Afatinib_CHP-212 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Afatinib perturbation in CHP-212 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Afatinib_CHP-212 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.131622
MEIS2 Meis homeobox 2 0.0688011
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0679689
EEF2 eukaryotic translation elongation factor 2 0.059006
LPIN1 lipin 1 0.0542488
RPL3 ribosomal protein L3 0.0494789
NCOR2 nuclear receptor corepressor 2 0.0480635
NFE2L1 nuclear factor, erythroid 2-like 1 0.0458809
PTEN phosphatase and tensin homolog 0.0442172
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0441904
RPS2 ribosomal protein S2 0.043685
SRRM2 serine/arginine repetitive matrix 2 0.0416681
MYCN v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog 0.0414192
VEGFA vascular endothelial growth factor A 0.0380617
ERBIN erbb2 interacting protein 0.0377803
EEF1G eukaryotic translation elongation factor 1 gamma 0.0370115
WDR43 WD repeat domain 43 0.0367807
PCBP2 poly(rC) binding protein 2 0.036615
MAP1B microtubule-associated protein 1B 0.0365344
SP100 SP100 nuclear antigen 0.0363466
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0359293
POTEF POTE ankyrin domain family, member F 0.0352763
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0336217
PNN pinin, desmosome associated protein 0.0331265
SEPTIN9 septin 9 0.0328765
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.0328054
RUNX1T1 runt-related transcription factor 1; translocated to, 1 (cyclin D-related) 0.0326037
DDX60L DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like 0.032383
SLITRK6 SLIT and NTRK-like family, member 6 0.0321478
FHIT fragile histidine triad 0.0317284
MED13L mediator complex subunit 13-like 0.031719
SFTPA2 surfactant protein A2 0.0313862
HNRNPDL heterogeneous nuclear ribonucleoprotein D-like 0.0311379
GOLGA4 golgin A4 0.0306455
ENAH enabled homolog (Drosophila) 0.030392
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 0.0302928
BCLAF1 BCL2-associated transcription factor 1 0.0301424
PRRC2C proline-rich coiled-coil 2C 0.0293516
RPL4 ribosomal protein L4 0.0293217
ZC3HAV1 zinc finger CCCH-type, antiviral 1 0.0290834
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0289035
FTH1 ferritin, heavy polypeptide 1 0.0288606
GPC5 glypican 5 0.0286546
TPM3 tropomyosin 3 0.0283922
RO60 Ro60, Y RNA binding protein 0.0283515
MX2 MX dynamin-like GTPase 2 0.0279856
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 0.0279745
HSPA8 heat shock 70kDa protein 8 0.0279621
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0278075
KIF26B kinesin family member 26B 0.0276583
B2M beta-2-microglobulin 0.0274242
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 0.0273339
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0267738
YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma 0.0265574
DNM3 dynamin 3 0.02653
DSTN destrin (actin depolymerizing factor) 0.0263571
SH3RF1 SH3 domain containing ring finger 1 0.0263144
PSME4 proteasome (prosome, macropain) activator subunit 4 0.0259536
FMNL2 formin-like 2 0.0258131
CCNL1 cyclin L1 0.0253826
SPATS2L spermatogenesis associated, serine-rich 2-like 0.0252343
BCAS3 breast carcinoma amplified sequence 3 0.0247054
DHX40 DEAH (Asp-Glu-Ala-His) box polypeptide 40 0.0243674
PUM1 pumilio RNA-binding family member 1 0.0243449
RPL21 ribosomal protein L21 0.0240184
ZFHX3 zinc finger homeobox 3 0.0239283
ZNF146 zinc finger protein 146 0.0238818
JUP junction plakoglobin 0.023497
AP2B1 adaptor-related protein complex 2, beta 1 subunit 0.023472
RET ret proto-oncogene 0.0234068
RTN4 reticulon 4 0.0234005
LGALS3BP lectin, galactoside-binding, soluble, 3 binding protein 0.0233521
ASPH aspartate beta-hydroxylase 0.0233127
TNRC6B trinucleotide repeat containing 6B 0.0231656
DGKH diacylglycerol kinase, eta 0.0230858
COL6A1 collagen, type VI, alpha 1 0.0229713
PTPRE protein tyrosine phosphatase, receptor type, E 0.0229442
VIRMA vir like m6A methyltransferase associated 0.0227986
TMTC2 transmembrane and tetratricopeptide repeat containing 2 0.0227303
MEF2D myocyte enhancer factor 2D 0.0225834
PDAP1 PDGFA associated protein 1 0.0225688
BRD2 bromodomain containing 2 0.0225036
DDX1 DEAD (Asp-Glu-Ala-Asp) box helicase 1 0.0224719
ZMIZ1 zinc finger, MIZ-type containing 1 0.0224433
PCM1 pericentriolar material 1 0.0221534
KLC1 kinesin light chain 1 0.0220334
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0217913
ITGAV integrin, alpha V 0.021702
KCTD3 potassium channel tetramerization domain containing 3 0.0216233
PDE4D phosphodiesterase 4D, cAMP-specific 0.0215887
ROCK1 Rho-associated, coiled-coil containing protein kinase 1 0.0215074
NRP1 neuropilin 1 0.0214628
RUNX1 runt-related transcription factor 1 0.0214126
RNASEH2A ribonuclease H2, subunit A 0.0212284
PDGFRB platelet-derived growth factor receptor, beta polypeptide 0.0212079
CRH corticotropin releasing hormone 0.021004
EIF4G1 eukaryotic translation initiation factor 4 gamma, 1 0.0209712
AKAP9 A kinase (PRKA) anchor protein 9 0.0208112
RIGI RNA sensor RIG-I 0.0207665
PRPF4B pre-mRNA processing factor 4B 0.0205486

decreased expression

Symbol Name Standardized Value
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.15892
