Adenosine_COLO 205 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in COLO 205 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TSC22D1 TSC22 domain family, member 1 0.158499
LCN2 lipocalin 2 0.114097
VEGFA vascular endothelial growth factor A 0.108226
MLPH melanophilin 0.0939521
SMAD3 SMAD family member 3 0.0804344
FAT1 FAT atypical cadherin 1 0.0694911
MYH9 myosin, heavy chain 9, non-muscle 0.0686975
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0611591
STS steroid sulfatase (microsomal), isozyme S 0.0597215
SIPA1L2 signal-induced proliferation-associated 1 like 2 0.0556561
SHB Src homology 2 domain containing adaptor protein B 0.0551941
LRCH1 leucine-rich repeats and calponin homology (CH) domain containing 1 0.0547809
EFNB2 ephrin-B2 0.0495192
AKAP13 A kinase (PRKA) anchor protein 13 0.049314
MYO1E myosin IE 0.046822
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0460913
PHF3 PHD finger protein 3 0.0453042
SEPTIN9 septin 9 0.0451093
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0448156
CLDN4 claudin 4 0.0431419
LMO7 LIM domain 7 0.0428303
BCL2L1 BCL2-like 1 0.0427937
DIAPH1 diaphanous-related formin 1 0.0408567
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0404907
STK24 serine/threonine kinase 24 0.0384504
C6ORF132 chromosome 6 open reading frame 132 0.037514
ANXA11 annexin A11 0.0372105
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0361948
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.036122
FHL2 four and a half LIM domains 2 0.0358325
MT2A metallothionein 2A 0.0356932
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa 0.0355299
PRRC2C proline-rich coiled-coil 2C 0.035236
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0346697
ST14 suppression of tumorigenicity 14 (colon carcinoma) 0.0340048
EPB41L1 erythrocyte membrane protein band 4.1-like 1 0.0329792
TMC5 transmembrane channel-like 5 0.0310039
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 0.0303138
ZHX2 zinc fingers and homeoboxes 2 0.0293362
CST3 cystatin C 0.0293195
HNRNPU heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) 0.0292182
RPL23 ribosomal protein L23 0.0289797
ASPH aspartate beta-hydroxylase 0.0286207
AREG amphiregulin 0.0283384
ANXA2 annexin A2 0.0278423
MYO5B myosin VB 0.0277593
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0277476
SRRM2 serine/arginine repetitive matrix 2 0.0275422
CEMIP cell migration inducing protein, hyaluronan binding 0.0275013
PDZD8 PDZ domain containing 8 0.0274582
PLAUR plasminogen activator, urokinase receptor 0.0273501
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0272055
NCOR2 nuclear receptor corepressor 2 0.0271738
LRP5 low density lipoprotein receptor-related protein 5 0.0270008
SLK STE20-like kinase 0.0269856
EEF2 eukaryotic translation elongation factor 2 0.0263567
BAIAP2L1 BAI1-associated protein 2-like 1 0.0261973
CTSB cathepsin B 0.0258031
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0256408
PRSS22 protease, serine, 22 0.0254285
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0253509
RHPN2 rhophilin, Rho GTPase binding protein 2 0.0251914
AOPEP aminopeptidase O (putative) 0.0245395
RND3 Rho family GTPase 3 0.0242804
ATP10B ATPase, class V, type 10B 0.0241711
FTL ferritin, light polypeptide 0.0240849
FZR1 fizzy/cell division cycle 20 related 1 (Drosophila) 0.0240269
ANKRD11 ankyrin repeat domain 11 0.0233289
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0233257
IGF1R insulin-like growth factor 1 receptor 0.0230798
CTNND1 catenin (cadherin-associated protein), delta 1 0.0229707
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0227457
KRT18 keratin 18, type I 0.0225203
FHIT fragile histidine triad 0.0223905
HLA-B major histocompatibility complex, class I, B 0.0222734
LPP LIM domain containing preferred translocation partner in lipoma 0.0222002
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.022069
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0220639
SPINT1 serine peptidase inhibitor, Kunitz type 1 0.0220201
JUP junction plakoglobin 0.0220005
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0218479
EPHA2 EPH receptor A2 0.0217144
OARD1 O-acyl-ADP-ribose deacylase 1 0.0215955
TRIB1 tribbles pseudokinase 1 0.0215237
EPAS1 endothelial PAS domain protein 1 0.0214171
ACTN4 actinin, alpha 4 0.0214086
DSPP dentin sialophosphoprotein 0.0211672
ZFP36 ZFP36 ring finger protein 0.0210603
FTH1 ferritin, heavy polypeptide 1 0.0207201
RPS3 ribosomal protein S3 0.0206601
MACF1 microtubule-actin crosslinking factor 1 0.0205884
SFTPA2 surfactant protein A2 0.0203596
ARRDC3 arrestin domain containing 3 0.0202551
MATR3 matrin 3 0.020212
PADI1 peptidyl arginine deiminase, type I 0.0202023
HDAC4 histone deacetylase 4 0.0201467
ABHD17C abhydrolase domain containing 17C 0.0200649
ZC3H13 zinc finger CCCH-type containing 13 0.0200401
BICRAL BICRA like chromatin remodeling complex associated protein 0.0199393
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0198901

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.175023
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.132986
