Afatinib_LS 180 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Afatinib perturbation in LS 180 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Afatinib_LS 180 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
RPS12 ribosomal protein S12 0.0773286
RPL37A ribosomal protein L37a 0.0605863
RPS3 ribosomal protein S3 0.0584189
EREG epiregulin 0.0552566
PNISR PNN-interacting serine/arginine-rich protein 0.0491723
SRRM2 serine/arginine repetitive matrix 2 0.041576
RPL9 ribosomal protein L9 0.0371882
RPL36 ribosomal protein L36 0.0349078
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0343389
DDIT4 DNA-damage-inducible transcript 4 0.0301742
TNS4 tensin 4 0.0293247
RPL37 ribosomal protein L37 0.0282896
RPL17-C18ORF32 RPL17-C18orf32 readthrough 0.027362
SET SET nuclear proto-oncogene 0.0254501
ESRP1 epithelial splicing regulatory protein 1 0.0247032
SLC25A3 solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 0.0245883
RPS6 ribosomal protein S6 0.0244834
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) 0.0235886
RPL11 ribosomal protein L11 0.0226125
RPL26 ribosomal protein L26 0.0225775
RPL18 ribosomal protein L18 0.0217717
FLNB filamin B, beta 0.0216489
RPL30 ribosomal protein L30 0.02153
TAF1D TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa 0.0214635
GPRC5A G protein-coupled receptor, class C, group 5, member A 0.0210166
YTHDC1 YTH domain containing 1 0.0204111
RPL13A ribosomal protein L13a 0.0203746
FAM13A family with sequence similarity 13, member A 0.019769
KLF3 Kruppel-like factor 3 (basic) 0.0197386
MKNK2 MAP kinase interacting serine/threonine kinase 2 0.0196385
UQCRB ubiquinol-cytochrome c reductase binding protein 0.0186124
AREG amphiregulin 0.0185693
RBM25 RNA binding motif protein 25 0.0179934
CD46 CD46 molecule, complement regulatory protein 0.0178281
S100P S100 calcium binding protein P 0.0177759
VDR vitamin D (1,25- dihydroxyvitamin D3) receptor 0.0175827
RPS29 ribosomal protein S29 0.0174973
PTMA prothymosin, alpha 0.0171531
CCNL1 cyclin L1 0.0169669
RPS27A ribosomal protein S27a 0.0168614
ANP32B acidic (leucine-rich) nuclear phosphoprotein 32 family, member B 0.0160713
COX6C cytochrome c oxidase subunit VIc 0.0158573
RPL7 ribosomal protein L7 0.0155284
THOC2 THO complex 2 0.015333
RPS27 ribosomal protein S27 0.0151961
PABPN1 poly(A) binding protein, nuclear 1 0.0151815
RPS17 ribosomal protein S17 0.0150702
INSIG2 insulin induced gene 2 0.014822
TMEM45B transmembrane protein 45B 0.0147882
RPL21 ribosomal protein L21 0.0145507
VIM vimentin 0.0131751
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 0.0128786
SRSF11 serine/arginine-rich splicing factor 11 0.0125301
KIF16B kinesin family member 16B 0.012384
RPS7 ribosomal protein S7 0.0121861
TIAL1 TIA1 cytotoxic granule-associated RNA binding protein-like 1 0.0120489
ATF4 activating transcription factor 4 0.0120281
PRRC2C proline-rich coiled-coil 2C 0.0119989
ARGLU1 arginine and glutamate rich 1 0.01186
TFF3 trefoil factor 3 (intestinal) 0.0118575
ZBTB7A zinc finger and BTB domain containing 7A 0.0118324
NACA nascent polypeptide-associated complex alpha subunit 0.0118211
ZBTB20 zinc finger and BTB domain containing 20 0.0118147
EIF2S2 eukaryotic translation initiation factor 2, subunit 2 beta, 38kDa 0.0117945
ANKRD36 ankyrin repeat domain 36 0.0117586
WDR11 WD repeat domain 11 0.0117544
