Adenine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
Similar Terms
Downloads & Tools

Genes

200 genes differentially expressed following the Adenine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
POTEF POTE ankyrin domain family, member F 0.0634685
TSC22D2 TSC22 domain family, member 2 0.0590624
TENM3 teneurin transmembrane protein 3 0.0558576
PDGFC platelet derived growth factor C 0.0483357
ANK2 ankyrin 2, neuronal 0.0482793
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.0457535
PCLO piccolo presynaptic cytomatrix protein 0.0446294
DST dystonin 0.0440424
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0432109
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0396061
PRTG protogenin 0.0387956
NTM neurotrimin 0.0371126
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0368077
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0343508
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0341128
TOX thymocyte selection-associated high mobility group box 0.0334801
ZFR zinc finger RNA binding protein 0.0331767
XPO1 exportin 1 0.0327028
MKI67 marker of proliferation Ki-67 0.0326285
ZNF608 zinc finger protein 608 0.0323331
ELF2 E74-like factor 2 (ets domain transcription factor) 0.0318062
NCOA2 nuclear receptor coactivator 2 0.0316355
ADGRV1 adhesion G protein-coupled receptor V1 0.0312279
STAG2 stromal antigen 2 0.0305775
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0298672
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.02981
NHSL1 NHS-like 1 0.0290534
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0288498
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.028646
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0283873
ZNF292 zinc finger protein 292 0.0283465
FNDC3B fibronectin type III domain containing 3B 0.0276347
SFPQ splicing factor proline/glutamine-rich 0.0266491
FER fer (fps/fes related) tyrosine kinase 0.0263876
SMYD3 SET and MYND domain containing 3 0.0263131
HDAC9 histone deacetylase 9 0.0260916
GOLPH3 golgi phosphoprotein 3 (coat-protein) 0.0256403
TENM2 teneurin transmembrane protein 2 0.0244967
AMBRA1 autophagy/beclin-1 regulator 1 0.0240548
RANBP9 RAN binding protein 9 0.0239812
YBX1 Y box binding protein 1 0.0237851
ARB2A ARB2 cotranscriptional regulator A 0.0236347
CENPF centromere protein F, 350/400kDa 0.023606
DPYD dihydropyrimidine dehydrogenase 0.0233495
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0233389
TCF12 transcription factor 12 0.0228679
PCBP2 poly(rC) binding protein 2 0.0228592
RB1CC1 RB1-inducible coiled-coil 1 0.022726
ARID1B AT rich interactive domain 1B (SWI1-like) 0.0225349
TRPS1 trichorhinophalangeal syndrome I 0.0224958
CADM2 cell adhesion molecule 2 0.0223109
RREB1 ras responsive element binding protein 1 0.0220833
MICAL3 microtubule associated monooxygenase, calponin and LIM domain containing 3 0.0220089
GARS1 glycyl-tRNA synthetase 1 0.0219426
GPC4 glypican 4 0.0218823
ANXA5 annexin A5 0.0216806
FAT1 FAT atypical cadherin 1 0.0212597
TUBA1B tubulin, alpha 1b 0.021167
NDC80 NDC80 kinetochore complex component 0.0211104
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A 0.0206447
DNMT1 DNA (cytosine-5-)-methyltransferase 1 0.0206065
GREB1L growth regulation by estrogen in breast cancer-like 0.0205834
RICTOR RPTOR independent companion of MTOR, complex 2 0.0205796
SDHA succinate dehydrogenase complex, subunit A, flavoprotein (Fp) 0.0205582
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0205199
TOP2A topoisomerase (DNA) II alpha 170kDa 0.0205139
TPM3 tropomyosin 3 0.0204299
EEF2 eukaryotic translation elongation factor 2 0.0203227
SNX13 sorting nexin 13 0.0202965
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 0.0201866
THOC1 THO complex 1 0.0201643
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0200406
CRISPLD1 cysteine-rich secretory protein LCCL domain containing 1 0.0199536
CUL2 cullin 2 0.0198756
DYNC1I2 dynein, cytoplasmic 1, intermediate chain 2 0.019793
CEP135 centrosomal protein 135kDa 0.0197415
HNRNPM heterogeneous nuclear ribonucleoprotein M 0.0197139
PRKD1 protein kinase D1 0.0196922
LEMD3 LEM domain containing 3 0.0196596
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0195927
SFMBT1 Scm-like with four mbt domains 1 0.0194592
EXOC2 exocyst complex component 2 0.0193114
RBM33 RNA binding motif protein 33 0.0192963
EPB41L2 erythrocyte membrane protein band 4.1-like 2 0.0192366
ACSL3 acyl-CoA synthetase long-chain family member 3 0.0191168
NFIB nuclear factor I/B 0.0191002
HMGB2 high mobility group box 2 0.0187888
PFN1 profilin 1 0.018787
PCDH18 protocadherin 18 0.0186839
TAOK1 TAO kinase 1 0.0186759
ASXL2 additional sex combs like transcriptional regulator 2 0.0185766
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 0.0183898
PBX3 pre-B-cell leukemia homeobox 3 0.018368
NUP58 nucleoporin 58 0.0183186
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0182265
CLSPN claspin 0.018201
TEX11 testis expressed 11 0.0181778
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 0.0181113
SPECC1 sperm antigen with calponin homology and coiled-coil domains 1 0.0179152
U2SURP U2 snRNP-associated SURP domain containing 0.0179049

