| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H2030 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H2030 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.142422 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.122698 |
| MT2A | metallothionein 2A | 0.119329 |
| IER3 | immediate early response 3 | 0.0791786 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | 0.0728925 |
| PTMA | prothymosin, alpha | 0.0690842 |
| VIM | vimentin | 0.0552786 |
| C15ORF48 | chromosome 15 open reading frame 48 | 0.05257 |
| TM4SF1 | transmembrane 4 L six family member 1 | 0.0518023 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0498497 |
| S100A6 | S100 calcium binding protein A6 | 0.0497925 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.0470406 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0449496 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0444396 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | 0.0441222 |
| ASPH | aspartate beta-hydroxylase | 0.0440134 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0400055 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0398276 |
| IL6 | interleukin 6 | 0.0372549 |
| PYGL | phosphorylase, glycogen, liver | 0.0348441 |
| AHNAK | AHNAK nucleoprotein | 0.0347826 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0345862 |
| CCL2 | chemokine (C-C motif) ligand 2 | 0.034176 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0335713 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0330595 |
| KDM3A | lysine (K)-specific demethylase 3A | 0.0327931 |
| CFLAR | CASP8 and FADD-like apoptosis regulator | 0.0326203 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0322929 |
| RPS8 | ribosomal protein S8 | 0.0311663 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0311262 |
| RPL37A | ribosomal protein L37a | 0.0309588 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0296468 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | 0.028981 |
| TFPI2 | tissue factor pathway inhibitor 2 | 0.0287017 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | 0.0283478 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0283099 |
| TFPI | tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor) | 0.0282525 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0280661 |
| FAM107B | family with sequence similarity 107, member B | 0.0278825 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0276457 |
| TPT1 | tumor protein, translationally-controlled 1 | 0.0276037 |
| TPM4 | tropomyosin 4 | 0.027375 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0270302 |
| CDC42 | cell division cycle 42 | 0.0268709 |
| RPS27A | ribosomal protein S27a | 0.0263836 |
| SET | SET nuclear proto-oncogene | 0.0261104 |
| JAK1 | Janus kinase 1 | 0.0260079 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0259542 |
| CANX | calnexin | 0.024585 |
| BZW1 | basic leucine zipper and W2 domains 1 | 0.0245347 |
| SLC38A1 | solute carrier family 38, member 1 | 0.0244371 |
| MYOF | myoferlin | 0.0244137 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0243752 |
| S100A10 | S100 calcium binding protein A10 | 0.0243732 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0240033 |
| BIRC3 | baculoviral IAP repeat containing 3 | 0.0237586 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0231203 |
| RAI1 | retinoic acid induced 1 | 0.0230486 |
| FGD6 | FYVE, RhoGEF and PH domain containing 6 | 0.0230093 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0225777 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0225655 |
| ACTG1 | actin gamma 1 | 0.0225499 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0219828 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 0.0215285 |
| IL6ST | interleukin 6 signal transducer | 0.0214579 |
| SLC2A3 | solute carrier family 2 (facilitated glucose transporter), member 3 | 0.0214469 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0213672 |
| PGK1 | phosphoglycerate kinase 1 | 0.0208683 |
| BIRC2 | baculoviral IAP repeat containing 2 | 0.0207664 |
| SERINC1 | serine incorporator 1 | 0.0204745 |
| ZFHX3 | zinc finger homeobox 3 | 0.0203795 |
