Adenosine_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.201965
FAT1 FAT atypical cadherin 1 0.1935
ONECUT3 one cut homeobox 3 0.114556
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.110252
CEMIP cell migration inducing protein, hyaluronan binding 0.103414
KRT18 keratin 18, type I 0.0999345
LDHA lactate dehydrogenase A 0.0980842
DSPP dentin sialophosphoprotein 0.0788009
TNS4 tensin 4 0.0723679
HSPA8 heat shock 70kDa protein 8 0.0710648
KRT8 keratin 8, type II 0.067873
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0617384
MT2A metallothionein 2A 0.061393
EEF2 eukaryotic translation elongation factor 2 0.0568138
ENO1 enolase 1, (alpha) 0.0523922
TSC22D1 TSC22 domain family, member 1 0.0520297
MYH9 myosin, heavy chain 9, non-muscle 0.047662
RPS3 ribosomal protein S3 0.0451841
H1-0 H1.0 linker histone 0.0420231
TUBB4B tubulin, beta 4B class IVb 0.0395857
TMEM45B transmembrane protein 45B 0.0391908
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0382738
RPL3 ribosomal protein L3 0.0376762
NDRG1 N-myc downstream regulated 1 0.0376747
RPS12 ribosomal protein S12 0.0365794
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0357898
PLAUR plasminogen activator, urokinase receptor 0.0354891
PLEC plectin 0.0354577
RPS18 ribosomal protein S18 0.0350566
ETS2 v-ets avian erythroblastosis virus E26 oncogene homolog 2 0.0348423
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0336046
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0333138
ABHD17C abhydrolase domain containing 17C 0.0330773
CDH17 cadherin 17, LI cadherin (liver-intestine) 0.0308828
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0301709
MUC5B mucin 5B, oligomeric mucus/gel-forming 0.030126
AREG amphiregulin 0.0300181
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0292706
KRT19 keratin 19, type I 0.0287539
TPM3 tropomyosin 3 0.0283259
EZR ezrin 0.028202
EIF3A eukaryotic translation initiation factor 3, subunit A 0.028123
CST3 cystatin C 0.0275594
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0273007
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0272479
RPS2 ribosomal protein S2 0.0270611
CENPF centromere protein F, 350/400kDa 0.026959
CYP3A5 cytochrome P450, family 3, subfamily A, polypeptide 5 0.0269372
CD44 CD44 molecule (Indian blood group) 0.0267311
LAMC2 laminin, gamma 2 0.0265846
MUC6 mucin 6, oligomeric mucus/gel-forming 0.0263955
NKD1 naked cuticle homolog 1 (Drosophila) 0.0263734
PTPRR protein tyrosine phosphatase, receptor type, R 0.0263419
PRRC2C proline-rich coiled-coil 2C 0.0252597
CLDN4 claudin 4 0.0251841
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 0.0246448
ITPRID2 ITPR interacting domain containing 2 0.024477
SLC6A20 solute carrier family 6 (proline IMINO transporter), member 20 0.0243498
TMSB4X thymosin beta 4, X-linked 0.0240213
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0238871
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.023295
ITGB4 integrin, beta 4 0.0230106
PGK1 phosphoglycerate kinase 1 0.0229962
MACF1 microtubule-actin crosslinking factor 1 0.0229386
EIF4B eukaryotic translation initiation factor 4B 0.0227095
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 0.0226972
SRRM2 serine/arginine repetitive matrix 2 0.022583
ZFP36 ZFP36 ring finger protein 0.0225007
CALB1 calbindin 1, 28kDa 0.0224857
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.022404
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0221064
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0220397
PRSS3 protease, serine, 3 0.0219282
ATP1A4 ATPase, Na+/K+ transporting, alpha 4 polypeptide 0.0217298
LAMB3 laminin, beta 3 0.0216476
SOX9 SRY (sex determining region Y)-box 9 0.0212425
SEMA3B sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B 0.0212312
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0211877
BMP4 bone morphogenetic protein 4 0.0211479
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.02091
PRELID2 PRELI domain containing 2 0.0205985
EPHA2 EPH receptor A2 0.0205836
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0198697
CALM3 calmodulin 3 (phosphorylase kinase, delta) 0.0196399
MT1E metallothionein 1E 0.0194329
MUC13 mucin 13, cell surface associated 0.0193019
MKI67 marker of proliferation Ki-67 0.0192235
ASPH aspartate beta-hydroxylase 0.0192199
DSG2 desmoglein 2 0.0191976
PTCH1 patched 1 0.018943
FLNB filamin B, beta 0.0189186
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0188598
EIF4H eukaryotic translation initiation factor 4H 0.0187153
MYL6 myosin, light chain 6, alkali, smooth muscle and non-muscle 0.0186544
KLF5 Kruppel-like factor 5 (intestinal) 0.0186026
SHB Src homology 2 domain containing adaptor protein B 0.0184079
KLF6 Kruppel-like factor 6 0.0182501
JUN jun proto-oncogene 0.0180069
AHNAK2 AHNAK nucleoprotein 2 0.0178192
EHF ets homologous factor 0.0178027

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.230202
NPSR1 neuropeptide S receptor 1 -0.130391
