Adenosine_NCI-H460 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in NCI-H460 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PM20D1 peptidase M20 domain containing 1 0.135684
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.121004
GRAMD1B GRAM domain containing 1B 0.097714
PDE10A phosphodiesterase 10A 0.0957306
DST dystonin 0.0956658
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0837911
FN1 fibronectin 1 0.0826842
PDLIM5 PDZ and LIM domain 5 0.0806243
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0773924
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0696522
COL8A1 collagen, type VIII, alpha 1 0.0692851
EEF2 eukaryotic translation elongation factor 2 0.0600525
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0595122
SMOC1 SPARC related modular calcium binding 1 0.0589586
GDA guanine deaminase 0.0583437
EPB41L3 erythrocyte membrane protein band 4.1-like 3 0.056657
CTIF CBP80/20-dependent translation initiation factor 0.054143
COL4A5 collagen, type IV, alpha 5 0.0531205
RPH3AL rabphilin 3A-like (without C2 domains) 0.0487527
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 0.0483951
CD109 CD109 molecule 0.0470252
COL5A2 collagen, type V, alpha 2 0.0470029
ZEB2 zinc finger E-box binding homeobox 2 0.0461234
AKAP13 A kinase (PRKA) anchor protein 13 0.0460616
DYNC1H1 dynein, cytoplasmic 1, heavy chain 1 0.0458317
NPAS2 neuronal PAS domain protein 2 0.0453017
BCAR3 breast cancer anti-estrogen resistance 3 0.045001
PCBP3 poly(rC) binding protein 3 0.0437679
RAB3B RAB3B, member RAS oncogene family 0.0432831
PRRC2C proline-rich coiled-coil 2C 0.0412323
TRIO trio Rho guanine nucleotide exchange factor 0.0408055
KYNU kynureninase 0.0405356
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0404629
SH3KBP1 SH3-domain kinase binding protein 1 0.0403402
ESYT2 extended synaptotagmin-like protein 2 0.0403046
INHBA inhibin, beta A 0.0402226
RPS3 ribosomal protein S3 0.0396699
COL4A6 collagen, type IV, alpha 6 0.0394824
DOCK4 dedicator of cytokinesis 4 0.0393232
HSPA8 heat shock 70kDa protein 8 0.0376951
FLNB filamin B, beta 0.037041
DOCK5 dedicator of cytokinesis 5 0.0367419
FMNL2 formin-like 2 0.0365082
CEP72 centrosomal protein 72kDa 0.0361481
NAMPT nicotinamide phosphoribosyltransferase 0.0354217
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0351521
MAFK v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog K 0.0349776
TBXT T-box transcription factor T 0.0347291
BASP1 brain abundant, membrane attached signal protein 1 0.032891
MYH9 myosin, heavy chain 9, non-muscle 0.0325786
LAMC1 laminin, gamma 1 (formerly LAMB2) 0.0323867
EZR ezrin 0.0322551
LAMA5 laminin, alpha 5 0.0310837
NCOR2 nuclear receptor corepressor 2 0.0309946
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 0.0308164
DUSP4 dual specificity phosphatase 4 0.0299951
ELL2 elongation factor, RNA polymerase II, 2 0.0296581
MSN moesin 0.0292623
ITPK1 inositol-tetrakisphosphate 1-kinase 0.0289516
NR4A1 nuclear receptor subfamily 4, group A, member 1 0.0288993
BMP6 bone morphogenetic protein 6 0.0286513
NRCAM neuronal cell adhesion molecule 0.0274432
CD44 CD44 molecule (Indian blood group) 0.0268676
TSC22D1 TSC22 domain family, member 1 0.0268578
ATXN1 ataxin 1 0.0267703
TM4SF1 transmembrane 4 L six family member 1 0.0259261
PPFIBP1 PTPRF interacting protein, binding protein 1 (liprin beta 1) 0.025919
MACF1 microtubule-actin crosslinking factor 1 0.0257065
ADGRD1 adhesion G protein-coupled receptor D1 0.0256281
FNDC3A fibronectin type III domain containing 3A 0.0252214
TNFRSF19 tumor necrosis factor receptor superfamily, member 19 0.0249102
SAMD4A sterile alpha motif domain containing 4A 0.024701
FAT1 FAT atypical cadherin 1 0.0245401
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) 0.0243613
FLNA filamin A, alpha 0.0243581
WWTR1 WW domain containing transcription regulator 1 0.0243479
ALPK2 alpha-kinase 2 0.023862
ITPRID2 ITPR interacting domain containing 2 0.0238022
EIF4H eukaryotic translation initiation factor 4H 0.0235067
SFTPA2 surfactant protein A2 0.0234408
NTN4 netrin 4 0.0232342
MFSD12 major facilitator superfamily domain containing 12 0.0231575
VEGFA vascular endothelial growth factor A 0.0231532
RPS18 ribosomal protein S18 0.0228916
CASP7 caspase 7, apoptosis-related cysteine peptidase 0.0227853
SRRM2 serine/arginine repetitive matrix 2 0.0227561
UBAP2L ubiquitin associated protein 2-like 0.0226929
SVIL supervillin 0.0221644
IGF1R insulin-like growth factor 1 receptor 0.0221251
MAML3 mastermind-like 3 (Drosophila) 0.0219444
PRELID2 PRELI domain containing 2 0.0212638
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0211197
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0208444
RGS2 regulator of G-protein signaling 2 0.0206362
NCAM1 neural cell adhesion molecule 1 0.0206186
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0205829
SPOCK1 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 0.0205414
SLC39A8 solute carrier family 39 (zinc transporter), member 8 0.0202406
CRLF2 cytokine receptor-like factor 2 0.0198795
EIF4B eukaryotic translation initiation factor 4B 0.0194709

decreased expression

Symbol Name Standardized Value
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.173321
