| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in HepG2/C3A cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Afatinib_HepG2/C3A drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.147712 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.12378 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0801429 |
| SVIL | supervillin | 0.0649469 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0589022 |
| ASPH | aspartate beta-hydroxylase | 0.0534184 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0455134 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0385524 |
| FAM107B | family with sequence similarity 107, member B | 0.0360191 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0355962 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0308713 |
| PLCB1 | phospholipase C, beta 1 (phosphoinositide-specific) | 0.0282078 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0267838 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0221323 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0205787 |
| ERN1 | endoplasmic reticulum to nucleus signaling 1 | 0.0197576 |
| IGFBP1 | insulin-like growth factor binding protein 1 | 0.0195406 |
| NDRG1 | N-myc downstream regulated 1 | 0.0195296 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | 0.0192896 |
| PALLD | palladin, cytoskeletal associated protein | 0.0186734 |
| EGFR | epidermal growth factor receptor | 0.018526 |
| TNS1 | tensin 1 | 0.0183151 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0170721 |
| INTS6 | integrator complex subunit 6 | 0.0168189 |
| TNFRSF21 | tumor necrosis factor receptor superfamily, member 21 | 0.0165868 |
| JAG1 | jagged 1 | 0.0164181 |
| RPS2 | ribosomal protein S2 | 0.0163931 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.016102 |
| GOLGB1 | golgin B1 | 0.0160516 |
| FRMD5 | FERM domain containing 5 | 0.0158932 |
| FAT1 | FAT atypical cadherin 1 | 0.0157942 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | 0.0157689 |
| KYNU | kynureninase | 0.0157221 |
| PTPRN2 | protein tyrosine phosphatase, receptor type, N polypeptide 2 | 0.0156372 |
| CTNNAL1 | catenin (cadherin-associated protein), alpha-like 1 | 0.015289 |
| FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 0.0146643 |
| TPM3 | tropomyosin 3 | 0.0146241 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | 0.0144546 |
| FOXP1 | forkhead box P1 | 0.0144092 |
| PPARD | peroxisome proliferator-activated receptor delta | 0.0143209 |
| ARHGAP9 | Rho GTPase activating protein 9 | 0.0142468 |
| RASA2 | RAS p21 protein activator 2 | 0.0141593 |
| GRB10 | growth factor receptor-bound protein 10 | 0.014156 |
| CSGALNACT2 | chondroitin sulfate N-acetylgalactosaminyltransferase 2 | 0.0133902 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0132433 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0131875 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.012941 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0128815 |
| FAM13A | family with sequence similarity 13, member A | 0.0126409 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0126086 |
| STK17A | serine/threonine kinase 17a | 0.0124293 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0121549 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0121337 |
| MYADM | myeloid-associated differentiation marker | 0.0120686 |
| USP53 | ubiquitin specific peptidase 53 | 0.0117632 |
| RPL21 | ribosomal protein L21 | 0.011625 |
| AHR | aryl hydrocarbon receptor | 0.0115113 |
| SPSB1 | splA/ryanodine receptor domain and SOCS box containing 1 | 0.0114771 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0111783 |
| MBNL1 | muscleblind-like splicing regulator 1 | 0.0109414 |
| PGM3 | phosphoglucomutase 3 | 0.0109288 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0109117 |
| LMO7 | LIM domain 7 | 0.0108857 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0108556 |
| ITGA6 | integrin, alpha 6 | 0.0108208 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.0105224 |
| EFL1 | elongation factor like GTPase 1 | 0.0105172 |
| KALRN | kalirin, RhoGEF kinase | 0.0103988 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0103752 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0103726 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | 0.0101998 |
| TLN1 | talin 1 | 0.0100823 |
| BRD2 | bromodomain containing 2 | 0.0100475 |
| CAPRIN2 | caprin family member 2 | 0.0100456 |
| FHL2 | four and a half LIM domains 2 | 0.0100303 |
| RPS7 | ribosomal protein S7 | 0.00986694 |
| SYNE1 | spectrin repeat containing, nuclear envelope 1 | 0.00984409 |
| ATXN1 | ataxin 1 | 0.00980925 |
| SEMA4A | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A | 0.00965732 |
| MTSS1 | metastasis suppressor 1 | 0.00962504 |
| ASAP1 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 | 0.00939533 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.00936582 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | 0.00936172 |
| EXT1 | exostosin glycosyltransferase 1 | 0.00927216 |
| SORBS1 | sorbin and SH3 domain containing 1 | 0.00925952 |
| TFF1 | trefoil factor 1 | 0.00923594 |
| EFNA5 | ephrin-A5 | 0.00919621 |
| DCBLD1 | discoidin, CUB and LCCL domain containing 1 | 0.00917699 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.00899993 |
| MYOF | myoferlin | 0.00896085 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | 0.00895384 |
| F2RL1 | coagulation factor II (thrombin) receptor-like 1 | 0.00889222 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | 0.00887271 |
| EZR | ezrin | 0.00879163 |
| ERI2 | ERI1 exoribonuclease family member 2 | 0.00876683 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.00869561 |
| EMP1 | epithelial membrane protein 1 | 0.00862185 |
