Adenine_SW 1088 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenine perturbation in SW 1088 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenine_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL6A3 collagen, type VI, alpha 3 0.25394
MYH9 myosin, heavy chain 9, non-muscle 0.0674456
FN1 fibronectin 1 0.0622724
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0605449
COL5A1 collagen, type V, alpha 1 0.0569636
AHNAK AHNAK nucleoprotein 0.0568918
TRIO trio Rho guanine nucleotide exchange factor 0.0540897
PRELID2 PRELI domain containing 2 0.0536478
ERRFI1 ERBB receptor feedback inhibitor 1 0.0526524
CDH13 cadherin 13 0.049841
CALR calreticulin 0.0475454
ELL2 elongation factor, RNA polymerase II, 2 0.0457463
MAP1B microtubule-associated protein 1B 0.041903
HMGA2 high mobility group AT-hook 2 0.041206
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0397758
POTEF POTE ankyrin domain family, member F 0.0393598
ABLIM3 actin binding LIM protein family, member 3 0.0393497
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 0.0381329
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0381025
MACF1 microtubule-actin crosslinking factor 1 0.0372578
FNDC3B fibronectin type III domain containing 3B 0.0371803
ASPH aspartate beta-hydroxylase 0.036662
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0355265
MSN moesin 0.0338532
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0332665
SMAD3 SMAD family member 3 0.0316536
CD44 CD44 molecule (Indian blood group) 0.0310079
AKAP9 A kinase (PRKA) anchor protein 9 0.0303677
FAF1 Fas (TNFRSF6) associated factor 1 0.0302919
IGFBP3 insulin-like growth factor binding protein 3 0.0299085
LOXL2 lysyl oxidase-like 2 0.0298244
EEF2 eukaryotic translation elongation factor 2 0.0297623
ZMIZ1 zinc finger, MIZ-type containing 1 0.0289539
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0284734
KIF16B kinesin family member 16B 0.0273892
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0270576
AOPEP aminopeptidase O (putative) 0.0266067
MICAL2 microtubule associated monooxygenase, calponin and LIM domain containing 2 0.0265082
TEAD1 TEA domain family member 1 (SV40 transcriptional enhancer factor) 0.0261075
HDLBP high density lipoprotein binding protein 0.0259347
VEGFA vascular endothelial growth factor A 0.0256074
AKAP12 A kinase (PRKA) anchor protein 12 0.025311
ARB2A ARB2 cotranscriptional regulator A 0.0251681
AUTS2 autism susceptibility candidate 2 0.0249123
EXT1 exostosin glycosyltransferase 1 0.0247314
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0244557
KLF7 Kruppel-like factor 7 (ubiquitous) 0.023854
GSE1 Gse1 coiled-coil protein 0.0231857
EXOC4 exocyst complex component 4 0.0231646
YEATS2 YEATS domain containing 2 0.0228472
TNS3 tensin 3 0.0228301
SSBP2 single-stranded DNA binding protein 2 0.0227939
BTBD9 BTB (POZ) domain containing 9 0.0226497
SMYD3 SET and MYND domain containing 3 0.0226121
TSC22D1 TSC22 domain family, member 1 0.0225941
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0222266
TNIP1 TNFAIP3 interacting protein 1 0.0221656
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.0219791
ANKRD36 ankyrin repeat domain 36 0.0219315
HIP1 huntingtin interacting protein 1 0.0219161
NUDCD3 NudC domain containing 3 0.0218237
JAZF1 JAZF zinc finger 1 0.0215882
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0214497
PALM2AKAP2 PALM2 and AKAP2 fusion 0.0213271
YAP1 Yes-associated protein 1 0.0212586
FTH1 ferritin, heavy polypeptide 1 0.0212199
RAI14 retinoic acid induced 14 0.0211238
HLA-A major histocompatibility complex, class I, A 0.0211186
COA1 cytochrome c oxidase assembly factor 1 homolog (S. cerevisiae) 0.0210362
PCM1 pericentriolar material 1 0.0209255
SSH2 slingshot protein phosphatase 2 0.0208363
NBAS neuroblastoma amplified sequence 0.0207493
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0206183
AVL9 AVL9 homolog (S. cerevisiase) 0.0206042
MYO10 myosin X 0.0205947
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) 0.0205698
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0204217
PTK2 protein tyrosine kinase 2 0.0202945
PTPN14 protein tyrosine phosphatase, non-receptor type 14 0.0202828
PLEC plectin 0.0200181
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase 0.020003
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0199295
SYNJ2 synaptojanin 2 0.0197532
CDK14 cyclin-dependent kinase 14 0.0196545
MAML2 mastermind-like 2 (Drosophila) 0.0195786
GLG1 golgi glycoprotein 1 0.0194135
PIBF1 progesterone immunomodulatory binding factor 1 0.0193413
ZNF407 zinc finger protein 407 0.0192956
CDK6 cyclin-dependent kinase 6 0.0192255
TRIM24 tripartite motif containing 24 0.0190262
ANO6 anoctamin 6 0.0189834
HAPSTR1 HUWE1 associated protein modifying stress responses 0.0189809
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.018975
SBF2 SET binding factor 2 0.0189622
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) 0.0189382
CFDP1 craniofacial development protein 1 0.0189157
P4HB prolyl 4-hydroxylase, beta polypeptide 0.0188535
