Adenosine_HepG2/C3A Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in HepG2/C3A cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.190426
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) 0.137841
IGF2 insulin-like growth factor 2 0.113098
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.101612
SAMD4A sterile alpha motif domain containing 4A 0.095241
TNS1 tensin 1 0.0758397
DSPP dentin sialophosphoprotein 0.0729923
FN1 fibronectin 1 0.0704967
NKD1 naked cuticle homolog 1 (Drosophila) 0.0645691
C3 complement component 3 0.0637941
SVIL supervillin 0.0619798
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0601614
MYH9 myosin, heavy chain 9, non-muscle 0.0590085
FAT1 FAT atypical cadherin 1 0.0579149
MACF1 microtubule-actin crosslinking factor 1 0.0569511
RALGAPA2 Ral GTPase activating protein, alpha subunit 2 (catalytic) 0.0521395
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 0.0519086
AFDN afadin, adherens junction formation factor 0.0509159
SMAD3 SMAD family member 3 0.0437422
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0430197
LRRTM4 leucine rich repeat transmembrane neuronal 4 0.0425645
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0418633
DHRS2 dehydrogenase/reductase (SDR family) member 2 0.0408423
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0406157
PLEC plectin 0.0405393
IQSEC1 IQ motif and Sec7 domain 1 0.0400517
TIMP1 TIMP metallopeptidase inhibitor 1 0.0396113
DOCK4 dedicator of cytokinesis 4 0.0369716
ITGB5 integrin, beta 5 0.0367445
ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 0.0364864
RUNX1 runt-related transcription factor 1 0.0361354
BCL2L1 BCL2-like 1 0.0354632
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.035412
COL7A1 collagen, type VII, alpha 1 0.0353551
SHB Src homology 2 domain containing adaptor protein B 0.0334033
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 0.0333472
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0328971
TBC1D22A TBC1 domain family, member 22A 0.0328228
ABTB3 ankyrin repeat and BTB domain containing 3 0.0326115
CHST15 carbohydrate (N-acetylgalactosamine 4-sulfate 6-O) sulfotransferase 15 0.0324957
SORL1 sortilin-related receptor, L(DLR class) A repeats containing 0.0316477
FLNA filamin A, alpha 0.0314191
ZMIZ1 zinc finger, MIZ-type containing 1 0.031143
DOCK5 dedicator of cytokinesis 5 0.0311343
DNAH17 dynein, axonemal, heavy chain 17 0.0286678
PPARD peroxisome proliferator-activated receptor delta 0.0286586
GPAM glycerol-3-phosphate acyltransferase, mitochondrial 0.0285501
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0284029
ARHGAP9 Rho GTPase activating protein 9 0.0281374
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0267091
MALT1 MALT1 paracaspase 0.0265067
KIAA1217 KIAA1217 0.0262786
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0260137
EPAS1 endothelial PAS domain protein 1 0.0255995
PRELID2 PRELI domain containing 2 0.0248331
MT2A metallothionein 2A 0.024251
NFE2L1 nuclear factor, erythroid 2-like 1 0.0228765
GRB10 growth factor receptor-bound protein 10 0.022729
JAG1 jagged 1 0.0214266
ALPK2 alpha-kinase 2 0.0213198
CEMIP2 cell migration inducing hyaluronidase 2 0.0208685
RPS18 ribosomal protein S18 0.0204921
PACSIN2 protein kinase C and casein kinase substrate in neurons 2 0.0204143
EIF4B eukaryotic translation initiation factor 4B 0.0193764
SORBS1 sorbin and SH3 domain containing 1 0.0192801
WDR1 WD repeat domain 1 0.019262
SPATS2L spermatogenesis associated, serine-rich 2-like 0.019214
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0192038
CEP250 centrosomal protein 250kDa 0.0191996
BRD4 bromodomain containing 4 0.0188025
NPTN neuroplastin 0.0185282
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0185046
GSE1 Gse1 coiled-coil protein 0.0183017
PKP4 plakophilin 4 0.0182674
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.0182611
LMCD1 LIM and cysteine-rich domains 1 0.0181051
TNS3 tensin 3 0.0180647
ACSL5 acyl-CoA synthetase long-chain family member 5 0.0180373
FLNB filamin B, beta 0.0179792
BCAR3 breast cancer anti-estrogen resistance 3 0.0178904
PRKCZ protein kinase C, zeta 0.0177951
TNFSF14 tumor necrosis factor (ligand) superfamily, member 14 0.0177273
NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase 0.0177078
OPTN optineurin 0.0174058
PTPRH protein tyrosine phosphatase, receptor type, H 0.0170836
CTNND1 catenin (cadherin-associated protein), delta 1 0.0169177
DNMBP dynamin binding protein 0.0169145
C1D C1D nuclear receptor corepressor 0.0168122
CORO1C coronin, actin binding protein, 1C 0.0168021
ACTN4 actinin, alpha 4 0.0164203
PRAG1 PEAK1 related, kinase-activating pseudokinase 1 0.0164181
GIGYF2 GRB10 interacting GYF protein 2 0.0164118
NCOR2 nuclear receptor corepressor 2 0.01635
DSCAM Down syndrome cell adhesion molecule 0.0162901
RNF43 ring finger protein 43 0.0162507
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 0.0162025
SKI SKI proto-oncogene 0.0159285
