| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in HS-578T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_HS-578T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ENO1 | enolase 1, (alpha) | 0.147243 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.133005 |
| COL6A3 | collagen, type VI, alpha 3 | 0.127052 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.122768 |
| CDH13 | cadherin 13 | 0.119503 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.111771 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.110298 |
| STC1 | stanniocalcin 1 | 0.0925424 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0853365 |
| AHNAK | AHNAK nucleoprotein | 0.0680055 |
| ATP13A3 | ATPase type 13A3 | 0.0663123 |
| VIM | vimentin | 0.0630093 |
| SPOCK1 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 1 | 0.0619338 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0613308 |
| INHBA | inhibin, beta A | 0.0607832 |
| CALR | calreticulin | 0.0600443 |
| COL5A1 | collagen, type V, alpha 1 | 0.0583408 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0566665 |
| ASPH | aspartate beta-hydroxylase | 0.0554803 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.054764 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0530863 |
| RACK1 | receptor for activated C kinase 1 | 0.0526965 |
| UBC | ubiquitin C | 0.0479929 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0469317 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0427039 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.041657 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0408657 |
| MYO10 | myosin X | 0.0407385 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0403465 |
| NAV1 | neuron navigator 1 | 0.0384843 |
| MT2A | metallothionein 2A | 0.0384246 |
| COL4A1 | collagen, type IV, alpha 1 | 0.0377117 |
| PCBP2 | poly(rC) binding protein 2 | 0.0375992 |
| TMSB4X | thymosin beta 4, X-linked | 0.037272 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0369549 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0363107 |
| RPL3 | ribosomal protein L3 | 0.0353793 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0352332 |
| RUNX1 | runt-related transcription factor 1 | 0.0349825 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0343693 |
| ARRDC3 | arrestin domain containing 3 | 0.0343492 |
| VCAN | versican | 0.0337546 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0336542 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0333358 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0333099 |
| FMNL2 | formin-like 2 | 0.0327963 |
| RPL23 | ribosomal protein L23 | 0.032093 |
| RPS3 | ribosomal protein S3 | 0.0316631 |
| FLNA | filamin A, alpha | 0.0316296 |
| B2M | beta-2-microglobulin | 0.0312409 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0311029 |
| TLN1 | talin 1 | 0.0305858 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0305175 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0299214 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.029689 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.0291041 |
| COL3A1 | collagen, type III, alpha 1 | 0.0288149 |
| JUN | jun proto-oncogene | 0.0286547 |
| DOCK5 | dedicator of cytokinesis 5 | 0.0285629 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0281966 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0281483 |
| IL6 | interleukin 6 | 0.0280936 |
| RPS27A | ribosomal protein S27a | 0.027957 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.027906 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.0278856 |
| DPYSL2 | dihydropyrimidinase-like 2 | 0.0277322 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0276845 |
| RPS12 | ribosomal protein S12 | 0.027427 |
| CADM1 | cell adhesion molecule 1 | 0.0273124 |
| SET | SET nuclear proto-oncogene | 0.0270189 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0267572 |
| EFNA5 | ephrin-A5 | 0.0266166 |
| IQGAP1 | IQ motif containing GTPase activating protein 1 | 0.0265598 |
| APP | amyloid beta (A4) precursor protein | 0.0261105 |
| ATP2B4 | ATPase, Ca++ transporting, plasma membrane 4 | 0.0253678 |
| LIMS1 | LIM and senescent cell antigen-like domains 1 | 0.0253487 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0253084 |
| FAT1 | FAT atypical cadherin 1 | 0.0248394 |
| TPI1 | triosephosphate isomerase 1 | 0.0247176 |
| FLNB | filamin B, beta | 0.0244429 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0240224 |
| RPL7 | ribosomal protein L7 | 0.0234965 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0233977 |
| SON | SON DNA binding protein | 0.0228068 |
| DIP2C | DIP2 disco-interacting protein 2 homolog C (Drosophila) | 0.022243 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0222389 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.021961 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0219537 |
| JARID2 | jumonji, AT rich interactive domain 2 | 0.0214976 |
| GNAI3 | guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 | 0.0213919 |
| RPL4 | ribosomal protein L4 | 0.0211048 |
| PDIA4 | protein disulfide isomerase family A, member 4 | 0.0210745 |
| TPM3 | tropomyosin 3 | 0.0210134 |
| HNRNPM | heterogeneous nuclear ribonucleoprotein M | 0.0206592 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0203644 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0201613 |
| AXL | AXL receptor tyrosine kinase | 0.0199 |
| SLC5A3 | solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 | 0.0198199 |
| NCOR2 | nuclear receptor corepressor 2 | 0.0192804 |
| CA12 | carbonic anhydrase XII | 0.0192675 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.442325 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.211669 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.202888 |
