Adenoma Gene Set

Dataset DISEASES Experimental Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.|A neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated but non-invasive. The neoplastic epithelial cells may or may not display cellular atypia or dysplasia. In the gastrointestinal tract, when dysplasia becomes severe it is sometimes called carcinoma in situ. Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract. (Experimental Factor Ontology, EFO_0000232)
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Genes

176 genes associated with the disease Adenoma in GWAS datasets from the DISEASES Experimental Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
GREM1 gremlin 1, DAN family BMP antagonist 1.955
FMN1 formin 1 1.955
ARHGAP11A Rho GTPase activating protein 11A 1.939
SCG5 secretogranin V 1.939
POU5F1B POU class 5 homeobox 1B 1.929
EIF3H eukaryotic translation initiation factor 3, subunit H 1.912
CTIF CBP80/20-dependent translation initiation factor 1.807
SMAD7 SMAD family member 7 1.807
TIGAR TP53 induced glycolysis regulatory phosphatase 1.804
CCND2 cyclin D2 1.804
BMP4 bone morphogenetic protein 4 1.802
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 1.773
FGF23 fibroblast growth factor 23 1.75
ZMIZ1 zinc finger, MIZ-type containing 1 1.727
SLC6A18 solute carrier family 6 (neutral amino acid transporter), member 18 1.718
TERT telomerase reverse transcriptase 1.718
CLPTM1L CLPTM1-like 1.718
SLC6A19 solute carrier family 6 (neutral amino acid transporter), member 19 1.718
POU2AF1 POU class 2 associating factor 1 1.712
BTG4 B-cell translocation gene 4 1.712
OSBPL2 oxysterol binding protein-like 2 1.673
ADRM1 adhesion regulating molecule 1 1.673
CABLES2 Cdk5 and Abl enzyme substrate 2 1.673
LAMA5 laminin, alpha 5 1.673
RPS21 ribosomal protein S21 1.673
RBBP8NL RBBP8 N-terminal like 1.673
ATF1 activating transcription factor 1 1.633
TMPRSS12 transmembrane (C-terminal) protease, serine 12 1.633
DIP2B DIP2 disco-interacting protein 2 homolog B (Drosophila) 1.633
FAAP24 FA core complex associated protein 24 1.627
RHPN2 rhophilin, Rho GTPase binding protein 2 1.627
GPATCH1 G patch domain containing 1 1.627
CEP89 centrosomal protein 89kDa 1.627
LIPT2 lipoyl(octanoyl) transferase 2 (putative) 1.584
RNF169 ring finger protein 169 1.539
CHRDL2 chordin-like 2 1.539
XRRA1 X-ray radiation resistance associated 1 1.539
TIMM22 translocase of inner mitochondrial membrane 22 homolog (yeast) 1.489
MRM3 mitochondrial rRNA methyltransferase 3 1.489
ABR active BCR-related 1.489
NXN nucleoredoxin 1.489
SHCBP1L SHC SH2-domain binding protein 1-like 1.473
UTP23 UTP23, small subunit (SSU) processome component, homolog (yeast) 1.473
LAMC1 laminin, gamma 1 (formerly LAMB2) 1.473
RAD21 RAD21 homolog (S. pombe) 1.473
ATXN2 ataxin 2 1.464
SH2B3 SH2B adaptor protein 3 1.464
GOLGA8N golgin A8 family, member N 1.451
PITX1 paired-like homeodomain 1 1.411
PREX1 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 1.406
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) 1.406
BMP2 bone morphogenetic protein 2 1.375
DACT1 dishevelled-binding antagonist of beta-catenin 1 1.346
AAGAB alpha- and gamma-adaptin binding protein 1.344
SMAD3 SMAD family member 3 1.344
PCDH15 protocadherin-related 15 1.303
ALG5 ALG5, dolichyl-phosphate beta-glucosyltransferase 1.294
SMAD9 SMAD family member 9 1.294
RFXAP regulatory factor X-associated protein 1.294
APC adenomatous polyposis coli 1.263
SRP19 signal recognition particle 19kDa 1.263
VTI1A vesicle transport through interaction with t-SNAREs 1A 1.225
ZDHHC6 zinc finger, DHHC-type containing 6 1.225
PIRT phosphoinositide-interacting regulator of transient receptor potential channels 1.211
TMEM220 transmembrane protein 220 1.211
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent 1.211
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7 1.2
FADS1 fatty acid desaturase 1 1.191
FADS2 fatty acid desaturase 2 1.191
FADS3 fatty acid desaturase 3 1.191
TMEM258 transmembrane protein 258 1.191
DAGLA diacylglycerol lipase, alpha 1.191
MYRF myelin regulatory factor 1.191
FEN1 flap structure-specific endonuclease 1 1.191
PNKD paroxysmal nonkinesigenic dyskinesia 1.177
TMBIM1 transmembrane BAX inhibitor motif containing 1 1.177
SLC11A1 solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1 1.177
ARPC2 actin related protein 2/3 complex, subunit 2, 34kDa 1.177
GPBAR1 G protein-coupled bile acid receptor 1 1.177
VIL1 villin 1 1.177
CATIP ciliogenesis associated TTC17 interacting protein 1.177
CTDSP1 CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase 1 1.177
AAMP angio-associated, migratory cell protein 1.177
TTC4 tetratricopeptide repeat domain 4 1.159
