Adenosine_Hs 766T Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in Hs 766T cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TIMP3 TIMP metallopeptidase inhibitor 3 0.205676
CD44 CD44 molecule (Indian blood group) 0.10573
MSN moesin 0.0870181
LDHA lactate dehydrogenase A 0.0869227
NDRG1 N-myc downstream regulated 1 0.0835111
PODXL podocalyxin-like 0.0812761
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0727467
CALB1 calbindin 1, 28kDa 0.0710077
B2M beta-2-microglobulin 0.0645062
FTH1 ferritin, heavy polypeptide 1 0.0629637
VEGFA vascular endothelial growth factor A 0.0568661
PLEC plectin 0.0564912
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.0530472
ENO1 enolase 1, (alpha) 0.0518071
HSPG2 heparan sulfate proteoglycan 2 0.0512425
LMO7 LIM domain 7 0.049032
DOK5 docking protein 5 0.0475673
MKI67 marker of proliferation Ki-67 0.0470446
NCOR2 nuclear receptor corepressor 2 0.0470278
TPM3 tropomyosin 3 0.0467083
SLC35F3 solute carrier family 35, member F3 0.0463923
PCDH1 protocadherin 1 0.0463822
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0453479
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0451535
STC1 stanniocalcin 1 0.044197
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0436203
POTEF POTE ankyrin domain family, member F 0.0435231
ITGA6 integrin, alpha 6 0.0433752
HLA-B major histocompatibility complex, class I, B 0.0433258
IGF2 insulin-like growth factor 2 0.0430791
SULF2 sulfatase 2 0.0417854
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0416348
SLK STE20-like kinase 0.0411079
SWAP70 SWAP switching B-cell complex 70kDa subunit 0.0405523
DPYSL2 dihydropyrimidinase-like 2 0.0399432
EHBP1L1 EH domain binding protein 1-like 1 0.0398112
MACF1 microtubule-actin crosslinking factor 1 0.0395249
RPS3 ribosomal protein S3 0.0393698
FN1 fibronectin 1 0.0391689
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0385723
CLU clusterin 0.0379596
KTN1 kinectin 1 (kinesin receptor) 0.037942
AHNAK2 AHNAK nucleoprotein 2 0.0378375
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.037696
SET SET nuclear proto-oncogene 0.037406
ZFP36L1 ZFP36 ring finger protein-like 1 0.0373922
FAM107B family with sequence similarity 107, member B 0.0367918
APP amyloid beta (A4) precursor protein 0.0365883
ANGPTL4 angiopoietin-like 4 0.0364229
EMP1 epithelial membrane protein 1 0.0361519
TXNIP thioredoxin interacting protein 0.0360592
TUBB4B tubulin, beta 4B class IVb 0.0354545
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 0.0352806
KIAA1671 KIAA1671 0.0350545
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 0.0350191
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0349793
TGM2 transglutaminase 2 0.0346387
LOXL2 lysyl oxidase-like 2 0.0342703
PPDPF pancreatic progenitor cell differentiation and proliferation factor 0.0335377
MYO10 myosin X 0.0334995
PRRC2C proline-rich coiled-coil 2C 0.033156
SRRM2 serine/arginine repetitive matrix 2 0.0330043
SPINK5 serine peptidase inhibitor, Kazal type 5 0.0328627
THOC2 THO complex 2 0.0326753
ZMIZ1 zinc finger, MIZ-type containing 1 0.0323593
APLP2 amyloid beta (A4) precursor-like protein 2 0.0320938
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0320821
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0318516
TMSB4X thymosin beta 4, X-linked 0.0315511
ECE1 endothelin converting enzyme 1 0.0314597
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.030972
SEPTIN9 septin 9 0.0308298
CYB5R3 cytochrome b5 reductase 3 0.0305831
ABLIM3 actin binding LIM protein family, member 3 0.0301399
TPR translocated promoter region, nuclear basket protein 0.0301201
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.029803
SNX9 sorting nexin 9 0.0294435
MYH9 myosin, heavy chain 9, non-muscle 0.0292941
DIAPH1 diaphanous-related formin 1 0.0289359
EZR ezrin 0.0288231
LAMA5 laminin, alpha 5 0.0286786
MT1E metallothionein 1E 0.0286428
HSD17B2 hydroxysteroid (17-beta) dehydrogenase 2 0.0286127
RPLP0 ribosomal protein, large, P0 0.028541
ST3GAL6 ST3 beta-galactoside alpha-2,3-sialyltransferase 6 0.0282369
CSTB cystatin B (stefin B) 0.0281347
DUSP4 dual specificity phosphatase 4 0.0279999
IGFBP4 insulin-like growth factor binding protein 4 0.0277601
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0272367
JAK2 Janus kinase 2 0.0270158
CSNK1E casein kinase 1, epsilon 0.0267709
DSTN destrin (actin depolymerizing factor) 0.0267249
ANKRD28 ankyrin repeat domain 28 0.0266964
KPNB1 karyopherin (importin) beta 1 0.0266159
RPS6 ribosomal protein S6 0.0262273
SFTPA2 surfactant protein A2 0.0261458
FTL ferritin, light polypeptide 0.0260571
OPTN optineurin 0.0260362
KMT2C lysine (K)-specific methyltransferase 2C 0.0258668
SRRM1 serine/arginine repetitive matrix 1 0.0258228

decreased expression

Symbol Name Standardized Value
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.105005
MTSS1 metastasis suppressor 1 -0.102128
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.100408
INTS6 integrator complex subunit 6 -0.0942216
