| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H1792 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H1792 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.108258 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0767415 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0696119 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0623589 |
| SOD2 | superoxide dismutase 2, mitochondrial | 0.0519417 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.0436842 |
| RPL4 | ribosomal protein L4 | 0.038922 |
| ANGPTL4 | angiopoietin-like 4 | 0.0384252 |
| PCBP2 | poly(rC) binding protein 2 | 0.0355775 |
| MT2A | metallothionein 2A | 0.0352304 |
| BASP1 | brain abundant, membrane attached signal protein 1 | 0.0329087 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0325299 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0292223 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0284496 |
| RPL3 | ribosomal protein L3 | 0.0276982 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0276721 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0273173 |
| SFTPA2 | surfactant protein A2 | 0.0270428 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0259909 |
| B2M | beta-2-microglobulin | 0.0259869 |
| YBX1 | Y box binding protein 1 | 0.0250646 |
| KLF6 | Kruppel-like factor 6 | 0.0244508 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0243457 |
| LOX | lysyl oxidase | 0.0229409 |
| RPS12 | ribosomal protein S12 | 0.0220157 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.021735 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0216606 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0215562 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0211392 |
| RPS3 | ribosomal protein S3 | 0.021056 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0206824 |
| AOPEP | aminopeptidase O (putative) | 0.0206442 |
| MYADM | myeloid-associated differentiation marker | 0.0204682 |
| CSDE1 | cold shock domain containing E1, RNA-binding | 0.0202214 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0201869 |
| TPI1 | triosephosphate isomerase 1 | 0.0200748 |
| APP | amyloid beta (A4) precursor protein | 0.0192917 |
| ANXA1 | annexin A1 | 0.0186968 |
| PHF14 | PHD finger protein 14 | 0.0184302 |
| FLNB | filamin B, beta | 0.0182892 |
| KYNU | kynureninase | 0.0182727 |
| EZR | ezrin | 0.018099 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.017414 |
| AHNAK | AHNAK nucleoprotein | 0.0169672 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0169652 |
| CXCL5 | chemokine (C-X-C motif) ligand 5 | 0.016936 |
| TPM3 | tropomyosin 3 | 0.0168493 |
| RACK1 | receptor for activated C kinase 1 | 0.0165315 |
| CA12 | carbonic anhydrase XII | 0.0163759 |
| FAM13A | family with sequence similarity 13, member A | 0.0163377 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0162899 |
| DEPP1 | DEPP autophagy regulator 1 | 0.0162155 |
| JUN | jun proto-oncogene | 0.0161733 |
| RPL18 | ribosomal protein L18 | 0.0160702 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.0158114 |
| EEA1 | early endosome antigen 1 | 0.0154837 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0154459 |
| PHF21A | PHD finger protein 21A | 0.0152951 |
| GSTP1 | glutathione S-transferase pi 1 | 0.0150513 |
| CDH2 | cadherin 2, type 1, N-cadherin (neuronal) | 0.0149283 |
| WWOX | WW domain containing oxidoreductase | 0.0148218 |
| DPYSL3 | dihydropyrimidinase-like 3 | 0.0147777 |
| ENAH | enabled homolog (Drosophila) | 0.0146726 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0146275 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 0.0145802 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0144257 |
| FBXO32 | F-box protein 32 | 0.0144041 |
| KIF5B | kinesin family member 5B | 0.0142347 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0141047 |
| H1-0 | H1.0 linker histone | 0.0140731 |
| KDELR1 | KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1 | 0.0139718 |
| IFI44L | interferon-induced protein 44-like | 0.0137866 |
| SMARCA5 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 | 0.0137437 |
| RAB8B | RAB8B, member RAS oncogene family | 0.0137151 |
| SLC7A5 | solute carrier family 7 (amino acid transporter light chain, L system), member 5 | 0.0137036 |
| SLC6A6 | solute carrier family 6 (neurotransmitter transporter), member 6 | 0.0137025 |
| SKAP2 | src kinase associated phosphoprotein 2 | 0.013688 |
| NFATC2 | nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 | 0.0136598 |
| PLIN2 | perilipin 2 | 0.0132945 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 0.0132809 |
| EIF4H | eukaryotic translation initiation factor 4H | 0.0132524 |
| MXI1 | MAX interactor 1, dimerization protein | 0.0132453 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0132426 |
| RPS2 | ribosomal protein S2 | 0.0130049 |
| SYNJ2 | synaptojanin 2 | 0.0129031 |
| RNF24 | ring finger protein 24 | 0.0128633 |
| HMGB2 | high mobility group box 2 | 0.0127499 |
| PTPRR | protein tyrosine phosphatase, receptor type, R | 0.0127441 |
| SAMD9 | sterile alpha motif domain containing 9 | 0.0127177 |
| FOXP1 | forkhead box P1 | 0.012707 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0126775 |
| OS9 | osteosarcoma amplified 9, endoplasmic reticulum lectin | 0.0126621 |
| EIF2AK1 | eukaryotic translation initiation factor 2-alpha kinase 1 | 0.0125997 |
| HLA-E | major histocompatibility complex, class I, E | 0.0125844 |
| RPL23 | ribosomal protein L23 | 0.01251 |
| DHRS3 | dehydrogenase/reductase (SDR family) member 3 | 0.0124831 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0120558 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0120485 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0119876 |