PARS2 prolyl-tRNA synthetase 2, mitochondrial (putative) 1.159
TTC22 tetratricopeptide repeat domain 22 1.159
MROH7 maestro heat-like repeat family member 7 1.159
DHCR24 24-dehydrocholesterol reductase 1.159
WASF3 WAS protein family, member 3 1.11
CDK8 cyclin-dependent kinase 8 1.11
SCNN1A sodium channel, non voltage gated 1 alpha subunit 1.074
CD9 CD9 molecule 1.074
PLEKHG6 pleckstrin homology domain containing, family G (with RhoGef domain) member 6 1.074
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.074
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.074
KLF2 Kruppel-like factor 2 1.032
AP1M1 adaptor-related protein complex 1, mu 1 subunit 1.032
EPS15L1 epidermal growth factor receptor pathway substrate 15-like 1 1.032
SLC6A3 solute carrier family 6 (neurotransmitter transporter), member 3 0.966
TRPC6 transient receptor potential cation channel, subfamily C, member 6 0.966
ANGPTL5 angiopoietin-like 5 0.966
RAB20 RAB20, member RAS oncogene family 0.946
COL4A2 collagen, type IV, alpha 2 0.946
KLF5 Kruppel-like factor 5 (intestinal) 0.916
LPAR1 lysophosphatidic acid receptor 1 0.916
BMP5 bone morphogenetic protein 5 0.916
HMGCLL1 3-hydroxymethyl-3-methylglutaryl-CoA lyase-like 1 0.916
PIBF1 progesterone immunomodulatory binding factor 1 0.916
RYK receptor-like tyrosine kinase 0.891
SLCO2A1 solute carrier organic anion transporter family, member 2A1 0.891
RAB6B RAB6B, member RAS oncogene family 0.891
CHD1 chromodomain helicase DNA binding protein 1 0.863
RGMB repulsive guidance molecule family member b 0.863
TOX2 TOX high mobility group box family member 2 0.859
JPH2 junctophilin 2 0.859
LRP1 low density lipoprotein receptor-related protein 1 0.843
NXPH4 neurexophilin 4 0.843
SHMT2 serine hydroxymethyltransferase 2 (mitochondrial) 0.843
NDUFA4L2 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, 4-like 2 0.843
NAB2 NGFI-A binding protein 2 (EGR1 binding protein 2) 0.843
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 0.843
NEMP1 nuclear envelope integral membrane protein 1 0.843
MYO1A myosin IA 0.843
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) 0.829
DMRTA1 DMRT-like family A1 0.829
TTC33 tetratricopeptide repeat domain 33 0.819
CFAP44 cilia and flagella associated protein 44 0.8
BOC BOC cell adhesion associated, oncogene regulated 0.8
TET2 tet methylcytosine dioxygenase 2 0.8
COL15A1 collagen, type XV, alpha 1 0.764
CDH1 cadherin 1, type 1, E-cadherin (epithelial) 0.764
GALNT12 polypeptide N-acetylgalactosaminyltransferase 12 0.764
PPIF peptidylprolyl isomerase F 0.764
ANAPC10 anaphase promoting complex subunit 10 0.764
CDH3 cadherin 3, type 1, P-cadherin (placental) 0.764
ZCCHC24 zinc finger, CCHC domain containing 24 0.764
HHIP hedgehog interacting protein 0.764
B3GNTL1 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase-like 1 0.763
METRNL meteorin, glial cell differentiation regulator-like 0.763
ZNF446 zinc finger protein 446 0.742
CHMP2A charged multivesicular body protein 2A 0.742
ZBTB45 zinc finger and BTB domain containing 45 0.742
ZNF324 zinc finger protein 324 0.742
MZF1 myeloid zinc finger 1 0.742
FKBP5 FK506 binding protein 5 0.742
TANC1 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 0.742
TULP1 tubby like protein 1 0.742
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 0.742
UBE2M ubiquitin-conjugating enzyme E2M 0.742
TRIM28 tripartite motif containing 28 0.742
STMN3 stathmin-like 3 0.717
LIME1 Lck interacting transmembrane adaptor 1 0.717
ARFRP1 ADP-ribosylation factor related protein 1 0.717
SLC2A4RG SLC2A4 regulator 0.717
ZGPAT zinc finger, CCCH-type with G patch domain 0.717
RTEL1 regulator of telomere elongation helicase 1 0.717
GMEB2 glucocorticoid modulatory element binding protein 2 0.717
ZBTB46 zinc finger and BTB domain containing 46 0.717
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.717
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 0.676
HLA-DRB5 major histocompatibility complex, class II, DR beta 5 0.676
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 0.676
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 0.654
ENTPD7 ectonucleoside triphosphate diphosphohydrolase 7 0.654
NKX2-3 NK2 homeobox 3 0.654
NEBL nebulette 0.633
PTPN1 protein tyrosine phosphatase, non-receptor type 1 0.617
HAO1 hydroxyacid oxidase (glycolate oxidase) 1 0.604
PLCL1 phospholipase C-like 1 0.576
A1CF APOBEC1 complementation factor 0.563
ASAH2B N-acylsphingosine amidohydrolase (non-lysosomal ceramidase) 2B 0.563
FHL3 four and a half LIM domains 3 0.549
INPP5B inositol polyphosphate-5-phosphatase, 75kDa 0.549
POU3F1 POU class 3 homeobox 1 0.549
UTP11 UTP11 small subunit processome component 0.549
SF3A3 splicing factor 3a, subunit 3, 60kDa 0.549