Adenosine_NCI-H1573 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in NCI-H1573 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
CST3 cystatin C 0.1362
ERO1A endoplasmic reticulum oxidoreductase 1 alpha 0.12777
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.125663
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.114236
CYP24A1 cytochrome P450, family 24, subfamily A, polypeptide 1 0.105654
LAMC2 laminin, gamma 2 0.0968846
RPS3 ribosomal protein S3 0.0849264
VEGFA vascular endothelial growth factor A 0.0804252
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 0.0800603
EFNA5 ephrin-A5 0.0705969
LAMA4 laminin, alpha 4 0.0681572
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0680001
MT2A metallothionein 2A 0.0643222
RNF213 ring finger protein 213 0.0603147
EGFR epidermal growth factor receptor 0.0590867
FAM13A family with sequence similarity 13, member A 0.0587821
CES1 carboxylesterase 1 0.0574623
AREG amphiregulin 0.051466
STC1 stanniocalcin 1 0.0504287
CAV2 caveolin 2 0.0499485
IFI6 interferon, alpha-inducible protein 6 0.0490176
ELF3 E74-like factor 3 (ets domain transcription factor, epithelial-specific ) 0.0488884
RPS12 ribosomal protein S12 0.0481806
ANKRD11 ankyrin repeat domain 11 0.048094
NAMPT nicotinamide phosphoribosyltransferase 0.0473687
TMSB10 thymosin beta 10 0.0471314
KRT18 keratin 18, type I 0.0471228
CEMIP cell migration inducing protein, hyaluronan binding 0.0462749
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0458247
MSN moesin 0.0450311
AKAP12 A kinase (PRKA) anchor protein 12 0.0449582
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) 0.0439599
SMAD3 SMAD family member 3 0.0435022
B2M beta-2-microglobulin 0.0433012
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0414808
SRRM2 serine/arginine repetitive matrix 2 0.0412222
THSD4 thrombospondin, type I, domain containing 4 0.0409015
EGR1 early growth response 1 0.0386673
ARRDC3 arrestin domain containing 3 0.0379124
SHANK2 SH3 and multiple ankyrin repeat domains 2 0.036979
MACF1 microtubule-actin crosslinking factor 1 0.0369639
SEC61G Sec61 gamma subunit 0.0368967
DSPP dentin sialophosphoprotein 0.0365062
TMEM45B transmembrane protein 45B 0.0358278
CXCL8 chemokine (C-X-C motif) ligand 8 0.0357924
LAMB3 laminin, beta 3 0.0356369
HSPA8 heat shock 70kDa protein 8 0.0346951
NDRG1 N-myc downstream regulated 1 0.0345946
PLAUR plasminogen activator, urokinase receptor 0.0340363
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 0.0337907
ENO1 enolase 1, (alpha) 0.0337766
RPL37A ribosomal protein L37a 0.0321605
MCL1 myeloid cell leukemia 1 0.0315142
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0313117
GRB10 growth factor receptor-bound protein 10 0.0313018
SLK STE20-like kinase 0.0311093
LANCL2 LanC lantibiotic synthetase component C-like 2 (bacterial) 0.0309252
EPAS1 endothelial PAS domain protein 1 0.0304535
LDHA lactate dehydrogenase A 0.0299192
HLA-B major histocompatibility complex, class I, B 0.029743
MYH9 myosin, heavy chain 9, non-muscle 0.0280888
CALM1 calmodulin 1 (phosphorylase kinase, delta) 0.0279858
FTH1 ferritin, heavy polypeptide 1 0.0278397
AKAP13 A kinase (PRKA) anchor protein 13 0.0274229
NTSR1 neurotensin receptor 1 (high affinity) 0.0273492
EMP1 epithelial membrane protein 1 0.0271984
YBX3 Y box binding protein 3 0.0265844
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0265518
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 0.0264177
ZMYND8 zinc finger, MYND-type containing 8 0.0262508
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0260395
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0260078
RPS17 ribosomal protein S17 0.0259908
CIB1 calcium and integrin binding 1 (calmyrin) 0.0256986
BCAR3 breast cancer anti-estrogen resistance 3 0.0255304
ATN1 atrophin 1 0.0255142
TPM3 tropomyosin 3 0.0254952
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0253901
XDH xanthine dehydrogenase 0.0251607
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0251063
MLKL mixed lineage kinase domain-like 0.0246768
PKM pyruvate kinase, muscle 0.0244235
NDUFV2 NADH dehydrogenase (ubiquinone) flavoprotein 2, 24kDa 0.0243485
DOCK5 dedicator of cytokinesis 5 0.0243009
ANXA1 annexin A1 0.0242995
ANGPTL4 angiopoietin-like 4 0.0241511
CLDN4 claudin 4 0.0240487
RPL23 ribosomal protein L23 0.0239275
IFI44L interferon-induced protein 44-like 0.0236948
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.0236099
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0235944
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0234231
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0233747
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.0231242
KCNK1 potassium channel, two pore domain subfamily K, member 1 0.0229655
SLTM SAFB-like, transcription modulator 0.0229114
RPS8 ribosomal protein S8 0.0227759
FNDC3B fibronectin type III domain containing 3B 0.0226216
AHNAK2 AHNAK nucleoprotein 2 0.0225078
S100P S100 calcium binding protein P 0.0223563

decreased expression

Symbol Name Standardized Value
TXNRD1 thioredoxin reductase 1 -0.182695
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0945846
