Adenine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
LSAMP limbic system-associated membrane protein 0.131649
NALF1 NALCN channel auxiliary factor 1 0.109371
RNF213 ring finger protein 213 0.0717014
EEF2 eukaryotic translation elongation factor 2 0.0595563
PDE10A phosphodiesterase 10A 0.0590303
MSI2 musashi RNA-binding protein 2 0.054302
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0535073
TRIB2 tribbles pseudokinase 2 0.0531815
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0529818
PTPRD protein tyrosine phosphatase, receptor type, D 0.0529687
PLPP1 phospholipid phosphatase 1 0.0511789
RAD51B RAD51 paralog B 0.0498688
NPAS2 neuronal PAS domain protein 2 0.0494667
COL4A2 collagen, type IV, alpha 2 0.0491119
ACTG1 actin gamma 1 0.0491033
SRRM2 serine/arginine repetitive matrix 2 0.0486317
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0485024
FAM107B family with sequence similarity 107, member B 0.0479424
LRFN5 leucine rich repeat and fibronectin type III domain containing 5 0.0471795
IGFBP3 insulin-like growth factor binding protein 3 0.0471443
PACS1 phosphofurin acidic cluster sorting protein 1 0.0438478
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0435049
AOPEP aminopeptidase O (putative) 0.0408652
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0398546
IGF1R insulin-like growth factor 1 receptor 0.0394667
GSE1 Gse1 coiled-coil protein 0.0392046
PTPRG protein tyrosine phosphatase, receptor type, G 0.0387455
FTH1 ferritin, heavy polypeptide 1 0.0370413
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.0365765
SLC38A2 solute carrier family 38, member 2 0.035399
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0353911
DLC1 DLC1 Rho GTPase activating protein 0.0351536
CDH10 cadherin 10, type 2 (T2-cadherin) 0.034896
CALR calreticulin 0.0348585
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0347743
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0343962
NME2 NME/NM23 nucleoside diphosphate kinase 2 0.0340852
DTNA dystrobrevin, alpha 0.0338928
COL4A5 collagen, type IV, alpha 5 0.0336105
TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 0.0328839
PCBP3 poly(rC) binding protein 3 0.0326616
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0326493
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0325342
MTAP methylthioadenosine phosphorylase 0.0317518
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0311166
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0308713
TULP4 tubby like protein 4 0.0307929
EIF4A3 eukaryotic translation initiation factor 4A3 0.0305079
COL3A1 collagen, type III, alpha 1 0.0302095
RPLP0 ribosomal protein, large, P0 0.0300375
RPL31 ribosomal protein L31 0.030017
ARHGAP42 Rho GTPase activating protein 42 0.0297889
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0297825
TENM4 teneurin transmembrane protein 4 0.0295273
FN1 fibronectin 1 0.0294165
DNM3 dynamin 3 0.0289496
AFF3 AF4/FMR2 family, member 3 0.0285841
THSD7A thrombospondin, type I, domain containing 7A 0.0285329
CNTN4 contactin 4 0.0284791
CENPP centromere protein P 0.0284611
CSDE1 cold shock domain containing E1, RNA-binding 0.0278211
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 0.0273941
FHIT fragile histidine triad 0.0273398
ZNF609 zinc finger protein 609 0.0270583
CACNB2 calcium channel, voltage-dependent, beta 2 subunit 0.0268726
THSD4 thrombospondin, type I, domain containing 4 0.0266064
TBC1D4 TBC1 domain family, member 4 0.026591
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0261918
CPED1 cadherin-like and PC-esterase domain containing 1 0.026146
GAB2 GRB2-associated binding protein 2 0.0260423
TRPA1 transient receptor potential cation channel, subfamily A, member 1 0.0258262
PTPRK protein tyrosine phosphatase, receptor type, K 0.0257969
DDX42 DEAD (Asp-Glu-Ala-Asp) box helicase 42 0.0255407
RPL34 ribosomal protein L34 0.0249636
ARHGAP24 Rho GTPase activating protein 24 0.0249293
RPL36A ribosomal protein L36a 0.0249285
TGFB1 transforming growth factor, beta 1 0.0247978
CTSB cathepsin B 0.0247813
AHNAK AHNAK nucleoprotein 0.024594
RNF144A ring finger protein 144A 0.0245087
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0244989
MACROD1 MACRO domain containing 1 0.0244771
NUMA1 nuclear mitotic apparatus protein 1 0.0241249
VAV2 vav 2 guanine nucleotide exchange factor 0.0240561
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0239866
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.023662
PLAGL1 pleiomorphic adenoma gene-like 1 0.023543
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0234846
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0234676
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0233659
HDAC4 histone deacetylase 4 0.0233533
RBM39 RNA binding motif protein 39 0.0230841
RPL13A ribosomal protein L13a 0.0229031
SMAD6 SMAD family member 6 0.022876
CALU calumenin 0.0227853
CEMIP2 cell migration inducing hyaluronidase 2 0.0226969
PRSS12 protease, serine, 12 (neurotrypsin, motopsin) 0.0226235
