Adenosine_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.242116
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.132304
TXNRD1 thioredoxin reductase 1 0.0893245
EEF2 eukaryotic translation elongation factor 2 0.0855032
YBX3 Y box binding protein 3 0.0770213
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0725884
GRAMD1B GRAM domain containing 1B 0.0720044
TPM3 tropomyosin 3 0.0642773
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0568247
POTEF POTE ankyrin domain family, member F 0.0558789
MYH9 myosin, heavy chain 9, non-muscle 0.0555689
TPI1 triosephosphate isomerase 1 0.0534175
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa 0.0531294
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0500938
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0471401
ERRFI1 ERBB receptor feedback inhibitor 1 0.0457761
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0445751
DOCK5 dedicator of cytokinesis 5 0.0430754
TM4SF1 transmembrane 4 L six family member 1 0.0425247
BRD2 bromodomain containing 2 0.0396381
ATP11A ATPase, class VI, type 11A 0.0390386
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0383436
KRT18 keratin 18, type I 0.0376131
CDK17 cyclin-dependent kinase 17 0.0373228
CCNL1 cyclin L1 0.0370706
EGR1 early growth response 1 0.0370392
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0363777
MT2A metallothionein 2A 0.0343744
PFN1 profilin 1 0.0342747
HSPA8 heat shock 70kDa protein 8 0.0342494
STC1 stanniocalcin 1 0.0333301
ELL2 elongation factor, RNA polymerase II, 2 0.0324158
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0318309
MEF2D myocyte enhancer factor 2D 0.0311469
WWOX WW domain containing oxidoreductase 0.0309031
PNN pinin, desmosome associated protein 0.0308264
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0307398
LATS2 large tumor suppressor kinase 2 0.0302852
RRM2 ribonucleotide reductase M2 0.0302785
VMP1 vacuole membrane protein 1 0.0300787
ACTN1 actinin, alpha 1 0.0291426
UBAP2L ubiquitin associated protein 2-like 0.028789
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0286577
PRRC2C proline-rich coiled-coil 2C 0.0283038
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0281843
KLF7 Kruppel-like factor 7 (ubiquitous) 0.0279158
ZFP36L1 ZFP36 ring finger protein-like 1 0.0277492
CTTN cortactin 0.0275116
SET SET nuclear proto-oncogene 0.0274031
NR4A3 nuclear receptor subfamily 4, group A, member 3 0.0270308
FLNA filamin A, alpha 0.0269229
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 0.0269154
RAB7A RAB7A, member RAS oncogene family 0.0266876
PDE10A phosphodiesterase 10A 0.0264621
ANXA5 annexin A5 0.0263621
SFPQ splicing factor proline/glutamine-rich 0.0261134
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0260628
RPL3 ribosomal protein L3 0.0260244
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 0.0258288
SRRM2 serine/arginine repetitive matrix 2 0.025571
CALD1 caldesmon 1 0.0255457
MSN moesin 0.0255102
LDHA lactate dehydrogenase A 0.0255
SYNE2 spectrin repeat containing, nuclear envelope 2 0.0253796
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0252984
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 0.025113
MSH6 mutS homolog 6 0.0249078
MARCHF4 membrane associated ring-CH-type finger 4 0.0248728
CSDE1 cold shock domain containing E1, RNA-binding 0.0247112
ACTR3 ARP3 actin-related protein 3 homolog (yeast) 0.0244463
PTPRF protein tyrosine phosphatase, receptor type, F 0.0243071
PTPN12 protein tyrosine phosphatase, non-receptor type 12 0.0240874
DNMBP dynamin binding protein 0.023907
UBE2D3 ubiquitin-conjugating enzyme E2D 3 0.0237582
NCAPG2 non-SMC condensin II complex, subunit G2 0.0237095
DDAH1 dimethylarginine dimethylaminohydrolase 1 0.0235848
KMT2D lysine (K)-specific methyltransferase 2D 0.0235784
SNX9 sorting nexin 9 0.0235627
RNF145 ring finger protein 145 0.0234242
PRPF8 pre-mRNA processing factor 8 0.0232294
TLN1 talin 1 0.0231251
YBX1 Y box binding protein 1 0.0230477
CEP250 centrosomal protein 250kDa 0.0222387
IQGAP3 IQ motif containing GTPase activating protein 3 0.0221828
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0220844
IL6ST interleukin 6 signal transducer 0.0219949
SNRNP200 small nuclear ribonucleoprotein 200kDa (U5) 0.0219946
TBK1 TANK-binding kinase 1 0.0218915
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0217527
FUS FUS RNA binding protein 0.0216784
RBM25 RNA binding motif protein 25 0.0215118
EML4 echinoderm microtubule associated protein like 4 0.0213546
MAPK8 mitogen-activated protein kinase 8 0.0212832
SPRED2 sprouty-related, EVH1 domain containing 2 0.0210988
PRRC2A proline-rich coiled-coil 2A 0.0210957
LUZP1 leucine zipper protein 1 0.0210609
EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 0.0207514
ATP13A3 ATPase type 13A3 0.0206003
EIF4A1 eukaryotic translation initiation factor 4A1 0.0205074
FOXM1 forkhead box M1 0.0203784