RPL36AL ribosomal protein L36a-like 0.0116659
RNF145 ring finger protein 145 0.0116362
RPL23 ribosomal protein L23 0.0116087
RPS19 ribosomal protein S19 0.0115804
PNN pinin, desmosome associated protein 0.0115752
RBM26 RNA binding motif protein 26 0.0115638
SERINC1 serine incorporator 1 0.0113649
RPLP2 ribosomal protein, large, P2 0.0112983
ADD3 adducin 3 (gamma) 0.0112184
CNOT8 CCR4-NOT transcription complex, subunit 8 0.0112122
NAP1L1 nucleosome assembly protein 1-like 1 0.0111546
EIF5B eukaryotic translation initiation factor 5B 0.0111057
N4BP2L2 NEDD4 binding protein 2-like 2 0.0107864
CDK19 cyclin-dependent kinase 19 0.0107183
COX5A cytochrome c oxidase subunit Va 0.0106436
IP6K2 inositol hexakisphosphate kinase 2 0.0105548
ST3GAL4 ST3 beta-galactoside alpha-2,3-sialyltransferase 4 0.0105498
MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase 0.0105092
NDUFB4 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa 0.0105039
EPCAM epithelial cell adhesion molecule 0.0105014
TPR translocated promoter region, nuclear basket protein 0.0103749
SESN1 sestrin 1 0.0102743
RABL6 RAB, member RAS oncogene family-like 6 0.0102568
TMEM165 transmembrane protein 165 0.0101178
PCCA propionyl CoA carboxylase, alpha polypeptide 0.010098
PCBP2 poly(rC) binding protein 2 0.0100971
RPL31 ribosomal protein L31 0.010088
CELF1 CUGBP, Elav-like family member 1 0.0100607
ADAM9 ADAM metallopeptidase domain 9 0.0100536
GPX4 glutathione peroxidase 4 0.0100505
TPI1 triosephosphate isomerase 1 0.0100166
CCNC cyclin C 0.0099943
NFE2L1 nuclear factor, erythroid 2-like 1 0.00990658
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 0.00984281

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.423344
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.359403
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.225537
SLC12A2 solute carrier family 12 (sodium/potassium/chloride transporter), member 2 -0.111496
GMDS GDP-mannose 4,6-dehydratase -0.109385
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) -0.107586
FAT1 FAT atypical cadherin 1 -0.0967163
LMO7 LIM domain 7 -0.0895189
SPTBN1 spectrin, beta, non-erythrocytic 1 -0.0744966
ASPH aspartate beta-hydroxylase -0.0733932
LOC112694756 uncharaterized LOC112694756 -0.0699941
CEMIP cell migration inducing protein, hyaluronan binding -0.0685849
MYO1E myosin IE -0.0681405
GPHN gephyrin -0.0674188
NPSR1 neuropeptide S receptor 1 -0.0672415
KRT18 keratin 18, type I -0.0661885
SLC7A11 solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 -0.0631321
EZR ezrin -0.060521
TPT1 tumor protein, translationally-controlled 1 -0.0598469
H1-0 H1.0 linker histone -0.0578705
AHNAK AHNAK nucleoprotein -0.0576586
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0567157
ACTG1 actin gamma 1 -0.0558278
GREB1L growth regulation by estrogen in breast cancer-like -0.053638
CALR calreticulin -0.0523815
LDHA lactate dehydrogenase A -0.0507486
GRIN2B glutamate receptor, ionotropic, N-methyl D-aspartate 2B -0.0502106
EXT1 exostosin glycosyltransferase 1 -0.0501359
KRT8 keratin 8, type II -0.0491567
UBC ubiquitin C -0.0466102
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0465742
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide -0.0449715
TNFRSF10B tumor necrosis factor receptor superfamily, member 10b -0.0447513
S100A10 S100 calcium binding protein A10 -0.0447145
