Adrenoleukodystrophy Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A leukodystrophy that disrupts the breakdown of very-long-chain fatty acids resulting in progressive brain damage, failure of the adrenal glands and eventually death. (Human Disease Ontology, DOID_10588)
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Genes

471 genes co-occuring with the disease Adrenoleukodystrophy in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
ABCD1 ATP-binding cassette, sub-family D (ALD), member 1 3.907
ABCD2 ATP-binding cassette, sub-family D (ALD), member 2 3.141
ABCD3 ATP-binding cassette, sub-family D (ALD), member 3 3.05
PEX5 peroxisomal biogenesis factor 5 2.859
ABCD4 ATP-binding cassette, sub-family D (ALD), member 4 2.792
PEX6 peroxisomal biogenesis factor 6 2.772
PEX10 peroxisomal biogenesis factor 10 2.753
ACOX1 acyl-CoA oxidase 1, palmitoyl 2.734
PEX13 peroxisomal biogenesis factor 13 2.717
HSD17B4 hydroxysteroid (17-beta) dehydrogenase 4 2.692
PEX19 peroxisomal biogenesis factor 19 2.668
PEX12 peroxisomal biogenesis factor 12 2.66
PEX16 peroxisomal biogenesis factor 16 2.648
PEX26 peroxisomal biogenesis factor 26 2.617
PEX7 peroxisomal biogenesis factor 7 2.612
ELOVL1 ELOVL fatty acid elongase 1 2.563
ARSA arylsulfatase A 2.498
ACOX3 acyl-CoA oxidase 3, pristanoyl 2.491
PEX2 peroxisomal biogenesis factor 2 2.437
PEX11B peroxisomal biogenesis factor 11 beta 2.423
PEX11A peroxisomal biogenesis factor 11 alpha 2.38
POMC proopiomelanocortin 2.379
GALC galactosylceramidase 2.358
GNPAT glyceronephosphate O-acyltransferase 2.329
SLC27A2 solute carrier family 27 (fatty acid transporter), member 2 2.243
PEX3 peroxisomal biogenesis factor 3 2.227
PEX1 peroxisomal biogenesis factor 1 2.226
SCP2 sterol carrier protein 2 2.179
PHYH phytanoyl-CoA 2-hydroxylase 2.168
CD34 CD34 molecule 2.153
AGPS alkylglycerone phosphate synthase 2.152
NR0B1 nuclear receptor subfamily 0, group B, member 1 2.152
ADA adenosine deaminase 2.125
PLP1 proteolipid protein 1 2.107
ACBD5 acyl-CoA binding domain containing 5 2.064
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 2.009
SPAST spastin 2.003
LMO2 LIM domain only 2 (rhombotin-like 1) 1.991
IDUA iduronidase, alpha-L- 1.975
CH25H cholesterol 25-hydroxylase 1.968
PXMP2 peroxisomal membrane protein 2, 22kDa 1.962
PEX14 peroxisomal biogenesis factor 14 1.92
PEX11G peroxisomal biogenesis factor 11 gamma 1.919
AARS2 alanyl-tRNA synthetase 2, mitochondrial 1.918
ACAA1 acetyl-CoA acyltransferase 1 1.918
HADHB hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), beta subunit 1.894
MBP myelin basic protein 1.891
MC2R melanocortin 2 receptor (adrenocorticotropic hormone) 1.884
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) 1.879
AASDH aminoadipate-semialdehyde dehydrogenase 1.867
FAR1 fatty acyl CoA reductase 1 1.857
GJC2 gap junction protein, gamma 2, 47kDa 1.853
BCAP31 B-cell receptor-associated protein 31 1.849
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 1.83
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa 1.83
ACOX2 acyl-CoA oxidase 2, branched chain 1.81
ACSBG1 acyl-CoA synthetase bubblegum family member 1 1.801
ECI2 enoyl-CoA delta isomerase 2 1.797
ELOVL4 ELOVL fatty acid elongase 4 1.793
TAP2 transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) 1.781
