| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H1573 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H1573 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| TXNRD1 | thioredoxin reductase 1 | 0.210551 |
| RNF213 | ring finger protein 213 | 0.151787 |
| MYOF | myoferlin | 0.124144 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.107484 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0949687 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0841248 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0783553 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0729341 |
| LRP1B | low density lipoprotein receptor-related protein 1B | 0.0596819 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0588157 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0556548 |
| GULP1 | GULP, engulfment adaptor PTB domain containing 1 | 0.0548643 |
| PM20D1 | peptidase M20 domain containing 1 | 0.0540157 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0536407 |
| CCSER1 | coiled-coil serine-rich protein 1 | 0.0534518 |
| GCLC | glutamate-cysteine ligase, catalytic subunit | 0.0512823 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0464149 |
| DST | dystonin | 0.0419164 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0407997 |
| IGFBP5 | insulin-like growth factor binding protein 5 | 0.0403897 |
| WWOX | WW domain containing oxidoreductase | 0.0400787 |
| PCBP2 | poly(rC) binding protein 2 | 0.0390702 |
| DSPP | dentin sialophosphoprotein | 0.0381623 |
| NAALADL2 | N-acetylated alpha-linked acidic dipeptidase-like 2 | 0.0375938 |
| NTN4 | netrin 4 | 0.0375441 |
| LANCL2 | LanC lantibiotic synthetase component C-like 2 (bacterial) | 0.0372835 |
| B2M | beta-2-microglobulin | 0.0363413 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0361945 |
| AHR | aryl hydrocarbon receptor | 0.0356171 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0345186 |
| SAMD12 | sterile alpha motif domain containing 12 | 0.0343846 |
| UGDH | UDP-glucose 6-dehydrogenase | 0.0341334 |
| ADAM9 | ADAM metallopeptidase domain 9 | 0.033646 |
| PTPRD | protein tyrosine phosphatase, receptor type, D | 0.0330937 |
| KIAA0319 | KIAA0319 | 0.0325482 |
| RAD51B | RAD51 paralog B | 0.0318825 |
| NFKB1 | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 | 0.031705 |
| ABCC2 | ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | 0.0314816 |
| ARHGEF38 | Rho guanine nucleotide exchange factor (GEF) 38 | 0.0314053 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0308195 |
| ADGRV1 | adhesion G protein-coupled receptor V1 | 0.0306073 |
| YBX3 | Y box binding protein 3 | 0.0297886 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0296941 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0287551 |
| CEACAM5 | carcinoembryonic antigen-related cell adhesion molecule 5 | 0.0286579 |
| DTNB | dystrobrevin, beta | 0.0283943 |
| ANK3 | ankyrin 3, node of Ranvier (ankyrin G) | 0.0279204 |
| LITAF | lipopolysaccharide-induced TNF factor | 0.0273866 |
| NQO1 | NAD(P)H dehydrogenase, quinone 1 | 0.0265384 |
| VAV3 | vav 3 guanine nucleotide exchange factor | 0.0257319 |
| RBM47 | RNA binding motif protein 47 | 0.0256895 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0256457 |
| MGAT4C | MGAT4 family, member C | 0.0253235 |
| MLPH | melanophilin | 0.0251755 |
| FAAH2 | fatty acid amide hydrolase 2 | 0.0245565 |
| BCAS1 | breast carcinoma amplified sequence 1 | 0.0243587 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0242915 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | 0.024036 |
| PRDX1 | peroxiredoxin 1 | 0.0239411 |
| PBX1 | pre-B-cell leukemia homeobox 1 | 0.0237205 |
| CPE | carboxypeptidase E | 0.0232977 |
| TJP1 | tight junction protein 1 | 0.0228746 |
| RAB10 | RAB10, member RAS oncogene family | 0.0225563 |
| GPAT3 | glycerol-3-phosphate acyltransferase 3 | 0.0224732 |
| SLK | STE20-like kinase | 0.0224651 |
| TAPBP | TAP binding protein (tapasin) | 0.0222301 |
| NEBL | nebulette | 0.0222261 |
| MACC1 | metastasis associated in colon cancer 1 | 0.0221817 |
| FOXP1 | forkhead box P1 | 0.0221187 |
| IRS2 | insulin receptor substrate 2 | 0.022073 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0218066 |
| CPEB2 | cytoplasmic polyadenylation element binding protein 2 | 0.0217478 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0214793 |
| VOPP1 | vesicular, overexpressed in cancer, prosurvival protein 1 | 0.0213215 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0212546 |
| CYP24A1 | cytochrome P450, family 24, subfamily A, polypeptide 1 | 0.0210574 |
| ABCC1 | ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | 0.0208443 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.020667 |
| PTEN | phosphatase and tensin homolog | 0.0205852 |
| TES | testin LIM domain protein | 0.0203787 |
| JAK1 | Janus kinase 1 | 0.0202128 |
| SEPTIN9 | septin 9 | 0.0201912 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0201862 |
| HACD2 | 3-hydroxyacyl-CoA dehydratase 2 | 0.02009 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0200428 |
| LPGAT1 | lysophosphatidylglycerol acyltransferase 1 | 0.019547 |
| SMYD3 | SET and MYND domain containing 3 | 0.0195455 |
| TACC2 | transforming, acidic coiled-coil containing protein 2 | 0.0195235 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | 0.0189082 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0187531 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0186557 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0186039 |
| BCL9L | B-cell CLL/lymphoma 9-like | 0.0184923 |
| GAREM1 | GRB2 associated regulator of MAPK1 subtype 1 | 0.0184839 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0184324 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0179306 |
| PNN | pinin, desmosome associated protein | 0.0178178 |
