Adenosine_NCI-H1792 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in NCI-H1792 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.178481
AKAP12 A kinase (PRKA) anchor protein 12 0.145577
GRB10 growth factor receptor-bound protein 10 0.091475
SMAD3 SMAD family member 3 0.0837513
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0773313
ZEB2 zinc finger E-box binding homeobox 2 0.0660597
CD44 CD44 molecule (Indian blood group) 0.0553324
NAV2 neuron navigator 2 0.051579
COL7A1 collagen, type VII, alpha 1 0.0507157
LOXL2 lysyl oxidase-like 2 0.0482719
SIK3 SIK family kinase 3 0.0443306
ITPR1 inositol 1,4,5-trisphosphate receptor, type 1 0.0443166
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0440791
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 0.0437611
ECE1 endothelin converting enzyme 1 0.0435371
TIMP1 TIMP metallopeptidase inhibitor 1 0.0413546
DOCK5 dedicator of cytokinesis 5 0.0407047
TGM2 transglutaminase 2 0.0390349
NCOR2 nuclear receptor corepressor 2 0.0380541
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0364346
OPTN optineurin 0.035838
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0358031
PMEPA1 prostate transmembrane protein, androgen induced 1 0.0354876
RAD51B RAD51 paralog B 0.0352855
FTH1 ferritin, heavy polypeptide 1 0.0346492
MYC v-myc avian myelocytomatosis viral oncogene homolog 0.0327522
ANGPTL4 angiopoietin-like 4 0.0318556
PFKP phosphofructokinase, platelet 0.0310278
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0308573
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.0308184
MLPH melanophilin 0.0305516
SHB Src homology 2 domain containing adaptor protein B 0.0302721
ARHGAP5 Rho GTPase activating protein 5 0.0299169
BHLHE40 basic helix-loop-helix family, member e40 0.0293488
SYNJ2 synaptojanin 2 0.0288674
FHL2 four and a half LIM domains 2 0.0280428
WWTR1 WW domain containing transcription regulator 1 0.0279028
EZR ezrin 0.0276677
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0275286
MACF1 microtubule-actin crosslinking factor 1 0.0274935
SPRED2 sprouty-related, EVH1 domain containing 2 0.0274705
AMPD3 adenosine monophosphate deaminase 3 0.0274394
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0274131
RUNX1 runt-related transcription factor 1 0.0269442
MAP1B microtubule-associated protein 1B 0.0268687
NRP1 neuropilin 1 0.026501
ZFP36L1 ZFP36 ring finger protein-like 1 0.0263195
C1D C1D nuclear receptor corepressor 0.0263161
MSN moesin 0.0260938
VEGFC vascular endothelial growth factor C 0.0259587
NHS Nance-Horan syndrome (congenital cataracts and dental anomalies) 0.0259049
WLS wntless Wnt ligand secretion mediator 0.0256017
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0253895
NDRG1 N-myc downstream regulated 1 0.0251793
ESYT2 extended synaptotagmin-like protein 2 0.0249441
FLNB filamin B, beta 0.024931
DAB2 Dab, mitogen-responsive phosphoprotein, homolog 2 (Drosophila) 0.0248864
ANKRD28 ankyrin repeat domain 28 0.0245988
DPYSL3 dihydropyrimidinase-like 3 0.0244243
HAS2 hyaluronan synthase 2 0.0239919
EGR1 early growth response 1 0.0239916
ELL2 elongation factor, RNA polymerase II, 2 0.0237399
PODXL podocalyxin-like 0.02371
CA12 carbonic anhydrase XII 0.0236725
ABTB2 ankyrin repeat and BTB (POZ) domain containing 2 0.0236009
CEP250 centrosomal protein 250kDa 0.023505
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 0.0233595
RNASEH2A ribonuclease H2, subunit A 0.0232346
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 0.0231016
FOSB FBJ murine osteosarcoma viral oncogene homolog B 0.0230156
CHD1L chromodomain helicase DNA binding protein 1-like 0.0228906
STRA6 stimulated by retinoic acid 6 0.0227972
TNS1 tensin 1 0.0226736
RHBDF2 rhomboid 5 homolog 2 (Drosophila) 0.0225312
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0221893
ITGAV integrin, alpha V 0.0219538
KIAA1217 KIAA1217 0.0218198
HMGA1 high mobility group AT-hook 1 0.0217648
IRAK2 interleukin-1 receptor-associated kinase 2 0.0216925
MAST4 microtubule associated serine/threonine kinase family member 4 0.0216862
LHFPL2 lipoma HMGIC fusion partner-like 2 0.0214609
RNF24 ring finger protein 24 0.0213661
HIPK2 homeodomain interacting protein kinase 2 0.0212318
ZNRF1 zinc and ring finger 1, E3 ubiquitin protein ligase 0.0212137
ZNF469 zinc finger protein 469 0.0209634
SVIL supervillin 0.0209346
NTN4 netrin 4 0.0209229
ACTN4 actinin, alpha 4 0.0207896
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0207024
SEPTIN9 septin 9 0.020665
FOSL1 FOS-like antigen 1 0.020564
GPAT3 glycerol-3-phosphate acyltransferase 3 0.0205184
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 0.0203561
STK38L serine/threonine kinase 38 like 0.0202462
FAM13A family with sequence similarity 13, member A 0.0201456
RPL36 ribosomal protein L36 0.0200986
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0200749
SREBF2 sterol regulatory element binding transcription factor 2 0.0200226
MYO10 myosin X 0.019976
ADAM17 ADAM metallopeptidase domain 17 0.0197917

decreased expression

Symbol Name Standardized Value
