Adenosine_NCI-H661 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in NCI-H661 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
COL11A1 collagen, type XI, alpha 1 0.195427
UACA uveal autoantigen with coiled-coil domains and ankyrin repeats 0.151327
PCLO piccolo presynaptic cytomatrix protein 0.120161
CTNNA2 catenin (cadherin-associated protein), alpha 2 0.119699
PARD3B par-3 family cell polarity regulator beta 0.0889618
ERBB4 erb-b2 receptor tyrosine kinase 4 0.0811688
PEG10 paternally expressed 10 0.0737362
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0651931
CADM2 cell adhesion molecule 2 0.0620694
SAMD4A sterile alpha motif domain containing 4A 0.0606959
CTNNA3 catenin (cadherin-associated protein), alpha 3 0.0601703
EEF2 eukaryotic translation elongation factor 2 0.0581633
MEIS2 Meis homeobox 2 0.0564404
NTM neurotrimin 0.0559974
GSE1 Gse1 coiled-coil protein 0.0528697
CDH10 cadherin 10, type 2 (T2-cadherin) 0.05266
PRRC2C proline-rich coiled-coil 2C 0.0508119
VPS13B vacuolar protein sorting 13 homolog B (yeast) 0.0506539
RBMS3 RNA binding motif, single stranded interacting protein 3 0.0499461
HCN1 hyperpolarization activated cyclic nucleotide gated potassium channel 1 0.0492198
ARB2A ARB2 cotranscriptional regulator A 0.0489473
MACF1 microtubule-actin crosslinking factor 1 0.0434449
PRELID2 PRELI domain containing 2 0.0425326
CDH6 cadherin 6, type 2, K-cadherin (fetal kidney) 0.0424307
VEGFA vascular endothelial growth factor A 0.0411255
NFIA nuclear factor I/A 0.0387361
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0367522
IGF2BP3 insulin-like growth factor 2 mRNA binding protein 3 0.036243
PCDH7 protocadherin 7 0.0361658
METAP2 methionyl aminopeptidase 2 0.0360111
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0356499
USP9X ubiquitin specific peptidase 9, X-linked 0.0353602
CDH4 cadherin 4, type 1, R-cadherin (retinal) 0.0349539
APLP2 amyloid beta (A4) precursor-like protein 2 0.0343482
SMYD3 SET and MYND domain containing 3 0.0332798
SIPA1L3 signal-induced proliferation-associated 1 like 3 0.0329902
ZC3H12B zinc finger CCCH-type containing 12B 0.0329006
GALNTL6 polypeptide N-acetylgalactosaminyltransferase-like 6 0.0326763
RIMKLB ribosomal modification protein rimK-like family member B 0.0323586
DOCK5 dedicator of cytokinesis 5 0.0321843
ANXA1 annexin A1 0.0317133
PDIA6 protein disulfide isomerase family A, member 6 0.0316408
ADGRV1 adhesion G protein-coupled receptor V1 0.0315831
PRKD1 protein kinase D1 0.0310933
ENO1 enolase 1, (alpha) 0.0307134
UTRN utrophin 0.0304578
CALR calreticulin 0.0300662
ZFP36L1 ZFP36 ring finger protein-like 1 0.0290545
KCTD16 potassium channel tetramerization domain containing 16 0.028896
GARS1 glycyl-tRNA synthetase 1 0.0288207
WWOX WW domain containing oxidoreductase 0.0283153
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0283114
SET SET nuclear proto-oncogene 0.0282123
GREB1L growth regulation by estrogen in breast cancer-like 0.0280903
MYH9 myosin, heavy chain 9, non-muscle 0.0278033
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0276015
ARID1A AT rich interactive domain 1A (SWI-like) 0.0275346
TENM2 teneurin transmembrane protein 2 0.027333
UBAP2L ubiquitin associated protein 2-like 0.0272635
SEC63 SEC63 homolog (S. cerevisiae) 0.0271447
HMCN1 hemicentin 1 0.0271134
UBR4 ubiquitin protein ligase E3 component n-recognin 4 0.0270147
LRRC4C leucine rich repeat containing 4C 0.0268037
