| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in COLO 205 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_COLO 205 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| LCN2 | lipocalin 2 | 0.0599763 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0515384 |
| STS | steroid sulfatase (microsomal), isozyme S | 0.0407152 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | 0.0395718 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.0383705 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.0343544 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0340366 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0337745 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0315428 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0292491 |
| RPS6 | ribosomal protein S6 | 0.0286191 |
| PLSCR2 | phospholipid scramblase 2 | 0.0279923 |
| IFNGR1 | interferon gamma receptor 1 | 0.025718 |
| RPS12 | ribosomal protein S12 | 0.0256546 |
| PTGR1 | prostaglandin reductase 1 | 0.0241077 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0239523 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0232356 |
| FTL | ferritin, light polypeptide | 0.0221892 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0221789 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.022095 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0217155 |
| BICRAL | BICRA like chromatin remodeling complex associated protein | 0.0216292 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0211346 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0208251 |
| RPL9 | ribosomal protein L9 | 0.0205276 |
| HKDC1 | hexokinase domain containing 1 | 0.0202423 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0201289 |
| RABGAP1L | RAB GTPase activating protein 1-like | 0.0196223 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0195853 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0195188 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0194389 |
| ARGLU1 | arginine and glutamate rich 1 | 0.0191808 |
| TSHZ2 | teashirt zinc finger homeobox 2 | 0.0187975 |
| DST | dystonin | 0.0183236 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | 0.0176658 |
| RPS3 | ribosomal protein S3 | 0.0175988 |
| RPS8 | ribosomal protein S8 | 0.0175594 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0175378 |
| RPL37A | ribosomal protein L37a | 0.0171538 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0165452 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0163311 |
| WWOX | WW domain containing oxidoreductase | 0.0163038 |
| MT2A | metallothionein 2A | 0.0162294 |
| UBR2 | ubiquitin protein ligase E3 component n-recognin 2 | 0.0151898 |
| BCL2L1 | BCL2-like 1 | 0.0151676 |
| FBXL17 | F-box and leucine-rich repeat protein 17 | 0.0150176 |
| TAF15 | TAF15 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 68kDa | 0.0147764 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0146425 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | 0.0145929 |
| ZHX2 | zinc fingers and homeoboxes 2 | 0.014378 |
| MLPH | melanophilin | 0.0142569 |
| MUC13 | mucin 13, cell surface associated | 0.0142519 |
| RPL21 | ribosomal protein L21 | 0.0141784 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0141631 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0141473 |
| ZMYM2 | zinc finger, MYM-type 2 | 0.0140496 |
| DIP2B | DIP2 disco-interacting protein 2 homolog B (Drosophila) | 0.0140386 |
| BAZ1A | bromodomain adjacent to zinc finger domain, 1A | 0.0138167 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | 0.0137663 |
| RPL31 | ribosomal protein L31 | 0.01375 |
| VIM | vimentin | 0.0137498 |
| TRIP12 | thyroid hormone receptor interactor 12 | 0.0135981 |
| PDZD8 | PDZ domain containing 8 | 0.0135388 |
| NPLOC4 | nuclear protein localization 4 homolog (S. cerevisiae) | 0.0134981 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0134956 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0132524 |
| EPB41L1 | erythrocyte membrane protein band 4.1-like 1 | 0.0131412 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0130878 |
| EFNA5 | ephrin-A5 | 0.0130413 |
| ATP10B | ATPase, class V, type 10B | 0.0129688 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | 0.0128657 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0128136 |
| OARD1 | O-acyl-ADP-ribose deacylase 1 | 0.0127884 |
| CHD8 | chromodomain helicase DNA binding protein 8 | 0.012788 |
| RPS17 | ribosomal protein S17 | 0.0127857 |
| PCBP2 | poly(rC) binding protein 2 | 0.0127762 |
| TRIM14 | tripartite motif containing 14 | 0.0127683 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0125804 |
| AKR1C2 | aldo-keto reductase family 1, member C2 | 0.0124335 |
| IFITM3 | interferon induced transmembrane protein 3 | 0.012398 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0123937 |
| SET | SET nuclear proto-oncogene | 0.0123804 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.0122573 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0120195 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0119454 |
| PNN | pinin, desmosome associated protein | 0.0119206 |
| CCND3 | cyclin D3 | 0.0118384 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0118359 |
| FOXO1 | forkhead box O1 | 0.0118239 |
| RPS27 | ribosomal protein S27 | 0.0115344 |
| AKAP11 | A kinase (PRKA) anchor protein 11 | 0.0113553 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0113459 |
| TPM3 | tropomyosin 3 | 0.0113382 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | 0.0112529 |
| SIPA1L2 | signal-induced proliferation-associated 1 like 2 | 0.0112444 |
| ZNF148 | zinc finger protein 148 | 0.0111973 |
| PTK2 | protein tyrosine kinase 2 | 0.0111496 |
| HDGF | hepatoma-derived growth factor | 0.0111191 |