ENO1 enolase 1, (alpha) -0.0446603
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -0.044297
AGR2 anterior gradient 2 -0.0441976
PDIA3 protein disulfide isomerase family A, member 3 -0.0438705
MED13 mediator complex subunit 13 -0.0438116
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0435064
RPLP0 ribosomal protein, large, P0 -0.0433676
PDIA4 protein disulfide isomerase family A, member 4 -0.0432155
HDLBP high density lipoprotein binding protein -0.0427946
ITGA6 integrin, alpha 6 -0.0424147
TPM4 tropomyosin 4 -0.042071
BCAT1 branched chain amino-acid transaminase 1, cytosolic -0.0416766
PSD3 pleckstrin and Sec7 domain containing 3 -0.040957
PIGR polymeric immunoglobulin receptor -0.0409086
ANXA1 annexin A1 -0.0408414
PTPRK protein tyrosine phosphatase, receptor type, K -0.0407057
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 -0.0406314
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.0399873
POTEF POTE ankyrin domain family, member F -0.0398506
ABLIM1 actin binding LIM protein 1 -0.039145
FTH1 ferritin, heavy polypeptide 1 -0.0384182
EPS8 epidermal growth factor receptor pathway substrate 8 -0.0378273
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta -0.0378269
NDRG1 N-myc downstream regulated 1 -0.0365608
CANX calnexin -0.0357163
LRRFIP1 leucine rich repeat (in FLII) interacting protein 1 -0.0347843
RPL8 ribosomal protein L8 -0.0346136
PPP3CA protein phosphatase 3, catalytic subunit, alpha isozyme -0.0342819
FOS FBJ murine osteosarcoma viral oncogene homolog -0.0334231
ANXA2 annexin A2 -0.033291
RHPN2 rhophilin, Rho GTPase binding protein 2 -0.0332822
GAREM1 GRB2 associated regulator of MAPK1 subtype 1 -0.0332716
YBX1 Y box binding protein 1 -0.0331191
SAMD5 sterile alpha motif domain containing 5 -0.0330623
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 -0.0329003
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 -0.032652
ITPRID2 ITPR interacting domain containing 2 -0.0320621
MYO5B myosin VB -0.03155
FOXO1 forkhead box O1 -0.0313156
ANTXR2 anthrax toxin receptor 2 -0.0312031
EHBP1 EH domain binding protein 1 -0.0310935
DSG2 desmoglein 2 -0.0310466
ANKRD17 ankyrin repeat domain 17 -0.0307238
GLG1 golgi glycoprotein 1 -0.0303823
BAIAP2L1 BAI1-associated protein 2-like 1 -0.0301762
MUC17 mucin 17, cell surface associated -0.0301473
PPDPF pancreatic progenitor cell differentiation and proliferation factor -0.02993
TRIM2 tripartite motif containing 2 -0.0296937
PPIB peptidylprolyl isomerase B (cyclophilin B) -0.0294646
FHIP1A FHF complex subunit HOOK interacting protein 1A -0.0292248
PRKDC protein kinase, DNA-activated, catalytic polypeptide -0.0291327
RAB1A RAB1A, member RAS oncogene family -0.0290244
CEMIP2 cell migration inducing hyaluronidase 2 -0.0288606
RPS24 ribosomal protein S24 -0.0287483
FNDC3B fibronectin type III domain containing 3B -0.0285283
UBE2H ubiquitin-conjugating enzyme E2H -0.0283204
HNRNPK heterogeneous nuclear ribonucleoprotein K -0.0278351
SH3D19 SH3 domain containing 19 -0.0277875
SNX9 sorting nexin 9 -0.0277659
JMJD1C jumonji domain containing 1C -0.0276128
RPS23 ribosomal protein S23 -0.0271781
EMP1 epithelial membrane protein 1 -0.0270798
HMGA1 high mobility group AT-hook 1 -0.0270798
ZSWIM6 zinc finger, SWIM-type containing 6 -0.027067
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0267455
SVIL supervillin -0.0265895