TPM3 tropomyosin 3 0.0187557
MAP4 microtubule-associated protein 4 0.0185363
USP33 ubiquitin specific peptidase 33 0.0183363

decreased expression

Symbol Name Standardized Value
MT2A metallothionein 2A -0.183624
TMSB10 thymosin beta 10 -0.142602
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.13413
VIM vimentin -0.130292
HLA-B major histocompatibility complex, class I, B -0.0790753
TPT1 tumor protein, translationally-controlled 1 -0.077856
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0762034
COL1A1 collagen, type I, alpha 1 -0.0721551
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0677758
TMEM158 transmembrane protein 158 (gene/pseudogene) -0.0612977
FTL ferritin, light polypeptide -0.054237
PTMA prothymosin, alpha -0.0528235
IGFBP7 insulin-like growth factor binding protein 7 -0.0449721
NDRG1 N-myc downstream regulated 1 -0.0426955
RPL35A ribosomal protein L35a -0.0413911
PGK1 phosphoglycerate kinase 1 -0.0396757
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0396136
RPS6 ribosomal protein S6 -0.0383311
LGALS1 lectin, galactoside-binding, soluble, 1 -0.0381181
IL6 interleukin 6 -0.037395
MT1X metallothionein 1X -0.0362681
ADM adrenomedullin -0.0352265
RPS8 ribosomal protein S8 -0.0333925
TM4SF1 transmembrane 4 L six family member 1 -0.0331239
LMNA lamin A/C -0.0323468
CALU calumenin -0.0323357
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0322552
RPL23 ribosomal protein L23 -0.0304128
STC1 stanniocalcin 1 -0.0299059
RPS25 ribosomal protein S25 -0.0288038
RPL37A ribosomal protein L37a -0.0279507
RPL11 ribosomal protein L11 -0.0279462
RPLP1 ribosomal protein, large, P1 -0.0272685
RPS13 ribosomal protein S13 -0.0267594
RPS24 ribosomal protein S24 -0.0267191
RPL34 ribosomal protein L34 -0.0265114
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0265058
S100A6 S100 calcium binding protein A6 -0.0265006
RRBP1 ribosome binding protein 1 -0.0262409
RPS19 ribosomal protein S19 -0.0261817
S100A10 S100 calcium binding protein A10 -0.0260343
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0259319
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 -0.0259203
EIF1 eukaryotic translation initiation factor 1 -0.0259154
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0252739
SEC61G Sec61 gamma subunit -0.024989
RPL26 ribosomal protein L26 -0.0246657
TIMP3 TIMP metallopeptidase inhibitor 3 -0.0243316
COL1A2 collagen, type I, alpha 2 -0.0242152
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0240702
SQSTM1 sequestosome 1 -0.0240455
KMT2E lysine (K)-specific methyltransferase 2E -0.023735
RPL19 ribosomal protein L19 -0.0236475
NAP1L1 nucleosome assembly protein 1-like 1 -0.0236461
TMEM165 transmembrane protein 165 -0.023466
RPS14 ribosomal protein S14 -0.0226708
DSTN destrin (actin depolymerizing factor) -0.0226576
CADM1 cell adhesion molecule 1 -0.0225391
SEPTIN7 septin 7 -0.0220462
RPS12 ribosomal protein S12 -0.0219484
PTGES2 prostaglandin E synthase 2 -0.0217991
RSAD2 radical S-adenosyl methionine domain containing 2 -0.0216941
TGFBI transforming growth factor, beta-induced, 68kDa -0.0214624
SLC39A14 solute carrier family 39 (zinc transporter), member 14 -0.0213972
RPS11 ribosomal protein S11 -0.0213963
CHCHD2 coiled-coil-helix-coiled-coil-helix domain containing 2 -0.0208905
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0205373
ASTN2 astrotactin 2 -0.0200306
TUBB4B tubulin, beta 4B class IVb -0.0199744
MORF4L2 mortality factor 4 like 2 -0.0198898
S100A9 S100 calcium binding protein A9 -0.0198836
TOMM7 translocase of outer mitochondrial membrane 7 homolog (yeast) -0.0198832
RPL31 ribosomal protein L31 -0.0197707
B2M beta-2-microglobulin -0.0196894
PFN1 profilin 1 -0.0195956
TPM1 tropomyosin 1 (alpha) -0.0195708
RPS27A ribosomal protein S27a -0.019469
MCL1 myeloid cell leukemia 1 -0.0189922
RPS17 ribosomal protein S17 -0.0189656
MMP14 matrix metallopeptidase 14 (membrane-inserted) -0.0188804
RPL15 ribosomal protein L15 -0.0188659
CALD1 caldesmon 1 -0.0185201
SPDYA speedy/RINGO cell cycle regulator family member A -0.0184687
SGIP1 SH3-domain GRB2-like (endophilin) interacting protein 1 -0.0182936
RPS29 ribosomal protein S29 -0.0182148
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0179863
TIMP1 TIMP metallopeptidase inhibitor 1 -0.0179739
HNRNPD heterogeneous nuclear ribonucleoprotein D (AU-rich element RNA binding protein 1, 37kDa) -0.0178827
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0178503
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.0176927
RPLP2 ribosomal protein, large, P2 -0.01768
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -0.0176217
RPS15 ribosomal protein S15 -0.0174954
RIGI RNA sensor RIG-I -0.0174227
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0173968
SH3BGRL3 SH3 domain binding glutamate-rich protein like 3 -0.0173729
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0172762
RSL1D1 ribosomal L1 domain containing 1 -0.0172288
EGR1 early growth response 1 -0.0172203
FRMD4A FERM domain containing 4A -0.0171562