Adenosine_MIA PaCa-2 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
TM4SF1 transmembrane 4 L six family member 1 0.113861
WWTR1 WW domain containing transcription regulator 1 0.102491
BCAR3 breast cancer anti-estrogen resistance 3 0.0954253
TXNRD1 thioredoxin reductase 1 0.0884398
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0765537
MT2A metallothionein 2A 0.068756
CAPRIN2 caprin family member 2 0.0681882
ERRFI1 ERBB receptor feedback inhibitor 1 0.0607601
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0565162
KMT2E lysine (K)-specific methyltransferase 2E 0.0548007
ANGPTL4 angiopoietin-like 4 0.051354
TMEM41B transmembrane protein 41B 0.049106
MT1X metallothionein 1X 0.0449455
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0436363
RAI1 retinoic acid induced 1 0.0427005
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0420036
PRRC2C proline-rich coiled-coil 2C 0.0406489
SLC20A1 solute carrier family 20 (phosphate transporter), member 1 0.0388998
RTN4 reticulon 4 0.038106
MACF1 microtubule-actin crosslinking factor 1 0.037509
PTP4A2 protein tyrosine phosphatase type IVA, member 2 0.0362914
NAMPT nicotinamide phosphoribosyltransferase 0.035244
BIRC3 baculoviral IAP repeat containing 3 0.0350069
VEGFA vascular endothelial growth factor A 0.0326377
CAPN2 calpain 2, (m/II) large subunit 0.0323697
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 0.0322453
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0316653
HLA-B major histocompatibility complex, class I, B 0.0315569
EZR ezrin 0.0314547
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0313752
CD44 CD44 molecule (Indian blood group) 0.0304918
SPRY4 sprouty homolog 4 (Drosophila) 0.0302445
KLF6 Kruppel-like factor 6 0.030179
EEF2 eukaryotic translation elongation factor 2 0.0290674
TPT1 tumor protein, translationally-controlled 1 0.0286484
UBAP2L ubiquitin associated protein 2-like 0.0281212
SQSTM1 sequestosome 1 0.0277893
EREG epiregulin 0.027742
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0275332
AMPD3 adenosine monophosphate deaminase 3 0.0269317
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 0.0266287
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0263545
HSPA8 heat shock 70kDa protein 8 0.0263279
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0256271
RPS3 ribosomal protein S3 0.025492
RTTN rotatin 0.0254082
HPCAL1 hippocalcin-like 1 0.0252984
SERPINB9 serpin peptidase inhibitor, clade B (ovalbumin), member 9 0.0252586
TFPI tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) 0.0249242
VCL vinculin 0.0247911
USP9X ubiquitin specific peptidase 9, X-linked 0.024238
MATR3 matrin 3 0.0242105
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0242104
SPRED2 sprouty-related, EVH1 domain containing 2 0.023992
DENND5A DENN/MADD domain containing 5A 0.0236757
ACTG1 actin gamma 1 0.0235114
HIVEP3 human immunodeficiency virus type I enhancer binding protein 3 0.0232469
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b 0.0231728
PARP4 poly (ADP-ribose) polymerase family, member 4 0.0231008
CCNL1 cyclin L1 0.0229504
PRRC2B proline-rich coiled-coil 2B 0.0228136
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 0.0227586
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0224102
RAB7A RAB7A, member RAS oncogene family 0.022235
ADAM17 ADAM metallopeptidase domain 17 0.0221848
EMP1 epithelial membrane protein 1 0.0221514
F2R coagulation factor II (thrombin) receptor 0.0219475
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0218166
SMURF2 SMAD specific E3 ubiquitin protein ligase 2 0.021464
WDR43 WD repeat domain 43 0.021172
NPAS2 neuronal PAS domain protein 2 0.0211429
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.020917
ZBTB38 zinc finger and BTB domain containing 38 0.0208892
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0206484
BMERB1 bMERB domain containing 1 0.0206273
JMJD1C jumonji domain containing 1C 0.0206164
B4GALT5 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 0.0205808
AREG amphiregulin 0.0205171
MT1E metallothionein 1E 0.0204732
GCLM glutamate-cysteine ligase, modifier subunit 0.0204484
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.020363
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 0.0203114
ZFP36L1 ZFP36 ring finger protein-like 1 0.0201403
STAT1 signal transducer and activator of transcription 1, 91kDa 0.020002
CACNG8 calcium channel, voltage-dependent, gamma subunit 8 0.0199814
YBX3 Y box binding protein 3 0.0198715
SYAP1 synapse associated protein 1 0.0193832
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.0193449
BHLHE40 basic helix-loop-helix family, member e40 0.0193
RACK1 receptor for activated C kinase 1 0.0188353
FOSL1 FOS-like antigen 1 0.0184958
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0184644
SPAG9 sperm associated antigen 9 0.0182819
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0182764
TRA2B transformer 2 beta homolog (Drosophila) 0.0182232
RNF168 ring finger protein 168, E3 ubiquitin protein ligase 0.0180444
ILF3 interleukin enhancer binding factor 3, 90kDa 0.0179843
WARS1 tryptophanyl-tRNA synthetase 1 0.0179649
FUS FUS RNA binding protein 0.0178364
RPS18 ribosomal protein S18 0.0177832

