| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in A-427 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_A-427 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.171594 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | 0.126139 |
| PTMA | prothymosin, alpha | 0.0995057 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0971992 |
| CALR | calreticulin | 0.0833404 |
| RPS2 | ribosomal protein S2 | 0.0762809 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0755854 |
| RPS12 | ribosomal protein S12 | 0.0645704 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0638321 |
| TPM3 | tropomyosin 3 | 0.0615481 |
| TMEM41B | transmembrane protein 41B | 0.0613328 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | 0.0592945 |
| CANX | calnexin | 0.0582178 |
| MMP12 | matrix metallopeptidase 12 | 0.0575481 |
| SET | SET nuclear proto-oncogene | 0.0520479 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0509976 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0495489 |
| TUBA1B | tubulin, alpha 1b | 0.0450233 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0440315 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0438031 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0433887 |
| HDGF | hepatoma-derived growth factor | 0.0431541 |
| MKI67 | marker of proliferation Ki-67 | 0.042601 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0424172 |
| XPOT | exportin, tRNA | 0.0407644 |
| ENO1 | enolase 1, (alpha) | 0.0391763 |
| TPM4 | tropomyosin 4 | 0.0383555 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0375128 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0371188 |
| VIM | vimentin | 0.0370452 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.036754 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0358183 |
| JMJD1C | jumonji domain containing 1C | 0.0345856 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.0342719 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0339392 |
| XPO1 | exportin 1 | 0.0339387 |
| SPATS2 | spermatogenesis associated, serine-rich 2 | 0.0326745 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0326687 |
| PDGFC | platelet derived growth factor C | 0.0326538 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0325387 |
| RTN4 | reticulon 4 | 0.0320226 |
| DSPP | dentin sialophosphoprotein | 0.0310393 |
| NIBAN1 | niban apoptosis regulator 1 | 0.0310261 |
| PCBP2 | poly(rC) binding protein 2 | 0.0308402 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0306945 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0306327 |
| RPS8 | ribosomal protein S8 | 0.0293081 |
| ANK2 | ankyrin 2, neuronal | 0.0288926 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0287109 |
| KIF5B | kinesin family member 5B | 0.0269957 |
| FNIP1 | folliculin interacting protein 1 | 0.0269139 |
| CLTC | clathrin, heavy chain (Hc) | 0.0268734 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0267848 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0264184 |
| PDIA3 | protein disulfide isomerase family A, member 3 | 0.0263301 |
| BCHE | butyrylcholinesterase | 0.0263136 |
| NRXN3 | neurexin 3 | 0.0261896 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0259193 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0257613 |
| MED13L | mediator complex subunit 13-like | 0.0254883 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0253265 |
| CENPF | centromere protein F, 350/400kDa | 0.0249214 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0246795 |
| HNRNPA3 | heterogeneous nuclear ribonucleoprotein A3 | 0.0246621 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0243589 |
| MCL1 | myeloid cell leukemia 1 | 0.024344 |
| ANKS1B | ankyrin repeat and sterile alpha motif domain containing 1B | 0.024322 |
| SFTPA2 | surfactant protein A2 | 0.0241728 |
| RPS7 | ribosomal protein S7 | 0.0240242 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0239994 |
| NEGR1 | neuronal growth regulator 1 | 0.0237159 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0232347 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0232148 |
| HSPA4 | heat shock 70kDa protein 4 | 0.0229236 |
| RPL26 | ribosomal protein L26 | 0.0228787 |
| SSR1 | signal sequence receptor, alpha | 0.0225143 |
| NR2F1 | nuclear receptor subfamily 2, group F, member 1 | 0.0223295 |
| RPS3 | ribosomal protein S3 | 0.0221736 |
| DENND5B | DENN/MADD domain containing 5B | 0.0220863 |
| VMP1 | vacuole membrane protein 1 | 0.0220033 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0216359 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0216358 |
| SESN2 | sestrin 2 | 0.0216337 |
| USP14 | ubiquitin specific peptidase 14 (tRNA-guanine transglycosylase) | 0.0216316 |
| RPS18 | ribosomal protein S18 | 0.02141 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0213297 |
| MYADM | myeloid-associated differentiation marker | 0.0209664 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | 0.02087 |
| TXNRD1 | thioredoxin reductase 1 | 0.0207197 |
| EPRS1 | glutamyl-prolyl-tRNA synthetase 1 | 0.0205314 |
| EZR | ezrin | 0.0203118 |
| EIF4B | eukaryotic translation initiation factor 4B | 0.0202957 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0202379 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0202234 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0201646 |
| ATP9A | ATPase, class II, type 9A | 0.0200066 |
| MAP4 | microtubule-associated protein 4 | 0.0198116 |
| TPI1 | triosephosphate isomerase 1 | 0.0194801 |
| PNN | pinin, desmosome associated protein | 0.0194766 |
| RSL1D1 | ribosomal L1 domain containing 1 | 0.019338 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.161352 |
