Adenosine_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
IGF2 insulin-like growth factor 2 0.385867
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.070141
VEGFA vascular endothelial growth factor A 0.0682601
PDE10A phosphodiesterase 10A 0.0498661
TRIO trio Rho guanine nucleotide exchange factor 0.0479274
FN1 fibronectin 1 0.0452617
NALF1 NALCN channel auxiliary factor 1 0.0431366
BPTF bromodomain PHD finger transcription factor 0.0398539
EEF2 eukaryotic translation elongation factor 2 0.0392529
CEMIP cell migration inducing protein, hyaluronan binding 0.0361761
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0342137
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0341071
RPL23 ribosomal protein L23 0.0322252
RPS3 ribosomal protein S3 0.0316484
ITPRID2 ITPR interacting domain containing 2 0.0313087
GSE1 Gse1 coiled-coil protein 0.0309674
BRD2 bromodomain containing 2 0.0303676
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.030329
GAB2 GRB2-associated binding protein 2 0.0264044
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0254411
PDE4D phosphodiesterase 4D, cAMP-specific 0.0252029
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.024942
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0245357
SMYD3 SET and MYND domain containing 3 0.0244002
ST6GALNAC3 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3 0.0242533
BOD1L1 biorientation of chromosomes in cell division 1-like 1 0.0241121
SMAD3 SMAD family member 3 0.0235955
EPC2 enhancer of polycomb homolog 2 (Drosophila) 0.022817
DNMBP dynamin binding protein 0.0219991
NACA nascent polypeptide-associated complex alpha subunit 0.021927
TPST1 tyrosylprotein sulfotransferase 1 0.0218883
RPL34 ribosomal protein L34 0.0218732
MACF1 microtubule-actin crosslinking factor 1 0.0210139
HLA-B major histocompatibility complex, class I, B 0.0207594
SET SET nuclear proto-oncogene 0.0201161
LAMB1 laminin, beta 1 0.0201004
TBX2 T-box 2 0.0198357
NPAS2 neuronal PAS domain protein 2 0.0195352
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0192339
AOPEP aminopeptidase O (putative) 0.0189969
RACK1 receptor for activated C kinase 1 0.0187253
MT2A metallothionein 2A 0.0186666
CDK6 cyclin-dependent kinase 6 0.0186524
RPS17 ribosomal protein S17 0.0186124
ZMIZ1 zinc finger, MIZ-type containing 1 0.018483
HSPA8 heat shock 70kDa protein 8 0.0182801
FRMD6 FERM domain containing 6 0.0181248
PTPRE protein tyrosine phosphatase, receptor type, E 0.0179456
THRAP3 thyroid hormone receptor associated protein 3 0.0178396
PCCA propionyl CoA carboxylase, alpha polypeptide 0.0177856
FAT1 FAT atypical cadherin 1 0.0176196
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0173285
LUC7L2 LUC7-like 2 (S. cerevisiae) 0.0172923
EP300 E1A binding protein p300 0.0172796
CTSB cathepsin B 0.0172448
FLT1 fms-related tyrosine kinase 1 0.0170514
CAMK1D calcium/calmodulin-dependent protein kinase ID 0.0169347
EIF4B eukaryotic translation initiation factor 4B 0.0165919
PRRC2B proline-rich coiled-coil 2B 0.0165787
PNN pinin, desmosome associated protein 0.0165307
JARID2 jumonji, AT rich interactive domain 2 0.0165139
COL5A2 collagen, type V, alpha 2 0.0162648
TSC22D1 TSC22 domain family, member 1 0.0161771
PRRC2A proline-rich coiled-coil 2A 0.0161318
PABPN1 poly(A) binding protein, nuclear 1 0.0161237
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0160605
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0159484
RPL11 ribosomal protein L11 0.0159241
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0159216
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0159015
PLAT plasminogen activator, tissue 0.0158545
ADAMTS9 ADAM metallopeptidase with thrombospondin type 1 motif, 9 0.015841
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0158113
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0155994
SKIL SKI-like proto-oncogene 0.0155254
ZNF146 zinc finger protein 146 0.0154584
ATN1 atrophin 1 0.0154062
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0152557
SRRM2 serine/arginine repetitive matrix 2 0.0152135
PDE3A phosphodiesterase 3A, cGMP-inhibited 0.0151097
THADA thyroid adenoma associated 0.0151048
SYTL3 synaptotagmin-like 3 0.0149397
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.0149315
IMPDH2 IMP (inosine 5'-monophosphate) dehydrogenase 2 0.014823
GLI2 GLI family zinc finger 2 0.0148189
HDAC4 histone deacetylase 4 0.0144201
ANGPTL4 angiopoietin-like 4 0.0143629
UBE3A ubiquitin protein ligase E3A 0.014171
PLEC plectin 0.0141579
ANTXR1 anthrax toxin receptor 1 0.0140716
TSHZ1 teashirt zinc finger homeobox 1 0.0139582
ANKRD11 ankyrin repeat domain 11 0.0138395
FOXO1 forkhead box O1 0.0137622
SRRM1 serine/arginine repetitive matrix 1 0.0136845
FAM107B family with sequence similarity 107, member B 0.0135956
RPL37A ribosomal protein L37a 0.0134859
PHOX2B paired-like homeobox 2b 0.0134637
BASP1 brain abundant, membrane attached signal protein 1 0.0134347
RPL3 ribosomal protein L3 0.0134246
MAPK8 mitogen-activated protein kinase 8 0.0133814