decreased expression

Symbol Name Standardized Value
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.137873
TP63 tumor protein p63 -0.122849
DST dystonin -0.121235
CADM2 cell adhesion molecule 2 -0.1043
EFNA5 ephrin-A5 -0.0921915
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C -0.0898368
EPHA4 EPH receptor A4 -0.0763936
CFAP299 cilia and flagella associated protein 299 -0.0744271
DLG1 discs, large homolog 1 (Drosophila) -0.0730842
TNS3 tensin 3 -0.0729923
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0714893
EXOC4 exocyst complex component 4 -0.069417
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0669506
EHBP1 EH domain binding protein 1 -0.0663779
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0662419
CSMD3 CUB and Sushi multiple domains 3 -0.0656976
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.0603033
POTEF POTE ankyrin domain family, member F -0.0581163
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0573276
PIAS2 protein inhibitor of activated STAT, 2 -0.0563149
LPP LIM domain containing preferred translocation partner in lipoma -0.0558331
HDAC9 histone deacetylase 9 -0.0549607
FNDC3B fibronectin type III domain containing 3B -0.0548814
MBNL2 muscleblind-like splicing regulator 2 -0.0530992
DPYD dihydropyrimidine dehydrogenase -0.0506357
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0505552
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0493051
EGFR epidermal growth factor receptor -0.0486476
MYOF myoferlin -0.0480114
PSD3 pleckstrin and Sec7 domain containing 3 -0.0478995
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0472858
VIM vimentin -0.0471139
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0443248
PRELID2 PRELI domain containing 2 -0.0441733
CANX calnexin -0.0439153
PTMA prothymosin, alpha -0.043243
ZDHHC14 zinc finger, DHHC-type containing 14 -0.0430451
TTC3 tetratricopeptide repeat domain 3 -0.0428717
KDM4C lysine (K)-specific demethylase 4C -0.042105
PTK2 protein tyrosine kinase 2 -0.0419663
SLC39A10 solute carrier family 39 (zinc transporter), member 10 -0.0419202
TMSB10 thymosin beta 10 -0.040322
TSC22D1 TSC22 domain family, member 1 -0.0400521
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like -0.0398267
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0371557
DENND1A DENN/MADD domain containing 1A -0.0369777
SMCHD1 structural maintenance of chromosomes flexible hinge domain containing 1 -0.0361287
FNIP1 folliculin interacting protein 1 -0.036052
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0345832
AHNAK AHNAK nucleoprotein -0.0342037
DOCK11 dedicator of cytokinesis 11 -0.0340532
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0337395
TRIO trio Rho guanine nucleotide exchange factor -0.033735
HDLBP high density lipoprotein binding protein -0.0336781
MBD5 methyl-CpG binding domain protein 5 -0.0330381
GNPDA1 glucosamine-6-phosphate deaminase 1 -0.0321803
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0319713
P4HB prolyl 4-hydroxylase, beta polypeptide -0.030887
LYST lysosomal trafficking regulator -0.0306802
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0299202
SLCO1B3 solute carrier organic anion transporter family, member 1B3 -0.029696
TAS2R14 taste receptor, type 2, member 14 -0.0292826
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0292204
COL5A2 collagen, type V, alpha 2 -0.029179
CUX1 cut-like homeobox 1 -0.0289268
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0285938
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -0.0285371
SBF2 SET binding factor 2 -0.0282377
ESYT2 extended synaptotagmin-like protein 2 -0.0280952
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase -0.0279
ZNF292 zinc finger protein 292 -0.0278374
ARHGAP12 Rho GTPase activating protein 12 -0.0277199
APP amyloid beta (A4) precursor protein -0.0275714
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0267681
AEBP2 AE binding protein 2 -0.026758
LOC112694756 uncharaterized LOC112694756 -0.0267407
EPB41 erythrocyte membrane protein band 4.1 -0.0266695
OGDH oxoglutarate (alpha-ketoglutarate) dehydrogenase (lipoamide) -0.0265062
MYCBP2 MYC binding protein 2, E3 ubiquitin protein ligase -0.0264266
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0261568
MYO9A myosin IXA -0.0260419
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0258589
WDR59 WD repeat domain 59 -0.0254186
WDR27 WD repeat domain 27 -0.0251626
AKAP9 A kinase (PRKA) anchor protein 9 -0.025148
SOD2 superoxide dismutase 2, mitochondrial -0.0250475
ADGRL3 adhesion G protein-coupled receptor L3 -0.025034
TTC28 tetratricopeptide repeat domain 28 -0.0248343
FOXN3 forkhead box N3 -0.0245024
LMAN1 lectin, mannose-binding, 1 -0.0244297
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0243811
HSPG2 heparan sulfate proteoglycan 2 -0.0243406
ZMYND8 zinc finger, MYND-type containing 8 -0.024152
RNF213 ring finger protein 213 -0.0241286
GOLGB1 golgin B1 -0.0240609
MTCL1 microtubule crosslinking factor 1 -0.024045
PIK3C2A phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha -0.0238646
TXNIP thioredoxin interacting protein -0.0234765
SP100 SP100 nuclear antigen -0.0234057
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0233499