SPG11 spastic paraplegia 11 (autosomal recessive) 1.78
ELOVL7 ELOVL fatty acid elongase 7 1.773
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.772
PEX5L peroxisomal biogenesis factor 5-like 1.771
PPARA peroxisome proliferator-activated receptor alpha 1.767
ABCG5 ATP-binding cassette, sub-family G (WHITE), member 5 1.763
ABCA4 ATP-binding cassette, sub-family A (ABC1), member 4 1.762
ASPA aspartoacylase 1.762
FXN frataxin 1.756
POLR3A polymerase (RNA) III (DNA directed) polypeptide A, 155kDa 1.74
SLC6A8 solute carrier family 6 (neurotransmitter transporter), member 8 1.737
ALDH3A2 aldehyde dehydrogenase 3 family, member A2 1.728
SLC25A17 solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17 1.71
ABCB11 ATP-binding cassette, sub-family B (MDR/TAP), member 11 1.693
MECOM MDS1 and EVI1 complex locus 1.691
GFAP glial fibrillary acidic protein 1.691
ABCG8 ATP-binding cassette, sub-family G (WHITE), member 8 1.681
CSF1R colony stimulating factor 1 receptor 1.674
NEFL neurofilament, light polypeptide 1.672
NPC1 Niemann-Pick disease, type C1 1.671
NR5A1 nuclear receptor subfamily 5, group A, member 1 1.67
SLC27A4 solute carrier family 27 (fatty acid transporter), member 4 1.666
MOG myelin oligodendrocyte glycoprotein 1.664
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 1.662
SUMF1 sulfatase modifying factor 1 1.646
SLC27A6 solute carrier family 27 (fatty acid transporter), member 6 1.644
CYP11A1 cytochrome P450, family 11, subfamily A, polypeptide 1 1.643
IL2RG interleukin 2 receptor, gamma 1.641
GAMT guanidinoacetate N-methyltransferase 1.638
HMGA2 high mobility group AT-hook 2 1.63
ELOVL5 ELOVL fatty acid elongase 5 1.627
ABCC6 ATP-binding cassette, sub-family C (CFTR/MRP), member 6 1.623
CYP21A2 cytochrome P450, family 21, subfamily A, polypeptide 2 1.622
ABCA3 ATP-binding cassette, sub-family A (ABC1), member 3 1.616
PSAP prosaposin 1.615
CYP27A1 cytochrome P450, family 27, subfamily A, polypeptide 1 1.605
NPC2 Niemann-Pick disease, type C2 1.605
ACBD4 acyl-CoA binding domain containing 4 1.603
PPARG peroxisome proliferator-activated receptor gamma 1.602
DNAH8 dynein, axonemal, heavy chain 8 1.601
CHIT1 chitinase 1 (chitotriosidase) 1.599
SMN2 survival of motor neuron 2, centromeric 1.596
ABCE1 ATP-binding cassette, sub-family E (OABP), member 1 1.595
MOCS2 molybdenum cofactor synthesis 2 1.595
POLR3B polymerase (RNA) III (DNA directed) polypeptide B 1.592
SMN1 survival of motor neuron 1, telomeric 1.586
MECP2 methyl CpG binding protein 2 1.585
ZFYVE26 zinc finger, FYVE domain containing 26 1.584
ABCC11 ATP-binding cassette, sub-family C (CFTR/MRP), member 11 1.584
AIF1 allograft inflammatory factor 1 1.581
TUBB4A tubulin, beta 4A class IVa 1.562
ABCC2 ATP-binding cassette, sub-family C (CFTR/MRP), member 2 1.561
AAAS achalasia, adrenocortical insufficiency, alacrimia 1.56
FA2H fatty acid 2-hydroxylase 1.558
TYSND1 trypsin domain containing 1 1.552
NNT nicotinamide nucleotide transhydrogenase 1.547
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 1.547
PPARD peroxisome proliferator-activated receptor delta 1.547
TREM2 triggering receptor expressed on myeloid cells 2 1.545
IDS iduronate 2-sulfatase 1.536
REEP1 receptor accessory protein 1 1.531
SPG7 spastic paraplegia 7 (pure and complicated autosomal recessive) 1.529
