Adrenocortical Carcinoma Gene Set

Dataset DisGeNET Gene-Disease Associations
Category disease or phenotype associations
Type disease
Description An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells. (Human Disease Ontology, DOID_3948)
External Link https://www.disgenet.org/browser/0/1/0/C0206686
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Genes

262 genes associated with the disease Adrenocortical Carcinoma in GWAS and other genetic association datasets from the DisGeNET Gene-Disease Associations dataset.

Symbol Name
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group)
ACACA acetyl-CoA carboxylase alpha
ACAT1 acetyl-CoA acetyltransferase 1
ACOT7 acyl-CoA thioesterase 7
ACTBL2 actin, beta-like 2
ACTG1 actin gamma 1
ACTG2 actin, gamma 2, smooth muscle, enteric
ADM adrenomedullin
AGT angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
AGTR1 angiotensin II receptor, type 1
AHSA1 AHA1, activator of heat shock 90kDa protein ATPase homolog 1 (yeast)
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2
AIP aryl hydrocarbon receptor interacting protein
AKR1B1 aldo-keto reductase family 1, member B1 (aldose reductase)
AKR1C3 aldo-keto reductase family 1, member C3
AKT1 v-akt murine thymoma viral oncogene homolog 1
ALB albumin
ANGPT1 angiopoietin 1
APC adenomatous polyposis coli
AR androgen receptor
ARMC5 armadillo repeat containing 5
ATF3 activating transcription factor 3
ATM ATM serine/threonine kinase
ATP1A1 ATPase, Na+/K+ transporting, alpha 1 polypeptide
ATP2B3 ATPase, Ca++ transporting, plasma membrane 3
ATR ATR serine/threonine kinase
AXIN1 axin 1
AXIN2 axin 2
BAP1 BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase)
BCL9 B-cell CLL/lymphoma 9
BMP2 bone morphogenetic protein 2
BMP5 bone morphogenetic protein 5
BMS1 BMS1 ribosome biogenesis factor
BRAF B-Raf proto-oncogene, serine/threonine kinase
BRCA2 breast cancer 2, early onset
CACNA1H calcium channel, voltage-dependent, T type, alpha 1H subunit
CASP3 caspase 3, apoptosis-related cysteine peptidase
CCND1 cyclin D1
CD22 CD22 molecule
CD274 CD274 molecule
CDK4 cyclin-dependent kinase 4
CDK6 cyclin-dependent kinase 6
CDKN1A cyclin-dependent kinase inhibitor 1A (p21, Cip1)
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1)
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2)
CDKN2A cyclin-dependent kinase inhibitor 2A
CDKN2B cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4)
CDKN2C cyclin-dependent kinase inhibitor 2C (p18, inhibits CDK4)
CDKN3 cyclin-dependent kinase inhibitor 3
CHGA chromogranin A
CHST3 carbohydrate (chondroitin 6) sulfotransferase 3
CITED2 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2
CORO7 coronin 7
CP ceruloplasmin (ferroxidase)
CPA1 carboxypeptidase A1 (pancreatic)
CRK v-crk avian sarcoma virus CT10 oncogene homolog
CRYGD crystallin, gamma D
CTNNB1 catenin (cadherin-associated protein), beta 1, 88kDa
CXCL10 chemokine (C-X-C motif) ligand 10
CXCL8 chemokine (C-X-C motif) ligand 8
CXCR4 chemokine (C-X-C motif) receptor 4
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2
CYP17A1 cytochrome P450, family 17, subfamily A, polypeptide 1
CYP19A1 cytochrome P450, family 19, subfamily A, polypeptide 1
CYP2A6 cytochrome P450, family 2, subfamily A, polypeptide 6
CYP2B6 cytochrome P450, family 2, subfamily B, polypeptide 6
CYP2S1 cytochrome P450, family 2, subfamily S, polypeptide 1
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1
CYP4B1 cytochrome P450, family 4, subfamily B, polypeptide 1
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2
DAXX death-domain associated protein
DCUN1D1 DCN1, defective in cullin neddylation 1, domain containing 1
DHCR24 24-dehydrocholesterol reductase
