Adenosine_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Adenosine perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Adenosine_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
VEGFA vascular endothelial growth factor A 0.181023
AKAP12 A kinase (PRKA) anchor protein 12 0.0836013
HLA-B major histocompatibility complex, class I, B 0.068963
STC2 stanniocalcin 2 0.0633658
TMEM156 transmembrane protein 156 0.052954
FTL ferritin, light polypeptide 0.0522918
MT2A metallothionein 2A 0.0472774
SFTPA2 surfactant protein A2 0.0465828
ITGA3 integrin, alpha 3 (antigen CD49C, alpha 3 subunit of VLA-3 receptor) 0.0461998
MLPH melanophilin 0.044536
CDH11 cadherin 11, type 2, OB-cadherin (osteoblast) 0.0424586
AHNAK2 AHNAK nucleoprotein 2 0.0389669
LOXL2 lysyl oxidase-like 2 0.0377158
DCBLD2 discoidin, CUB and LCCL domain containing 2 0.0373688
LRP5 low density lipoprotein receptor-related protein 5 0.0336501
HIPK2 homeodomain interacting protein kinase 2 0.0327524
SMAD3 SMAD family member 3 0.0318158
RPS3 ribosomal protein S3 0.0315122
IGF2 insulin-like growth factor 2 0.0314665
DUSP6 dual specificity phosphatase 6 0.0306338
SOX4 SRY (sex determining region Y)-box 4 0.0287016
PITPNC1 phosphatidylinositol transfer protein, cytoplasmic 1 0.0281931
CST3 cystatin C 0.0281154
PLEC plectin 0.0259202
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0258873
EZR ezrin 0.0258495
ST3GAL1 ST3 beta-galactoside alpha-2,3-sialyltransferase 1 0.0254618
LMNA lamin A/C 0.0252921
TMED9 transmembrane emp24 protein transport domain containing 9 0.0244107
MAPKAPK2 mitogen-activated protein kinase-activated protein kinase 2 0.0242363
SEPTIN9 septin 9 0.0240049
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 0.0237039
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.023638
CTSB cathepsin B 0.0232999
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0228183
GLUL glutamate-ammonia ligase 0.0225495
FTH1 ferritin, heavy polypeptide 1 0.0222638
ANGPTL4 angiopoietin-like 4 0.0222485
SPSB1 splA/ryanodine receptor domain and SOCS box containing 1 0.0221682
NECTIN2 nectin cell adhesion molecule 2 0.0215759
FLNA filamin A, alpha 0.0215362
CAPN2 calpain 2, (m/II) large subunit 0.0212347
ADAM8 ADAM metallopeptidase domain 8 0.0207356
HPCAL1 hippocalcin-like 1 0.0206807
ATN1 atrophin 1 0.0205953
PHC2 polyhomeotic homolog 2 (Drosophila) 0.0205777
DHRS3 dehydrogenase/reductase (SDR family) member 3 0.0203864
AOPEP aminopeptidase O (putative) 0.0198302
EGFR epidermal growth factor receptor 0.0196273
PRRC2C proline-rich coiled-coil 2C 0.019232
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.019158
LAMA4 laminin, alpha 4 0.0191295
ACTG1 actin gamma 1 0.0187667
BASP1 brain abundant, membrane attached signal protein 1 0.018531
IL6 interleukin 6 0.0184463
LPCAT1 lysophosphatidylcholine acyltransferase 1 0.018366
SAMD4A sterile alpha motif domain containing 4A 0.0183055
LAMB3 laminin, beta 3 0.0182248
ITGB5 integrin, beta 5 0.017988
HSPA8 heat shock 70kDa protein 8 0.0177641
IFI6 interferon, alpha-inducible protein 6 0.0176622
SRRM2 serine/arginine repetitive matrix 2 0.0175519
NFE2L1 nuclear factor, erythroid 2-like 1 0.0175374
TCIM transcriptional and immune response regulator 0.0175006
OBSCN obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF 0.0173249
RPL37A ribosomal protein L37a 0.0172527
EIF4H eukaryotic translation initiation factor 4H 0.016935
ZFP36L1 ZFP36 ring finger protein-like 1 0.0168348
NPAS2 neuronal PAS domain protein 2 0.0167638
ENO2 enolase 2 (gamma, neuronal) 0.0166109
SHB Src homology 2 domain containing adaptor protein B 0.01624
HLA-C major histocompatibility complex, class I, C 0.0162361
AHDC1 AT hook, DNA binding motif, containing 1 0.0161425
SLC6A6 solute carrier family 6 (neurotransmitter transporter), member 6 0.0161415
ZMIZ1 zinc finger, MIZ-type containing 1 0.0160911
TSPYL2 TSPY-like 2 0.015991
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0158611
RPL36 ribosomal protein L36 0.0153356
EMP1 epithelial membrane protein 1 0.0151378
AREG amphiregulin 0.0150645
RNASEH2A ribonuclease H2, subunit A 0.0150318
CNIH3 cornichon family AMPA receptor auxiliary protein 3 0.0150095
MYH9 myosin, heavy chain 9, non-muscle 0.0150039
SUPT5H suppressor of Ty 5 homolog (S. cerevisiae) 0.0149105
WWTR1 WW domain containing transcription regulator 1 0.0147398
TPR translocated promoter region, nuclear basket protein 0.0146643
SVIL supervillin 0.0146295
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0145702
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0145334
SF3B1 splicing factor 3b, subunit 1, 155kDa 0.0145171
DUSP12 dual specificity phosphatase 12 0.0143864
TSC22D1 TSC22 domain family, member 1 0.0142078
PTPRF protein tyrosine phosphatase, receptor type, F 0.0142043
NTN4 netrin 4 0.0141813
ABCC3 ATP-binding cassette, sub-family C (CFTR/MRP), member 3 0.0140186
NCOR2 nuclear receptor corepressor 2 0.0137565
RACK1 receptor for activated C kinase 1 0.0136293
TMSB10 thymosin beta 10 0.0135757
FAM13A family with sequence similarity 13, member A 0.0135442
RUNX2 runt-related transcription factor 2 0.013536

decreased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.206468
