Adenine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
MTSS1 metastasis suppressor 1 0.148078
TIMP3 TIMP metallopeptidase inhibitor 3 0.104977
LMO7 LIM domain 7 0.0883455
PODXL podocalyxin-like 0.0765803
FTH1 ferritin, heavy polypeptide 1 0.0716047
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0715633
PLEC plectin 0.0663233
SLC35F3 solute carrier family 35, member F3 0.0607953
TRIO trio Rho guanine nucleotide exchange factor 0.0580841
INTS6 integrator complex subunit 6 0.0572888
TGM2 transglutaminase 2 0.055166
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0538051
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0536653
SQSTM1 sequestosome 1 0.0528716
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0497458
RAI14 retinoic acid induced 14 0.0468683
LAMC2 laminin, gamma 2 0.0455126
PDLIM5 PDZ and LIM domain 5 0.0446706
NAV2 neuron navigator 2 0.0391229
ZMYND8 zinc finger, MYND-type containing 8 0.0385676
SULF2 sulfatase 2 0.0381863
MACF1 microtubule-actin crosslinking factor 1 0.0369857
MSN moesin 0.0368538
PCDH1 protocadherin 1 0.0358686
MEF2A myocyte enhancer factor 2A 0.0352567
PLS3 plastin 3 0.0347768
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 0.0344198
PTK2 protein tyrosine kinase 2 0.0336282
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0333821
HM13 histocompatibility (minor) 13 0.0317479
HLA-E major histocompatibility complex, class I, E 0.0317311
ALCAM activated leukocyte cell adhesion molecule 0.0314208
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.0291307
BCAR3 breast cancer anti-estrogen resistance 3 0.0281659
PDE4D phosphodiesterase 4D, cAMP-specific 0.0279768
EXT1 exostosin glycosyltransferase 1 0.027071
TINAGL1 tubulointerstitial nephritis antigen-like 1 0.0268552
AHNAK AHNAK nucleoprotein 0.026772
MPRIP myosin phosphatase Rho interacting protein 0.0259304
ZMIZ1 zinc finger, MIZ-type containing 1 0.0253847
SMYD3 SET and MYND domain containing 3 0.0251084
ANKRD11 ankyrin repeat domain 11 0.0250992
ANO1 anoctamin 1, calcium activated chloride channel 0.0248222
JMJD1C jumonji domain containing 1C 0.0247388
CDK6 cyclin-dependent kinase 6 0.0243942
DOK5 docking protein 5 0.0242582
CEMIP cell migration inducing protein, hyaluronan binding 0.02422
MYH9 myosin, heavy chain 9, non-muscle 0.0239324
DENND1A DENN/MADD domain containing 1A 0.0231396
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0230176
CDKN2A cyclin-dependent kinase inhibitor 2A 0.0226539
NCOR2 nuclear receptor corepressor 2 0.0224891
EHBP1L1 EH domain binding protein 1-like 1 0.0223596
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221259
HIVEP1 human immunodeficiency virus type I enhancer binding protein 1 0.0220973
VEGFA vascular endothelial growth factor A 0.0218651
EGFR epidermal growth factor receptor 0.0218345
CLIC4 chloride intracellular channel 4 0.0217352
HDAC9 histone deacetylase 9 0.0215643
SPIRE1 spire-type actin nucleation factor 1 0.0215218
AOPEP aminopeptidase O (putative) 0.0214537
N4BP2L2 NEDD4 binding protein 2-like 2 0.0213737
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0213402
EFNA5 ephrin-A5 0.0213313
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0211858
RALY RALY heterogeneous nuclear ribonucleoprotein 0.0206628
THSD4 thrombospondin, type I, domain containing 4 0.0204946
TRAPPC9 trafficking protein particle complex 9 0.0204239
ABI3BP ABI family, member 3 (NESH) binding protein 0.0203294
HSPG2 heparan sulfate proteoglycan 2 0.0202216
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0200993
KIAA1217 KIAA1217 0.0200942
WDFY2 WD repeat and FYVE domain containing 2 0.0200922
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0200516
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 0.0199873
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0199234
IARS1 isoleucyl-tRNA synthetase 1 0.0198659
HMGA2 high mobility group AT-hook 2 0.0198391
LAMA5 laminin, alpha 5 0.0198196
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0196562
UTRN utrophin 0.0194026
ASPH aspartate beta-hydroxylase 0.0192926
RNF217 ring finger protein 217 0.0189747
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0189398
CMIP c-Maf inducing protein 0.0189153
EXOC4 exocyst complex component 4 0.0188293
CORO2A coronin, actin binding protein, 2A 0.018741
PSD3 pleckstrin and Sec7 domain containing 3 0.0187373
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0186302
CDR2 cerebellar degeneration-related protein 2, 62kDa 0.0185825
RAD51B RAD51 paralog B 0.0184839
NIBAN2 niban apoptosis regulator 2 0.0184297
BHLHE40 basic helix-loop-helix family, member e40 0.0183128
PLTP phospholipid transfer protein 0.0182887
KDM4C lysine (K)-specific demethylase 4C 0.0182696
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 0.0182674
ATP9A ATPase, class II, type 9A 0.0182639
PTPRB protein tyrosine phosphatase, receptor type, B 0.0182492
BLCAP bladder cancer associated protein 0.0182302