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.131144
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.122375
PDE4D phosphodiesterase 4D, cAMP-specific -0.120209
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0812573
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.0804675
EFNA5 ephrin-A5 -0.0693344
VIM vimentin -0.067925
NALF1 NALCN channel auxiliary factor 1 -0.066772
CANX calnexin -0.0600541
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0572091
DPP10 dipeptidyl-peptidase 10 (non-functional) -0.0502804
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0426983
PDIA3 protein disulfide isomerase family A, member 3 -0.0423113
SOD2 superoxide dismutase 2, mitochondrial -0.0420061
SEMA3A sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A -0.0418094
RPS24 ribosomal protein S24 -0.0409548
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0399179
HSPD1 heat shock 60kDa protein 1 (chaperonin) -0.0384823
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0383361
NCKAP5 NCK-associated protein 5 -0.0370678
IGFBP3 insulin-like growth factor binding protein 3 -0.0365851
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0365482
SMYD3 SET and MYND domain containing 3 -0.0361409
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0361069
RPL35A ribosomal protein L35a -0.0323893
PTMA prothymosin, alpha -0.0316292
PLCB1 phospholipase C, beta 1 (phosphoinositide-specific) -0.0315494
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0307961
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide -0.0306256
NBEAL1 neurobeachin-like 1 -0.0298424
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0292269
VDAC1 voltage-dependent anion channel 1 -0.0270871
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0269293
LIMCH1 LIM and calponin homology domains 1 -0.0256944
MORF4L2 mortality factor 4 like 2 -0.025666
RPLP1 ribosomal protein, large, P1 -0.0251305
GNAS GNAS complex locus -0.0243687
CADM2 cell adhesion molecule 2 -0.024342
BIRC6 baculoviral IAP repeat containing 6 -0.0238363
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0236091
RAB1A RAB1A, member RAS oncogene family -0.022784
NCAM2 neural cell adhesion molecule 2 -0.0226483
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0225458
RPS25 ribosomal protein S25 -0.0225428
LSAMP limbic system-associated membrane protein -0.022436
SEC31A SEC31 homolog A (S. cerevisiae) -0.0221129
DIAPH2 diaphanous-related formin 2 -0.0219122
MAGT1 magnesium transporter 1 -0.0218775
ADGRB3 adhesion G protein-coupled receptor B3 -0.021397
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0212218
S100A6 S100 calcium binding protein A6 -0.0210079
SLC16A6 solute carrier family 16, member 6 -0.0208712
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0207948
VCL vinculin -0.0207731
RPL39 ribosomal protein L39 -0.0207068
IARS1 isoleucyl-tRNA synthetase 1 -0.0197079
TMSB10 thymosin beta 10 -0.0196589
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0194262
RPS6 ribosomal protein S6 -0.0192539
RPS23 ribosomal protein S23 -0.0189897
SOX6 SRY (sex determining region Y)-box 6 -0.0189064
FBXO11 F-box protein 11 -0.0187215
S100A10 S100 calcium binding protein A10 -0.0186218
TKT transketolase -0.0185718
PTPRD protein tyrosine phosphatase, receptor type, D -0.0181285
TAX1BP1 Tax1 (human T-cell leukemia virus type I) binding protein 1 -0.0180731
STARD4 StAR-related lipid transfer (START) domain containing 4 -0.0179387
GOLGA4 golgin A4 -0.0176955
MARCHF1 membrane associated ring-CH-type finger 1 -0.01768
CDK13 cyclin-dependent kinase 13 -0.0175443
NCOA7 nuclear receptor coactivator 7 -0.0173882
PDE1C phosphodiesterase 1C, calmodulin-dependent 70kDa -0.0172193
PCDH15 protocadherin-related 15 -0.0172132
TFPI2 tissue factor pathway inhibitor 2 -0.0171869
LOC112694756 uncharaterized LOC112694756 -0.0169895
SPDYA speedy/RINGO cell cycle regulator family member A -0.0169441
SCN3A sodium channel, voltage gated, type III alpha subunit -0.0167741
LMAN1 lectin, mannose-binding, 1 -0.0167147
ZNF804A zinc finger protein 804A -0.0164972
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0164841
DLGAP1 discs, large (Drosophila) homolog-associated protein 1 -0.0164322
GALNT15 polypeptide N-acetylgalactosaminyltransferase 15 -0.0163992
BZW2 basic leucine zipper and W2 domains 2 -0.0163667
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0163636
NAP1L1 nucleosome assembly protein 1-like 1 -0.016262
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -0.0161615
DPYD dihydropyrimidine dehydrogenase -0.0161141
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0160358
MAML2 mastermind-like 2 (Drosophila) -0.0159761
USP34 ubiquitin specific peptidase 34 -0.0159219
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0159114
PAPSS2 3'-phosphoadenosine 5'-phosphosulfate synthase 2 -0.0158852
GNGT1 guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 -0.0158263
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0157893
POTEF POTE ankyrin domain family, member F -0.0155224
RPS8 ribosomal protein S8 -0.0154789
AGR2 anterior gradient 2 -0.0154201
RPS16 ribosomal protein S16 -0.0153984
AHNAK AHNAK nucleoprotein -0.0153734