| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in MIA PaCa-2 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_MIA PaCa-2 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.123594 |
| HLA-B | major histocompatibility complex, class I, B | 0.119077 |
| TMSB4X | thymosin beta 4, X-linked | 0.110535 |
| RPS12 | ribosomal protein S12 | 0.102614 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0939401 |
| VIM | vimentin | 0.0911009 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0840338 |
| RPS6 | ribosomal protein S6 | 0.0759974 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0645839 |
| RPS8 | ribosomal protein S8 | 0.0644644 |
| RPL36A | ribosomal protein L36a | 0.058797 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0547095 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0536044 |
| RPL37A | ribosomal protein L37a | 0.0529669 |
| SET | SET nuclear proto-oncogene | 0.0527907 |
| B2M | beta-2-microglobulin | 0.0526876 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0499601 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0492478 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.047755 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0470814 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.046378 |
| RPL26 | ribosomal protein L26 | 0.0455811 |
| RPS23 | ribosomal protein S23 | 0.0446177 |
| RPS27A | ribosomal protein S27a | 0.0437753 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0426113 |
| RPL37 | ribosomal protein L37 | 0.0419797 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0412196 |
| EREG | epiregulin | 0.0398905 |
| SLK | STE20-like kinase | 0.0398051 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0391816 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0378927 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0371878 |
| RPS2 | ribosomal protein S2 | 0.0369181 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0368044 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0364932 |
| RPS17 | ribosomal protein S17 | 0.0361175 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0356869 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0355126 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0347883 |
| RPL31 | ribosomal protein L31 | 0.0346822 |
| TPM3 | tropomyosin 3 | 0.0346764 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0340897 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0336752 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0336364 |
| RPS3 | ribosomal protein S3 | 0.0329589 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0327792 |
| HLA-A | major histocompatibility complex, class I, A | 0.0326975 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.03258 |
| RPS27 | ribosomal protein S27 | 0.0325224 |
| RPLP2 | ribosomal protein, large, P2 | 0.0320427 |
| PCBP2 | poly(rC) binding protein 2 | 0.0319865 |
| PLEKHA4 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 | 0.0319389 |
| WDR43 | WD repeat domain 43 | 0.0316502 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0314551 |
| RPL12 | ribosomal protein L12 | 0.029809 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0297971 |
| RPS25 | ribosomal protein S25 | 0.0295048 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0289892 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0284044 |
| ASPH | aspartate beta-hydroxylase | 0.028105 |
| RPL9 | ribosomal protein L9 | 0.0274737 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0273578 |
| RAB27B | RAB27B, member RAS oncogene family | 0.0266461 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.026342 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0261781 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0256036 |
| MATR3 | matrin 3 | 0.0254271 |
| NUP58 | nucleoporin 58 | 0.0246516 |
| RPS10 | ribosomal protein S10 | 0.0245485 |
| PODXL | podocalyxin-like | 0.0243696 |
| RPL36 | ribosomal protein L36 | 0.0242261 |
| ATP13A3 | ATPase type 13A3 | 0.0241822 |
| ENO1 | enolase 1, (alpha) | 0.0240471 |
| HLA-E | major histocompatibility complex, class I, E | 0.0239109 |
| RPL35A | ribosomal protein L35a | 0.0238701 |
| IPO7 | importin 7 | 0.0232465 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0230731 |
| RPL30 | ribosomal protein L30 | 0.0227714 |
| F2R | coagulation factor II (thrombin) receptor | 0.0225735 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0225347 |
| RPL7A | ribosomal protein L7a | 0.0225144 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0224733 |
| ARF6 | ADP-ribosylation factor 6 | 0.022347 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0221916 |
| RPS13 | ribosomal protein S13 | 0.0220467 |
| DCAF7 | DDB1 and CUL4 associated factor 7 | 0.0219898 |
| FUT11 | fucosyltransferase 11 (alpha (1,3) fucosyltransferase) | 0.0218668 |
| RPL28 | ribosomal protein L28 | 0.0215125 |
| TRIM56 | tripartite motif containing 56 | 0.0214503 |
| RACK1 | receptor for activated C kinase 1 | 0.0213653 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0212332 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0211727 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0211097 |
| B4GALT5 | UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 5 | 0.020934 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0207508 |
| SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | 0.0205321 |
| DFFA | DNA fragmentation factor, 45kDa, alpha polypeptide | 0.0203224 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0200288 |
| RNF145 | ring finger protein 145 | 0.019987 |
| RPS29 | ribosomal protein S29 | 0.0194724 |
| Symbol | Name | Standardized Value |
|---|---|---|