AHNAK AHNAK nucleoprotein -0.0928951
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0696604
ASPH aspartate beta-hydroxylase -0.0694405
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0656327
TRIO trio Rho guanine nucleotide exchange factor -0.0649955
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0628011
PSD3 pleckstrin and Sec7 domain containing 3 -0.0616418
PRELID2 PRELI domain containing 2 -0.0611791
PHLDB2 pleckstrin homology-like domain, family B, member 2 -0.0602571
FNDC3B fibronectin type III domain containing 3B -0.0579177
DPYD dihydropyrimidine dehydrogenase -0.0572228
ADAMTS16 ADAM metallopeptidase with thrombospondin type 1 motif, 16 -0.0549548
TMSB10 thymosin beta 10 -0.0539691
PALLD palladin, cytoskeletal associated protein -0.0522635
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0516225
COG6 component of oligomeric golgi complex 6 -0.0511719
HMGA2 high mobility group AT-hook 2 -0.0488591
EXT1 exostosin glycosyltransferase 1 -0.0473497
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0436401
MECOM MDS1 and EVI1 complex locus -0.0421459
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0414015
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0407011
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0401228
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0397086
THSD4 thrombospondin, type I, domain containing 4 -0.0396286
RAP1B RAP1B, member of RAS oncogene family -0.0389448
EXOC6B exocyst complex component 6B -0.0377939
RIGI RNA sensor RIG-I -0.0375742
NRIP1 nuclear receptor interacting protein 1 -0.0372238
CANX calnexin -0.0363462
DGKH diacylglycerol kinase, eta -0.0358684
UBE2H ubiquitin-conjugating enzyme E2H -0.0358343
VCL vinculin -0.0355573
CDK13 cyclin-dependent kinase 13 -0.0353759
KLF12 Kruppel-like factor 12 -0.0353081
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0352015
CLINT1 clathrin interactor 1 -0.0345166
ANO1 anoctamin 1, calcium activated chloride channel -0.034099
FNDC3A fibronectin type III domain containing 3A -0.0339292
TRA2A transformer 2 alpha homolog (Drosophila) -0.0338315
PRSS23 protease, serine, 23 -0.0337153
SOX5 SRY (sex determining region Y)-box 5 -0.0336349
MBD5 methyl-CpG binding domain protein 5 -0.033054
ANKRD10 ankyrin repeat domain 10 -0.0328153
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0325799
SBF2 SET binding factor 2 -0.0323923
CAMSAP2 calmodulin regulated spectrin-associated protein family, member 2 -0.0322616
SULF1 sulfatase 1 -0.0321734
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0321298
TM9SF3 transmembrane 9 superfamily member 3 -0.0318522
PDE4D phosphodiesterase 4D, cAMP-specific -0.0314838
SLCO1B3-SLCO1B7 SLCO1B3-SLCO1B7 readthrough -0.0312205
MBOAT2 membrane bound O-acyltransferase domain containing 2 -0.0311101
SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A -0.0310335
SEC24D SEC24 family member D -0.0306298
ATXN1 ataxin 1 -0.0304671
COPB1 coatomer protein complex, subunit beta 1 -0.030382
DDAH1 dimethylarginine dimethylaminohydrolase 1 -0.0302065
KRT17 keratin 17, type I -0.0300951
RPL11 ribosomal protein L11 -0.0296478
GRB10 growth factor receptor-bound protein 10 -0.0296318
NSMCE2 non-SMC element 2, MMS21 homolog (S. cerevisiae) -0.0291653
PDLIM5 PDZ and LIM domain 5 -0.0287928
HM13 histocompatibility (minor) 13 -0.0287451
DYNLRB1 dynein, light chain, roadblock-type 1 -0.0284894
RBM39 RNA binding motif protein 39 -0.0283103
RPLP2 ribosomal protein, large, P2 -0.0280965
PLCE1 phospholipase C, epsilon 1 -0.0279112
HDAC9 histone deacetylase 9 -0.0278918
CDC42BPA CDC42 binding protein kinase alpha (DMPK-like) -0.0277912
BIRC6 baculoviral IAP repeat containing 6 -0.0277881
COPB2 coatomer protein complex, subunit beta 2 (beta prime) -0.0277077
RCOR1 REST corepressor 1 -0.0275528
METTL15 methyltransferase like 15 -0.0274441
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0273126
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -0.0273054
KDM3A lysine (K)-specific demethylase 3A -0.027219
MBNL2 muscleblind-like splicing regulator 2 -0.0271679
PAIP2 poly(A) binding protein interacting protein 2 -0.0264864
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0264041
COG5 component of oligomeric golgi complex 5 -0.0263872
RPLP1 ribosomal protein, large, P1 -0.025702
NF1 neurofibromin 1 -0.0256326
DENND1A DENN/MADD domain containing 1A -0.0254774
CSTF3 cleavage stimulation factor, 3' pre-RNA, subunit 3, 77kDa -0.0253694
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 -0.0253163
DDX60 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60 -0.0252318
ALDH3A1 aldehyde dehydrogenase 3 family, member A1 -0.0252177
DHFR dihydrofolate reductase -0.0249471
TAS2R14 taste receptor, type 2, member 14 -0.0248468
ZRANB2 zinc finger, RAN-binding domain containing 2 -0.0247403
CCNH cyclin H -0.0246452
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0246433
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.024488
TOP1 topoisomerase (DNA) I -0.0244443
RPS21 ribosomal protein S21 -0.0241