Adenosine_SNU-423 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in SNU-423 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.316526
AKAP12 A kinase (PRKA) anchor protein 12 0.145494
CD44 CD44 molecule (Indian blood group) 0.1258
NDRG1 N-myc downstream regulated 1 0.0807457
MT2A metallothionein 2A 0.0763566
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.074152
MYH9 myosin, heavy chain 9, non-muscle 0.0622049
IGFN1 immunoglobulin-like and fibronectin type III domain containing 1 0.0615012
NAMPT nicotinamide phosphoribosyltransferase 0.0587352
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0566376
EEF2 eukaryotic translation elongation factor 2 0.0552617
BACE2 beta-site APP-cleaving enzyme 2 0.0429562
COL6A3 collagen, type VI, alpha 3 0.0390805
SFTPA2 surfactant protein A2 0.0385429
RPS3 ribosomal protein S3 0.036606
MLPH melanophilin 0.0356627
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 0.0344079
OPTN optineurin 0.033671
STC1 stanniocalcin 1 0.0309596
ARRDC3 arrestin domain containing 3 0.0308934
LDHA lactate dehydrogenase A 0.0297625
LOXL2 lysyl oxidase-like 2 0.0294363
FTH1 ferritin, heavy polypeptide 1 0.0292655
CEP250 centrosomal protein 250kDa 0.0271082
ADM adrenomedullin 0.026899
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0268798
HLA-A major histocompatibility complex, class I, A 0.0268377
SMAD3 SMAD family member 3 0.0254873
ERRFI1 ERBB receptor feedback inhibitor 1 0.0243299
RPS12 ribosomal protein S12 0.0234635
RASA3 RAS p21 protein activator 3 0.0225283
BASP1 brain abundant, membrane attached signal protein 1 0.0222956
EZR ezrin 0.0215069
RPS18 ribosomal protein S18 0.0213703
MT1X metallothionein 1X 0.0210669
MATR3 matrin 3 0.0209453
DNTTIP1 deoxynucleotidyltransferase, terminal, interacting protein 1 0.0206057
HLA-C major histocompatibility complex, class I, C 0.0205716
ZMIZ1 zinc finger, MIZ-type containing 1 0.0203913
MSN moesin 0.0199825
HIVEP2 human immunodeficiency virus type I enhancer binding protein 2 0.0198654
ZFP36L1 ZFP36 ring finger protein-like 1 0.0196912
GBE1 glucan (1,4-alpha-), branching enzyme 1 0.0194297
JUN jun proto-oncogene 0.0192456
SYNCRIP synaptotagmin binding, cytoplasmic RNA interacting protein 0.0191453
ADAMTS14 ADAM metallopeptidase with thrombospondin type 1 motif, 14 0.0191147
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0190656
STC2 stanniocalcin 2 0.0188591
PPARD peroxisome proliferator-activated receptor delta 0.0188213
BRD2 bromodomain containing 2 0.0180724
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0178908
RUNX1 runt-related transcription factor 1 0.017853
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0177043
DOCK5 dedicator of cytokinesis 5 0.0176715
APP amyloid beta (A4) precursor protein 0.0175856
PFKFB3 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 0.0174703
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 0.0172552
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 0.0167562
FLNB filamin B, beta 0.0166629
HLA-B major histocompatibility complex, class I, B 0.0165402
EIF3A eukaryotic translation initiation factor 3, subunit A 0.0162886
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0161426
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) 0.0157401
GFPT2 glutamine-fructose-6-phosphate transaminase 2 0.0156745
HSPA8 heat shock 70kDa protein 8 0.0153753
ZNF841 zinc finger protein 841 0.0153323
NT5E 5'-nucleotidase, ecto (CD73) 0.0151091
AHNAK2 AHNAK nucleoprotein 2 0.0151091
GPC6 glypican 6 0.0148943
EIF4H eukaryotic translation initiation factor 4H 0.01479
RACK1 receptor for activated C kinase 1 0.0145672
CRYBG3 beta-gamma crystallin domain containing 3 0.0144454
AMPD3 adenosine monophosphate deaminase 3 0.0141755
PHF3 PHD finger protein 3 0.0139262
SRRM2 serine/arginine repetitive matrix 2 0.0139223
SLK STE20-like kinase 0.0138888
IL1RAP interleukin 1 receptor accessory protein 0.0138513
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like 0.0138184
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0137164
SLCO4A1 solute carrier organic anion transporter family, member 4A1 0.0136523
TRAM2 translocation associated membrane protein 2 0.013651
EIF4B eukaryotic translation initiation factor 4B 0.0134626
PRRC2C proline-rich coiled-coil 2C 0.0134588
SIPA1L1 signal-induced proliferation-associated 1 like 1 0.0134267
FAM219A family with sequence similarity 219, member A 0.0133853
ANGPTL4 angiopoietin-like 4 0.0131613
DDIT4 DNA-damage-inducible transcript 4 0.0131208
RND3 Rho family GTPase 3 0.0129446
PHRF1 PHD and ring finger domains 1 0.0126134
CTSB cathepsin B 0.0124912
NFE2L1 nuclear factor, erythroid 2-like 1 0.0122329
CDCP1 CUB domain containing protein 1 0.0121115
PLEKHA4 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 0.0119797
TMEM14C transmembrane protein 14C 0.0119764
C3 complement component 3 0.0117344
HLA-E major histocompatibility complex, class I, E 0.0116062
ANXA1 annexin A1 0.0113423
ZBTB38 zinc finger and BTB domain containing 38 0.0113092
