219244 |
| CCNH | cyclin H | -0.021718 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | -0.0215749 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0214732 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0214398 |
| MAP3K5 | mitogen-activated protein kinase kinase kinase 5 | -0.0211381 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0210698 |
| GLG1 | golgi glycoprotein 1 | -0.0208857 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0208803 |
| RUNX1 | runt-related transcription factor 1 | -0.0208457 |
| VEZT | vezatin, adherens junctions transmembrane protein | -0.0208395 |
| TFG | TRK-fused gene | -0.0207359 |
| CDC27 | cell division cycle 27 | -0.0206534 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0205694 |
| EIF2AK3 | eukaryotic translation initiation factor 2-alpha kinase 3 | -0.0205643 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0205602 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0204861 |
| ERO1B | endoplasmic reticulum oxidoreductase 1 beta | -0.020423 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0199161 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0198095 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0198032 |
| SLC38A1 | solute carrier family 38, member 1 | -0.0193913 |
| NUP58 | nucleoporin 58 | -0.0189582 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0189513 |
| GOLPH3L | golgi phosphoprotein 3-like | -0.0189223 |
| FOSL1 | FOS-like antigen 1 | -0.0188936 |