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.159957
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0945872
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0887884
TAS2R14 taste receptor, type 2, member 14 -0.0781971
RPL37 ribosomal protein L37 -0.0707725
RPL35A ribosomal protein L35a -0.0689749
ZBTB20 zinc finger and BTB domain containing 20 -0.0626951
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0617858
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0617553
AHNAK AHNAK nucleoprotein -0.0544754
CANX calnexin -0.0532663
PTMA prothymosin, alpha -0.0510404
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0499449
GOLGB1 golgin B1 -0.0492129
EIF1 eukaryotic translation initiation factor 1 -0.0460418
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0447699
USP34 ubiquitin specific peptidase 34 -0.0446227
TPT1 tumor protein, translationally-controlled 1 -0.0439605
VIM vimentin -0.0431763
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0427502
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0423879
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0414624
FBXO11 F-box protein 11 -0.040893
RAB10 RAB10, member RAS oncogene family -0.0381294
KDM3A lysine (K)-specific demethylase 3A -0.035707
GNAS GNAS complex locus -0.0355211
AFF3 AF4/FMR2 family, member 3 -0.0352699
RSF1 remodeling and spacing factor 1 -0.0344957
MBD5 methyl-CpG binding domain protein 5 -0.0339733
NCOA7 nuclear receptor coactivator 7 -0.0333714
AEBP2 AE binding protein 2 -0.0332945
SRP72 signal recognition particle 72kDa -0.0332749
HMGA2 high mobility group AT-hook 2 -0.0329125
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0324973
PRH1 proline-rich protein HaeIII subfamily 1 -0.0320835
N4BP2L2 NEDD4 binding protein 2-like 2 -0.0317357
AGO3 argonaute RISC catalytic component 3 -0.0316852
RPS8 ribosomal protein S8 -0.0315805
ERC1 ELKS/RAB6-interacting/CAST family member 1 -0.0313606
BBX bobby sox homolog (Drosophila) -0.0312986
RPL32 ribosomal protein L32 -0.0312255
RPS24 ribosomal protein S24 -0.0308266
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0307704
RPL37A ribosomal protein L37a -0.0307538
RPS27A ribosomal protein S27a -0.0301198
RPS29 ribosomal protein S29 -0.0294728
RPL26 ribosomal protein L26 -0.0294463
ZNF609 zinc finger protein 609 -0.0294136
NBEAL1 neurobeachin-like 1 -0.0292783
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0292094
RPS25 ribosomal protein S25 -0.0291762
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0290237
WNT2B wingless-type MMTV integration site family, member 2B -0.0288524
IARS1 isoleucyl-tRNA synthetase 1 -0.0284977
CAMKMT calmodulin-lysine N-methyltransferase -0.0284809
CDK13 cyclin-dependent kinase 13 -0.0282282
MAP4 microtubule-associated protein 4 -0.0282134
UBE3C ubiquitin protein ligase E3C -0.0279416
KDM4B lysine (K)-specific demethylase 4B -0.0278413
RPL38 ribosomal protein L38 -0.027698
RYR3 ryanodine receptor 3 -0.0273667
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0269874
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0264716
INTS6 integrator complex subunit 6 -0.0262319
RPS15 ribosomal protein S15 -0.0261015
S100A10 S100 calcium binding protein A10 -0.0258619
GOLGA4 golgin A4 -0.0255695
RABGAP1L RAB GTPase activating protein 1-like -0.0250363
EHBP1 EH domain binding protein 1 -0.0249672
VDAC1 voltage-dependent anion channel 1 -0.0248952
GPATCH2L G patch domain containing 2-like -0.0248214
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -0.0242781
LMAN1 lectin, mannose-binding, 1 -0.024235
ZBTB1 zinc finger and BTB domain containing 1 -0.0241714
HLA-B major histocompatibility complex, class I, B -0.0240283
PYGL phosphorylase, glycogen, liver -0.0239698
RPL31 ribosomal protein L31 -0.0239133
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 -0.0238326
RPLP1 ribosomal protein, large, P1 -0.0237323
TFPI2 tissue factor pathway inhibitor 2 -0.0236596
ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) -0.0235525
LRRC23 leucine rich repeat containing 23 -0.0235154
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0231846
RPS16 ribosomal protein S16 -0.0230947
BIRC6 baculoviral IAP repeat containing 6 -0.0229926
RPL30 ribosomal protein L30 -0.0228492
TPTEP2-CSNK1E TPTEP2-CSNK1E readthrough -0.022769
PDIA5 protein disulfide isomerase family A, member 5 -0.0225388
ARMH4 armadillo like helical domain containing 4 -0.0225105
RAB1A RAB1A, member RAS oncogene family -0.0223944
DENND5B DENN/MADD domain containing 5B -0.02237
PDIA4 protein disulfide isomerase family A, member 4 -0.022349
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0222509
HLA-E major histocompatibility complex, class I, E -0.0221855
TTC3 tetratricopeptide repeat domain 3 -0.0216896
TAOK1 TAO kinase 1 -0.02155
TTC17 tetratricopeptide repeat domain 17 -0.0214967
TFCP2 transcription factor CP2 -0.0212535
GOLGA3 golgin A3 -0.0210791
KIAA1328 KIAA1328 -0.0210113