Adenine_SNU-1 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in SNU-1 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenine_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PTMA prothymosin, alpha 0.0766217
EEF2 eukaryotic translation elongation factor 2 0.0753267
PKM pyruvate kinase, muscle 0.0700132
TMSB4X thymosin beta 4, X-linked 0.0630563
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0597877
POTEF POTE ankyrin domain family, member F 0.0595333
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0589402
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0535536
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0528117
ZNF292 zinc finger protein 292 0.0511375
ADAM10 ADAM metallopeptidase domain 10 0.0504583
EML4 echinoderm microtubule associated protein like 4 0.0460761
RTN4 reticulon 4 0.0458201
TXNRD1 thioredoxin reductase 1 0.0438362
EZR ezrin 0.0430974
B2M beta-2-microglobulin 0.0427938
AHNAK AHNAK nucleoprotein 0.0427937
SCD stearoyl-CoA desaturase (delta-9-desaturase) 0.0410125
ZFAND3 zinc finger, AN1-type domain 3 0.0403679
RHOA ras homolog family member A 0.0386937
MINDY2 MINDY lysine 48 deubiquitinase 2 0.0383181
PYGB phosphorylase, glycogen; brain 0.0381808
SSBP2 single-stranded DNA binding protein 2 0.0357939
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 0.0342717
KMT2E lysine (K)-specific methyltransferase 2E 0.033994
ACTG1 actin gamma 1 0.0338434
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 0.0336769
NCKAP1 NCK-associated protein 1 0.0336199
PDE4D phosphodiesterase 4D, cAMP-specific 0.0331222
ZEB1 zinc finger E-box binding homeobox 1 0.0326317
UBR5 ubiquitin protein ligase E3 component n-recognin 5 0.0325523
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme 0.0321645
EGFR epidermal growth factor receptor 0.0318935
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) 0.0313378
PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 0.0310533
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A 0.0310288
NAMPT nicotinamide phosphoribosyltransferase 0.0301024
CCNL1 cyclin L1 0.0299181
SRRM2 serine/arginine repetitive matrix 2 0.0298565
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0297016
KDM3A lysine (K)-specific demethylase 3A 0.0278388
WAC WW domain containing adaptor with coiled-coil 0.0271034
KIF5B kinesin family member 5B 0.0269026
RNF145 ring finger protein 145 0.0258163
NCEH1 neutral cholesterol ester hydrolase 1 0.025634
TFG TRK-fused gene 0.0255786
CDC73 cell division cycle 73 0.0244518
SPTAN1 spectrin, alpha, non-erythrocytic 1 0.0242383
LPP LIM domain containing preferred translocation partner in lipoma 0.0239895
MACF1 microtubule-actin crosslinking factor 1 0.0235488
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0235436
LDHA lactate dehydrogenase A 0.0235167
ADAM9 ADAM metallopeptidase domain 9 0.023311
QKI QKI, KH domain containing, RNA binding 0.0233054
HDAC9 histone deacetylase 9 0.0231778
FXR1 fragile X mental retardation, autosomal homolog 1 0.0231414
ANKRD11 ankyrin repeat domain 11 0.0231172
NBAS neuroblastoma amplified sequence 0.0229337
CNOT6L CCR4-NOT transcription complex, subunit 6-like 0.0228525
CALR calreticulin 0.0225951
ARL15 ADP-ribosylation factor-like 15 0.022495
GSK3B glycogen synthase kinase 3 beta 0.0222467
DSCAM Down syndrome cell adhesion molecule 0.0221555
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0217774
SETD5 SET domain containing 5 0.0217119
DSTN destrin (actin depolymerizing factor) 0.0216947
BMP2K BMP2 inducible kinase 0.0213869
EIF4A2 eukaryotic translation initiation factor 4A2 0.0211621
BRWD1 bromodomain and WD repeat domain containing 1 0.0211509
FLNB filamin B, beta 0.0211447
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0210481
HSPA9 heat shock 70kDa protein 9 (mortalin) 0.0209043
PHIP pleckstrin homology domain interacting protein 0.0208638
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0208551
RERE arginine-glutamic acid dipeptide (RE) repeats 0.0208441
SNX9 sorting nexin 9 0.0206623
PRRC2C proline-rich coiled-coil 2C 0.0206613
TXNIP thioredoxin interacting protein 0.0204538
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) 0.0201863
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0200183
DOCK3 dedicator of cytokinesis 3 0.0199822
PTBP2 polypyrimidine tract binding protein 2 0.0198621
AMOTL2 angiomotin like 2 0.0196717
STRN3 striatin, calmodulin binding protein 3 0.0194937
JMJD1C jumonji domain containing 1C 0.0192759
RAD23B RAD23 homolog B (S. cerevisiae) 0.0192164
VMP1 vacuole membrane protein 1 0.019173
BTBD9 BTB (POZ) domain containing 9 0.0191664
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0191456
XPO1 exportin 1 0.0189198
RPL13A ribosomal protein L13a 0.0189092
ANXA1 annexin A1 0.0187514
GARS1 glycyl-tRNA synthetase 1 0.0187419
USP3 ubiquitin specific peptidase 3 0.018577
VGLL4 vestigial-like family member 4 0.0185372
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0184934
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0184757
EIF4A1 eukaryotic translation initiation factor 4A1 0.0183653
PDGFC platelet derived growth factor C 0.0183317
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform 0.0182142

decreased expression

Symbol Name Standardized Value