| RNF19A | ring finger protein 19A, RBR E3 ubiquitin protein ligase | 0.0177238 |
| MKI67 | marker of proliferation Ki-67 | 0.0174419 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 0.0174321 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.14131 |
| NDRG1 | N-myc downstream regulated 1 | -0.135566 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.118304 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.1174 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.114777 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.108564 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0946679 |
| EGFR | epidermal growth factor receptor | -0.0929555 |
| SEMA4B | sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B | -0.0899925 |
| SHANK2 | SH3 and multiple ankyrin repeat domains 2 | -0.0894067 |
| LAMC2 | laminin, gamma 2 | -0.0876378 |
| MCL1 | myeloid cell leukemia 1 | -0.0867647 |
| PTMA | prothymosin, alpha | -0.0858238 |
| TMSB10 | thymosin beta 10 | -0.085146 |
| PTGS2 | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | -0.0824506 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0789998 |
| H1-0 | H1.0 linker histone | -0.0761048 |
| ACTG1 | actin gamma 1 | -0.0738149 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0737527 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0730495 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0727796 |
| INTS6 | integrator complex subunit 6 | -0.0716377 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.064311 |
| LMO7 | LIM domain 7 | -0.0640264 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0572368 |
| AGO2 | argonaute RISC catalytic component 2 | -0.0559059 |
| NABP1 | nucleic acid binding protein 1 | -0.0551328 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0544439 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0540995 |
| ASPH | aspartate beta-hydroxylase | -0.0523186 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | -0.0521191 |
| STC1 | stanniocalcin 1 | -0.0511718 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0495571 |
| S100A10 | S100 calcium binding protein A10 | -0.0472541 |
| MYL12A | myosin, light chain 12A, regulatory, non-sarcomeric | -0.0465372 |
| USP34 | ubiquitin specific peptidase 34 | -0.046002 |
| FAM13A | family with sequence similarity 13, member A | -0.0454742 |
| IER3 | immediate early response 3 | -0.0453083 |
| GRB10 | growth factor receptor-bound protein 10 | -0.044963 |
| RPS24 | ribosomal protein S24 | -0.0443049 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0436026 |
| CD163L1 | CD163 molecule-like 1 | -0.0434944 |
| RPL35A | ribosomal protein L35a | -0.0432479 |
| EFNA5 | ephrin-A5 | -0.043191 |
| LAMB3 | laminin, beta 3 | -0.0428743 |
| KANSL1 | KAT8 regulatory NSL complex subunit 1 | -0.0428475 |
| CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | -0.0425955 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | -0.0423297 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0423297 |
| OGA | O-GlcNAcase | -0.0417685 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0415469 |
| TMEM165 | transmembrane protein 165 | -0.0413796 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.041352 |
| MORF4L2 | mortality factor 4 like 2 | -0.0409037 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0408029 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0405963 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.040477 |
| SEC61G | Sec61 gamma subunit | -0.0398561 |
| HDLBP | high density lipoprotein binding protein | -0.0397368 |
| DDX17 | DEAD (Asp-Glu-Ala-Asp) box helicase 17 | -0.0395303 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0393607 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0392365 |
| FBXO11 | F-box protein 11 | -0.0387612 |
| NGLY1 | N-glycanase 1 | -0.0386662 |
| CANX | calnexin | -0.0376777 |
| TOP1 | topoisomerase (DNA) I | -0.0370699 |
| WASF2 | WAS protein family, member 2 | -0.0368799 |
| ATG7 | autophagy related 7 | -0.0366315 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0363925 |
| ZC3H11A | zinc finger CCCH-type containing 11A | -0.0361807 |
| TBC1D22A | TBC1 domain family, member 22A | -0.0359693 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | -0.0351452 |
| SBF2 | SET binding factor 2 | -0.0345998 |
| RASA2 | RAS p21 protein activator 2 | -0.0344363 |
| HOOK2 | hook microtubule-tethering protein 2 | -0.0341712 |
| GM2A | GM2 ganglioside activator | -0.0335347 |
| MCTP1 | multiple C2 domains, transmembrane 1 | -0.0332676 |
| SEPTIN2 | septin 2 | -0.0330775 |
| RNMT | RNA (guanine-7-) methyltransferase | -0.0328964 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | -0.0326697 |
| ATP1B1 | ATPase, Na+/K+ transporting, beta 1 polypeptide | -0.0326256 |
| NTSR1 | neurotensin receptor 1 (high affinity) | -0.0322118 |
| HBP1 | HMG-box transcription factor 1 | -0.0321849 |
| CALM1 | calmodulin 1 (phosphorylase kinase, delta) | -0.0321626 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0321075 |
| PLEC | plectin | -0.0319326 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | -0.0318527 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0317503 |
| ABLIM1 | actin binding LIM protein 1 | -0.031474 |
| PATJ | PATJ crumbs cell polarity complex component | -0.0313579 |
| RPLP1 | ribosomal protein, large, P1 | -0.0309087 |
| BACE2 | beta-site APP-cleaving enzyme 2 | -0.0308491 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0308387 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0306561 |
| SCEL | sciellin | -0.0304138 |
| FLNB | filamin B, beta | -0.0302789 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0302201 |
| WDR45B | WD repeat domain 45B | -0.0301929 |
| MARF1 | meiosis regulator and mRNA stability factor 1 | -0.0300197 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0295332 |