CLTB clathrin, light chain B 0.0159253
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.0156555
HDAC4 histone deacetylase 4 0.0155369

decreased expression

Symbol Name Standardized Value
AHSG alpha-2-HS-glycoprotein -0.132241
AKAP12 A kinase (PRKA) anchor protein 12 -0.12285
GPC3 glypican 3 -0.112223
TPT1 tumor protein, translationally-controlled 1 -0.112196
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.108996
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.108289
FNDC3B fibronectin type III domain containing 3B -0.107256
APOA2 apolipoprotein A-II -0.106244
RPS6 ribosomal protein S6 -0.105348
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0991098
RPS24 ribosomal protein S24 -0.0920585
SLC38A2 solute carrier family 38, member 2 -0.0878983
CP ceruloplasmin (ferroxidase) -0.0875016
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0871252
PLIN2 perilipin 2 -0.0852533
GPC6 glypican 6 -0.0849292
RPS8 ribosomal protein S8 -0.0795799
EHBP1 EH domain binding protein 1 -0.0756433
FBF1 Fas (TNFRSF6) binding factor 1 -0.072443
ROBO1 roundabout, axon guidance receptor, homolog 1 (Drosophila) -0.0715151
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0699041
RPL35A ribosomal protein L35a -0.0686022
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0679054
RPL11 ribosomal protein L11 -0.0635123
GMDS GDP-mannose 4,6-dehydratase -0.0632443
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0630744
ENO1 enolase 1, (alpha) -0.0625799
RPLP1 ribosomal protein, large, P1 -0.0618874
GNAS GNAS complex locus -0.0593231
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0583861
FTL ferritin, light polypeptide -0.0575839
TMEM123 transmembrane protein 123 -0.0573886
GK glycerol kinase -0.0571205
RPLP0 ribosomal protein, large, P0 -0.057018
RPL34 ribosomal protein L34 -0.0561457
RPL37A ribosomal protein L37a -0.0560502
CPE carboxypeptidase E -0.0546801
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.053778
TMSB10 thymosin beta 10 -0.0532806
ZBTB20 zinc finger and BTB domain containing 20 -0.0525148
DTNA dystrobrevin, alpha -0.051653
HMGA1 high mobility group AT-hook 1 -0.0501947
NPAS2 neuronal PAS domain protein 2 -0.0490926
RPS27A ribosomal protein S27a -0.048559
RPS25 ribosomal protein S25 -0.0482325
TPM4 tropomyosin 4 -0.0473822
SOD2 superoxide dismutase 2, mitochondrial -0.0464615
ASPH aspartate beta-hydroxylase -0.0464251
PERP PERP, TP53 apoptosis effector -0.046046
CANX calnexin -0.0447585
RPS12 ribosomal protein S12 -0.0443784
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0441916
NAP1L1 nucleosome assembly protein 1-like 1 -0.0439643
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0438604
RPL31 ribosomal protein L31 -0.0438174
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0437848
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0437834
AMBP alpha-1-microglobulin/bikunin precursor -0.0433508
TM4SF1 transmembrane 4 L six family member 1 -0.0427669
PEG3 paternally expressed 3 -0.0425638
LYZ lysozyme -0.0417001
PTTG1IP pituitary tumor-transforming 1 interacting protein -0.040572
SDC4 syndecan 4 -0.0405662
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) -0.0405091
RAB1A RAB1A, member RAS oncogene family -0.0403739
RPS23 ribosomal protein S23 -0.0402967
EML4 echinoderm microtubule associated protein like 4 -0.0399542
EIF1 eukaryotic translation initiation factor 1 -0.0394263
SOX5 SRY (sex determining region Y)-box 5 -0.0393651
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.0393512
RPL9 ribosomal protein L9 -0.038807
RPL5 ribosomal protein L5 -0.0387817
PTCHD4 patched domain containing 4 -0.0385154
RPL12 ribosomal protein L12 -0.038417
CCL20 chemokine (C-C motif) ligand 20 -0.0381239
PDIA3 protein disulfide isomerase family A, member 3 -0.038104
RPL26 ribosomal protein L26 -0.0380197
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0375473
MAN1A1 mannosidase, alpha, class 1A, member 1 -0.0354993
RPL37 ribosomal protein L37 -0.0353592
WDR45B WD repeat domain 45B -0.0352849
RPS16 ribosomal protein S16 -0.0352203
STAU1 staufen double-stranded RNA binding protein 1 -0.0346109
ARID4B AT rich interactive domain 4B (RBP1-like) -0.034395
SLC38A1 solute carrier family 38, member 1 -0.0339901
RPS13 ribosomal protein S13 -0.0339339
RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 -0.0336582
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0336439
TRIM26 tripartite motif containing 26 -0.0336413
HSPH1 heat shock 105kDa/110kDa protein 1 -0.0335345
NPR2 natriuretic peptide receptor 2 -0.0335264
RPS29 ribosomal protein S29 -0.0330256
RPS14 ribosomal protein S14 -0.0328712
UBC ubiquitin C -0.0325572
STK17A serine/threonine kinase 17a -0.0321817
PTBP3 polypyrimidine tract binding protein 3 -0.0320967
ZFAND3 zinc finger, AN1-type domain 3 -0.0319131
RPS19 ribosomal protein S19 -0.0319055
LOC112694756 uncharaterized LOC112694756 -0.0318311
RPLP2 ribosomal protein, large, P2 -0.0317955