| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in Hs 766T cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_Hs 766T drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.0961991 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | 0.0774675 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0418359 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0411333 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0377961 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0372045 |
| IFI44L | interferon-induced protein 44-like | 0.0362626 |
| B2M | beta-2-microglobulin | 0.031204 |
| FTL | ferritin, light polypeptide | 0.029476 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0284882 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.027582 |
| KLF5 | Kruppel-like factor 5 (intestinal) | 0.0255903 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0251011 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0248147 |
| MXRA5 | matrix-remodelling associated 5 | 0.0244194 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0243969 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0238721 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0219957 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0207943 |
| RFX2 | regulatory factor X, 2 (influences HLA class II expression) | 0.0205546 |
| ABI3BP | ABI family, member 3 (NESH) binding protein | 0.0191523 |
| GBP2 | guanylate binding protein 2, interferon-inducible | 0.0189125 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0184865 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0183607 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0181407 |
| RPL3 | ribosomal protein L3 | 0.0180277 |
| ITGB8 | integrin, beta 8 | 0.0177368 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0177223 |
| RPL4 | ribosomal protein L4 | 0.0175141 |
| RPS2 | ribosomal protein S2 | 0.016837 |
| RPS12 | ribosomal protein S12 | 0.0168205 |
| GMDS | GDP-mannose 4,6-dehydratase | 0.0166693 |
| EXT1 | exostosin glycosyltransferase 1 | 0.0165196 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0164906 |
| RNF213 | ring finger protein 213 | 0.0164024 |
| SQSTM1 | sequestosome 1 | 0.0159475 |
| RACK1 | receptor for activated C kinase 1 | 0.0159149 |
| KYNU | kynureninase | 0.0157271 |
| TAPBP | TAP binding protein (tapasin) | 0.0157162 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.0155964 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0155399 |
| SEMA5A | sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A | 0.0150237 |
| SP100 | SP100 nuclear antigen | 0.0149949 |
| KCTD12 | potassium channel tetramerization domain containing 12 | 0.0149365 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0148843 |
| PELI2 | pellino E3 ubiquitin protein ligase family member 2 | 0.0145785 |
| EEPD1 | endonuclease/exonuclease/phosphatase family domain containing 1 | 0.0141768 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0141528 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0141419 |
| AHNAK2 | AHNAK nucleoprotein 2 | 0.0141193 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | 0.0141026 |
| HSPH1 | heat shock 105kDa/110kDa protein 1 | 0.0139603 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0138697 |
| IFITM1 | interferon induced transmembrane protein 1 | 0.0137638 |
| ENO2 | enolase 2 (gamma, neuronal) | 0.0134154 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0133642 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0131749 |
| OAS2 | 2'-5'-oligoadenylate synthetase 2, 69/71kDa | 0.0130158 |
| DSPP | dentin sialophosphoprotein | 0.0128914 |
| SYN3 | synapsin III | 0.0126708 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0125743 |
| MT1E | metallothionein 1E | 0.0124566 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0124378 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0123671 |
| RPL21 | ribosomal protein L21 | 0.0123424 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0123386 |
| PTGIS | prostaglandin I2 (prostacyclin) synthase | 0.0122006 |
| WWOX | WW domain containing oxidoreductase | 0.0121887 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0114593 |
| TMOD3 | tropomodulin 3 (ubiquitous) | 0.0113456 |
| VIM | vimentin | 0.011315 |
| TPI1 | triosephosphate isomerase 1 | 0.0112238 |
| DNAJA1 | DnaJ (Hsp40) homolog, subfamily A, member 1 | 0.0111807 |
| GUCY1A1 | guanylate cyclase 1 soluble subunit alpha 1 | 0.0111415 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.0110137 |
| MX1 | MX dynamin-like GTPase 1 | 0.0109459 |
| SIK3 | SIK family kinase 3 | 0.0108139 |
| GBP4 | guanylate binding protein 4 | 0.0107856 |
| LMO4 | LIM domain only 4 | 0.0105919 |
| SLC12A2 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 | 0.0103576 |
| PCBP2 | poly(rC) binding protein 2 | 0.0103568 |
| SESTD1 | SEC14 and spectrin domains 1 | 0.0102915 |
| MX2 | MX dynamin-like GTPase 2 | 0.0101023 |
| SPOCK3 | sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 3 | 0.00992396 |
| RPS17 | ribosomal protein S17 | 0.00991958 |
| PCDH9 | protocadherin 9 | 0.00983275 |
| CFB | complement factor B | 0.00979785 |
| RPS3 | ribosomal protein S3 | 0.0097627 |
| NUPR1 | nuclear protein, transcriptional regulator, 1 | 0.00966394 |
| PMAIP1 | phorbol-12-myristate-13-acetate-induced protein 1 | 0.00962091 |
| EGFR | epidermal growth factor receptor | 0.00948892 |
| YBX1 | Y box binding protein 1 | 0.00948738 |
| EPSTI1 | epithelial stromal interaction 1 (breast) | 0.00933139 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.00929269 |
| IFI27 | interferon, alpha-inducible protein 27 | 0.00928859 |
| SLC6A8 | solute carrier family 6 (neurotransmitter transporter), member 8 | 0.00926008 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.00925573 |