ABCG4 ATP-binding cassette, sub-family G (WHITE), member 4 1.529
MAG myelin associated glycoprotein 1.526
ABCA12 ATP-binding cassette, sub-family A (ABC1), member 12 1.521
SOD1 superoxide dismutase 1, soluble 1.52
APP amyloid beta (A4) precursor protein 1.52
PIPOX pipecolic acid oxidase 1.518
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 1.517
UNC45A unc-45 homolog A (C. elegans) 1.506
NUDT10 nudix (nucleoside diphosphate linked moiety X)-type motif 10 1.504
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 1.504
ABCC1 ATP-binding cassette, sub-family C (CFTR/MRP), member 1 1.503
SNCA synuclein, alpha (non A4 component of amyloid precursor) 1.502
ABCB6 ATP-binding cassette, sub-family B (MDR/TAP), member 6 (Langereis blood group) 1.501
HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit 1.5
TXNRD2 thioredoxin reductase 2 1.498
ELOVL3 ELOVL fatty acid elongase 3 1.497
IL1B interleukin 1, beta 1.496
LPL lipoprotein lipase 1.495
ALB albumin 1.495
CHMP1B charged multivesicular body protein 1B 1.493
ABCC8 ATP-binding cassette, sub-family C (CFTR/MRP), member 8 1.485
F9 coagulation factor IX 1.483
ABCG2 ATP-binding cassette, sub-family G (WHITE), member 2 (Junior blood group) 1.477
OTC ornithine carbamoyltransferase 1.475
SLC25A20 solute carrier family 25 (carnitine/acylcarnitine translocase), member 20 1.474
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 1.472
DBI diazepam binding inhibitor (GABA receptor modulator, acyl-CoA binding protein) 1.471
HTT huntingtin 1.467
SGSH N-sulfoglucosamine sulfohydrolase 1.467
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 1.466
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 1.464
ABCG1 ATP-binding cassette, sub-family G (WHITE), member 1 1.462
ABCB1 ATP-binding cassette, sub-family B (MDR/TAP), member 1 1.459
NAGLU N-acetylglucosaminidase, alpha 1.456
ECHS1 enoyl CoA hydratase, short chain, 1, mitochondrial 1.455
TNF tumor necrosis factor 1.453
CNP 2',3'-cyclic nucleotide 3' phosphodiesterase 1.453
PPT1 palmitoyl-protein thioesterase 1 1.452
XPR1 xenotropic and polytropic retrovirus receptor 1 1.45
SMPD1 sphingomyelin phosphodiesterase 1, acid lysosomal 1.447
VAPB VAMP (vesicle-associated membrane protein)-associated protein B and C 1.445
AMACR alpha-methylacyl-CoA racemase 1.444
EIF2B5 eukaryotic translation initiation factor 2B, subunit 5 epsilon, 82kDa 1.441
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 1.441
ABCC9 ATP-binding cassette, sub-family C (CFTR/MRP), member 9 1.438
CLN3 ceroid-lipofuscinosis, neuronal 3 1.437
IST1 increased sodium tolerance 1 homolog (yeast) 1.435
AIRE autoimmune regulator 1.435
STAR steroidogenic acute regulatory protein 1.434
RPE65 retinal pigment epithelium-specific protein 65kDa 1.434
KITLG KIT ligand 1.43
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 1.429
IL6 interleukin 6 1.429
REN renin 1.425
CYP2U1 cytochrome P450, family 2, subfamily U, polypeptide 1 1.425
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 1.421
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 1.415
SYT7 synaptotagmin VII 1.412
TPP1 tripeptidyl peptidase I 1.408
FLT3LG fms-related tyrosine kinase 3 ligand 1.405
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 1.403
BTD biotinidase 1.402
NOTCH3 notch 3 1.402
CEL carboxyl ester lipase 1.4
