Adenine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.133779
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.102425
THSD4 thrombospondin, type I, domain containing 4 0.100723
GRAMD1B GRAM domain containing 1B 0.0881051
MCL1 myeloid cell leukemia 1 0.0736417
PDE10A phosphodiesterase 10A 0.0663871
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0630902
POTEF POTE ankyrin domain family, member F 0.058951
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0490011
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.048679
AFF3 AF4/FMR2 family, member 3 0.0485922
DOCK5 dedicator of cytokinesis 5 0.0484703
ATP11A ATPase, class VI, type 11A 0.0457034
SMAD3 SMAD family member 3 0.0449901
FMNL2 formin-like 2 0.044495
PDE4D phosphodiesterase 4D, cAMP-specific 0.0442383
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0442117
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.0438207
EEF2 eukaryotic translation elongation factor 2 0.0430476
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0425077
ERRFI1 ERBB receptor feedback inhibitor 1 0.0406868
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0406544
ZCCHC7 zinc finger, CCHC domain containing 7 0.0389064
PRKCE protein kinase C, epsilon 0.0375256
COPA coatomer protein complex, subunit alpha 0.037213
IGF1R insulin-like growth factor 1 receptor 0.0370142
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0355936
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0355489
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0352037
EPAS1 endothelial PAS domain protein 1 0.0351761
OSMR oncostatin M receptor 0.0350733
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0349258
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 0.0348352
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0332336
EXOC4 exocyst complex component 4 0.0330826
MACF1 microtubule-actin crosslinking factor 1 0.0329615
EGFR epidermal growth factor receptor 0.0324122
UBAP2L ubiquitin associated protein 2-like 0.03149
SHB Src homology 2 domain containing adaptor protein B 0.0303665
YAP1 Yes-associated protein 1 0.0302323
ATXN1 ataxin 1 0.0297031
ERC1 ELKS/RAB6-interacting/CAST family member 1 0.0294207
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0289374
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 0.0288859
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 0.0279511
WWOX WW domain containing oxidoreductase 0.0279042
RNF213 ring finger protein 213 0.0274204
LPP LIM domain containing preferred translocation partner in lipoma 0.0264727
RABGAP1L RAB GTPase activating protein 1-like 0.0261377
RAD51B RAD51 paralog B 0.0259895
HMGA2 high mobility group AT-hook 2 0.0258548
PLEC plectin 0.0254075
ATP13A3 ATPase type 13A3 0.0253559
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0249882
PRELID2 PRELI domain containing 2 0.0249358
PDLIM5 PDZ and LIM domain 5 0.0249167
ANKRD36 ankyrin repeat domain 36 0.0243651
OGT O-linked N-acetylglucosamine (GlcNAc) transferase 0.0240529
VMP1 vacuole membrane protein 1 0.0238031
FNDC3B fibronectin type III domain containing 3B 0.0237802
MYH9 myosin, heavy chain 9, non-muscle 0.0233833
PYGL phosphorylase, glycogen, liver 0.0232863
ACTN1 actinin, alpha 1 0.0231905
LOXL2 lysyl oxidase-like 2 0.0230026
SND1 staphylococcal nuclease and tudor domain containing 1 0.0227836
PTK2 protein tyrosine kinase 2 0.0226024
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0223836
HDAC4 histone deacetylase 4 0.0223326
ANO6 anoctamin 6 0.0220594
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0218445
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like 0.0215455
INTS1 integrator complex subunit 1 0.0214233
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0210501
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0206735
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0205125
DPYSL2 dihydropyrimidinase-like 2 0.0203544
CCNL1 cyclin L1 0.0202626
DOCK1 dedicator of cytokinesis 1 0.0200948
TPM3 tropomyosin 3 0.0200792
AEBP2 AE binding protein 2 0.0200046
PDE4B phosphodiesterase 4B, cAMP-specific 0.0198721
FTH1 ferritin, heavy polypeptide 1 0.0198263
SVIL supervillin 0.0196081
AGRN agrin 0.0193918
EXT1 exostosin glycosyltransferase 1 0.0191454
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0189494
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.0189373
SAMD4A sterile alpha motif domain containing 4A 0.0189015
NTSR1 neurotensin receptor 1 (high affinity) 0.0188635
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0185112
PHF21A PHD finger protein 21A 0.0184665
KIRREL1 kirre like nephrin family adhesion molecule 1 0.0183936
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0180735
ZYX zyxin 0.018069
INTS3 integrator complex subunit 3 0.0180514