CALB2 calbindin 2 0.0112906
GALNT2 polypeptide N-acetylgalactosaminyltransferase 2 0.011165

decreased expression

Symbol Name Standardized Value
SOD2 superoxide dismutase 2, mitochondrial -0.200699
VIM vimentin -0.199802
FRMD4A FERM domain containing 4A -0.148151
FN1 fibronectin 1 -0.124274
SPARC secreted protein, acidic, cysteine-rich (osteonectin) -0.0933387
CADM1 cell adhesion molecule 1 -0.0869215
FNDC3B fibronectin type III domain containing 3B -0.0786073
VCL vinculin -0.0779163
EXT1 exostosin glycosyltransferase 1 -0.0772512
ZFAND3 zinc finger, AN1-type domain 3 -0.071489
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.0692862
IER3 immediate early response 3 -0.0625446
TMSB10 thymosin beta 10 -0.061956
FTL ferritin, light polypeptide -0.0618245
MARCKS myristoylated alanine-rich protein kinase C substrate -0.0584537
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0576173
RPS24 ribosomal protein S24 -0.0532604
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0510027
DLG1 discs, large homolog 1 (Drosophila) -0.0502856
PTMA prothymosin, alpha -0.0486737
DIAPH2 diaphanous-related formin 2 -0.0470716
RPL35A ribosomal protein L35a -0.0470569
GNAS GNAS complex locus -0.0444728
KYNU kynureninase -0.0443911
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0437803
TRIO trio Rho guanine nucleotide exchange factor -0.0436611
GLIS3 GLIS family zinc finger 3 -0.0433252
QKI QKI, KH domain containing, RNA binding -0.0432561
AHNAK AHNAK nucleoprotein -0.042356
IQCJ-SCHIP1 IQCJ-SCHIP1 readthrough -0.0414014
ERBIN erbb2 interacting protein -0.0408455
PGK1 phosphoglycerate kinase 1 -0.0406069
UBE2E2 ubiquitin-conjugating enzyme E2E 2 -0.0406017
WTAP Wilms tumor 1 associated protein -0.0396005
TUBB tubulin, beta class I -0.0387322
DST dystonin -0.0385918
SPAG9 sperm associated antigen 9 -0.0379246
LAMP2 lysosomal-associated membrane protein 2 -0.037816
RPS6 ribosomal protein S6 -0.0374603
RBM39 RNA binding motif protein 39 -0.0372713
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 -0.037133
MORF4L2 mortality factor 4 like 2 -0.0370794
LPP LIM domain containing preferred translocation partner in lipoma -0.0369433
EDIL3 EGF-like repeats and discoidin I-like domains 3 -0.0369003
SBF2 SET binding factor 2 -0.0368102
HMGA2 high mobility group AT-hook 2 -0.0366056
TPM4 tropomyosin 4 -0.035381
CANX calnexin -0.0351918
RAB1A RAB1A, member RAS oncogene family -0.0342058
AKT3 v-akt murine thymoma viral oncogene homolog 3 -0.0340997
ZSWIM6 zinc finger, SWIM-type containing 6 -0.033989
POTEF POTE ankyrin domain family, member F -0.0339664
PALLD palladin, cytoskeletal associated protein -0.0336377
TMEM123 transmembrane protein 123 -0.0335228
MAML2 mastermind-like 2 (Drosophila) -0.0333702
PTPRK protein tyrosine phosphatase, receptor type, K -0.0330832
RPS23 ribosomal protein S23 -0.0330421
TPM1 tropomyosin 1 (alpha) -0.032496
TKT transketolase -0.0321955
PARP14 poly (ADP-ribose) polymerase family, member 14 -0.0320574
CLIC4 chloride intracellular channel 4 -0.0317464
WSB1 WD repeat and SOCS box containing 1 -0.0310671
SDK1 sidekick cell adhesion molecule 1 -0.0310257
TAPBP TAP binding protein (tapasin) -0.0309013
LOC112694756 uncharaterized LOC112694756 -0.0307413
MAP4 microtubule-associated protein 4 -0.0305177
HELZ helicase with zinc finger -0.0301903
LCORL ligand dependent nuclear receptor corepressor-like -0.0299416
RAI14 retinoic acid induced 14 -0.0298815
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0298213
BICC1 BicC family RNA binding protein 1 -0.0297348
TSC22D2 TSC22 domain family, member 2 -0.0295932
TPT1 tumor protein, translationally-controlled 1 -0.0295047
TGFBI transforming growth factor, beta-induced, 68kDa -0.029402
ANXA2 annexin A2 -0.0291799
ACTG1 actin gamma 1 -0.0291709
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0291359
CTSD cathepsin D -0.0286669
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.028599
ACSL4 acyl-CoA synthetase long-chain family member 4 -0.028324
SLC38A2 solute carrier family 38, member 2 -0.0281884
KMT2E lysine (K)-specific methyltransferase 2E -0.0280432
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0280064
FRMPD4 FERM and PDZ domain containing 4 -0.0278447
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0275011
ZNF207 zinc finger protein 207 -0.0274424
UBC ubiquitin C -0.0274235
COL1A1 collagen, type I, alpha 1 -0.0273427
PCBP2 poly(rC) binding protein 2 -0.027335
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0272488
RPL19 ribosomal protein L19 -0.0271958
NPEPPS aminopeptidase puromycin sensitive -0.0271345
UGCG UDP-glucose ceramide glucosyltransferase -0.0270478
PNISR PNN-interacting serine/arginine-rich protein -0.0269267
MYOF myoferlin -0.0269259
PSD3 pleckstrin and Sec7 domain containing 3 -0.0268848
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0268514
ZBTB20 zinc finger and BTB domain containing 20 -0.0268315
COL1A2 collagen, type I, alpha 2 -0.026767
COL8A1 collagen, type VIII, alpha 1 -0.026636