Adenosine_A-172 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in A-172 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.283389
PODXL podocalyxin-like 0.263694
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.172505
CD44 CD44 molecule (Indian blood group) 0.105183
LOXL2 lysyl oxidase-like 2 0.0970026
VEGFA vascular endothelial growth factor A 0.0835791
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0820709
THBS2 thrombospondin 2 0.0804234
PLAT plasminogen activator, tissue 0.0756952
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0740887
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0685751
HLA-B major histocompatibility complex, class I, B 0.0619179
TRIO trio Rho guanine nucleotide exchange factor 0.0590226
BHLHE40 basic helix-loop-helix family, member e40 0.0550666
MT2A metallothionein 2A 0.05488
SEPTIN9 septin 9 0.044632
DST dystonin 0.0425256
DCLK2 doublecortin-like kinase 2 0.0421928
AHNAK2 AHNAK nucleoprotein 2 0.0421598
C1D C1D nuclear receptor corepressor 0.040958
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0403028
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0393561
ELL2 elongation factor, RNA polymerase II, 2 0.0346828
MYH9 myosin, heavy chain 9, non-muscle 0.0339223
UAP1 UDP-N-acetylglucosamine pyrophosphorylase 1 0.03371
MB21D2 Mab-21 domain containing 2 0.0334487
COL5A1 collagen, type V, alpha 1 0.0326111
FLNB filamin B, beta 0.0314382
RUNX1 runt-related transcription factor 1 0.0299278
LOX lysyl oxidase 0.0295659
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 0.029543
PLEC plectin 0.0290702
EIF4H eukaryotic translation initiation factor 4H 0.0289794
TUBB4B tubulin, beta 4B class IVb 0.0286693
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0279512
MKI67 marker of proliferation Ki-67 0.0272315
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.027218
PFKP phosphofructokinase, platelet 0.0272034
SERPINB6 serpin peptidase inhibitor, clade B (ovalbumin), member 6 0.027122
NAV1 neuron navigator 1 0.0260913
RAI1 retinoic acid induced 1 0.0259668
MAP1B microtubule-associated protein 1B 0.0235514
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0229059
RNF213 ring finger protein 213 0.0224105
TPR translocated promoter region, nuclear basket protein 0.0223657
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 0.0223553
ZMIZ1 zinc finger, MIZ-type containing 1 0.0221542
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.022152
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0218346
PRRC2C proline-rich coiled-coil 2C 0.0218299
SFTPA2 surfactant protein A2 0.0212093
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0209288
CST3 cystatin C 0.0209023
SHB Src homology 2 domain containing adaptor protein B 0.0208159
NFE2L1 nuclear factor, erythroid 2-like 1 0.0201596
PGK1 phosphoglycerate kinase 1 0.0200349
SVIL supervillin 0.0193077
MED15 mediator complex subunit 15 0.0186041
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0185238
EGR1 early growth response 1 0.0183724
B2M beta-2-microglobulin 0.0183101
PSD3 pleckstrin and Sec7 domain containing 3 0.0178184
ANKRD11 ankyrin repeat domain 11 0.0178129
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0177873
LENG8 leukocyte receptor cluster (LRC) member 8 0.0177562
ANXA6 annexin A6 0.0176662
L1CAM L1 cell adhesion molecule 0.0176533
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0175562
SH3BP2 SH3-domain binding protein 2 0.0173352
YWHAQ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta 0.0173331
ESYT2 extended synaptotagmin-like protein 2 0.017171
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0171137
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0170986
DNMBP dynamin binding protein 0.0169772
VEGFC vascular endothelial growth factor C 0.0169263
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0169223
KLF6 Kruppel-like factor 6 0.0168722
AFDN afadin, adherens junction formation factor 0.0166163
SPRED2 sprouty-related, EVH1 domain containing 2 0.0165552
MYOF myoferlin 0.0165279
MATR3 matrin 3 0.0162468
TRAM2 translocation associated membrane protein 2 0.0158996
IQSEC1 IQ motif and Sec7 domain 1 0.015618
PFKL phosphofructokinase, liver 0.0155442
RNF145 ring finger protein 145 0.0155072
TUBB6 tubulin, beta 6 class V 0.0154969
IGF2 insulin-like growth factor 2 0.0154333
RASA3 RAS p21 protein activator 3 0.0153766
NCOR2 nuclear receptor corepressor 2 0.0153295
COL4A2 collagen, type IV, alpha 2 0.0152764
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0152459
GSE1 Gse1 coiled-coil protein 0.0151493
RRBP1 ribosome binding protein 1 0.015121
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0151002
LAMA5 laminin, alpha 5 0.0150964
SLC22A23 solute carrier family 22, member 23 0.0150753
MSN moesin 0.0150245
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0150121
SFXN3 sideroflexin 3 0.0149323
BCL2L1 BCL2-like 1 0.014927

decreased expression

Symbol Name Standardized Value
