| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in A-172 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_A-172 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MT2A | metallothionein 2A | 0.0938665 |
| PLAT | plasminogen activator, tissue | 0.0881178 |
| FBN1 | fibrillin 1 | 0.0721761 |
| COL3A1 | collagen, type III, alpha 1 | 0.0689915 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0628962 |
| B2M | beta-2-microglobulin | 0.0568959 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | 0.0526291 |
| COL1A2 | collagen, type I, alpha 2 | 0.0454311 |
| TMSB4X | thymosin beta 4, X-linked | 0.0438889 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0438376 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0429374 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | 0.042078 |
| TMSB10 | thymosin beta 10 | 0.0413084 |
| ATP13A3 | ATPase type 13A3 | 0.0411757 |
| VIM | vimentin | 0.0397694 |
| PRSS23 | protease, serine, 23 | 0.0396421 |
| PTMA | prothymosin, alpha | 0.0376737 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0374265 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0357181 |
| PGK1 | phosphoglycerate kinase 1 | 0.0304624 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0287877 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0282642 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0267208 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0260988 |
| AFDN | afadin, adherens junction formation factor | 0.0258199 |
| FRMD4A | FERM domain containing 4A | 0.0258186 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0257663 |
| ANKRD10 | ankyrin repeat domain 10 | 0.025547 |
| S100A4 | S100 calcium binding protein A4 | 0.0246365 |
| RPL37A | ribosomal protein L37a | 0.0236593 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | 0.0231368 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0217965 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0213611 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0207593 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0204322 |
| ARL15 | ADP-ribosylation factor-like 15 | 0.0202423 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0199611 |
| AHNAK | AHNAK nucleoprotein | 0.0188992 |
| ARHGAP21 | Rho GTPase activating protein 21 | 0.0186975 |
| KIFAP3 | kinesin-associated protein 3 | 0.0176357 |
| VEGFC | vascular endothelial growth factor C | 0.0175682 |
| TOP2B | topoisomerase (DNA) II beta 180kDa | 0.0174097 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | 0.0172291 |
| DENND5A | DENN/MADD domain containing 5A | 0.0171557 |
| ABTB3 | ankyrin repeat and BTB domain containing 3 | 0.0170174 |
| CTSB | cathepsin B | 0.0167717 |
| SERINC1 | serine incorporator 1 | 0.0164188 |
| RPL26 | ribosomal protein L26 | 0.0157909 |
| SLC22A4 | solute carrier family 22 (organic cation/zwitterion transporter), member 4 | 0.015473 |
| MT1X | metallothionein 1X | 0.0151727 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0150995 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.015075 |
| NCKAP1 | NCK-associated protein 1 | 0.0149147 |
| ZEB1 | zinc finger E-box binding homeobox 1 | 0.0148998 |
| SSTR2 | somatostatin receptor 2 | 0.0147681 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0147581 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0145824 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0144857 |
| RPS27A | ribosomal protein S27a | 0.0144398 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0144343 |
| SERPINB6 | serpin peptidase inhibitor, clade B (ovalbumin), member 6 | 0.0144242 |
| DIRAS3 | DIRAS family, GTP-binding RAS-like 3 | 0.0144059 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0143865 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0142426 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0138803 |
| LINGO2 | leucine rich repeat and Ig domain containing 2 | 0.0137933 |
| WAC | WW domain containing adaptor with coiled-coil | 0.0137823 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0136469 |
| ADAM19 | ADAM metallopeptidase domain 19 | 0.0134566 |
| PODXL | podocalyxin-like | 0.0134302 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0133743 |
| SFTPA2 | surfactant protein A2 | 0.013288 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0132646 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0132425 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0131862 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0129038 |
| SSBP2 | single-stranded DNA binding protein 2 | 0.0128551 |
| RYK | receptor-like tyrosine kinase | 0.0127127 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0125831 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | 0.0124482 |
| XPOT | exportin, tRNA | 0.0123635 |
| MYADM | myeloid-associated differentiation marker | 0.0122838 |
| NT5C2 | 5'-nucleotidase, cytosolic II | 0.0122074 |
| CEMIP | cell migration inducing protein, hyaluronan binding | 0.012185 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.0119811 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0119793 |
| APAF1 | apoptotic peptidase activating factor 1 | 0.0117816 |
| CAP1 | CAP, adenylate cyclase-associated protein 1 (yeast) | 0.0117708 |
| FRMD5 | FERM domain containing 5 | 0.0116991 |
| USP9X | ubiquitin specific peptidase 9, X-linked | 0.0116501 |
| ZBTB7A | zinc finger and BTB domain containing 7A | 0.0114734 |
| HMGB2 | high mobility group box 2 | 0.0114426 |
| ZNF706 | zinc finger protein 706 | 0.011442 |
| CYLD | cylindromatosis (turban tumor syndrome) | 0.0114181 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.011391 |
| RAD21 | RAD21 homolog (S. pombe) | 0.0112988 |
| IL15 | interleukin 15 | 0.0112212 |
