Adenine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.13527
FAT1 FAT atypical cadherin 1 0.132493
CEMIP cell migration inducing protein, hyaluronan binding 0.131733
KRT8 keratin 8, type II 0.120151
SPTBN1 spectrin, beta, non-erythrocytic 1 0.103294
LDHA lactate dehydrogenase A 0.0989754
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0958896
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0866279
LMO7 LIM domain 7 0.0713592
KRT18 keratin 18, type I 0.0666124
EREG epiregulin 0.0631631
ANXA2 annexin A2 0.0584977
ASPH aspartate beta-hydroxylase 0.0578232
H1-0 H1.0 linker histone 0.0572777
HSPA8 heat shock 70kDa protein 8 0.0536164
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0508356
NDRG1 N-myc downstream regulated 1 0.0471966
KLF5 Kruppel-like factor 5 (intestinal) 0.045915
MACF1 microtubule-actin crosslinking factor 1 0.0426648
PLEC plectin 0.0408575
ONECUT3 one cut homeobox 3 0.0403369
EEF2 eukaryotic translation elongation factor 2 0.0386415
MYH9 myosin, heavy chain 9, non-muscle 0.0378454
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0377109
PRELID2 PRELI domain containing 2 0.0350753
CALR calreticulin 0.0334454
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0333383
FTL ferritin, light polypeptide 0.0328794
POTEF POTE ankyrin domain family, member F 0.0328417
CLTC clathrin, heavy chain (Hc) 0.0324194
CEMIP2 cell migration inducing hyaluronidase 2 0.0321243
DSPP dentin sialophosphoprotein 0.0313415
ACTG1 actin gamma 1 0.0309526
PLAUR plasminogen activator, urokinase receptor 0.0308553
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.030627
GFPT1 glutamine--fructose-6-phosphate transaminase 1 0.0302721
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0294784
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0280872
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0278734
PKM pyruvate kinase, muscle 0.0269861
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.0266826
ENO1 enolase 1, (alpha) 0.026578
EIF1 eukaryotic translation initiation factor 1 0.026406
UBC ubiquitin C 0.0263955
RAB1A RAB1A, member RAS oncogene family 0.0261929
CD164 CD164 molecule, sialomucin 0.026066
PDZD8 PDZ domain containing 8 0.0252109
CAB39 calcium binding protein 39 0.0252071
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0251748
APP amyloid beta (A4) precursor protein 0.0250749
PGK1 phosphoglycerate kinase 1 0.0248896
MYO5B myosin VB 0.0248522
LAMB3 laminin, beta 3 0.0242039
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.023958
OGA O-GlcNAcase 0.0236132
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.023021
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0228925
FAM13A family with sequence similarity 13, member A 0.0228861
GLCE glucuronic acid epimerase 0.022796
TPM3 tropomyosin 3 0.0227831
GRB10 growth factor receptor-bound protein 10 0.022264
MPRIP myosin phosphatase Rho interacting protein 0.0219675
SKP1 S-phase kinase-associated protein 1 0.0219163
AHNAK AHNAK nucleoprotein 0.0219059
MBNL2 muscleblind-like splicing regulator 2 0.0216405
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0215284
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0213799
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0213739
JAG1 jagged 1 0.0213141
NEBL nebulette 0.0211894
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0211464
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0210379
SAMD4A sterile alpha motif domain containing 4A 0.0210276
SEL1L sel-1 suppressor of lin-12-like (C. elegans) 0.0210148
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0208943
ITPRID2 ITPR interacting domain containing 2 0.0208639
TBC1D22A TBC1 domain family, member 22A 0.0207324
ARL15 ADP-ribosylation factor-like 15 0.0205343
PRSS3 protease, serine, 3 0.0204856
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.020412
TMSB4X thymosin beta 4, X-linked 0.0203809
KDM3A lysine (K)-specific demethylase 3A 0.0201455
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0200897
MUC13 mucin 13, cell surface associated 0.020083
TUBB4B tubulin, beta 4B class IVb 0.0199534
TM9SF2 transmembrane 9 superfamily member 2 0.0198282
HOOK2 hook microtubule-tethering protein 2 0.0196382
TMEM45B transmembrane protein 45B 0.0194536
SPAG9 sperm associated antigen 9 0.0192319
HDLBP high density lipoprotein binding protein 0.0190539
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 0.0188382
EPS8 epidermal growth factor receptor pathway substrate 8 0.0186136
AXIN2 axin 2 0.018598
EIF4A2 eukaryotic translation initiation factor 4A2 0.0185096
ARFGEF3 ARFGEF family member 3 0.0185062
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0184926
UBE2E1 ubiquitin-conjugating enzyme E2E 1 0.0184805
ZFAND3 zinc finger, AN1-type domain 3 0.0183404
SPRED2 sprouty-related, EVH1 domain containing 2 0.0181815
TPM4 tropomyosin 4 0.0181084

decreased expression

Symbol Name Standardized Value
TMSB10 thymosin beta 10 -0.296184