CXCL8 chemokine (C-X-C motif) ligand 8 -0.222602
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.164739
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.155122
PDE4D phosphodiesterase 4D, cAMP-specific -0.133433
NRG1 neuregulin 1 -0.125971
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.124103
SOD2 superoxide dismutase 2, mitochondrial -0.11829
CDH13 cadherin 13 -0.106864
SDK1 sidekick cell adhesion molecule 1 -0.101451
LOX lysyl oxidase -0.0960843
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0749669
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 -0.0721301
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0720324
RAB1A RAB1A, member RAS oncogene family -0.0703164
CANX calnexin -0.0700172
TFPI2 tissue factor pathway inhibitor 2 -0.0674964
NCOA7 nuclear receptor coactivator 7 -0.066576
TAS2R14 taste receptor, type 2, member 14 -0.0616908
AHNAK AHNAK nucleoprotein -0.0602062
MTSS1 metastasis suppressor 1 -0.0598573
PSD3 pleckstrin and Sec7 domain containing 3 -0.0586822
USP34 ubiquitin specific peptidase 34 -0.0551818
ZNF804A zinc finger protein 804A -0.0544273
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0531442
GPC6 glypican 6 -0.0514799
FN1 fibronectin 1 -0.0514636
HMGA2 high mobility group AT-hook 2 -0.0507257
DLG1 discs, large homolog 1 (Drosophila) -0.05067
DPYD dihydropyrimidine dehydrogenase -0.0494517
FBN1 fibrillin 1 -0.049284
HDLBP high density lipoprotein binding protein -0.0490668
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 -0.0485025
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0482263
CSGALNACT1 chondroitin sulfate N-acetylgalactosaminyltransferase 1 -0.0473027
UBC ubiquitin C -0.0470673
KDM3A lysine (K)-specific demethylase 3A -0.0461786
STC1 stanniocalcin 1 -0.0454861
RBM39 RNA binding motif protein 39 -0.0453075
FAM20C family with sequence similarity 20, member C -0.0451377
DNER delta/notch-like EGF repeat containing -0.0440377
PID1 phosphotyrosine interaction domain containing 1 -0.0428812
LMAN1 lectin, mannose-binding, 1 -0.0423264
CDK14 cyclin-dependent kinase 14 -0.0422307
EFCAB13 EF-hand calcium binding domain 13 -0.0421595
GOLGA4 golgin A4 -0.0421419
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0408046
ASPH aspartate beta-hydroxylase -0.0399419
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0393547
SEC31A SEC31 homolog A (S. cerevisiae) -0.0389102
COL12A1 collagen, type XII, alpha 1 -0.0387878
EREG epiregulin -0.0387592
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0385189
NLK nemo-like kinase -0.0384277
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0383351
SP100 SP100 nuclear antigen -0.037654
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0372383
ADAMTS6 ADAM metallopeptidase with thrombospondin type 1 motif, 6 -0.0372072
SOS1 son of sevenless homolog 1 (Drosophila) -0.0368961
BRIP1 BRCA1 interacting protein C-terminal helicase 1 -0.0354623
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0351437
NAP1L1 nucleosome assembly protein 1-like 1 -0.0343555
TMEM263 transmembrane protein 263 -0.034319
TTC3 tetratricopeptide repeat domain 3 -0.034058
MBD5 methyl-CpG binding domain protein 5 -0.0339298
ATG7 autophagy related 7 -0.0336303
NUMB numb homolog (Drosophila) -0.0333077
PTMA prothymosin, alpha -0.0332625
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0331815
NF1 neurofibromin 1 -0.0331426
AADAC arylacetamide deacetylase -0.0330821
PDIA3 protein disulfide isomerase family A, member 3 -0.0328215
PHF3 PHD finger protein 3 -0.0325688
BTG1 B-cell translocation gene 1, anti-proliferative -0.0322206
DDIT3 DNA-damage-inducible transcript 3 -0.0321992
RPS24 ribosomal protein S24 -0.0320399
HERC4 HECT and RLD domain containing E3 ubiquitin protein ligase 4 -0.0320344
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0319514
MSRB3 methionine sulfoxide reductase B3 -0.0319119
VCL vinculin -0.0313707
BZW1 basic leucine zipper and W2 domains 1 -0.0313103
TMTC1 transmembrane and tetratricopeptide repeat containing 1 -0.0311758
ANKIB1 ankyrin repeat and IBR domain containing 1 -0.0311325
SAMD9 sterile alpha motif domain containing 9 -0.0310994
SPDYA speedy/RINGO cell cycle regulator family member A -0.0310973
IER3 immediate early response 3 -0.030454
ENO1 enolase 1, (alpha) -0.030437
MON2 MON2 homolog (S. cerevisiae) -0.0303756
MAGI2 membrane associated guanylate kinase, WW and PDZ domain containing 2 -0.0302838
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0300229
TRPS1 trichorhinophalangeal syndrome I -0.0299565
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0299191
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0297545
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0295442
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0294655
GLCCI1 glucocorticoid induced 1 -0.0293975
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 -0.0292826
DIAPH2 diaphanous-related formin 2 -0.0292312
ZFAND3 zinc finger, AN1-type domain 3 -0.0291495
BIRC6 baculoviral IAP repeat containing 6 -0.0290374
CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 -0.0290123