| FMNL2 | formin-like 2 | 0.0111249 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0109588 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0109447 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.422579 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.18475 |
| NDRG1 | N-myc downstream regulated 1 | -0.166426 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.134245 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.119913 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.110991 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.106557 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.104961 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | -0.100277 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0942483 |
| MAP1B | microtubule-associated protein 1B | -0.0845253 |
| RTN4 | reticulon 4 | -0.0813489 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0808101 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0787588 |
| SQSTM1 | sequestosome 1 | -0.0759713 |
| TPM4 | tropomyosin 4 | -0.0742938 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0693032 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0689681 |
| UBC | ubiquitin C | -0.0668397 |
| RUNX1 | runt-related transcription factor 1 | -0.0636479 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0625079 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0620913 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0614462 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0614214 |
| DCLK2 | doublecortin-like kinase 2 | -0.0549883 |
| EGFR | epidermal growth factor receptor | -0.0545813 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | -0.0535493 |
| LDHA | lactate dehydrogenase A | -0.0526014 |
| FOSL1 | FOS-like antigen 1 | -0.0519385 |
| LOXL2 | lysyl oxidase-like 2 | -0.051697 |
| ANXA2 | annexin A2 | -0.0508161 |
| RND3 | Rho family GTPase 3 | -0.0508129 |
| HS3ST3A1 | heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 | -0.0506588 |
| S100A10 | S100 calcium binding protein A10 | -0.0483405 |
| HDAC9 | histone deacetylase 9 | -0.0482334 |
| PRKAG2 | protein kinase, AMP-activated, gamma 2 non-catalytic subunit | -0.0481187 |
| CD99 | CD99 molecule | -0.0480686 |
| GOLGA4 | golgin A4 | -0.0480453 |
| PKM | pyruvate kinase, muscle | -0.0477416 |
| BSG | basigin (Ok blood group) | -0.0473967 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0470073 |
| POTEF | POTE ankyrin domain family, member F | -0.046881 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0459991 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.045909 |
| ADAM9 | ADAM metallopeptidase domain 9 | -0.0457206 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0455051 |
| MEIS2 | Meis homeobox 2 | -0.0453776 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0449565 |
| FTL | ferritin, light polypeptide | -0.0447409 |
| VEGFA | vascular endothelial growth factor A | -0.043918 |
| LOX | lysyl oxidase | -0.0433614 |
| CENPF | centromere protein F, 350/400kDa | -0.0420538 |
| SIPA1L3 | signal-induced proliferation-associated 1 like 3 | -0.041769 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0414618 |
| USP34 | ubiquitin specific peptidase 34 | -0.0405796 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0401208 |
| SLC39A11 | solute carrier family 39, member 11 | -0.0398503 |
| TENM3 | teneurin transmembrane protein 3 | -0.0398184 |
| TAOK1 | TAO kinase 1 | -0.0389451 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.038922 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0388048 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0387314 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0382769 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0382126 |
| NAV2 | neuron navigator 2 | -0.0376786 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0375762 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0374523 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0371992 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0370333 |
| CCND1 | cyclin D1 | -0.0365173 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.036492 |
| ADM | adrenomedullin | -0.0364575 |
| GOLGB1 | golgin B1 | -0.0360706 |
| JMJD1C | jumonji domain containing 1C | -0.0356459 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0354957 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0349984 |
| EGR1 | early growth response 1 | -0.0349469 |
| CDH13 | cadherin 13 | -0.0341123 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | -0.0340496 |
| RNF168 | ring finger protein 168, E3 ubiquitin protein ligase | -0.0340039 |
| CD44 | CD44 molecule (Indian blood group) | -0.0338475 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0338027 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | -0.0336448 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0334614 |
| MEF2D | myocyte enhancer factor 2D | -0.0332595 |
| UAP1 | UDP-N-acetylglucosamine pyrophosphorylase 1 | -0.0332292 |
| MYO9B | myosin IXB | -0.0331847 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0329458 |
| VCL | vinculin | -0.0328514 |
| EPAS1 | endothelial PAS domain protein 1 | -0.0324634 |
| SETD5 | SET domain containing 5 | -0.0324242 |
| RPL28 | ribosomal protein L28 | -0.0320097 |
| PPDPF | pancreatic progenitor cell differentiation and proliferation factor | -0.0319877 |
| UGCG | UDP-glucose ceramide glucosyltransferase | -0.0318377 |
| TXNRD1 | thioredoxin reductase 1 | -0.0312539 |
| ANXA5 | annexin A5 | -0.0311317 |
| ZNF292 | zinc finger protein 292 | -0.0309423 |
| CD109 | CD109 molecule | -0.0307893 |
| ACBD3 | acyl-CoA binding domain containing 3 | -0.0306689 |
| ACTN4 | actinin, alpha 4 | -0.0304897 |