CANX calnexin -0.131161
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.127077
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.112063
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.105607
CXCL8 chemokine (C-X-C motif) ligand 8 -0.103845
VCL vinculin -0.0924413
FNDC3B fibronectin type III domain containing 3B -0.0886759
NRG1 neuregulin 1 -0.0807445
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0750166
SOD2 superoxide dismutase 2, mitochondrial -0.0742894
AHR aryl hydrocarbon receptor -0.072161
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0719968
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) -0.0718835
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0671262
EXT1 exostosin glycosyltransferase 1 -0.063614
CENPF centromere protein F, 350/400kDa -0.0611202
TAS2R14 taste receptor, type 2, member 14 -0.058603
AEBP2 AE binding protein 2 -0.0542682
LCORL ligand dependent nuclear receptor corepressor-like -0.050981
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.050856
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0495808
SPAG9 sperm associated antigen 9 -0.0486842
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0484037
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0483994
BIRC6 baculoviral IAP repeat containing 6 -0.0482766
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0480011
ETNK1 ethanolamine kinase 1 -0.04789
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0465119
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0460055
TRIO trio Rho guanine nucleotide exchange factor -0.0458743
PLEKHA5 pleckstrin homology domain containing, family A member 5 -0.0457823
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0449596
VMP1 vacuole membrane protein 1 -0.0441586
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0440502
PHLDA1 pleckstrin homology-like domain, family A, member 1 -0.0440239
RAB1A RAB1A, member RAS oncogene family -0.0435666
PTK2 protein tyrosine kinase 2 -0.0435477
INTS6 integrator complex subunit 6 -0.0421091
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.0418731
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0418204
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0412881
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0410438
SUCO SUN domain containing ossification factor -0.0405664
SEC31A SEC31 homolog A (S. cerevisiae) -0.0384955
ZNF292 zinc finger protein 292 -0.0379771
NCOA7 nuclear receptor coactivator 7 -0.0376427
RBM39 RNA binding motif protein 39 -0.037627
TRA2A transformer 2 alpha homolog (Drosophila) -0.0374155
KMT2E lysine (K)-specific methyltransferase 2E -0.0368652
SYT1 synaptotagmin I -0.0361646
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.0361168
MBD5 methyl-CpG binding domain protein 5 -0.0360271
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0359725
COPA coatomer protein complex, subunit alpha -0.0359556
TFG TRK-fused gene -0.0356805
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0355888
COG5 component of oligomeric golgi complex 5 -0.0349257
ZC3H11A zinc finger CCCH-type containing 11A -0.0346436
PKM pyruvate kinase, muscle -0.0345988
CLTC clathrin, heavy chain (Hc) -0.0343749
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) -0.0343021
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -0.0342887
ZMYM2 zinc finger, MYM-type 2 -0.0339458
NAP1L1 nucleosome assembly protein 1-like 1 -0.033766
GLIS3 GLIS family zinc finger 3 -0.0332617
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0327679
ZFAND3 zinc finger, AN1-type domain 3 -0.032614
GOLT1B golgi transport 1B -0.0319018
RHEB Ras homolog enriched in brain -0.0311634
SPDYA speedy/RINGO cell cycle regulator family member A -0.0306998
ARIH1 ariadne RBR E3 ubiquitin protein ligase 1 -0.0302795
CALU calumenin -0.030136
KDM5B lysine (K)-specific demethylase 5B -0.0300849
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0300491
BRAF B-Raf proto-oncogene, serine/threonine kinase -0.030008
TRAM1 translocation associated membrane protein 1 -0.0299768
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0299298
RNF145 ring finger protein 145 -0.0296906
ANLN anillin, actin binding protein -0.029165
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0291371
SDCBP syndecan binding protein (syntenin) -0.0290959
NEK7 NIMA-related kinase 7 -0.0288146
FRYL FRY-like -0.0288026
VIM vimentin -0.0286669
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0286178
TBL1XR1 transducin (beta)-like 1 X-linked receptor 1 -0.0285927
TMEM165 transmembrane protein 165 -0.0284726
HYCC1 hyccin PI4KA lipid kinase complex subunit 1 -0.0284667
MIS18BP1 MIS18 binding protein 1 -0.0284294
FNDC3A fibronectin type III domain containing 3A -0.0283671
LRRC23 leucine rich repeat containing 23 -0.0283537
HELZ helicase with zinc finger -0.0281676
XPO1 exportin 1 -0.0281401
CADM1 cell adhesion molecule 1 -0.0279445
GPATCH2L G patch domain containing 2-like -0.0278847
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0278123
MAP4K5 mitogen-activated protein kinase kinase kinase kinase 5 -0.0277771
SEPTIN7 septin 7 -0.0277163
NUP58 nucleoporin 58 -0.0276066