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0914505
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0663421
LMO7 LIM domain 7 -0.0653971
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0593312
SPAG9 sperm associated antigen 9 -0.0592543
TOP1 topoisomerase (DNA) I -0.0581015
CAMTA1 calmodulin binding transcription activator 1 -0.0579572
CANX calnexin -0.0578376
HDLBP high density lipoprotein binding protein -0.0576156
BIRC6 baculoviral IAP repeat containing 6 -0.0544304
SOD2 superoxide dismutase 2, mitochondrial -0.0535512
LOC112694756 uncharaterized LOC112694756 -0.0527867
USP34 ubiquitin specific peptidase 34 -0.0496823
ZC3H11A zinc finger CCCH-type containing 11A -0.0459554
TMEM165 transmembrane protein 165 -0.0450287
AHNAK AHNAK nucleoprotein -0.0447107
DSCAM Down syndrome cell adhesion molecule -0.0446444
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0443049
MORF4L2 mortality factor 4 like 2 -0.0437418
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0393285
RAB1A RAB1A, member RAS oncogene family -0.0390749
ZBTB20 zinc finger and BTB domain containing 20 -0.0386567
NABP1 nucleic acid binding protein 1 -0.0384596
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0375065
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0374334
KDM3A lysine (K)-specific demethylase 3A -0.0373337
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 -0.0367092
VCL vinculin -0.0366821
SEPTIN2 septin 2 -0.0362423
GCLC glutamate-cysteine ligase, catalytic subunit -0.0356848
ABLIM1 actin binding LIM protein 1 -0.0354998
GSK3B glycogen synthase kinase 3 beta -0.0339235
GPC6 glypican 6 -0.0333682
TMTC2 transmembrane and tetratricopeptide repeat containing 2 -0.0333306
FBXO11 F-box protein 11 -0.0330111
MARF1 meiosis regulator and mRNA stability factor 1 -0.0326102
SEC31A SEC31 homolog A (S. cerevisiae) -0.0325348
RBM39 RNA binding motif protein 39 -0.0318061
HBP1 HMG-box transcription factor 1 -0.0313874
NBEAL1 neurobeachin-like 1 -0.0313292
INTS6 integrator complex subunit 6 -0.0312428
PPFIA1 protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 -0.0312338
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0310895
ZMYM2 zinc finger, MYM-type 2 -0.0309291
HOMER1 homer scaffolding protein 1 -0.0308304
BRWD1 bromodomain and WD repeat domain containing 1 -0.0307271
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0305087
ASPH aspartate beta-hydroxylase -0.0304202
H1-0 H1.0 linker histone -0.0302719
AGO2 argonaute RISC catalytic component 2 -0.0302285
MYOF myoferlin -0.0297945
WASF2 WAS protein family, member 2 -0.0288998
DDX17 DEAD (Asp-Glu-Ala-Asp) box helicase 17 -0.0288926
ARID2 AT rich interactive domain 2 (ARID, RFX-like) -0.0287323
GM2A GM2 ganglioside activator -0.028702
WDR45B WD repeat domain 45B -0.0284458
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0281605
TAS2R14 taste receptor, type 2, member 14 -0.0279879
VDAC1 voltage-dependent anion channel 1 -0.0279428
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0277977
RALGAPA1 Ral GTPase activating protein, alpha subunit 1 (catalytic) -0.0275886
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0275375
LRP1B low density lipoprotein receptor-related protein 1B -0.0274554
TKT transketolase -0.0273834
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0272981
HELZ helicase with zinc finger -0.0270886
NF1 neurofibromin 1 -0.0267736
SEMA4B sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B -0.0267216
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0266229
ANKRD10 ankyrin repeat domain 10 -0.0265566
SPDYA speedy/RINGO cell cycle regulator family member A -0.0263124
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0262304
SUCO SUN domain containing ossification factor -0.0258527
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0258039
SEC24D SEC24 family member D -0.0257272
MON2 MON2 homolog (S. cerevisiae) -0.0257143
PATJ PATJ crumbs cell polarity complex component -0.0254098
STRN3 striatin, calmodulin binding protein 3 -0.0252154
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase -0.0249586
TMCO3 transmembrane and coiled-coil domains 3 -0.0247678
NGLY1 N-glycanase 1 -0.0244239
ITFG1 integrin alpha FG-GAP repeat containing 1 -0.0241523
SCLT1 sodium channel and clathrin linker 1 -0.0241167
LRCH3 leucine-rich repeats and calponin homology (CH) domain containing 3 -0.0240563
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0238836
SRGAP1 SLIT-ROBO Rho GTPase activating protein 1 -0.0235193
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0233809
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.023282
ZFC3H1 zinc finger, C3H1-type containing -0.0230198
UVRAG UV radiation resistance associated -0.0229043
TSC22D2 TSC22 domain family, member 2 -0.0224926
PJA2 praja ring finger 2, E3 ubiquitin protein ligase -0.0223571
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0222965
RPS24 ribosomal protein S24 -0.0220741
SRP54 signal recognition particle 54kDa -0.0220276
TAOK1 TAO kinase 1 -0.0219895
RIMS2 regulating synaptic membrane exocytosis 2 -0.0218099
CLTC clathrin, heavy chain (Hc) -0.0217666