COL3A1 collagen, type III, alpha 1 0.0266837
WNK1 WNK lysine deficient protein kinase 1 0.0265788
SPIDR scaffolding protein involved in DNA repair 0.0264003
PHIP pleckstrin homology domain interacting protein 0.0263302
NONO non-POU domain containing, octamer-binding 0.0261865
NGFR nerve growth factor receptor 0.0260479
GPC3 glypican 3 0.0259543
AKAP9 A kinase (PRKA) anchor protein 9 0.0258337
RIMS2 regulating synaptic membrane exocytosis 2 0.0255801
RPL23 ribosomal protein L23 0.0253314
TMED9 transmembrane emp24 protein transport domain containing 9 0.0252436
NID1 nidogen 1 0.0252339
SUPT16H suppressor of Ty 16 homolog (S. cerevisiae) 0.0250916
HIBCH 3-hydroxyisobutyryl-CoA hydrolase 0.0250346
EIF4B eukaryotic translation initiation factor 4B 0.0249927
METTL15 methyltransferase like 15 0.0249639
RPS4X ribosomal protein S4, X-linked 0.0245157
CMSS1 cms1 ribosomal small subunit homolog (yeast) 0.0245003
EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 0.0240517
BMPR2 bone morphogenetic protein receptor, type II (serine/threonine kinase) 0.0240205
TOX thymocyte selection-associated high mobility group box 0.0239616
NRDC nardilysin convertase 0.0239608
SHROOM3 shroom family member 3 0.0238001
RPL3 ribosomal protein L3 0.0237009
NALF1 NALCN channel auxiliary factor 1 0.0236552
BRD2 bromodomain containing 2 0.0234476
TRIM2 tripartite motif containing 2 0.0234374
ANKRD12 ankyrin repeat domain 12 0.0233695
LYST lysosomal trafficking regulator 0.0233034
CEP290 centrosomal protein 290kDa 0.0232553
PHF21A PHD finger protein 21A 0.023057
EPRS1 glutamyl-prolyl-tRNA synthetase 1 0.0230068
SRRM2 serine/arginine repetitive matrix 2 0.0229994
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 0.0229852
MDK midkine (neurite growth-promoting factor 2) 0.0229739
NIPBL Nipped-B homolog (Drosophila) 0.0229505
NFIB nuclear factor I/B 0.0229376

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.109084
PTMA prothymosin, alpha -0.0951318
TSC22D2 TSC22 domain family, member 2 -0.0869523
VIM vimentin -0.0790231
SPAG9 sperm associated antigen 9 -0.0760541
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.073497
RPS16 ribosomal protein S16 -0.0717392
TMSB10 thymosin beta 10 -0.0688154
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 -0.0609815
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0581644
AHNAK AHNAK nucleoprotein -0.0576643
MRPS30 mitochondrial ribosomal protein S30 -0.0557105
USP3 ubiquitin specific peptidase 3 -0.0552458
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0549371
RPL37 ribosomal protein L37 -0.0548041
ANKRD33B ankyrin repeat domain 33B -0.0524438
KMT2E lysine (K)-specific methyltransferase 2E -0.0520646
RPS27A ribosomal protein S27a -0.0505671
RLF rearranged L-myc fusion -0.0503792
RHEB Ras homolog enriched in brain -0.0502431
RPLP1 ribosomal protein, large, P1 -0.0476628
ANXA2 annexin A2 -0.0452723
COL5A2 collagen, type V, alpha 2 -0.0448784
ZNF292 zinc finger protein 292 -0.0448353
STRN3 striatin, calmodulin binding protein 3 -0.0435991
FBXO11 F-box protein 11 -0.0432932
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0432038
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0425978
LOC102724023 ES1 protein homolog, mitochondrial -0.0419143
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha -0.041455
GNAS GNAS complex locus -0.0411658
FOXP2 forkhead box P2 -0.0405314
ATP5F1B ATP synthase F1 subunit beta -0.0401184
RPL35A ribosomal protein L35a -0.0383748