BTBD9 BTB (POZ) domain containing 9 -0.115547
LYZ lysozyme -0.115448
MBNL2 muscleblind-like splicing regulator 2 -0.114213
EPSTI1 epithelial stromal interaction 1 (breast) -0.101511
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0942407
TPT1 tumor protein, translationally-controlled 1 -0.0937881
CANX calnexin -0.0800778
PERP PERP, TP53 apoptosis effector -0.0797291
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0794618
STAT1 signal transducer and activator of transcription 1, 91kDa -0.077048
GMDS GDP-mannose 4,6-dehydratase -0.0746367
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0721948
RIGI RNA sensor RIG-I -0.0708004
AHI1 Abelson helper integration site 1 -0.070258
NPSR1 neuropeptide S receptor 1 -0.0687342
PLSCR1 phospholipid scramblase 1 -0.063068
PDIA3 protein disulfide isomerase family A, member 3 -0.059153
PTMA prothymosin, alpha -0.0574924
NDRG1 N-myc downstream regulated 1 -0.0567919
IRF1 interferon regulatory factor 1 -0.0552074
RHOBTB3 Rho-related BTB domain containing 3 -0.0551883
EGLN3 egl-9 family hypoxia-inducible factor 3 -0.0550138
SP100 SP100 nuclear antigen -0.0548767
RABGAP1L RAB GTPase activating protein 1-like -0.0527094
ZBTB20 zinc finger and BTB domain containing 20 -0.0517499
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0517199
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0504815
UBR2 ubiquitin protein ligase E3 component n-recognin 2 -0.0492981
ZKSCAN1 zinc finger with KRAB and SCAN domains 1 -0.0484605
FNDC3A fibronectin type III domain containing 3A -0.0482304
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.047582
PATJ PATJ crumbs cell polarity complex component -0.0470935
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 -0.0469554
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0469373
GOLGB1 golgin B1 -0.0457925
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0449634
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0446415
EGR1 early growth response 1 -0.04459
COG6 component of oligomeric golgi complex 6 -0.0444058
MX1 MX dynamin-like GTPase 1 -0.0437547
SEC31A SEC31 homolog A (S. cerevisiae) -0.0437328
NT5C3A 5'-nucleotidase, cytosolic IIIA -0.0433666
UFM1 ubiquitin-fold modifier 1 -0.0429963
RAB1A RAB1A, member RAS oncogene family -0.0427333
RNF213 ring finger protein 213 -0.0422983
DIAPH3 diaphanous-related formin 3 -0.0418439
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0417312
RUNX1 runt-related transcription factor 1 -0.0416106
PCK1 phosphoenolpyruvate carboxykinase 1 (soluble) -0.0415634
HLA-E major histocompatibility complex, class I, E -0.0405726
MECOM MDS1 and EVI1 complex locus -0.0404053
TTC3 tetratricopeptide repeat domain 3 -0.0393198
FNIP1 folliculin interacting protein 1 -0.0391055
XAF1 XIAP associated factor 1 -0.0385271
PIBF1 progesterone immunomodulatory binding factor 1 -0.0371703
CD46 CD46 molecule, complement regulatory protein -0.0370235
NCKAP5 NCK-associated protein 5 -0.0368992
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -0.0368489
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0367147
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.036585
UBC ubiquitin C -0.0365845
NF1 neurofibromin 1 -0.036337
XRN1 5'-3' exoribonuclease 1 -0.0360494
SQSTM1 sequestosome 1 -0.0358153
FUT8 fucosyltransferase 8 (alpha (1,6) fucosyltransferase) -0.03581
AHNAK AHNAK nucleoprotein -0.0356068
COPB1 coatomer protein complex, subunit beta 1 -0.0353087
FOXP1 forkhead box P1 -0.0350796
GNAS GNAS complex locus -0.0349673
EPB41 erythrocyte membrane protein band 4.1 -0.0339829
AGR2 anterior gradient 2 -0.0336206
RBM39 RNA binding motif protein 39 -0.0336019
MON2 MON2 homolog (S. cerevisiae) -0.0333564
MORF4L2 mortality factor 4 like 2 -0.0333159
H1-0 H1.0 linker histone -0.0332038
ABLIM1 actin binding LIM protein 1 -0.0330929
NAALADL2 N-acetylated alpha-linked acidic dipeptidase-like 2 -0.032528
SMC4 structural maintenance of chromosomes 4 -0.0324619
BCLAF1 BCL2-associated transcription factor 1 -0.0321186
VDAC1 voltage-dependent anion channel 1 -0.0320687
PMP22 peripheral myelin protein 22 -0.0319517
LRBA LPS-responsive vesicle trafficking, beach and anchor containing -0.031943
CLTC clathrin, heavy chain (Hc) -0.0317795
SEC24D SEC24 family member D -0.0316339
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0315585
DIS3 DIS3 exosome endoribonuclease and 3'-5' exoribonuclease -0.0315399
ANKRD10 ankyrin repeat domain 10 -0.0313824
HM13 histocompatibility (minor) 13 -0.0312874
NR6A1 nuclear receptor subfamily 6, group A, member 1 -0.0311471
ZMYM2 zinc finger, MYM-type 2 -0.0310169
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -0.0306451
ZNF292 zinc finger protein 292 -0.0306398
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0305066
PHACTR4 phosphatase and actin regulator 4 -0.0303267
GOLPH3L golgi phosphoprotein 3-like -0.0303239
SLC44A1 solute carrier family 44 (choline transporter), member 1 -0.0302311
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0301872
TNRC6B trinucleotide repeat containing 6B -0.0301555