Adenosine_NCI-H596 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in NCI-H596 cell line (Tahoe Therapeutics)
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Genes

145 genes differentially expressed following the Adenosine_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
PDE4D phosphodiesterase 4D, cAMP-specific 0.205964
EEF2 eukaryotic translation elongation factor 2 0.164175
ACTG1 actin gamma 1 0.137601
NDRG1 N-myc downstream regulated 1 0.128871
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 0.128568
FAT1 FAT atypical cadherin 1 0.115973
PGK1 phosphoglycerate kinase 1 0.115042
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) 0.113476
GRB10 growth factor receptor-bound protein 10 0.105656
JMJD1C jumonji domain containing 1C 0.104582
PMEPA1 prostate transmembrane protein, androgen induced 1 0.103585
RPS3 ribosomal protein S3 0.102045
CCNY cyclin Y 0.0957662
LPP LIM domain containing preferred translocation partner in lipoma 0.0856846
SMURF1 SMAD specific E3 ubiquitin protein ligase 1 0.0822873
FLNB filamin B, beta 0.0801515
PRKN parkin RBR E3 ubiquitin protein ligase 0.0781315
PRELID2 PRELI domain containing 2 0.0776428
AKAP12 A kinase (PRKA) anchor protein 12 0.0758886
RPL37 ribosomal protein L37 0.0728766
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 0.0708377
BDP1 B double prime 1, subunit of RNA polymerase III transcription initiation factor IIIB 0.0668966
SMAD3 SMAD family member 3 0.0650235
SPTBN1 spectrin, beta, non-erythrocytic 1 0.0616312
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 0.0611394
PRRC2C proline-rich coiled-coil 2C 0.0597898
RBM39 RNA binding motif protein 39 0.0590704
ASPH aspartate beta-hydroxylase 0.0578392
CD44 CD44 molecule (Indian blood group) 0.0572527
SETD5 SET domain containing 5 0.050287
MAP1B microtubule-associated protein 1B 0.0488651
SIK3 SIK family kinase 3 0.0485152
LDHA lactate dehydrogenase A 0.0478506
PTK2 protein tyrosine kinase 2 0.047727
GMDS GDP-mannose 4,6-dehydratase 0.0469997
GOLGA4 golgin A4 0.0469465
CSDE1 cold shock domain containing E1, RNA-binding 0.0392488
DTNA dystrobrevin, alpha 0.0383478
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0377454
SRPK2 SRSF protein kinase 2 0.0375189
PEAK1 pseudopodium-enriched atypical kinase 1 0.0366809
CDH13 cadherin 13 0.03466
MYO1E myosin IE 0.034386
DSCAM Down syndrome cell adhesion molecule 0.033713
EGFR epidermal growth factor receptor 0.0328367
SBF2 SET binding factor 2 0.0317887
NCOA3 nuclear receptor coactivator 3 0.0308381
RPS23 ribosomal protein S23 0.0282066
PTMA prothymosin, alpha 0.0243911
NSD3 nuclear receptor binding SET domain protein 3 0.0234991
DPP10 dipeptidyl-peptidase 10 (non-functional) 0.0228429
TCF12 transcription factor 12 0.0202626
ROBO2 roundabout, axon guidance receptor, homolog 2 (Drosophila) 0.0192249
POTEF POTE ankyrin domain family, member F 0.0167066
PTPRJ protein tyrosine phosphatase, receptor type, J 0.0125031
SRRM2 serine/arginine repetitive matrix 2 0.0113978
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0093494
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.00915105
OGA O-GlcNAcase 0.00850587
FLNA filamin A, alpha 0.00729617
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.00676924
AK1 adenylate kinase 1 0.00646351
ESYT2 extended synaptotagmin-like protein 2 0.00585921
CCDC91 coiled-coil domain containing 91 0.00549637
P4HB prolyl 4-hydroxylase, beta polypeptide 0.00445223
PABPC1 poly(A) binding protein, cytoplasmic 1 0.00437834
RBPJ recombination signal binding protein for immunoglobulin kappa J region 0.00426647
RPL7 ribosomal protein L7 0.0010818
RPL11 ribosomal protein L11 9.7429E-4
PPP6R3 protein phosphatase 6, regulatory subunit 3 7.17664E-4

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.239553