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0789518
CPED1 cadherin-like and PC-esterase domain containing 1 -0.0683575
PDE4B phosphodiesterase 4B, cAMP-specific -0.0631426
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.062408
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0536101
BMP10 bone morphogenetic protein 10 -0.0372659
CACNB4 calcium channel, voltage-dependent, beta 4 subunit -0.0360705
SLC1A3 solute carrier family 1 (glial high affinity glutamate transporter), member 3 -0.0343012
FHIT fragile histidine triad -0.0335515
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0286234
CAMKMT calmodulin-lysine N-methyltransferase -0.0253232
RFC3 replication factor C (activator 1) 3, 38kDa -0.0212145
DIAPH3 diaphanous-related formin 3 -0.0207955
TTC28 tetratricopeptide repeat domain 28 -0.0197063
MYOF myoferlin -0.0194453
PATJ PATJ crumbs cell polarity complex component -0.0192291
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0189956
NAV2 neuron navigator 2 -0.0173914
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0169233
SOX6 SRY (sex determining region Y)-box 6 -0.016026
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0158642
CENPE centromere protein E, 312kDa -0.0157185
ASPH aspartate beta-hydroxylase -0.0154484
TBC1D22A TBC1 domain family, member 22A -0.0152417
NBEA neurobeachin -0.0150538
TPT1 tumor protein, translationally-controlled 1 -0.0138409
MAPK8 mitogen-activated protein kinase 8 -0.0138336
GPHN gephyrin -0.0135237
RRBP1 ribosome binding protein 1 -0.0134578
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0132354
SDK1 sidekick cell adhesion molecule 1 -0.0132028
CSE1L CSE1 chromosome segregation 1-like (yeast) -0.0128805
RPS13 ribosomal protein S13 -0.0128379
ZNF655 zinc finger protein 655 -0.0126847
RSF1 remodeling and spacing factor 1 -0.0125788
FER1L6 fer-1-like family member 6 -0.012555
NUP98 nucleoporin 98kDa -0.012522
RPL9 ribosomal protein L9 -0.0125195
PRELID2 PRELI domain containing 2 -0.011988
CCDC138 coiled-coil domain containing 138 -0.0119281
NEBL nebulette -0.0119019
RPS21 ribosomal protein S21 -0.0118888
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0118046
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0117508
RAD18 RAD18 E3 ubiquitin protein ligase -0.0115322
CUX1 cut-like homeobox 1 -0.0115187
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 -0.0114306
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0113211
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0111278
GSE1 Gse1 coiled-coil protein -0.0110053
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0109878
GPATCH2L G patch domain containing 2-like -0.0108993
GLS2 glutaminase 2 (liver, mitochondrial) -0.0107808
COMMD10 COMM domain containing 10 -0.0106957
ENOSF1 enolase superfamily member 1 -0.010556
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0103273
MSH4 mutS homolog 4 -0.0102997
HJURP Holliday junction recognition protein -0.0102793
CDKL1 cyclin-dependent kinase-like 1 (CDC2-related kinase) -0.0102672
PCSK5 proprotein convertase subtilisin/kexin type 5 -0.010253
MFSD4B major facilitator superfamily domain containing 4B -0.0102423
TRAF3 TNF receptor-associated factor 3 -0.0101265
FARP2 FERM, RhoGEF and pleckstrin domain protein 2 -0.0101013
PSPC1 paraspeckle component 1 -0.00995199
SCFD1 sec1 family domain containing 1 -0.00992289
UNC5C unc-5 homolog C (C. elegans) -0.0098705
FBXO34 F-box protein 34 -0.00984903
MEIS2 Meis homeobox 2 -0.00977631
CENPF centromere protein F, 350/400kDa -0.00973147
CAMK1D calcium/calmodulin-dependent protein kinase ID -0.0097106
CDR2 cerebellar degeneration-related protein 2, 62kDa -0.00961105
PDE10A phosphodiesterase 10A -0.00939665
GNB5 guanine nucleotide binding protein (G protein), beta 5 -0.00938525
ATAD2 ATPase family, AAA domain containing 2 -0.00928982
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.00926726
GOSR1 golgi SNAP receptor complex member 1 -0.00925517
SBF2 SET binding factor 2 -0.00920951
PPP2R3A protein phosphatase 2, regulatory subunit B'', alpha -0.00920497
SRP19 signal recognition particle 19kDa -0.00915684
ZC3H12C zinc finger CCCH-type containing 12C -0.00911309
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.00910215
PDE7B phosphodiesterase 7B -0.00909799
TUBA1C tubulin, alpha 1c -0.00909683
PRH1 proline-rich protein HaeIII subfamily 1 -0.00900009
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 -0.00867648
LINC02798 long intergenic non-protein coding RNA 2798 -0.00864924
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.00860105
NUSAP1 nucleolar and spindle associated protein 1 -0.00854109
DENND1A DENN/MADD domain containing 1A -0.00846918
EHBP1 EH domain binding protein 1 -0.0084414
TUBB tubulin, beta class I -0.00840033
SCG5 secretogranin V -0.00834789
SLC2A13 solute carrier family 2 (facilitated glucose transporter), member 13 -0.00826223
TOP2A topoisomerase (DNA) II alpha 170kDa -0.00819529
SMAD4 SMAD family member 4 -0.00819342
GALNT1 polypeptide N-acetylgalactosaminyltransferase 1 -0.008113
MRPS6 mitochondrial ribosomal protein S6 -0.00811056
ANKUB1 ankyrin repeat and ubiquitin domain containing 1 -0.00798255
BCOR BCL6 corepressor -0.00798166
BABAM2 BRISC and BRCA1 A complex member 2 -0.00791406