GRB10 growth factor receptor-bound protein 10 0.0182171

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.114457
TMSB10 thymosin beta 10 -0.109795
MT2A metallothionein 2A -0.085126
RPS21 ribosomal protein S21 -0.059458
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0547643
CLU clusterin -0.0546979
TMSB4X thymosin beta 4, X-linked -0.0507238
GPRC5A G protein-coupled receptor, class C, group 5, member A -0.0480219
B2M beta-2-microglobulin -0.04468
YBX3 Y box binding protein 3 -0.0434667
ERC2 ELKS/RAB6-interacting/CAST family member 2 -0.0427504
LMNA lamin A/C -0.042356
VCL vinculin -0.0421261
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0412335
GNAS GNAS complex locus -0.0410695
RPS19 ribosomal protein S19 -0.040926
S100A10 S100 calcium binding protein A10 -0.0390269
PTMA prothymosin, alpha -0.0385023
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0375372
IFI16 interferon, gamma-inducible protein 16 -0.0367076
LOC112694756 uncharaterized LOC112694756 -0.0365951
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0350082
ANLN anillin, actin binding protein -0.0335272
ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein -0.0332749
NAMPT nicotinamide phosphoribosyltransferase -0.0328001
IFITM3 interferon induced transmembrane protein 3 -0.0326796
NDRG1 N-myc downstream regulated 1 -0.0324846
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0323092
RPL8 ribosomal protein L8 -0.0314669
RPLP2 ribosomal protein, large, P2 -0.0314327
MT1X metallothionein 1X -0.0311921
S100A4 S100 calcium binding protein A4 -0.0310544
IFI6 interferon, alpha-inducible protein 6 -0.030972
RPLP1 ribosomal protein, large, P1 -0.0304993
SLC25A5 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 -0.0299433
KRT17 keratin 17, type I -0.0298764
RPL32 ribosomal protein L32 -0.0290245
IER3 immediate early response 3 -0.0287994
S100A6 S100 calcium binding protein A6 -0.0282884
H1-0 H1.0 linker histone -0.0272507
ENO1 enolase 1, (alpha) -0.0271284
RPL12 ribosomal protein L12 -0.0267728
IFITM1 interferon induced transmembrane protein 1 -0.0267117
CUL4B cullin 4B -0.0264702
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -0.0263242
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0258533
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0249722
IGFBP4 insulin-like growth factor binding protein 4 -0.0249586
RPS6 ribosomal protein S6 -0.0249306
TAGLN2 transgelin 2 -0.0248548
KMT2E lysine (K)-specific methyltransferase 2E -0.0247434
SF3B2 splicing factor 3b, subunit 2, 145kDa -0.0243253
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0241614
RPL23 ribosomal protein L23 -0.0241495
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.024114
PFN1 profilin 1 -0.0239495
PGK1 phosphoglycerate kinase 1 -0.0236494
ATP5F1E ATP synthase F1 subunit epsilon -0.0234661
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0233023
TM4SF1 transmembrane 4 L six family member 1 -0.0231715
S100A9 S100 calcium binding protein A9 -0.0228277
ITGA6 integrin, alpha 6 -0.022485
PRELID2 PRELI domain containing 2 -0.0223984
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa -0.0223933
LMAN1 lectin, mannose-binding, 1 -0.0222387
SYPL1 synaptophysin-like 1 -0.0220165
CTNND1 catenin (cadherin-associated protein), delta 1 -0.0217846
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0217161
PLAT plasminogen activator, tissue -0.0216453
RPL36A ribosomal protein L36a -0.0215428
RPL35 ribosomal protein L35 -0.021354
WASF2 WAS protein family, member 2 -0.0212325
SAMD9 sterile alpha motif domain containing 9 -0.021141
SLC38A2 solute carrier family 38, member 2 -0.0210639
MORF4L2 mortality factor 4 like 2 -0.020702
DLG1 discs, large homolog 1 (Drosophila) -0.0205321
TPT1 tumor protein, translationally-controlled 1 -0.020457
FSCN1 fascin actin-bundling protein 1 -0.0204335
OGA O-GlcNAcase -0.020314
CNRIP1 cannabinoid receptor interacting protein 1 -0.0201884
UQCRB ubiquinol-cytochrome c reductase binding protein -0.0201827
ZNFX1 zinc finger, NFX1-type containing 1 -0.0201726
COX4I1 cytochrome c oxidase subunit IV isoform 1 -0.0197561
ITM2B integral membrane protein 2B -0.0192122
RSF1 remodeling and spacing factor 1 -0.0190235
TPX2 TPX2, microtubule-associated -0.0189722
RPS4X ribosomal protein S4, X-linked -0.0188261
IFIH1 interferon induced with helicase C domain 1 -0.0187404
RPL36 ribosomal protein L36 -0.0187358
MYL12B myosin, light chain 12B, regulatory -0.0187035
PLAC8 placenta-specific 8 -0.0183874
DSTN destrin (actin depolymerizing factor) -0.0183452
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0182275
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0182021
RB1CC1 RB1-inducible coiled-coil 1 -0.0181755
LIFR leukemia inhibitory factor receptor alpha -0.0181489
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.018141
RPLP0 ribosomal protein, large, P0 -0.0180936
IGF2 insulin-like growth factor 2 -0.0180926
MIDN midnolin -0.0180231