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.208597
EXT1 exostosin glycosyltransferase 1 -0.16602
TMSB10 thymosin beta 10 -0.15663
PSD3 pleckstrin and Sec7 domain containing 3 -0.136888
HMGA2 high mobility group AT-hook 2 -0.135517
PDE3A phosphodiesterase 3A, cGMP-inhibited -0.126293
WSB1 WD repeat and SOCS box containing 1 -0.116054
FNDC3B fibronectin type III domain containing 3B -0.11434
TRIO trio Rho guanine nucleotide exchange factor -0.11165
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 -0.110294
DST dystonin -0.108245
LIMS1 LIM and senescent cell antigen-like domains 1 -0.107293
NALF1 NALCN channel auxiliary factor 1 -0.10586
MYOF myoferlin -0.102006
TPT1 tumor protein, translationally-controlled 1 -0.0973058
PUM2 pumilio RNA-binding family member 2 -0.0956782
MAML3 mastermind-like 3 (Drosophila) -0.094114
INHBA inhibin, beta A -0.0924396
RAP1B RAP1B, member of RAS oncogene family -0.0912201
RORA RAR-related orphan receptor A -0.0910793
MMAB methylmalonic aciduria (cobalamin deficiency) cblB type -0.0772583
VIM vimentin -0.0758773
KCNQ5 potassium channel, voltage gated KQT-like subfamily Q, member 5 -0.0754439
EFNA5 ephrin-A5 -0.0751836
SAMD4A sterile alpha motif domain containing 4A -0.0732413
COL6A1 collagen, type VI, alpha 1 -0.0730471
ANKRD12 ankyrin repeat domain 12 -0.0708681
PKM pyruvate kinase, muscle -0.0706775
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0692294
NAP1L1 nucleosome assembly protein 1-like 1 -0.0676781
COL6A3 collagen, type VI, alpha 3 -0.0674203
IGFBP3 insulin-like growth factor binding protein 3 -0.0656104
RPS8 ribosomal protein S8 -0.0638061
RPS12 ribosomal protein S12 -0.0626883
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0605198
RPL23 ribosomal protein L23 -0.0591782
THSD4 thrombospondin, type I, domain containing 4 -0.0581524
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 -0.0568508
PDE10A phosphodiesterase 10A -0.0562001
KDM3A lysine (K)-specific demethylase 3A -0.0527164
STC1 stanniocalcin 1 -0.0450455
RPL5 ribosomal protein L5 -0.044072
MED13L mediator complex subunit 13-like -0.0418419
RAB7A RAB7A, member RAS oncogene family -0.0371202
SCAF11 SR-related CTD-associated factor 11 -0.0343131
KANSL1 KAT8 regulatory NSL complex subunit 1 -0.0338132
FN1 fibronectin 1 -0.0329857
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.0315657
PCCA propionyl CoA carboxylase, alpha polypeptide -0.0314757
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0306076
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0304317
KMT2E lysine (K)-specific methyltransferase 2E -0.0293052
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.029157
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0275863
ANKRD11 ankyrin repeat domain 11 -0.0252275
MBNL1 muscleblind-like splicing regulator 1 -0.025
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 -0.0231502
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0221374
KMT2C lysine (K)-specific methyltransferase 2C -0.0208296
NAMPT nicotinamide phosphoribosyltransferase -0.0202646
RB1CC1 RB1-inducible coiled-coil 1 -0.0200673
PRKG1 protein kinase, cGMP-dependent, type I -0.0173006
CTNNA1 catenin (cadherin-associated protein), alpha 1, 102kDa -0.0163499
RPS6 ribosomal protein S6 -0.0159794
ENO1 enolase 1, (alpha) -0.0148741
MT2A metallothionein 2A -0.0111091
ZBTB20 zinc finger and BTB domain containing 20 -0.0100929
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 -0.00949393
LUC7L3 LUC7-like 3 (S. cerevisiae) -0.00524867
ELL2 elongation factor, RNA polymerase II, 2 -0.00368051
VMP1 vacuole membrane protein 1 -0.00336955
FNIP1 folliculin interacting protein 1 -0.00331851
DCBLD2 discoidin, CUB and LCCL domain containing 2 -0.00187066
TXNRD1 thioredoxin reductase 1 -4.96584E-4