DIABLO diablo, IAP-binding mitochondrial protein
DICER1 dicer 1, ribonuclease type III
DKK3 dickkopf WNT signaling pathway inhibitor 3
DLK1 delta-like 1 homolog (Drosophila)
E2F1 E2F transcription factor 1
EDN1 endothelin 1
EGF epidermal growth factor
EGFR epidermal growth factor receptor
ELAVL2 ELAV like neuron-specific RNA binding protein 2
ENO2 enolase 2 (gamma, neuronal)
ENPEP glutamyl aminopeptidase (aminopeptidase A)
ENPP3 ectonucleotide pyrophosphatase/phosphodiesterase 3
EPHB2 EPH receptor B2
ERCC1 excision repair cross-complementation group 1
ESR1 estrogen receptor 1
ESR2 estrogen receptor 2 (ER beta)
ESRRA estrogen-related receptor alpha
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit
FATE1 fetal and adult testis expressed 1
FGF19 fibroblast growth factor 19
FGFR1 fibroblast growth factor receptor 1
FGFR2 fibroblast growth factor receptor 2
FH fumarate hydratase
FHL5 four and a half LIM domains 5
FN1 fibronectin 1
FOLH1 folate hydrolase (prostate-specific membrane antigen) 1
FOXM1 forkhead box M1
FSCN1 fascin actin-bundling protein 1
GATA3 GATA binding protein 3
GATA4 GATA binding protein 4
GATA6 GATA binding protein 6
GDE1 glycerophosphodiester phosphodiesterase 1
GEMIN2 gem (nuclear organelle) associated protein 2
GFAP glial fibrillary acidic protein
GHRHR growth hormone releasing hormone receptor
GHSR growth hormone secretagogue receptor
GIPR gastric inhibitory polypeptide receptor
GLB1 galactosidase, beta 1
GNAS GNAS complex locus
GRAP2 GRB2-related adaptor protein 2
H3F3A H3 histone, family 3A
HLA-DRB1 major histocompatibility complex, class II, DR beta 1
HOXC4 homeobox C4
HRAS Harvey rat sarcoma viral oncogene homolog
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa)
HTR7 5-hydroxytryptamine (serotonin) receptor 7, adenylate cyclase-coupled
IFNB1 interferon, beta 1, fibroblast
IGF1 insulin-like growth factor 1 (somatomedin C)
IGF1R insulin-like growth factor 1 receptor
IGF2 insulin-like growth factor 2
IGF2R insulin-like growth factor 2 receptor
IGFBP2 insulin-like growth factor binding protein 2, 36kDa
IL4R interleukin 4 receptor
INHA inhibin, alpha
IRS1 insulin receptor substrate 1
JAG1 jagged 1
JDP2 Jun dimerization protein 2
KCNJ5 potassium channel, inwardly rectifying subfamily J, member 5
KCNQ1 potassium channel, voltage gated KQT-like subfamily Q, member 1
KLHL1 kelch-like family member 1
KRAS Kirsten rat sarcoma viral oncogene homolog
KRT5 keratin 5, type II
LDLR low density lipoprotein receptor
LEP leptin
LGR6 leucine-rich repeat containing G protein-coupled receptor 6
LHCGR luteinizing hormone/choriogonadotropin receptor
LIN28A lin-28 homolog A (C. elegans)
MAP2K6 mitogen-activated protein kinase kinase 6
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
MAPK1 mitogen-activated protein kinase 1
MAPK14 mitogen-activated protein kinase 14
MAS1 MAS1 proto-oncogene, G protein-coupled receptor
MATR3 matrin 3
MC2R melanocortin 2 receptor (adrenocorticotropic hormone)
MCM3 minichromosome maintenance complex component 3
MDH2 malate dehydrogenase 2, NAD (mitochondrial)
MED12 mediator complex subunit 12
MED27 mediator complex subunit 27
MELK maternal embryonic leucine zipper kinase
MEN1 multiple endocrine neoplasia I
MET MET proto-oncogene, receptor tyrosine kinase
MRAP2 melanocortin 2 receptor accessory protein 2
MSH2 mutS homolog 2
MT3 metallothionein 3
MTOR mechanistic target of rapamycin (serine/threonine kinase)
MUTYH mutY homolog
NAGLU N-acetylglucosaminidase, alpha
NBAS neuroblastoma amplified sequence
NCOA1 nuclear receptor coactivator 1
NDRG4 NDRG family member 4
NES nestin
NGF nerve growth factor (beta polypeptide)