| TMSB10 | thymosin beta 10 | -0.196181 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.177571 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.152576 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.129409 |
| MT2A | metallothionein 2A | -0.125106 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.109566 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0759733 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.07442 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0740475 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0717991 |
| CADM2 | cell adhesion molecule 2 | -0.0680609 |
| FTL | ferritin, light polypeptide | -0.0679053 |
| EFNA5 | ephrin-A5 | -0.0665755 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0658956 |
| EXOC4 | exocyst complex component 4 | -0.0656991 |
| USP34 | ubiquitin specific peptidase 34 | -0.0651323 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0639569 |
| TNS3 | tensin 3 | -0.0627359 |
| DST | dystonin | -0.0607643 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.059662 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.059504 |
| MAP1LC3B | microtubule-associated protein 1 light chain 3 beta | -0.0579378 |
| EHBP1 | EH domain binding protein 1 | -0.0579342 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0578204 |
| MT1X | metallothionein 1X | -0.0570448 |
| TNFRSF10D | tumor necrosis factor receptor superfamily, member 10d, decoy with truncated death domain | -0.0569831 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0567124 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0565193 |
| POTEF | POTE ankyrin domain family, member F | -0.0543455 |
| ACTG1 | actin gamma 1 | -0.0535767 |
| APP | amyloid beta (A4) precursor protein | -0.0508434 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0497782 |
| LOXL2 | lysyl oxidase-like 2 | -0.0489621 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0488837 |
| CSMD3 | CUB and Sushi multiple domains 3 | -0.048862 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0488548 |
| MYOF | myoferlin | -0.0473719 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0472752 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0471698 |
| ZNF217 | zinc finger protein 217 | -0.0471503 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0471327 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0470583 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0464624 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.045886 |
| LDHA | lactate dehydrogenase A | -0.0445985 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0426175 |
| EPHA4 | EPH receptor A4 | -0.0420613 |
| GNGT1 | guanine nucleotide binding protein (G protein), gamma transducing activity polypeptide 1 | -0.0420406 |
| ADARB1 | adenosine deaminase, RNA-specific, B1 | -0.0418746 |
| FNIP1 | folliculin interacting protein 1 | -0.0415381 |
| HDLBP | high density lipoprotein binding protein | -0.041226 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0412228 |
| HDAC9 | histone deacetylase 9 | -0.0403061 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0399221 |
| DENND1A | DENN/MADD domain containing 1A | -0.0395882 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0394867 |
| GNAS | GNAS complex locus | -0.0387827 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.0387752 |
| SBF2 | SET binding factor 2 | -0.0382762 |
| PIAS2 | protein inhibitor of activated STAT, 2 | -0.0379824 |
| COG5 | component of oligomeric golgi complex 5 | -0.037787 |
| NAV2 | neuron navigator 2 | -0.0369791 |
| ANXA1 | annexin A1 | -0.0368405 |
| ZNF292 | zinc finger protein 292 | -0.0363029 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.03618 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0360602 |
| ZNF638 | zinc finger protein 638 | -0.0360175 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0357294 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0356716 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0350783 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0350532 |
| KDM4B | lysine (K)-specific demethylase 4B | -0.0350032 |
| CMIP | c-Maf inducing protein | -0.0346547 |
| TFRC | transferrin receptor | -0.0345986 |
| PRELID2 | PRELI domain containing 2 | -0.0343249 |
| RAD51B | RAD51 paralog B | -0.0342305 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0341489 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0337959 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.033674 |
| SPAG9 | sperm associated antigen 9 | -0.0336121 |
| RAPGEF6 | Rap guanine nucleotide exchange factor (GEF) 6 | -0.0332547 |
| BSG | basigin (Ok blood group) | -0.0331309 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0329749 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0328309 |
| GARS1 | glycyl-tRNA synthetase 1 | -0.0326788 |
| MORF4L2 | mortality factor 4 like 2 | -0.0325817 |
| BRWD1 | bromodomain and WD repeat domain containing 1 | -0.0321904 |
| SLCO1B3 | solute carrier organic anion transporter family, member 1B3 | -0.0320174 |
| YBX1 | Y box binding protein 1 | -0.0319246 |
| FBXO11 | F-box protein 11 | -0.0318616 |
| JMJD1C | jumonji domain containing 1C | -0.0318224 |
| PTK2 | protein tyrosine kinase 2 | -0.0317837 |
| CD44 | CD44 molecule (Indian blood group) | -0.0314877 |
| MBNL2 | muscleblind-like splicing regulator 2 | -0.0314115 |
| NF1 | neurofibromin 1 | -0.0312106 |
| SMYD3 | SET and MYND domain containing 3 | -0.0308518 |
| IGF1R | insulin-like growth factor 1 receptor | -0.030797 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0306665 |
| ARB2A | ARB2 cotranscriptional regulator A | -0.030666 |
| INTS6 | integrator complex subunit 6 | -0.0305357 |