ACADVL acyl-CoA dehydrogenase, very long chain 1.395
DDHD2 DDHD domain containing 2 1.395
CPT2 carnitine palmitoyltransferase 2 1.394
APOE apolipoprotein E 1.394
CSF3 colony stimulating factor 3 (granulocyte) 1.389
LONP2 lon peptidase 2, peroxisomal 1.379
CYP4F2 cytochrome P450, family 4, subfamily F, polypeptide 2 1.375
EIF2B3 eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa 1.374
ACSL1 acyl-CoA synthetase long-chain family member 1 1.371
CD4 CD4 molecule 1.37
GJB1 gap junction protein, beta 1, 32kDa 1.37
FIS1 fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae) 1.368
ACSBG2 acyl-CoA synthetase bubblegum family member 2 1.368
TMEM63A transmembrane protein 63A 1.364
WAS Wiskott-Aldrich syndrome 1.363
SLC22A5 solute carrier family 22 (organic cation/carnitine transporter), member 5 1.361
ABCB4 ATP-binding cassette, sub-family B (MDR/TAP), member 4 1.359
CD68 CD68 molecule 1.358
MRAP melanocortin 2 receptor accessory protein 1.357
ABCB5 ATP-binding cassette, sub-family B (MDR/TAP), member 5 1.353
IFNG interferon, gamma 1.351
SLC27A5 solute carrier family 27 (fatty acid transporter), member 5 1.351
DARS2 aspartyl-tRNA synthetase 2, mitochondrial 1.349
ST14 suppression of tumorigenicity 14 (colon carcinoma) 1.349
GLA galactosidase, alpha 1.348
CD19 CD19 molecule 1.346
MYRF myelin regulatory factor 1.344
PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 1.342
FMR1 fragile X mental retardation 1 1.34
PNPLA6 patatin-like phospholipase domain containing 6 1.339
ACTB actin, beta 1.337
GDNF glial cell derived neurotrophic factor 1.327
GSTK1 glutathione S-transferase kappa 1 1.321
ABCA8 ATP-binding cassette, sub-family A (ABC1), member 8 1.318
CLCN7 chloride channel, voltage-sensitive 7 1.317
PXDN peroxidasin 1.31
PGK2 phosphoglycerate kinase 2 1.31
INS insulin 1.308
TARDBP TAR DNA binding protein 1.307
PXDNL peroxidasin-like 1.306
NUDT19 nudix (nucleoside diphosphate linked moiety X)-type motif 19 1.306
OLIG2 oligodendrocyte lineage transcription factor 2 1.302
PRDM16 PR domain containing 16 1.3
ABCB10 ATP-binding cassette, sub-family B (MDR/TAP), member 10 1.3
CD8A CD8a molecule 1.296
IL3 interleukin 3 1.295
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 1.291
ACADM acyl-CoA dehydrogenase, C-4 to C-12 straight chain 1.29
SGPL1 sphingosine-1-phosphate lyase 1 1.286
PXMP4 peroxisomal membrane protein 4, 24kDa 1.285
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.281
SERAC1 serine active site containing 1 1.28
TYROBP TYRO protein tyrosine kinase binding protein 1.279
GLB1 galactosidase, beta 1 1.277
ABCB8 ATP-binding cassette, sub-family B (MDR/TAP), member 8 1.276
POLG polymerase (DNA directed), gamma 1.274
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase 1.273
PACS1 phosphofurin acidic cluster sorting protein 1 1.271
SOX2 SRY (sex determining region Y)-box 2 1.269
PTPRC protein tyrosine phosphatase, receptor type, C 1.268
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.267
ABCA5 ATP-binding cassette, sub-family A (ABC1), member 5 1.266
PPP1R12C protein phosphatase 1, regulatory subunit 12C 1.264
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 1.262
COL4A1 collagen, type IV, alpha 1 1.262
DHRS7B dehydrogenase/reductase (SDR family) member 7B 1.262
PPIF peptidylprolyl isomerase F 1.259