NLRP3 NLR family, pyrin domain containing 3
NNT nicotinamide nucleotide transhydrogenase
NOTCH1 notch 1
NPW neuropeptide W
NR0B1 nuclear receptor subfamily 0, group B, member 1
NR4A2 nuclear receptor subfamily 4, group A, member 2
NR5A1 nuclear receptor subfamily 5, group A, member 1
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog
PCLAF PCNA clamp associated factor
PCNA proliferating cell nuclear antigen
PCSK9 proprotein convertase subtilisin/kexin type 9
PDCD1LG2 programmed cell death 1 ligand 2
PDE11A phosphodiesterase 11A
PELP1 proline, glutamate and leucine rich protein 1
PGR progesterone receptor
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific)
PMPCA peptidase (mitochondrial processing) alpha
POLDIP2 polymerase (DNA-directed), delta interacting protein 2
POMC proopiomelanocortin
POTEM POTE ankyrin domain family, member M
PPARG peroxisome proliferator-activated receptor gamma
PRKACA protein kinase, cAMP-dependent, catalytic, alpha
PRKAR1A protein kinase, cAMP-dependent, regulatory, type I, alpha
PTK7 protein tyrosine kinase 7 (inactive)
PTTG1 pituitary tumor-transforming 1
RARRES2 retinoic acid receptor responder (tazarotene induced) 2
RASSF1 Ras association (RalGDS/AF-6) domain family member 1
RASSF7 Ras association (RalGDS/AF-6) domain family (N-terminal) member 7
RB1 retinoblastoma 1
REN renin
RMDN1 regulator of microtubule dynamics 1
RMDN2 regulator of microtubule dynamics 2
RMDN3 regulator of microtubule dynamics 3
RNF19A ring finger protein 19A, RBR E3 ubiquitin protein ligase
RNF31 ring finger protein 31
RRM1 ribonucleotide reductase M1
SCAF11 SR-related CTD-associated factor 11
SCARB1 scavenger receptor class B, member 1
SCN7A sodium channel, voltage gated, type VII alpha subunit
SCP2 sterol carrier protein 2
SDHB succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3
SF1 splicing factor 1
SGK1 serum/glucocorticoid regulated kinase 1
SH3KBP1 SH3-domain kinase binding protein 1
SIRT6 sirtuin 6
SLC12A7 solute carrier family 12 (potassium/chloride transporter), member 7
SLC25A1 solute carrier family 25 (mitochondrial carrier; citrate transporter), member 1
SLC9A3R2 solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3 regulator 2
SMAD4 SMAD family member 4
SNAI1 snail family zinc finger 1
SOAT1 sterol O-acyltransferase 1
SPARC secreted protein, acidic, cysteine-rich (osteonectin)
SPHK1 sphingosine kinase 1
SPP1 secreted phosphoprotein 1
SST somatostatin
STAR steroidogenic acute regulatory protein
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor)
STAT5A signal transducer and activator of transcription 5A
STAT5B signal transducer and activator of transcription 5B
STK11 serine/threonine kinase 11
STMN1 stathmin 1
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
SYBU syntabulin (syntaxin-interacting)
SYCE1L synaptonemal complex central element protein 1-like
SYP synaptophysin
TARBP2 TAR (HIV-1) RNA binding protein 2
TBC1D9 TBC1 domain family, member 9 (with GRAM domain)
TBX2 T-box 2
TCF21 transcription factor 21
TERT telomerase reverse transcriptase
TFE3 transcription factor binding to IGHM enhancer 3
TGFBR2 transforming growth factor, beta receptor II (70/80kDa)
THBS1 thrombospondin 1
TM7SF2 transmembrane 7 superfamily member 2
TNF tumor necrosis factor
TOP2A topoisomerase (DNA) II alpha 170kDa
TP53 tumor protein p53
TWIST1 twist family bHLH transcription factor 1
TYMS thymidylate synthetase
UTS2 urotensin 2
VAV2 vav 2 guanine nucleotide exchange factor
VIM vimentin
VIP vasoactive intestinal peptide
VSNL1 visinin-like 1
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
ZEB2 zinc finger E-box binding homeobox 2
ZNF410 zinc finger protein 410
ZNRF3 zinc and ring finger 3