PPP1R12A protein phosphatase 1, regulatory subunit 12A -0.0379705
RPS24 ribosomal protein S24 -0.0371101
ARID4B AT rich interactive domain 4B (RBP1-like) -0.036674
RBM39 RNA binding motif protein 39 -0.0364415
PTP4A2 protein tyrosine phosphatase type IVA, member 2 -0.0362296
ENAH enabled homolog (Drosophila) -0.0361436
WDR43 WD repeat domain 43 -0.0360885
TPT1 tumor protein, translationally-controlled 1 -0.0358513
EMP1 epithelial membrane protein 1 -0.0358192
RAB1A RAB1A, member RAS oncogene family -0.0351963
MARCHF6 membrane associated ring-CH-type finger 6 -0.0351405
TRA2A transformer 2 alpha homolog (Drosophila) -0.0349629
NAP1L1 nucleosome assembly protein 1-like 1 -0.0349491
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0347375
MTF2 metal response element binding transcription factor 2 -0.0347242
S100A10 S100 calcium binding protein A10 -0.0346469
PDE4D phosphodiesterase 4D, cAMP-specific -0.034184
ZNF207 zinc finger protein 207 -0.0338806
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.033718
RPS25 ribosomal protein S25 -0.0334904
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0332322
BIRC6 baculoviral IAP repeat containing 6 -0.0331396
KDM5B lysine (K)-specific demethylase 5B -0.0330722
G2E3 G2/M-phase specific E3 ubiquitin protein ligase -0.0327665
CAVIN1 caveolae associated protein 1 -0.0325375
BAZ1A bromodomain adjacent to zinc finger domain, 1A -0.032478
DSTN destrin (actin depolymerizing factor) -0.0321504
CXADR coxsackie virus and adenovirus receptor -0.0320136
FTL ferritin, light polypeptide -0.0317009
DCAF7 DDB1 and CUL4 associated factor 7 -0.0315542
MAP1LC3B microtubule-associated protein 1 light chain 3 beta -0.0314149
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0312986
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa -0.0312159
RTN3 reticulon 3 -0.0310856
NOP58 NOP58 ribonucleoprotein -0.0309487
RBM25 RNA binding motif protein 25 -0.03074
HMGB1 high mobility group box 1 -0.0304695
PAWR PRKC, apoptosis, WT1, regulator -0.0297874
LHFPL6 LHFPL tetraspan subfamily member 6 -0.0295737
HDAC2 histone deacetylase 2 -0.0294118
TBC1D12 TBC1 domain family, member 12 -0.0293976
KPNB1 karyopherin (importin) beta 1 -0.0292957
PDIA3 protein disulfide isomerase family A, member 3 -0.0291799
ZSWIM6 zinc finger, SWIM-type containing 6 -0.029027
UBE2G1 ubiquitin-conjugating enzyme E2G 1 -0.0290179
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0289646
PDGFC platelet derived growth factor C -0.028931
DYRK1A dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A -0.0287169
CENPE centromere protein E, 312kDa -0.0285141
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 -0.0284932
EPB41L5 erythrocyte membrane protein band 4.1 like 5 -0.0284742
LYPLA1 lysophospholipase I -0.0282945
PTK2 protein tyrosine kinase 2 -0.0281302
CD2AP CD2-associated protein -0.0280474
RPS8 ribosomal protein S8 -0.0279823
RPL10A ribosomal protein L10a -0.0276005
VMP1 vacuole membrane protein 1 -0.0275805
HP1BP3 heterochromatin protein 1, binding protein 3 -0.0275102
FOXC1 forkhead box C1 -0.0271717
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0271312
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0271134
RPS13 ribosomal protein S13 -0.0270969
VDAC1 voltage-dependent anion channel 1 -0.0266569
FUBP1 far upstream element (FUSE) binding protein 1 -0.0266365
YAP1 Yes-associated protein 1 -0.0264517
EIF3H eukaryotic translation initiation factor 3, subunit H -0.0263976