| LOC112694756 | uncharaterized LOC112694756 | 0.0119837 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.174981 |
| CDH13 | cadherin 13 | -0.156465 |
| SDK1 | sidekick cell adhesion molecule 1 | -0.129291 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.115086 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | -0.106165 |
| EFNA5 | ephrin-A5 | -0.102411 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0984702 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0942028 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0900061 |
| HMGA2 | high mobility group AT-hook 2 | -0.0884615 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0842695 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0796445 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0796034 |
| USP34 | ubiquitin specific peptidase 34 | -0.0785599 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0758488 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0756718 |
| RPL35A | ribosomal protein L35a | -0.0746443 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0703633 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0703122 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0691637 |
| GOLGA4 | golgin A4 | -0.0688117 |
| GLCCI1 | glucocorticoid induced 1 | -0.0682764 |
| TMSB10 | thymosin beta 10 | -0.0681429 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0656417 |
| MSRB3 | methionine sulfoxide reductase B3 | -0.0653833 |
| NRG1 | neuregulin 1 | -0.0593942 |
| MTSS1 | metastasis suppressor 1 | -0.0587677 |
| FAM20C | family with sequence similarity 20, member C | -0.0560598 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0550103 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0546489 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | -0.0542015 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0538323 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0522161 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0515471 |
| HM13 | histocompatibility (minor) 13 | -0.050402 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0481247 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0477179 |
| ATXN1 | ataxin 1 | -0.0477159 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0474386 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.046935 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0467532 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0466832 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0458171 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0457634 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.04473 |
| FN1 | fibronectin 1 | -0.0446113 |
| NUMB | numb homolog (Drosophila) | -0.0440324 |
| AADAC | arylacetamide deacetylase | -0.0437677 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0436113 |
| RPS25 | ribosomal protein S25 | -0.0432882 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.043275 |
| PARD3 | par-3 family cell polarity regulator | -0.0428307 |
| RBM39 | RNA binding motif protein 39 | -0.0421705 |
| ASCC3 | activating signal cointegrator 1 complex subunit 3 | -0.0416142 |
| INTS6 | integrator complex subunit 6 | -0.0414354 |
| NRP1 | neuropilin 1 | -0.0413864 |
| JMJD1C | jumonji domain containing 1C | -0.0413677 |
| CD44 | CD44 molecule (Indian blood group) | -0.0409603 |
| TTC3 | tetratricopeptide repeat domain 3 | -0.0404957 |
| CDK14 | cyclin-dependent kinase 14 | -0.0400331 |
| VMP1 | vacuole membrane protein 1 | -0.039618 |
| ATG7 | autophagy related 7 | -0.0392946 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0371742 |
| RPL31 | ribosomal protein L31 | -0.0369692 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0365981 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0364946 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.036277 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0362314 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.035667 |
| ASH1L | ash1 (absent, small, or homeotic)-like (Drosophila) | -0.0356521 |
| GREB1L | growth regulation by estrogen in breast cancer-like | -0.0351061 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0349593 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0348033 |
| RPS29 | ribosomal protein S29 | -0.0345966 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0345447 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0344416 |
| NLK | nemo-like kinase | -0.0344414 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | -0.0337511 |
| CLMP | CXADR-like membrane protein | -0.0337316 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0335957 |
| RPS24 | ribosomal protein S24 | -0.0334556 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0333801 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0332674 |
| TIMP1 | TIMP metallopeptidase inhibitor 1 | -0.0332604 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0330637 |
| NHS | Nance-Horan syndrome (congenital cataracts and dental anomalies) | -0.0330391 |
| CACNA2D3 | calcium channel, voltage-dependent, alpha 2/delta subunit 3 | -0.0328215 |
| DNER | delta/notch-like EGF repeat containing | -0.0325367 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0325156 |
| CALU | calumenin | -0.0324117 |
| NAV2 | neuron navigator 2 | -0.0321313 |
| DOCK5 | dedicator of cytokinesis 5 | -0.0320801 |
| RPS13 | ribosomal protein S13 | -0.0320697 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | -0.0318444 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0316155 |
| DENND4A | DENN/MADD domain containing 4A | -0.0314819 |
| OXR1 | oxidation resistance 1 | -0.0312706 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0312403 |
| ENO2 | enolase 2 (gamma, neuronal) | -0.0311967 |
| NDRG1 | N-myc downstream regulated 1 | -0.0311924 |