THPO thrombopoietin 1.252
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 1.249
ELOVL6 ELOVL fatty acid elongase 6 1.249
ABCC12 ATP-binding cassette, sub-family C (CFTR/MRP), member 12 1.245
LMBRD1 LMBR1 domain containing 1 1.24
ABCA13 ATP-binding cassette, sub-family A (ABC1), member 13 1.24
ABCF2 ATP-binding cassette, sub-family F (GCN20), member 2 1.24
TOMM20L translocase of outer mitochondrial membrane 20 homolog (yeast)-like 1.24
KLF4 Kruppel-like factor 4 (gut) 1.24
ACSL4 acyl-CoA synthetase long-chain family member 4 1.239
MFF mitochondrial fission factor 1.237
SUOX sulfite oxidase 1.236
CROT carnitine O-octanoyltransferase 1.235
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.234
HACL1 2-hydroxyacyl-CoA lyase 1 1.234
APTX aprataxin 1.233
HEPACAM hepatic and glial cell adhesion molecule 1.231
BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) 1.229
VAPA VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa 1.229
ABCA7 ATP-binding cassette, sub-family A (ABC1), member 7 1.228
DAO D-amino-acid oxidase 1.227
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.225
BDNF brain-derived neurotrophic factor 1.22
IGF1 insulin-like growth factor 1 (somatomedin C) 1.216
MRPS7 mitochondrial ribosomal protein S7 1.216
HLCS holocarboxylase synthetase (biotin-(proprionyl-CoA-carboxylase (ATP-hydrolysing)) ligase) 1.216
CYP4F8 cytochrome P450, family 4, subfamily F, polypeptide 8 1.215
NIPA1 non imprinted in Prader-Willi/Angelman syndrome 1 1.214
NRTN neurturin 1.211
MTR 5-methyltetrahydrofolate-homocysteine methyltransferase 1.21
ABCC4 ATP-binding cassette, sub-family C (CFTR/MRP), member 4 1.207
LRRK2 leucine-rich repeat kinase 2 1.203
GPX2 glutathione peroxidase 2 1.201
GPX7 glutathione peroxidase 7 1.199
ELOVL2 ELOVL fatty acid elongase 2 1.198
SLC33A1 solute carrier family 33 (acetyl-CoA transporter), member 1 1.198
GDAP1 ganglioside induced differentiation associated protein 1 1.197
HSD3B7 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 1.197
LIPA lipase A, lysosomal acid, cholesterol esterase 1.197
OSTM1 osteopetrosis associated transmembrane protein 1 1.196
SPART spartin 1.195
SLC27A1 solute carrier family 27 (fatty acid transporter), member 1 1.194
LMNB1 lamin B1 1.194
GPX6 glutathione peroxidase 6 1.193
GPX5 glutathione peroxidase 5 1.192
GPX3 glutathione peroxidase 3 1.192
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.192
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.191
SAMD9 sterile alpha motif domain containing 9 1.191
GBA2 glucosidase, beta (bile acid) 2 1.191
GPX8 glutathione peroxidase 8 (putative) 1.191
ABCB9 ATP-binding cassette, sub-family B (MDR/TAP), member 9 1.189
RAG1 recombination activating gene 1 1.187
CCL2 chemokine (C-C motif) ligand 2 1.187
RNASEH2B ribonuclease H2, subunit B 1.186
CYBB cytochrome b-245, beta polypeptide 1.186
DMD dystrophin 1.184
POU5F1 POU class 5 homeobox 1 1.182
FAR2 fatty acyl CoA reductase 2 1.18
GALK1 galactokinase 1 1.18
TMEM119 transmembrane protein 119 1.177
OPALIN oligodendrocytic myelin paranodal and inner loop protein 1.176
AP4B1 adaptor-related protein complex 4, beta 1 subunit 1.175
OSBPL5 oxysterol binding protein-like 5 1.173
ACOT8 acyl-CoA thioesterase 8 1.173
ABCC10 ATP-binding cassette, sub-family C (CFTR/MRP), member 10 1.172