| MEGF6 | multiple EGF-like-domains 6 | 0.00919297 |
| DTX3L | deltex 3 like, E3 ubiquitin ligase | 0.00919092 |
| FHIT | fragile histidine triad | 0.00916111 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FLNB | filamin B, beta | -0.294106 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.211788 |
| NDRG1 | N-myc downstream regulated 1 | -0.196205 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.114686 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.100929 |
| MYOF | myoferlin | -0.100272 |
| ITGA6 | integrin, alpha 6 | -0.0956154 |
| MTSS1 | metastasis suppressor 1 | -0.0882228 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.0874363 |
| FOXO1 | forkhead box O1 | -0.0869679 |
| BCL2L1 | BCL2-like 1 | -0.0831431 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0818217 |
| EMP1 | epithelial membrane protein 1 | -0.0803188 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.07821 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0771614 |
| RBM39 | RNA binding motif protein 39 | -0.0750806 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.0737382 |
| CUL4B | cullin 4B | -0.0688415 |
| ADAMTS16 | ADAM metallopeptidase with thrombospondin type 1 motif, 16 | -0.0684315 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0664442 |
| OSMR | oncostatin M receptor | -0.0662947 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0648178 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0647634 |
| TMSB4X | thymosin beta 4, X-linked | -0.0646503 |
| CD44 | CD44 molecule (Indian blood group) | -0.064256 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0626773 |
| MEF2A | myocyte enhancer factor 2A | -0.0608707 |
| TMSB10 | thymosin beta 10 | -0.0603753 |
| ANXA2 | annexin A2 | -0.0599968 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0592703 |
| RPS21 | ribosomal protein S21 | -0.0587958 |
| RIN2 | Ras and Rab interactor 2 | -0.0583929 |
| HSD17B2 | hydroxysteroid (17-beta) dehydrogenase 2 | -0.0528526 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0526231 |
| HM13 | histocompatibility (minor) 13 | -0.0505073 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0504266 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0479599 |
| OGA | O-GlcNAcase | -0.0479406 |
| SULF1 | sulfatase 1 | -0.0478206 |
| S100A10 | S100 calcium binding protein A10 | -0.0477215 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0475175 |
| ANKRD33B | ankyrin repeat domain 33B | -0.046689 |
| LMNA | lamin A/C | -0.0463541 |
| PTK2 | protein tyrosine kinase 2 | -0.0461569 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.045258 |
| HIVEP3 | human immunodeficiency virus type I enhancer binding protein 3 | -0.0451719 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.0450597 |
| BLCAP | bladder cancer associated protein | -0.0437572 |
| MSN | moesin | -0.043605 |
| CALU | calumenin | -0.0434656 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | -0.0434082 |
| NEK7 | NIMA-related kinase 7 | -0.0432672 |
| EFHD2 | EF-hand domain family, member D2 | -0.0431785 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0424117 |
| ST3GAL6 | ST3 beta-galactoside alpha-2,3-sialyltransferase 6 | -0.0421958 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | -0.0421285 |
| PGK1 | phosphoglycerate kinase 1 | -0.0419978 |
| ACTN4 | actinin, alpha 4 | -0.0414568 |
| MYO10 | myosin X | -0.0413528 |
| NRG1 | neuregulin 1 | -0.0412116 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0405222 |
| CAPRIN2 | caprin family member 2 | -0.040424 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | -0.0396181 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0396176 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0392361 |
| STC1 | stanniocalcin 1 | -0.0386954 |
| PLAT | plasminogen activator, tissue | -0.0385581 |
| SBF2 | SET binding factor 2 | -0.0384527 |
| PRELID2 | PRELI domain containing 2 | -0.0381668 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0379234 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0378816 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0378803 |
| IL1RAPL1 | interleukin 1 receptor accessory protein-like 1 | -0.0378103 |
| ASAP2 | ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 | -0.0377641 |
| ASPH | aspartate beta-hydroxylase | -0.0376801 |
| CMIP | c-Maf inducing protein | -0.0374696 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0368245 |
| AHNAK | AHNAK nucleoprotein | -0.0366746 |
| SMAD3 | SMAD family member 3 | -0.036658 |
| CDK6 | cyclin-dependent kinase 6 | -0.0364046 |
| EPHA2 | EPH receptor A2 | -0.0357371 |
| PALLD | palladin, cytoskeletal associated protein | -0.0356327 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0356135 |
| IGF2 | insulin-like growth factor 2 | -0.0355984 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0354644 |
| ARHGEF10 | Rho guanine nucleotide exchange factor (GEF) 10 | -0.0352305 |
| ID1 | inhibitor of DNA binding 1, dominant negative helix-loop-helix protein | -0.0351712 |
| ARHGAP29 | Rho GTPase activating protein 29 | -0.0349827 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0349102 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | -0.0349073 |
| PLEC | plectin | -0.0345687 |
| KIAA1217 | KIAA1217 | -0.0345577 |
| ITGBL1 | integrin, beta-like 1 (with EGF-like repeat domains) | -0.0341676 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0341147 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0340358 |
| NF1 | neurofibromin 1 | -0.0339901 |
| SMYD3 | SET and MYND domain containing 3 | -0.0338675 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0338451 |
| FOXP1 | forkhead box P1 | -0.0336397 |
| LDLR | low density lipoprotein receptor | -0.0335839 |