NCOR2 nuclear receptor corepressor 2 0.0179677
TBC1D22A TBC1 domain family, member 22A 0.0179197
CEP250 centrosomal protein 250kDa 0.0175186
R3HDM2 R3H domain containing 2 0.0174089
FLNA filamin A, alpha 0.0171789

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.208666
TFPI2 tissue factor pathway inhibitor 2 -0.158278
PTMA prothymosin, alpha -0.103549
TMSB10 thymosin beta 10 -0.102349
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0840625
VIM vimentin -0.0754091
CALM2 calmodulin 2 (phosphorylase kinase, delta) -0.0642679
RPS21 ribosomal protein S21 -0.0633834
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0632058
RPS3 ribosomal protein S3 -0.0629577
KTN1 kinectin 1 (kinesin receptor) -0.0600461
TXNRD1 thioredoxin reductase 1 -0.0580939
RPS8 ribosomal protein S8 -0.0571568
RPL12 ribosomal protein L12 -0.0560716
NIPBL Nipped-B homolog (Drosophila) -0.0554039
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0529581
RPL26 ribosomal protein L26 -0.0519096
RPL37A ribosomal protein L37a -0.0511847
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0502245
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0496137
MYL12B myosin, light chain 12B, regulatory -0.0495763
TPI1 triosephosphate isomerase 1 -0.0494328
TPT1 tumor protein, translationally-controlled 1 -0.0483312
RPL19 ribosomal protein L19 -0.0460264
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0442366
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0437454
RPL11 ribosomal protein L11 -0.0436624
RPL23 ribosomal protein L23 -0.0433819
RPL38 ribosomal protein L38 -0.0423936
RPL35A ribosomal protein L35a -0.0420228
RPL37 ribosomal protein L37 -0.0418134
RPS15 ribosomal protein S15 -0.0416442
RPS19 ribosomal protein S19 -0.0411899
RTN4 reticulon 4 -0.0409528
RPS29 ribosomal protein S29 -0.0408597
RPLP1 ribosomal protein, large, P1 -0.0403955
SMC4 structural maintenance of chromosomes 4 -0.0403594
MT2A metallothionein 2A -0.0393904
KDM3A lysine (K)-specific demethylase 3A -0.0389769
RPLP2 ribosomal protein, large, P2 -0.0382034
RPLP0 ribosomal protein, large, P0 -0.0381712
PHIP pleckstrin homology domain interacting protein -0.0378244
RPS12 ribosomal protein S12 -0.0368403
SEPTIN7 septin 7 -0.0365491
RPS6 ribosomal protein S6 -0.0364479
RPS27 ribosomal protein S27 -0.0359959
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0355567
RPS2 ribosomal protein S2 -0.0355473
PRRC2C proline-rich coiled-coil 2C -0.0343257
EIF5B eukaryotic translation initiation factor 5B -0.0342622
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0337122
PFN1 profilin 1 -0.033485
RPS27A ribosomal protein S27a -0.033346
XPO1 exportin 1 -0.0333442
NAP1L1 nucleosome assembly protein 1-like 1 -0.0333133
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0330636
RPL5 ribosomal protein L5 -0.0327329
YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta -0.0325788
RPL31 ribosomal protein L31 -0.032453
MKI67 marker of proliferation Ki-67 -0.0323344
RPL9 ribosomal protein L9 -0.0320721
EIF1 eukaryotic translation initiation factor 1 -0.0316749
RPL32 ribosomal protein L32 -0.031633
RPL34 ribosomal protein L34 -0.0311273
CENPF centromere protein F, 350/400kDa -0.0305212
RPL36 ribosomal protein L36 -0.0304956
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) -0.0298261
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0297052
ANKRD12 ankyrin repeat domain 12 -0.0294173
ACTR2 ARP2 actin-related protein 2 homolog (yeast) -0.0292158
RPS24 ribosomal protein S24 -0.0286223
RPS10 ribosomal protein S10 -0.0285291
FTL ferritin, light polypeptide -0.0281984
RPL8 ribosomal protein L8 -0.0280531
RB1CC1 RB1-inducible coiled-coil 1 -0.0269258
GNAS GNAS complex locus -0.0267633
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 -0.0265717
RACK1 receptor for activated C kinase 1 -0.0264975
S100A10 S100 calcium binding protein A10 -0.0264925
FBXO11 F-box protein 11 -0.0263271
RPS25 ribosomal protein S25 -0.0261218
SGO2 shugoshin 2 -0.0260511
RPL36A ribosomal protein L36a -0.0256568
TUBA1B tubulin, alpha 1b -0.0255789
NACA nascent polypeptide-associated complex alpha subunit -0.0255778
CAVIN1 caveolae associated protein 1 -0.02552
GOLGA4 golgin A4 -0.0253366
WSB1 WD repeat and SOCS box containing 1 -0.0252622
ZFR zinc finger RNA binding protein -0.0247939
RPS13 ribosomal protein S13 -0.0246621
H3-3B H3.3 histone B -0.0246146
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0245966
KIF5B kinesin family member 5B -0.0245964
CCND2 cyclin D2 -0.0243042
TPX2 TPX2, microtubule-associated -0.024056
SET SET nuclear proto-oncogene -0.0239453
CSDE1 cold shock domain containing E1, RNA-binding -0.0238734
S100A11 S100 calcium binding protein A11 -0.0237712
RPL17-C18ORF32 RPL17-C18orf32 readthrough -0.0234386
SRP72 signal recognition particle 72kDa -0.0233448