VIM vimentin -0.211457
AHNAK AHNAK nucleoprotein -0.168272
UBC ubiquitin C -0.152128
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.148553
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.147162
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.120724
TMSB10 thymosin beta 10 -0.0920035
COL3A1 collagen, type III, alpha 1 -0.0895307
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0744536
POTEF POTE ankyrin domain family, member F -0.0727721
CANX calnexin -0.0682159
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0635395
ABI3BP ABI family, member 3 (NESH) binding protein -0.0588903
S100A6 S100 calcium binding protein A6 -0.0561329
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0558601
CCND1 cyclin D1 -0.053966
CDH13 cadherin 13 -0.0538037
COL5A2 collagen, type V, alpha 2 -0.0506984
PTMA prothymosin, alpha -0.0498613
RPS27A ribosomal protein S27a -0.0478288
S100A10 S100 calcium binding protein A10 -0.0455774
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0440521
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0428982
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0406807
TPM4 tropomyosin 4 -0.0401712
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0400433
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0387509
PKM pyruvate kinase, muscle -0.0384682
AUTS2 autism susceptibility candidate 2 -0.0384558
SQSTM1 sequestosome 1 -0.038212
VCL vinculin -0.0374371
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0374306
SPDYA speedy/RINGO cell cycle regulator family member A -0.0373875
COL1A2 collagen, type I, alpha 2 -0.0343388
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0338548
SOD2 superoxide dismutase 2, mitochondrial -0.0335828
PBX3 pre-B-cell leukemia homeobox 3 -0.0325852
INTS6 integrator complex subunit 6 -0.0311967
FBN1 fibrillin 1 -0.0310664
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0298632
PDIA3 protein disulfide isomerase family A, member 3 -0.0298335
LIMS1 LIM and senescent cell antigen-like domains 1 -0.0296342
CD99 CD99 molecule -0.029523
MCL1 myeloid cell leukemia 1 -0.0288439
SLC39A11 solute carrier family 39, member 11 -0.0276902
RHOA ras homolog family member A -0.0276246
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0273322
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0272448
TAGLN2 transgelin 2 -0.027189
CDK13 cyclin-dependent kinase 13 -0.026976
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0269079
SP100 SP100 nuclear antigen -0.0264003
NAP1L1 nucleosome assembly protein 1-like 1 -0.0263808
XKR6 XK, Kell blood group complex subunit-related family, member 6 -0.0263574
RAB1A RAB1A, member RAS oncogene family -0.0262726
MSI2 musashi RNA-binding protein 2 -0.0258592
TTC3 tetratricopeptide repeat domain 3 -0.0257388
LOC112694756 uncharaterized LOC112694756 -0.0256647
RPS24 ribosomal protein S24 -0.0256548
TPT1 tumor protein, translationally-controlled 1 -0.0253756
ZNF207 zinc finger protein 207 -0.0251259
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0250033
PCBP2 poly(rC) binding protein 2 -0.0249371
TAOK1 TAO kinase 1 -0.0247736
RIGI RNA sensor RIG-I -0.0246718
ACTG1 actin gamma 1 -0.0245565
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 -0.0244692
SRPK2 SRSF protein kinase 2 -0.0242958
ASPH aspartate beta-hydroxylase -0.0242494
RPS6KA2 ribosomal protein S6 kinase, 90kDa, polypeptide 2 -0.0241949
AEBP2 AE binding protein 2 -0.0241607
ACBD3 acyl-CoA binding domain containing 3 -0.0240198
ZEB1 zinc finger E-box binding homeobox 1 -0.0237669
RHOBTB3 Rho-related BTB domain containing 3 -0.0233357
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0230648
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0229131
ENO1 enolase 1, (alpha) -0.0228068
HLA-E major histocompatibility complex, class I, E -0.0223605
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0222747
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0222405
COPB1 coatomer protein complex, subunit beta 1 -0.021891
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0215306
GDI2 GDP dissociation inhibitor 2 -0.0214654
CUX1 cut-like homeobox 1 -0.021378
INSIG1 insulin induced gene 1 -0.0212534
VDAC1 voltage-dependent anion channel 1 -0.0210827
NUMB numb homolog (Drosophila) -0.0210354
FBXO11 F-box protein 11 -0.0209208
TENM3 teneurin transmembrane protein 3 -0.0208316
PALM2AKAP2 PALM2 and AKAP2 fusion -0.020561
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0202405
SORBS2 sorbin and SH3 domain containing 2 -0.020181
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0201649
FBXL7 F-box and leucine-rich repeat protein 7 -0.0201362
BIRC6 baculoviral IAP repeat containing 6 -0.0199547
ZFAND3 zinc finger, AN1-type domain 3 -0.0198627
ARPC5 actin related protein 2/3 complex, subunit 5, 16kDa -0.0198129
TPM1 tropomyosin 1 (alpha) -0.0194638
ADAM32 ADAM metallopeptidase domain 32 -0.0193358
RPS8 ribosomal protein S8 -0.0192852