CLN6 ceroid-lipofuscinosis, neuronal 6, late infantile, variant 1.17
DARS1 aspartyl-tRNA synthetase 1 1.168
TMEM94 transmembrane protein 94 1.168
CACNA1A calcium channel, voltage-dependent, P/Q type, alpha 1A subunit 1.168
IL10 interleukin 10 1.167
VDAC1 voltage-dependent anion channel 1 1.166
PLXNB3 plexin B3 1.163
PGK1 phosphoglycerate kinase 1 1.163
BSCL2 Berardinelli-Seip congenital lipodystrophy 2 (seipin) 1.161
CP ceruloplasmin (ferroxidase) 1.16
HBB hemoglobin, beta 1.159
RTN2 reticulon 2 1.158
CTSA cathepsin A 1.158
CKM creatine kinase, muscle 1.155
MTHFR methylenetetrahydrofolate reductase (NAD(P)H) 1.154
HADH hydroxyacyl-CoA dehydrogenase 1.154
SRPK3 SRSF protein kinase 3 1.151
SLC25A24 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 24 1.15
PSIP1 PC4 and SFRS1 interacting protein 1 1.15
SLC2A1 solute carrier family 2 (facilitated glucose transporter), member 1 1.146
SLC29A3 solute carrier family 29 (equilibrative nucleoside transporter), member 3 1.146
MOBP myelin-associated oligodendrocyte basic protein 1.145
C9ORF72 chromosome 9 open reading frame 72 1.144
POLR3K polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa 1.144
SCARB2 scavenger receptor class B, member 2 1.143
SCAP SREBF chaperone 1.141
ATXN7 ataxin 7 1.14
RNASET2 ribonuclease T2 1.136
NEFH neurofilament, heavy polypeptide 1.136
HSD17B12 hydroxysteroid (17-beta) dehydrogenase 12 1.134
VAMP4 vesicle-associated membrane protein 4 1.133
OSBP oxysterol binding protein 1.132
CSF1 colony stimulating factor 1 (macrophage) 1.132
DHCR7 7-dehydrocholesterol reductase 1.131
MAPT microtubule-associated protein tau 1.127
KIAA0319L KIAA0319-like 1.126
CKB creatine kinase, brain 1.123
IL2 interleukin 2 1.123
PSEN1 presenilin 1 1.122
MCM4 minichromosome maintenance complex component 4 1.121
RAB3GAP2 RAB3 GTPase activating protein subunit 2 (non-catalytic) 1.12
ACSL6 acyl-CoA synthetase long-chain family member 6 1.12
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.119
HDAC9 histone deacetylase 9 1.118
CD36 CD36 molecule (thrombospondin receptor) 1.117
SOX10 SRY (sex determining region Y)-box 10 1.116
IDI1 isopentenyl-diphosphate delta isomerase 1 1.115
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.115
ABCA10 ATP-binding cassette, sub-family A (ABC1), member 10 1.114
SREBF2 sterol regulatory element binding transcription factor 2 1.114
RMDN3 regulator of microtubule dynamics 3 1.114
CKMT1B creatine kinase, mitochondrial 1B 1.114
NFASC neurofascin 1.108
NOTCH2NLC notch 2 N-terminal like C 1.107
MGAM maltase-glucoamylase 1.106
DDHD1 DDHD domain containing 1 1.105
SSR4 signal sequence receptor, delta 1.105
PC pyruvate carboxylase 1.105
RHO rhodopsin 1.104
DNM1L dynamin 1-like 1.104
TH tyrosine hydroxylase 1.104
DDO D-aspartate oxidase 1.103
SCARB1 scavenger receptor class B, member 1 1.101
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.101
CYCS cytochrome c, somatic 1.1
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.099
CYP46A1 cytochrome P450, family 46, subfamily A, polypeptide 1 1.095
IL34 interleukin 34 1.095
LAMA2 laminin, alpha 2 1.09
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria 1.088
LHX4 LIM homeobox 4 1.088
UGCG UDP-glucose ceramide glucosyltransferase 1.086
GBE1 glucan (1,4-alpha-), branching enzyme 1 1.085
PAH phenylalanine hydroxylase 1.085