decreased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha -0.213065
VIM vimentin -0.165043
RPS16 ribosomal protein S16 -0.131889
TMSB10 thymosin beta 10 -0.122405
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.114069
TPT1 tumor protein, translationally-controlled 1 -0.102991
RPL35A ribosomal protein L35a -0.0922652
RPS8 ribosomal protein S8 -0.0874665
ISG15 ISG15 ubiquitin-like modifier -0.0793367
RPL37 ribosomal protein L37 -0.0739118
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0734613
WSB1 WD repeat and SOCS box containing 1 -0.0718196
MDK midkine (neurite growth-promoting factor 2) -0.0692027
COL1A2 collagen, type I, alpha 2 -0.0681662
RPL31 ribosomal protein L31 -0.0675681
B2M beta-2-microglobulin -0.0656831
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 -0.0654421
GNAS GNAS complex locus -0.0640313
RPL11 ribosomal protein L11 -0.0624884
ANKRD33B ankyrin repeat domain 33B -0.0620866
RPS24 ribosomal protein S24 -0.0580734
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0580653
RPL9 ribosomal protein L9 -0.0570091
COL3A1 collagen, type III, alpha 1 -0.0568739
GPC3 glypican 3 -0.0567289
RPL37A ribosomal protein L37a -0.0551723
RPS27A ribosomal protein S27a -0.0550974
SPAG9 sperm associated antigen 9 -0.054811
CAVIN1 caveolae associated protein 1 -0.0525121
EIF1 eukaryotic translation initiation factor 1 -0.0514992
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0509245
RPL23 ribosomal protein L23 -0.0486048
RPS6 ribosomal protein S6 -0.0482726
RPL34 ribosomal protein L34 -0.0462807
RPL19 ribosomal protein L19 -0.0453234
RPS21 ribosomal protein S21 -0.0452832
RPS12 ribosomal protein S12 -0.044808
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.0431315
ANKRD12 ankyrin repeat domain 12 -0.0430525
NRG1 neuregulin 1 -0.04259
RPL26 ribosomal protein L26 -0.0425374
RIGI RNA sensor RIG-I -0.0416827
PLPP1 phospholipid phosphatase 1 -0.0408081
MYL12B myosin, light chain 12B, regulatory -0.0399354
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.039014
RPS25 ribosomal protein S25 -0.0389424
TBCA tubulin folding cofactor A -0.038878
PCDH9 protocadherin 9 -0.0388083
FNDC3A fibronectin type III domain containing 3A -0.038803
RPS19 ribosomal protein S19 -0.0386325
CTNNA2 catenin (cadherin-associated protein), alpha 2 -0.0386169
APOE apolipoprotein E -0.0378453
RPLP2 ribosomal protein, large, P2 -0.0373924
S100A10 S100 calcium binding protein A10 -0.0367847
PGAP1 post-GPI attachment to proteins 1 -0.0363743
PTGES3 prostaglandin E synthase 3 (cytosolic) -0.0362909
RPL12 ribosomal protein L12 -0.0362309
RPS13 ribosomal protein S13 -0.0361185
FTL ferritin, light polypeptide -0.0357408
NEBL nebulette -0.0353416
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0340901
RSL1D1 ribosomal L1 domain containing 1 -0.0339238
ATF4 activating transcription factor 4 -0.0334959
SYT1 synaptotagmin I -0.0332894
IFIH1 interferon induced with helicase C domain 1 -0.0325823
RPS10 ribosomal protein S10 -0.0325538
AKAP12 A kinase (PRKA) anchor protein 12 -0.0325283
RPL7A ribosomal protein L7a -0.0323522
RPS17 ribosomal protein S17 -0.032129
RACK1 receptor for activated C kinase 1 -0.0320476
MAP4 microtubule-associated protein 4 -0.0318369
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0316709
IGF2 insulin-like growth factor 2 -0.0314494
RPL38 ribosomal protein L38 -0.0305016
RPL27 ribosomal protein L27 -0.0304919
ACTG1 actin gamma 1 -0.0299262
RPL36A ribosomal protein L36a -0.0297938
MRPS6 mitochondrial ribosomal protein S6 -0.0297684
LYST lysosomal trafficking regulator -0.0294388
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0293195
CNRIP1 cannabinoid receptor interacting protein 1 -0.0292962
RPS3 ribosomal protein S3 -0.0291806
UBE2K ubiquitin-conjugating enzyme E2K -0.0290289
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0288319
PDE4D phosphodiesterase 4D, cAMP-specific -0.0287574
ST13 suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) -0.0285927
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0285799
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0285215
RPS15 ribosomal protein S15 -0.0284017
ADNP activity-dependent neuroprotector homeobox -0.0283715
AKAP9 A kinase (PRKA) anchor protein 9 -0.0282604
MCL1 myeloid cell leukemia 1 -0.0281387
ARID4B AT rich interactive domain 4B (RBP1-like) -0.028064
RAB2A RAB2A, member RAS oncogene family -0.0276826
IQGAP1 IQ motif containing GTPase activating protein 1 -0.0275651
MORF4L2 mortality factor 4 like 2 -0.027075
ZEB2 zinc finger E-box binding homeobox 2 -0.0269214
NACA nascent polypeptide-associated complex alpha subunit -0.0268753
INTS6 integrator complex subunit 6 -0.0268561
PCDH7 protocadherin 7 -0.0268039