LSAMP limbic system-associated membrane protein -0.138933
VCL vinculin -0.130568
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.12583
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.102293
EXT1 exostosin glycosyltransferase 1 -0.095249
COL1A1 collagen, type I, alpha 1 -0.0941436
TPT1 tumor protein, translationally-controlled 1 -0.0839086
CCDC47 coiled-coil domain containing 47 -0.0837606
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0818035
TRIB2 tribbles pseudokinase 2 -0.0782232
COL3A1 collagen, type III, alpha 1 -0.0767533
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0747816
DTNA dystrobrevin, alpha -0.0733435
RPS24 ribosomal protein S24 -0.0725531
FAM13A family with sequence similarity 13, member A -0.0721852
FNDC3B fibronectin type III domain containing 3B -0.0688061
TLE4 transducin-like enhancer of split 4 -0.0681158
RPL19 ribosomal protein L19 -0.0636835
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa -0.0628742
KDM3A lysine (K)-specific demethylase 3A -0.0623938
RPL38 ribosomal protein L38 -0.0620007
IRF2BP2 interferon regulatory factor 2 binding protein 2 -0.0596396
HELZ helicase with zinc finger -0.0594108
DSCAM Down syndrome cell adhesion molecule -0.0589953
TPM1 tropomyosin 1 (alpha) -0.0581744
WDR45B WD repeat domain 45B -0.0581152
NREP neuronal regeneration related protein -0.0575377
IER3 immediate early response 3 -0.0565677
TOP2A topoisomerase (DNA) II alpha 170kDa -0.0554324
NRG1 neuregulin 1 -0.0550612
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -0.053999
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase -0.0520628
ASCC3 activating signal cointegrator 1 complex subunit 3 -0.0514218
SPAG9 sperm associated antigen 9 -0.0507024
ARF1 ADP-ribosylation factor 1 -0.0489596
RPL34 ribosomal protein L34 -0.0481687
MED13 mediator complex subunit 13 -0.0479694
PCDH9 protocadherin 9 -0.0471215
RPL35A ribosomal protein L35a -0.0470371
RPLP1 ribosomal protein, large, P1 -0.0461952
VMP1 vacuole membrane protein 1 -0.0446112
NAMPT nicotinamide phosphoribosyltransferase -0.0444539
FNBP1 formin binding protein 1 -0.0439381
MBD5 methyl-CpG binding domain protein 5 -0.0434228
WDR26 WD repeat domain 26 -0.0432158
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -0.0429068
RPL31 ribosomal protein L31 -0.0426419
MARCHF6 membrane associated ring-CH-type finger 6 -0.0425942
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0423468
SLC38A2 solute carrier family 38, member 2 -0.0418903
MAML2 mastermind-like 2 (Drosophila) -0.0416668
ACTG1 actin gamma 1 -0.0416102
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0410297
OGA O-GlcNAcase -0.0408735
FKBP10 FK506 binding protein 10, 65 kDa -0.0407865
PCNP PEST proteolytic signal containing nuclear protein -0.0403796
RBMS3 RNA binding motif, single stranded interacting protein 3 -0.0398694
PTPRD protein tyrosine phosphatase, receptor type, D -0.0394943
RAP1B RAP1B, member of RAS oncogene family -0.0392115
SCD stearoyl-CoA desaturase (delta-9-desaturase) -0.0385564
PCBP3 poly(rC) binding protein 3 -0.037672
HAND2 heart and neural crest derivatives expressed 2 -0.0374841
SEC31A SEC31 homolog A (S. cerevisiae) -0.037335
NUFIP2 nuclear fragile X mental retardation protein interacting protein 2 -0.0371297
IGF1R insulin-like growth factor 1 receptor -0.0368643
PRKRIP1 PRKR interacting protein 1 (IL11 inducible) -0.0366084
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I -0.0363319
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0359622
VIM vimentin -0.0358236
GARS1 glycyl-tRNA synthetase 1 -0.0353141
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0350418
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0347501
HDLBP high density lipoprotein binding protein -0.0347325
VDAC1 voltage-dependent anion channel 1 -0.0344334
FAM162A family with sequence similarity 162, member A -0.0344188
ITPRID2 ITPR interacting domain containing 2 -0.0341484
PTMA prothymosin, alpha -0.0340418
RBM39 RNA binding motif protein 39 -0.0337871
ADGRG6 adhesion G protein-coupled receptor G6 -0.0334193
SLC25A37 solute carrier family 25 (mitochondrial iron transporter), member 37 -0.0333215
WSB1 WD repeat and SOCS box containing 1 -0.0327716
INTS6 integrator complex subunit 6 -0.0326602
MAP3K2 mitogen-activated protein kinase kinase kinase 2 -0.0326563
ZBTB20 zinc finger and BTB domain containing 20 -0.0325907
LCORL ligand dependent nuclear receptor corepressor-like -0.0322742
SEPTIN2 septin 2 -0.0321209
CEP95 centrosomal protein 95kDa -0.0320819
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.032025
TRMT11 tRNA methyltransferase 11 homolog (S. cerevisiae) -0.032005
FNDC3A fibronectin type III domain containing 3A -0.0319678
SEC24D SEC24 family member D -0.0319641
PNRC1 proline-rich nuclear receptor coactivator 1 -0.0319497
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -0.0314802
RPTOR regulatory associated protein of MTOR, complex 1 -0.0311417
PSMD3 proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 -0.0310864
SMYD3 SET and MYND domain containing 3 -0.0308919
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon -0.0307059
ERRFI1 ERBB receptor feedback inhibitor 1 -0.0306469
S100A6 S100 calcium binding protein A6 -0.0297647