NPSR1 neuropeptide S receptor 1 -0.224679
RPS6 ribosomal protein S6 -0.154073
MUC6 mucin 6, oligomeric mucus/gel-forming -0.139856
PTMA prothymosin, alpha -0.108975
GPHN gephyrin -0.105592
MUC5AC mucin 5AC, oligomeric mucus/gel-forming -0.10518
LOC102724023 ES1 protein homolog, mitochondrial -0.0832414
RPS19 ribosomal protein S19 -0.0706375
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0612934
RPLP1 ribosomal protein, large, P1 -0.0611917
RPL34 ribosomal protein L34 -0.0588874
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0573282
SOX4 SRY (sex determining region Y)-box 4 -0.0534748
TFF3 trefoil factor 3 (intestinal) -0.0498664
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0495257
MUC5B mucin 5B, oligomeric mucus/gel-forming -0.0476815
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0468663
RPS21 ribosomal protein S21 -0.0466938
HMGA1 high mobility group AT-hook 1 -0.0466559
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0436324
RPLP2 ribosomal protein, large, P2 -0.0430339
CD46 CD46 molecule, complement regulatory protein -0.0427917
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.0427895
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0420843
RPL36 ribosomal protein L36 -0.0420189
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0417658
RPL35A ribosomal protein L35a -0.0396961
RPL23 ribosomal protein L23 -0.0395373
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0393533
RPL5 ribosomal protein L5 -0.0391479
ALCAM activated leukocyte cell adhesion molecule -0.0386164
RPL18 ribosomal protein L18 -0.0375984
CALB1 calbindin 1, 28kDa -0.0371678
PFN1 profilin 1 -0.0368339
RPL8 ribosomal protein L8 -0.0366664
S100A6 S100 calcium binding protein A6 -0.0364214
PIGR polymeric immunoglobulin receptor -0.0363992
CBX3 chromobox homolog 3 -0.0361361
LGALS3 lectin, galactoside-binding, soluble, 3 -0.0358273
PDE4D phosphodiesterase 4D, cAMP-specific -0.0345084
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0335183
MECOM MDS1 and EVI1 complex locus -0.0332436
ANTXR2 anthrax toxin receptor 2 -0.0331243
RPS8 ribosomal protein S8 -0.0328662
RPL37A ribosomal protein L37a -0.0322873
INSIG1 insulin induced gene 1 -0.0322627
RPS14 ribosomal protein S14 -0.0320491
RBM25 RNA binding motif protein 25 -0.0320472
EIF5B eukaryotic translation initiation factor 5B -0.0319708
RPL12 ribosomal protein L12 -0.0318402
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.0318044
RPL32 ribosomal protein L32 -0.03175
PTPRK protein tyrosine phosphatase, receptor type, K -0.0310978
TFF1 trefoil factor 1 -0.0309875
RPS25 ribosomal protein S25 -0.0309789
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0306049
PPARG peroxisome proliferator-activated receptor gamma -0.0305199
LSAMP limbic system-associated membrane protein -0.0303787
ATRX alpha thalassemia/mental retardation syndrome X-linked -0.0299676
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.029603
PTEN phosphatase and tensin homolog -0.0295744
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0293863
RPL27A ribosomal protein L27a -0.0290788
SMARCC1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 -0.0288549
FHIT fragile histidine triad -0.0286431
ZFP36L2 ZFP36 ring finger protein-like 2 -0.0278898
GREB1L growth regulation by estrogen in breast cancer-like -0.0277579
ASTN2 astrotactin 2 -0.0277238
RPL9 ribosomal protein L9 -0.0274039
TPT1 tumor protein, translationally-controlled 1 -0.0273463
RPS27A ribosomal protein S27a -0.0257725
UBE2R2 ubiquitin-conjugating enzyme E2R 2 -0.0257497
HMGB1 high mobility group box 1 -0.0255022
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.025354
RNF217 ring finger protein 217 -0.0249675
GTF2A2 general transcription factor IIA, 2, 12kDa -0.0248761
BPTF bromodomain PHD finger transcription factor -0.024861
S100A14 S100 calcium binding protein A14 -0.0245911
S100A9 S100 calcium binding protein A9 -0.024261
PA2G4 proliferation-associated 2G4, 38kDa -0.0240277
BCKDHB branched chain keto acid dehydrogenase E1, beta polypeptide -0.0240086
RPS29 ribosomal protein S29 -0.0238619
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.0238404
TPM1 tropomyosin 1 (alpha) -0.0231666
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0229365
SCAF11 SR-related CTD-associated factor 11 -0.0229059
RPS16 ribosomal protein S16 -0.022704
PCBP2 poly(rC) binding protein 2 -0.0224268
VCL vinculin -0.0223956
EEPD1 endonuclease/exonuclease/phosphatase family domain containing 1 -0.0221943
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0220487
UBE2K ubiquitin-conjugating enzyme E2K -0.0218249
RPL21 ribosomal protein L21 -0.0217772
SRSF11 serine/arginine-rich splicing factor 11 -0.0213987
RPL26 ribosomal protein L26 -0.0213554
GTF2IRD1 GTF2I repeat domain containing 1 -0.0212801
RPL36A ribosomal protein L36a -0.0210853
MGST1 microsomal glutathione S-transferase 1 -0.0209762
GMDS GDP-mannose 4,6-dehydratase -0.0206956