| AREG | amphiregulin | -0.15868 |
| PCDH7 | protocadherin 7 | -0.157228 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.104603 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0969772 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | -0.0964565 |
| NLGN1 | neuroligin 1 | -0.0958457 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0943977 |
| CELF2 | CUGBP, Elav-like family member 2 | -0.0790863 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0743911 |
| FTL | ferritin, light polypeptide | -0.0712682 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.068385 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0581449 |
| BIRC3 | baculoviral IAP repeat containing 3 | -0.0552447 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0518158 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0517894 |
| TEAD1 | TEA domain family member 1 (SV40 transcriptional enhancer factor) | -0.0503206 |
| ZNF804A | zinc finger protein 804A | -0.0500309 |
| DDX5 | DEAD (Asp-Glu-Ala-Asp) box helicase 5 | -0.0497763 |
| INTS6 | integrator complex subunit 6 | -0.0495166 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0490814 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0481381 |
| RPL23 | ribosomal protein L23 | -0.0475946 |
| ADGRG6 | adhesion G protein-coupled receptor G6 | -0.0475539 |
| CCN2 | cellular communication network factor 2 | -0.0461491 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0457759 |
| EDN1 | endothelin 1 | -0.0451494 |
| SYT1 | synaptotagmin I | -0.0432744 |
| RPS19 | ribosomal protein S19 | -0.0431986 |
| POU2F1 | POU class 2 homeobox 1 | -0.0423984 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0400314 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0391001 |
| YAP1 | Yes-associated protein 1 | -0.0382775 |
| RPL36 | ribosomal protein L36 | -0.0379053 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0376146 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0375347 |
| PRIM2 | primase, DNA, polypeptide 2 (58kDa) | -0.0373069 |
| RPL28 | ribosomal protein L28 | -0.0370792 |
| RPL27A | ribosomal protein L27a | -0.0368712 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.036265 |
| NF1 | neurofibromin 1 | -0.0357291 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0354873 |
| USP34 | ubiquitin specific peptidase 34 | -0.0354228 |
| CCDC88A | coiled-coil domain containing 88A | -0.0353024 |
| RPL19 | ribosomal protein L19 | -0.03488 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0348102 |
| GPHN | gephyrin | -0.0340625 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0338335 |
| ELP4 | elongator acetyltransferase complex subunit 4 | -0.0336946 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0333635 |
| NABP1 | nucleic acid binding protein 1 | -0.0329213 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | -0.0326588 |
| CNRIP1 | cannabinoid receptor interacting protein 1 | -0.0325096 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0323146 |
| ADIPOR2 | adiponectin receptor 2 | -0.0321894 |
| LRRTM4 | leucine rich repeat transmembrane neuronal 4 | -0.032153 |
| RPLP1 | ribosomal protein, large, P1 | -0.0321476 |
| FBXO11 | F-box protein 11 | -0.0317938 |
| CUBN | cubilin (intrinsic factor-cobalamin receptor) | -0.0317674 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0317463 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0316129 |
| CARD16 | caspase recruitment domain family, member 16 | -0.0310168 |
| PPP1R10 | protein phosphatase 1, regulatory subunit 10 | -0.0308083 |
| CCND1 | cyclin D1 | -0.0307881 |
| FUS | FUS RNA binding protein | -0.0303212 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0293972 |
| PCNP | PEST proteolytic signal containing nuclear protein | -0.0293478 |
| RPLP0 | ribosomal protein, large, P0 | -0.0291969 |
| ZNF638 | zinc finger protein 638 | -0.0291295 |
| SMCHD1 | structural maintenance of chromosomes flexible hinge domain containing 1 | -0.0288078 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0287877 |
| NUP98 | nucleoporin 98kDa | -0.0286404 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0284353 |
| PFN1 | profilin 1 | -0.0284182 |
| ABI2 | abl-interactor 2 | -0.0284041 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0282811 |
| RPS20 | ribosomal protein S20 | -0.0282672 |
| EDARADD | EDAR-associated death domain | -0.028071 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.028009 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0278289 |
| TRA2B | transformer 2 beta homolog (Drosophila) | -0.0275381 |
| RPS4X | ribosomal protein S4, X-linked | -0.027525 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0271825 |
| BPTF | bromodomain PHD finger transcription factor | -0.0271689 |
| ATP11A | ATPase, class VI, type 11A | -0.0268983 |
| DKK1 | dickkopf WNT signaling pathway inhibitor 1 | -0.0266674 |
| TMEM131 | transmembrane protein 131 | -0.0266287 |
| RPS24 | ribosomal protein S24 | -0.0266269 |
| ERBIN | erbb2 interacting protein | -0.0264896 |
| CXADR | coxsackie virus and adenovirus receptor | -0.0263166 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0262935 |
| EGR1 | early growth response 1 | -0.025967 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.025543 |
| POLA1 | polymerase (DNA directed), alpha 1, catalytic subunit | -0.0254235 |
| MTAP | methylthioadenosine phosphorylase | -0.0254004 |
| HNRNPH1 | heterogeneous nuclear ribonucleoprotein H1 (H) | -0.0253257 |
| RPS5 | ribosomal protein S5 | -0.0252084 |
| ECT2 | epithelial cell transforming 2 | -0.0251785 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0250534 |
| WDR26 | WD repeat domain 26 | -0.0248813 |