| TXNRD1 | thioredoxin reductase 1 | 0.0110994 |
| SMYD3 | SET and MYND domain containing 3 | 0.0110797 |
| Symbol | Name | Standardized Value |
|---|---|---|
| LMO7 | LIM domain 7 | -0.228837 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.172732 |
| EZR | ezrin | -0.155838 |
| ANXA2 | annexin A2 | -0.143893 |
| EGR1 | early growth response 1 | -0.137636 |
| SQSTM1 | sequestosome 1 | -0.126418 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.108343 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.106126 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.103107 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | -0.100361 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0953091 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.094995 |
| MYO1E | myosin IE | -0.0926553 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0914564 |
| IRF1 | interferon regulatory factor 1 | -0.0912577 |
| MACC1 | metastasis associated in colon cancer 1 | -0.091074 |
| CHST11 | carbohydrate (chondroitin 4) sulfotransferase 11 | -0.0889461 |
| NDRG1 | N-myc downstream regulated 1 | -0.0847983 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0846154 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0815279 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0805523 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0799348 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0778799 |
| H1-0 | H1.0 linker histone | -0.0763142 |
| TNFRSF10B | tumor necrosis factor receptor superfamily, member 10b | -0.075086 |
| ITGA6 | integrin, alpha 6 | -0.0721019 |
| BTBD9 | BTB (POZ) domain containing 9 | -0.0696157 |
| GMDS | GDP-mannose 4,6-dehydratase | -0.0683578 |
| HLA-B | major histocompatibility complex, class I, B | -0.0672369 |
| RUNX1 | runt-related transcription factor 1 | -0.0663908 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0659961 |
| SPATA13 | spermatogenesis associated 13 | -0.0659209 |
| RHOBTB3 | Rho-related BTB domain containing 3 | -0.0654123 |
| MORF4L2 | mortality factor 4 like 2 | -0.0652076 |
| JUN | jun proto-oncogene | -0.0648457 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0645122 |
| PLSCR1 | phospholipid scramblase 1 | -0.06329 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0610211 |
| GOLGB1 | golgin B1 | -0.060178 |
| RRBP1 | ribosome binding protein 1 | -0.0592231 |
| EFNB2 | ephrin-B2 | -0.0587983 |
| UBC | ubiquitin C | -0.0581677 |
| DNAJC15 | DnaJ (Hsp40) homolog, subfamily C, member 15 | -0.0581385 |
| CCNL1 | cyclin L1 | -0.0568422 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0562753 |
| CYP3A5 | cytochrome P450, family 3, subfamily A, polypeptide 5 | -0.0558735 |
| HDLBP | high density lipoprotein binding protein | -0.0553512 |
| RBM39 | RNA binding motif protein 39 | -0.0544856 |
| PRKCA | protein kinase C, alpha | -0.0544197 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.053716 |
| HLA-E | major histocompatibility complex, class I, E | -0.0535179 |
| ITPKC | inositol-trisphosphate 3-kinase C | -0.052607 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0524999 |
| ACTN4 | actinin, alpha 4 | -0.050919 |
| AHI1 | Abelson helper integration site 1 | -0.0504983 |
| SDC4 | syndecan 4 | -0.0504616 |
| B2M | beta-2-microglobulin | -0.0500217 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0489581 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0481576 |
| BLZF1 | basic leucine zipper nuclear factor 1 | -0.0474003 |
| PERP | PERP, TP53 apoptosis effector | -0.0472375 |
| LOC102724023 | ES1 protein homolog, mitochondrial | -0.0471413 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | -0.0460125 |
| NCKAP5 | NCK-associated protein 5 | -0.0453148 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.044621 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0444642 |
| CALU | calumenin | -0.0444024 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0437601 |
| TMPRSS4 | transmembrane protease, serine 4 | -0.0433753 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0422685 |
| ABLIM1 | actin binding LIM protein 1 | -0.0421525 |
| SDCBP2 | syndecan binding protein (syntenin) 2 | -0.0421425 |
| UGDH | UDP-glucose 6-dehydrogenase | -0.0419985 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | -0.041314 |
| SPAG9 | sperm associated antigen 9 | -0.0411274 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0410471 |
| ZKSCAN1 | zinc finger with KRAB and SCAN domains 1 | -0.040664 |
| AGR2 | anterior gradient 2 | -0.0404752 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0402264 |
| DDIT3 | DNA-damage-inducible transcript 3 | -0.0396304 |
| ADIPOR2 | adiponectin receptor 2 | -0.0396256 |
| IRS2 | insulin receptor substrate 2 | -0.039175 |
| SEC24A | SEC24 family member A | -0.0391036 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0390363 |
| DNAJC3 | DnaJ (Hsp40) homolog, subfamily C, member 3 | -0.0388659 |
| TXNIP | thioredoxin interacting protein | -0.0387996 |
| CALR | calreticulin | -0.0387555 |
| INTS6 | integrator complex subunit 6 | -0.0386689 |
| SREBF2 | sterol regulatory element binding transcription factor 2 | -0.0386673 |
| UBL3 | ubiquitin-like 3 | -0.0382845 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0381717 |
| ARHGAP26 | Rho GTPase activating protein 26 | -0.0378029 |
| HLA-C | major histocompatibility complex, class I, C | -0.0375458 |
| TMEM263 | transmembrane protein 263 | -0.0375341 |
| HM13 | histocompatibility (minor) 13 | -0.0372754 |
| TRIM2 | tripartite motif containing 2 | -0.0370405 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0366674 |
| PCK1 | phosphoenolpyruvate carboxykinase 1 (soluble) | -0.0365517 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0361654 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | -0.0361186 |