ATP13A2 ATPase type 13A2 1.085
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 1.083
ATP7B ATPase, Cu++ transporting, beta polypeptide 1.081
ACSL5 acyl-CoA synthetase long-chain family member 5 1.08
SI sucrase-isomaltase (alpha-glucosidase) 1.08
RBFOX3 RNA binding protein, fox-1 homolog (C. elegans) 3 1.08
IL1RAPL1 interleukin 1 receptor accessory protein-like 1 1.078
PSEN2 presenilin 2 1.077
ATL1 atlastin GTPase 1 1.077
GCDH glutaryl-CoA dehydrogenase 1.077
CNTNAP1 contactin associated protein 1 1.077
PINK1 PTEN induced putative kinase 1 1.076
COL9A3 collagen, type IX, alpha 3 1.075
MFN2 mitofusin 2 1.075
PPCS phosphopantothenoylcysteine synthetase 1.074
SAA2 serum amyloid A2 1.073
IFNB1 interferon, beta 1, fibroblast 1.069
TCN2 transcobalamin II 1.066
GPR183 G protein-coupled receptor 183 1.066
RAG2 recombination activating gene 2 1.065
NDUFB8 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa 1.065
TP53 tumor protein p53 1.064
NAGS N-acetylglutamate synthase 1.064
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 1.063
HMOX1 heme oxygenase 1 1.063
NES nestin 1.058
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 1.057
RHOT1 ras homolog family member T1 1.057
RNF44 ring finger protein 44 1.055
MRTFB myocardin related transcription factor B 1.054
PRKN parkin RBR E3 ubiquitin protein ligase 1.053
PTH parathyroid hormone 1.053
CCND2 cyclin D2 1.051
TMEM135 transmembrane protein 135 1.049
ZFAND6 zinc finger, AN1-type domain 6 1.049
SDF2 stromal cell-derived factor 2 1.046
UBE3A ubiquitin protein ligase E3A 1.045
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.044
PANK1 pantothenate kinase 1 1.043
GSR glutathione reductase 1.042
HIKESHI heat shock protein nuclear import factor hikeshi 1.041
SCD stearoyl-CoA desaturase (delta-9-desaturase) 1.041
IL1A interleukin 1, alpha 1.041
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 1.041
RAB18 RAB18, member RAS oncogene family 1.041
TGFB1 transforming growth factor, beta 1 1.04
PYCR2 pyrroline-5-carboxylate reductase family, member 2 1.039
SAA1 serum amyloid A1 1.037
LYRM7 LYR motif containing 7 1.037
CD33 CD33 molecule 1.037
FGF2 fibroblast growth factor 2 (basic) 1.034
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 1.033
CLDN11 claudin 11 1.033
GNS glucosamine (N-acetyl)-6-sulfatase 1.031
ACSL3 acyl-CoA synthetase long-chain family member 3 1.03
ERVW-1 endogenous retrovirus group W, member 1 1.027
ACAA2 acetyl-CoA acyltransferase 2 1.026
NTF3 neurotrophin 3 1.025
SREBF1 sterol regulatory element binding transcription factor 1 1.024
GAN gigaxonin 1.017
VCP valosin containing protein 1.017
CLN5 ceroid-lipofuscinosis, neuronal 5 1.016
CLDN5 claudin 5 1.016
CCL4 chemokine (C-C motif) ligand 4 1.015
AGXT alanine-glyoxylate aminotransferase 1.014
FADS2 fatty acid desaturase 2 1.013
PANK2 pantothenate kinase 2 1.012
RPIA ribose 5-phosphate isomerase A 1.01
SNX14 sorting nexin 14 1.008
ACO2 aconitase 2, mitochondrial 1.008
CXCL8 chemokine (C-X-C motif) ligand 8 1.007
ZNF16 zinc finger protein 16 1.006
SAMHD1 SAM domain and HD domain 1 1.004
NOTCH2NLA notch 2 N-terminal like A 1.003
G6PD glucose-6-phosphate dehydrogenase 1.002
ISCA1 iron-sulfur cluster assembly 1 1.001
SOAT1 sterol O-acyltransferase 1 1.0
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) 1.0