decreased expression

Symbol Name Standardized Value
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 -0.404938
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.143778
NRG1 neuregulin 1 -0.134802
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0854423
HELZ helicase with zinc finger -0.0759628
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0747653
VIM vimentin -0.0739246
VCL vinculin -0.0606733
COL3A1 collagen, type III, alpha 1 -0.0537248
GULP1 GULP, engulfment adaptor PTB domain containing 1 -0.0516336
MED13 mediator complex subunit 13 -0.0461237
WDR45B WD repeat domain 45B -0.0458297
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0445662
LPIN1 lipin 1 -0.0444739
FAM13A family with sequence similarity 13, member A -0.044394
RPL35A ribosomal protein L35a -0.0429698
RAB1A RAB1A, member RAS oncogene family -0.0419005
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0410751
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0410743
TRIB2 tribbles pseudokinase 2 -0.0401915
MSI2 musashi RNA-binding protein 2 -0.0401873
AHNAK AHNAK nucleoprotein -0.0398226
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -0.0370509
NPEPPS aminopeptidase puromycin sensitive -0.0369466
SOS1 son of sevenless homolog 1 (Drosophila) -0.036525
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0360668
PTMA prothymosin, alpha -0.0355854
KDM3A lysine (K)-specific demethylase 3A -0.0354492
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0352681
CDH10 cadherin 10, type 2 (T2-cadherin) -0.0348717
FNDC3B fibronectin type III domain containing 3B -0.0331614
EXT1 exostosin glycosyltransferase 1 -0.0330111
NCAM2 neural cell adhesion molecule 2 -0.0330058
SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 -0.0327769
NREP neuronal regeneration related protein -0.0324912
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0323118
TNRC6B trinucleotide repeat containing 6B -0.0316252
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0308856
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0304876
SEC31A SEC31 homolog A (S. cerevisiae) -0.0304261
REV3L REV3-like, polymerase (DNA directed), zeta, catalytic subunit -0.0303907
SPAG9 sperm associated antigen 9 -0.0300595
PTK2 protein tyrosine kinase 2 -0.0296751
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0293498
ZNF292 zinc finger protein 292 -0.0292705
RPLP1 ribosomal protein, large, P1 -0.0280949
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0280357
B3GALT1 UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 -0.0279318
AUTS2 autism susceptibility candidate 2 -0.027525
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0275178
HMGB2 high mobility group box 2 -0.0274271
KPNB1 karyopherin (importin) beta 1 -0.027332
MEIS2 Meis homeobox 2 -0.0272728
CCND1 cyclin D1 -0.0271342
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0267596
CDC27 cell division cycle 27 -0.026122
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0260912
PCDH9 protocadherin 9 -0.0259393
HIP1 huntingtin interacting protein 1 -0.0255144
OGA O-GlcNAcase -0.0254479
CLTC clathrin, heavy chain (Hc) -0.0253976
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0251214
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.0248644
MBTD1 mbt domain containing 1 -0.0248017
QKI QKI, KH domain containing, RNA binding -0.0247207
LCORL ligand dependent nuclear receptor corepressor-like -0.0247117
PARD3 par-3 family cell polarity regulator -0.0246091
RPS24 ribosomal protein S24 -0.0245935
CLINT1 clathrin interactor 1 -0.0244277
WSB1 WD repeat and SOCS box containing 1 -0.0243585
TLK2 tousled-like kinase 2 -0.024307
MBD5 methyl-CpG binding domain protein 5 -0.0242455
SETD5 SET domain containing 5 -0.0241894
DLG1 discs, large homolog 1 (Drosophila) -0.0241296
BIRC6 baculoviral IAP repeat containing 6 -0.0241231
RLF rearranged L-myc fusion -0.0239585
DDIT4 DNA-damage-inducible transcript 4 -0.0239306
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0238459
ANXA2 annexin A2 -0.0238288
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0235755
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0233134
ITGA1 integrin, alpha 1 -0.0232061
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0231465
YTHDF3 YTH N(6)-methyladenosine RNA binding protein 3 -0.0231396
CANX calnexin -0.0230944
MEF2A myocyte enhancer factor 2A -0.0230367
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0230185
H3-3B H3.3 histone B -0.0229431
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.022932
NBEA neurobeachin -0.0228115
BICD1 bicaudal D homolog 1 (Drosophila) -0.0226632
ZNF609 zinc finger protein 609 -0.0226074
BSG basigin (Ok blood group) -0.0224054
LMNA lamin A/C -0.0223502
MYO6 myosin VI -0.0222733
FRMD4A FERM domain containing 4A -0.0221284
RPS6KC1 ribosomal protein S6 kinase, 52kDa, polypeptide 1 -0.0220878
FBXO11 F-box protein 11 -0.022044
SSBP2 single-stranded DNA binding protein 2 -0.0219678
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0219396