SIK2 salt-inducible kinase 2 0.0225505
WAPL WAPL cohesin release factor 0.0224319
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.022363

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.396387
IGF2 insulin-like growth factor 2 -0.112561
FMN1 formin 1 -0.10639
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0780877
PTMA prothymosin, alpha -0.0728552
CLTC clathrin, heavy chain (Hc) -0.071773
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0689948
GOLGA4 golgin A4 -0.0664732
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0650242
ITPRID2 ITPR interacting domain containing 2 -0.0560645
TLE4 transducin-like enhancer of split 4 -0.0538257
GLG1 golgi glycoprotein 1 -0.0502397
SBF2 SET binding factor 2 -0.0495124
NAP1L1 nucleosome assembly protein 1-like 1 -0.0488225
PRRC2C proline-rich coiled-coil 2C -0.0483311
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0475582
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like -0.0466731
RPL38 ribosomal protein L38 -0.0460261
LPIN1 lipin 1 -0.0451268
PCM1 pericentriolar material 1 -0.0451062
PARD3 par-3 family cell polarity regulator -0.0450354
AKAP12 A kinase (PRKA) anchor protein 12 -0.0449255
DSCAM Down syndrome cell adhesion molecule -0.0445277
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.044355
ENAH enabled homolog (Drosophila) -0.0439047
RTN4 reticulon 4 -0.0433185
OGA O-GlcNAcase -0.0425856
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0424076
DST dystonin -0.0419166
ZNF292 zinc finger protein 292 -0.0409819
PAPOLA poly(A) polymerase alpha -0.0399447
PCBP2 poly(rC) binding protein 2 -0.0399224
PIAS1 protein inhibitor of activated STAT, 1 -0.0398966
MEIS2 Meis homeobox 2 -0.0393503
ERBIN erbb2 interacting protein -0.0391942
RPL37A ribosomal protein L37a -0.0390286
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0390237
ACSL3 acyl-CoA synthetase long-chain family member 3 -0.0388443
ZC3H11A zinc finger CCCH-type containing 11A -0.0377269
PHF21A PHD finger protein 21A -0.0368086
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0367377
TMF1 TATA element modulatory factor 1 -0.0363214
RPS2 ribosomal protein S2 -0.0360093
TPR translocated promoter region, nuclear basket protein -0.0356859
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0355971
TOR1AIP2 torsin A interacting protein 2 -0.0353739
AHCTF1 AT hook containing transcription factor 1 -0.0353558
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0353105
CEP350 centrosomal protein 350kDa -0.0352598
NPEPPS aminopeptidase puromycin sensitive -0.034878
NEK7 NIMA-related kinase 7 -0.0347195
XPO1 exportin 1 -0.0345331
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0345283
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0344435
TMSB10 thymosin beta 10 -0.0343893
TENT5A terminal nucleotidyltransferase 5A -0.0342718
NIPBL Nipped-B homolog (Drosophila) -0.033816
SQSTM1 sequestosome 1 -0.0337152
SOS1 son of sevenless homolog 1 (Drosophila) -0.0329606
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0328793
GOLGB1 golgin B1 -0.0324153
AHR aryl hydrocarbon receptor -0.0319983
ZFAND3 zinc finger, AN1-type domain 3 -0.0317013
MBTD1 mbt domain containing 1 -0.0313401
ZMYM2 zinc finger, MYM-type 2 -0.0309492
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0309336
PLCB4 phospholipase C, beta 4 -0.0309281
COG6 component of oligomeric golgi complex 6 -0.0305907
RBM33 RNA binding motif protein 33 -0.0305895
MXI1 MAX interactor 1, dimerization protein -0.0305409
PIBF1 progesterone immunomodulatory binding factor 1 -0.030522
KDM3A lysine (K)-specific demethylase 3A -0.0305154
PICALM phosphatidylinositol binding clathrin assembly protein -0.0304854
FBXL20 F-box and leucine-rich repeat protein 20 -0.0304741
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0303404
RC3H1 ring finger and CCCH-type domains 1 -0.0301975
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.030176
MYO9A myosin IXA -0.0300428
AP2B1 adaptor-related protein complex 2, beta 1 subunit -0.0300384
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0300036
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0297794
VCL vinculin -0.0297377
ATOSA atos homolog A -0.0296216
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -0.0295548
PEAK1 pseudopodium-enriched atypical kinase 1 -0.0295168
FKBP1A FK506 binding protein 1A, 12kDa -0.0294968
NBEA neurobeachin -0.0293487
SETD5 SET domain containing 5 -0.0293347
RPL12 ribosomal protein L12 -0.0291602
NFKBIZ nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta -0.0290739
NKTR natural killer cell triggering receptor -0.0290633
BPTF bromodomain PHD finger transcription factor -0.0286495
TAS2R14 taste receptor, type 2, member 14 -0.0283854
PDE8A phosphodiesterase 8A -0.0281692
ARHGAP32 Rho GTPase activating protein 32 -0.0280942
SF3B3 splicing factor 3b, subunit 3, 130kDa -0.0276629
WDR43 WD repeat domain 43 -0.0276557
NUP153 nucleoporin 153kDa -0.0275554
HMGB2 high mobility group box 2 -0.027453
SSH1 slingshot protein phosphatase 1 -0.0271892