| GOSR2 | golgi SNAP receptor complex member 2 | 0.00852474 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.00849867 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.00849346 |
| Symbol | Name | Standardized Value |
|---|---|---|
| APOB | apolipoprotein B | -0.262922 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.247723 |
| C3 | complement component 3 | -0.218621 |
| IGF2 | insulin-like growth factor 2 | -0.179182 |
| SERPINA1 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 | -0.173951 |
| FN1 | fibronectin 1 | -0.172563 |
| LRMDA | leucine rich melanocyte differentiation associated | -0.147603 |
| GPC3 | glypican 3 | -0.134598 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0948603 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0913017 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | -0.0884963 |
| FBF1 | Fas (TNFRSF6) binding factor 1 | -0.0843034 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0805423 |
| APOA2 | apolipoprotein A-II | -0.0794639 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0726072 |
| TF | transferrin | -0.0703887 |
| RBM39 | RNA binding motif protein 39 | -0.0688969 |
| FTL | ferritin, light polypeptide | -0.0655619 |
| CP | ceruloplasmin (ferroxidase) | -0.0645068 |
| PEG3 | paternally expressed 3 | -0.0634386 |
| AHSG | alpha-2-HS-glycoprotein | -0.0618284 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0588063 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0584268 |
| RPL11 | ribosomal protein L11 | -0.0565613 |
| TMEM123 | transmembrane protein 123 | -0.0557377 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0552539 |
| ENO1 | enolase 1, (alpha) | -0.0546378 |
| ITPR2 | inositol 1,4,5-trisphosphate receptor, type 2 | -0.0529314 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | -0.0525328 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0506348 |
| A2M | alpha-2-macroglobulin | -0.0504541 |
| JMJD1C | jumonji domain containing 1C | -0.0499347 |
| APOE | apolipoprotein E | -0.0483055 |
| SDC4 | syndecan 4 | -0.0461771 |
| TRIM26 | tripartite motif containing 26 | -0.0459186 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0453501 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | -0.0441488 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0440029 |
| LYZ | lysozyme | -0.0437119 |
| GNAS | GNAS complex locus | -0.0426997 |
| PTCHD4 | patched domain containing 4 | -0.0425212 |
| PTPRK | protein tyrosine phosphatase, receptor type, K | -0.0420569 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0412722 |
| MSI2 | musashi RNA-binding protein 2 | -0.041224 |
| IGF1R | insulin-like growth factor 1 receptor | -0.0410954 |
| RNF213 | ring finger protein 213 | -0.0407812 |
| RPS24 | ribosomal protein S24 | -0.0393529 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0392911 |
| RPLP1 | ribosomal protein, large, P1 | -0.0387846 |
| CPE | carboxypeptidase E | -0.0383858 |
| ZNF644 | zinc finger protein 644 | -0.0382825 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0377959 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0374536 |
| NKD1 | naked cuticle homolog 1 (Drosophila) | -0.0369764 |
| MT2A | metallothionein 2A | -0.0366049 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0363752 |
| RRBP1 | ribosome binding protein 1 | -0.035754 |
| GPC6 | glypican 6 | -0.0356133 |
| MAN1A1 | mannosidase, alpha, class 1A, member 1 | -0.0355801 |
| SELENOP | selenoprotein P | -0.0353178 |
| UBE2D2 | ubiquitin-conjugating enzyme E2D 2 | -0.0349862 |
| ITIH2 | inter-alpha-trypsin inhibitor heavy chain 2 | -0.0346977 |
| RBM25 | RNA binding motif protein 25 | -0.0342954 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0342868 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0341415 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0336606 |
| AMBP | alpha-1-microglobulin/bikunin precursor | -0.0324082 |
| AFDN | afadin, adherens junction formation factor | -0.0323279 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0319235 |
| RPLP0 | ribosomal protein, large, P0 | -0.0319145 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0318766 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0313606 |
| SNTB1 | syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1) | -0.0313494 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | -0.0312653 |
| PTK2 | protein tyrosine kinase 2 | -0.0311133 |
| SOX5 | SRY (sex determining region Y)-box 5 | -0.0309502 |
| EIF3A | eukaryotic translation initiation factor 3, subunit A | -0.030903 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0307934 |
| TMSB10 | thymosin beta 10 | -0.0305984 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0305633 |
| EHBP1 | EH domain binding protein 1 | -0.0302743 |
| VCL | vinculin | -0.0302325 |
| RPL35A | ribosomal protein L35a | -0.0298409 |
| MATR3 | matrin 3 | -0.0298307 |
| GPAM | glycerol-3-phosphate acyltransferase, mitochondrial | -0.0294561 |
| DNAH17 | dynein, axonemal, heavy chain 17 | -0.0292971 |
| APOA1 | apolipoprotein A-I | -0.0292098 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | -0.0289864 |
| RPS19 | ribosomal protein S19 | -0.0289835 |
| RPS6 | ribosomal protein S6 | -0.028869 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | -0.0287956 |
| FARP1 | FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) | -0.0287705 |
| PEG10 | paternally expressed 10 | -0.0284684 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0284614 |
| QKI | QKI, KH domain containing, RNA binding | -0.0283069 |
| PTTG1IP | pituitary tumor-transforming 1 interacting protein | -0.0278491 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0276338 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0275196 |
| ARFGEF2 | ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited) | -0.0274134 |
| CDKAL1 | CDK5 regulatory subunit associated protein 1-like 1 | -0.0271609 |