TMSB10 thymosin beta 10 -0.112012
GPHN gephyrin -0.0951252
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0943716
GMDS GDP-mannose 4,6-dehydratase -0.0934928
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0921155
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0880852
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0868074
RPL35A ribosomal protein L35a -0.0799099
VCL vinculin -0.0736798
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0703245
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0701342
IARS1 isoleucyl-tRNA synthetase 1 -0.0607756
RPLP1 ribosomal protein, large, P1 -0.0596971
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0531445
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0530696
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0529295
PTPRK protein tyrosine phosphatase, receptor type, K -0.0513193
GDF15 growth differentiation factor 15 -0.0475229
AHNAK AHNAK nucleoprotein -0.0469506
GARS1 glycyl-tRNA synthetase 1 -0.0467546
S100A6 S100 calcium binding protein A6 -0.0459244
AGR2 anterior gradient 2 -0.0457177
RAB1A RAB1A, member RAS oncogene family -0.0456358
MED13L mediator complex subunit 13-like -0.0451114
ANKRD17 ankyrin repeat domain 17 -0.0449698
SLC38A2 solute carrier family 38, member 2 -0.0446314
CANX calnexin -0.0443783
RPS25 ribosomal protein S25 -0.0443251
RAB3GAP1 RAB3 GTPase activating protein subunit 1 (catalytic) -0.0424234
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0422984
ZFAND3 zinc finger, AN1-type domain 3 -0.0421861
EXT1 exostosin glycosyltransferase 1 -0.0418127
ANKRD11 ankyrin repeat domain 11 -0.0415429
SEC31A SEC31 homolog A (S. cerevisiae) -0.0415372
BIRC6 baculoviral IAP repeat containing 6 -0.0408871
SETD5 SET domain containing 5 -0.0404638
FBXO11 F-box protein 11 -0.0402024
RPS24 ribosomal protein S24 -0.0384977
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0383185
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0381818
RPL27A ribosomal protein L27a -0.038081
TTC3 tetratricopeptide repeat domain 3 -0.0377308
ANTXR2 anthrax toxin receptor 2 -0.0377278
GOLGA4 golgin A4 -0.0373416
RTN3 reticulon 3 -0.0368744
COG5 component of oligomeric golgi complex 5 -0.0366412
HMGA1 high mobility group AT-hook 1 -0.0362063
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0358389
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase -0.0354701
PDIA3 protein disulfide isomerase family A, member 3 -0.0354418
GNAS GNAS complex locus -0.0354145
RPS16 ribosomal protein S16 -0.0354006
RNF145 ring finger protein 145 -0.0353839
MBNL1 muscleblind-like splicing regulator 1 -0.0353087
TPT1 tumor protein, translationally-controlled 1 -0.0353022
RAB10 RAB10, member RAS oncogene family -0.0350913
MON2 MON2 homolog (S. cerevisiae) -0.0344672
GREB1L growth regulation by estrogen in breast cancer-like -0.0344237
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0339745
ALCAM activated leukocyte cell adhesion molecule -0.0339442
RAP1B RAP1B, member of RAS oncogene family -0.0338453
RPS23 ribosomal protein S23 -0.0337648
LOC112694756 uncharaterized LOC112694756 -0.0337436
RBM39 RNA binding motif protein 39 -0.0335748
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0334223
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0333864
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0332523
PNISR PNN-interacting serine/arginine-rich protein -0.0328562
RPL34 ribosomal protein L34 -0.0323973
CD46 CD46 molecule, complement regulatory protein -0.0319757
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0317082
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0314482
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.03129
PDLIM5 PDZ and LIM domain 5 -0.0311385
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0311372
FNDC3B fibronectin type III domain containing 3B -0.0308302
PTEN phosphatase and tensin homolog -0.0308257
KDM3A lysine (K)-specific demethylase 3A -0.0306384
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0303306
MED13 mediator complex subunit 13 -0.0299023
S100P S100 calcium binding protein P -0.0298194
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0295342
CNOT2 CCR4-NOT transcription complex, subunit 2 -0.0292881
TFRC transferrin receptor -0.0291295
INSIG1 insulin induced gene 1 -0.0291057
WDR45B WD repeat domain 45B -0.0290277
PTBP3 polypyrimidine tract binding protein 3 -0.0289458
PCBP2 poly(rC) binding protein 2 -0.0289083
MBNL2 muscleblind-like splicing regulator 2 -0.0286705
MYO1E myosin IE -0.0285526
ZNF207 zinc finger protein 207 -0.0284968
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0283259
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0282597
TFG TRK-fused gene -0.0282363
TAS2R14 taste receptor, type 2, member 14 -0.0281479
RPS6 ribosomal protein S6 -0.0279461
PERP PERP, TP53 apoptosis effector -0.0279381
EIF1 eukaryotic translation initiation factor 1 -0.0277073