| NDRG1 | N-myc downstream regulated 1 | -0.12623 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | -0.121783 |
| RPL35A | ribosomal protein L35a | -0.0699851 |
| IER3 | immediate early response 3 | -0.0692138 |
| SLC39A14 | solute carrier family 39 (zinc transporter), member 14 | -0.0655852 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.064061 |
| FTL | ferritin, light polypeptide | -0.0630971 |
| HLA-B | major histocompatibility complex, class I, B | -0.0540197 |
| PALLD | palladin, cytoskeletal associated protein | -0.05385 |
| HMGA2 | high mobility group AT-hook 2 | -0.0492924 |
| ACTG1 | actin gamma 1 | -0.0482393 |
| SPAG9 | sperm associated antigen 9 | -0.0467024 |
| CYB5R3 | cytochrome b5 reductase 3 | -0.0458755 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.043651 |
| LOX | lysyl oxidase | -0.0421554 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0406154 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0396708 |
| CD44 | CD44 molecule (Indian blood group) | -0.0387779 |
| NKAIN3 | Na+/K+ transporting ATPase interacting 3 | -0.0373259 |
| PDLIM5 | PDZ and LIM domain 5 | -0.0357307 |
| MAP1B | microtubule-associated protein 1B | -0.0352357 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | -0.034108 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0333297 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0333084 |
| COL1A1 | collagen, type I, alpha 1 | -0.0332476 |
| DPYSL3 | dihydropyrimidinase-like 3 | -0.0330716 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0330288 |
| VCL | vinculin | -0.031069 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0299088 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0294881 |
| OSMR | oncostatin M receptor | -0.0287803 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.028162 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0278145 |
| WWTR1 | WW domain containing transcription regulator 1 | -0.0276187 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0269501 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0265113 |
| HP1BP3 | heterochromatin protein 1, binding protein 3 | -0.0263338 |
| ADM | adrenomedullin | -0.0262363 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0262026 |
| NABP1 | nucleic acid binding protein 1 | -0.0261319 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | -0.0259406 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0255208 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0255153 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.0254177 |
| NREP | neuronal regeneration related protein | -0.0253639 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0252654 |
| TAPBP | TAP binding protein (tapasin) | -0.0248007 |
| GNG12 | guanine nucleotide binding protein (G protein), gamma 12 | -0.0247757 |
| EGR1 | early growth response 1 | -0.024734 |
| PXDN | peroxidasin | -0.0246539 |
| LOXL2 | lysyl oxidase-like 2 | -0.0245576 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0240808 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0236349 |
| RPL28 | ribosomal protein L28 | -0.0234383 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0234159 |
| JMJD1C | jumonji domain containing 1C | -0.0233352 |
| NKTR | natural killer cell triggering receptor | -0.022869 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0227909 |
| RPS11 | ribosomal protein S11 | -0.0225737 |
| RBM39 | RNA binding motif protein 39 | -0.0224723 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0223838 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0223136 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | -0.0221807 |
| GOLGA4 | golgin A4 | -0.0218381 |
| VDAC1 | voltage-dependent anion channel 1 | -0.021774 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0217737 |
| ARF4 | ADP-ribosylation factor 4 | -0.0216613 |
| JAK2 | Janus kinase 2 | -0.0216527 |
| WASF2 | WAS protein family, member 2 | -0.0215966 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.021539 |
| TPM4 | tropomyosin 4 | -0.0214689 |
| NF1 | neurofibromin 1 | -0.0213999 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.021297 |
| SBF2 | SET binding factor 2 | -0.0211439 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0210813 |
| RPS24 | ribosomal protein S24 | -0.0209549 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0208627 |
| PPIB | peptidylprolyl isomerase B (cyclophilin B) | -0.020811 |
| RAB6A | RAB6A, member RAS oncogene family | -0.0208021 |
| FAF1 | Fas (TNFRSF6) associated factor 1 | -0.0206831 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.02036 |
| COL1A2 | collagen, type I, alpha 2 | -0.0203588 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0202855 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -0.0200576 |
| TBC1D23 | TBC1 domain family, member 23 | -0.0199349 |
| RPLP1 | ribosomal protein, large, P1 | -0.0198565 |
| RPS6 | ribosomal protein S6 | -0.019697 |
| ZNF644 | zinc finger protein 644 | -0.0196813 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0195465 |
| PIEZO2 | piezo-type mechanosensitive ion channel component 2 | -0.0194143 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0192147 |
| RPS13 | ribosomal protein S13 | -0.0190947 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | -0.0189792 |
| KCTD9 | potassium channel tetramerization domain containing 9 | -0.0189789 |
| PRRC1 | proline-rich coiled-coil 1 | -0.018944 |
| VMP1 | vacuole membrane protein 1 | -0.0189403 |
| ARFGAP3 | ADP-ribosylation factor GTPase activating protein 3 | -0.0188687 |