| EGFR | epidermal growth factor receptor | 0.0202792 |
| ITGA6 | integrin, alpha 6 | 0.019865 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0194582 |
| YWHAB | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta | 0.0193363 |
| CAVIN1 | caveolae associated protein 1 | 0.0193183 |
| AGFG1 | ArfGAP with FG repeats 1 | 0.019315 |
| PTPRJ | protein tyrosine phosphatase, receptor type, J | 0.0189863 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0187605 |
| ZMYND8 | zinc finger, MYND-type containing 8 | 0.0185326 |
| ANGPTL4 | angiopoietin-like 4 | 0.0184086 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.018262 |
| PSMC6 | proteasome (prosome, macropain) 26S subunit, ATPase, 6 | 0.018048 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | 0.01792 |
| ST13 | suppression of tumorigenicity 13 (colon carcinoma) (Hsp70 interacting protein) | 0.0178851 |
| LAMB3 | laminin, beta 3 | 0.0178311 |
| KLF6 | Kruppel-like factor 6 | 0.0177581 |
| GABARAPL1 | GABA(A) receptor-associated protein like 1 | 0.0176545 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | 0.0174183 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | 0.0174162 |
| MT1X | metallothionein 1X | 0.0173729 |
| KIAA0319 | KIAA0319 | 0.0170038 |
| RPS18 | ribosomal protein S18 | 0.0168738 |
| KPNB1 | karyopherin (importin) beta 1 | 0.0168735 |
| INHBA | inhibin, beta A | 0.0168491 |
| LMAN1 | lectin, mannose-binding, 1 | 0.0165683 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0164207 |
| DSE | dermatan sulfate epimerase | 0.0163447 |
| TPM1 | tropomyosin 1 (alpha) | 0.0162331 |
| CDCP1 | CUB domain containing protein 1 | 0.0161777 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FTL | ferritin, light polypeptide | -0.248345 |
| TMSB10 | thymosin beta 10 | -0.154308 |
| POTEF | POTE ankyrin domain family, member F | -0.127042 |
| RPS4Y1 | ribosomal protein S4, Y-linked 1 | -0.12513 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.120205 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.11222 |
| EEF2 | eukaryotic translation elongation factor 2 | -0.107756 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.106735 |
| RPL23 | ribosomal protein L23 | -0.0988418 |
| EGR1 | early growth response 1 | -0.093927 |
| RPL3 | ribosomal protein L3 | -0.0932268 |
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | -0.0919318 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0908614 |
| IGF2 | insulin-like growth factor 2 | -0.0810342 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.075698 |
| MCL1 | myeloid cell leukemia 1 | -0.0682184 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0671805 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0668478 |
| YBX1 | Y box binding protein 1 | -0.0649405 |
| HMGA1 | high mobility group AT-hook 1 | -0.0631777 |
| LANCL1 | LanC lantibiotic synthetase component C-like 1 (bacterial) | -0.06132 |
| RBM39 | RNA binding motif protein 39 | -0.060871 |
| PFN1 | profilin 1 | -0.0599926 |
| PARD3 | par-3 family cell polarity regulator | -0.0577547 |
| BRD2 | bromodomain containing 2 | -0.0570596 |
| PTK2 | protein tyrosine kinase 2 | -0.0560678 |
| CNOT1 | CCR4-NOT transcription complex, subunit 1 | -0.0554683 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.055087 |
| RAB7A | RAB7A, member RAS oncogene family | -0.052476 |
| FGB | fibrinogen beta chain | -0.0514632 |
| THSD4 | thrombospondin, type I, domain containing 4 | -0.0496447 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0487005 |
| SPRED2 | sprouty-related, EVH1 domain containing 2 | -0.0481707 |
| RBM25 | RNA binding motif protein 25 | -0.0463601 |
| ERBIN | erbb2 interacting protein | -0.0459223 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.0434811 |
| RPS19 | ribosomal protein S19 | -0.0431401 |
| NOP58 | NOP58 ribonucleoprotein | -0.0427253 |
| PKM | pyruvate kinase, muscle | -0.042433 |
| EIF3H | eukaryotic translation initiation factor 3, subunit H | -0.0420216 |
| MBNL1 | muscleblind-like splicing regulator 1 | -0.0411354 |
| COPA | coatomer protein complex, subunit alpha | -0.0407238 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0398801 |
| TMEM131 | transmembrane protein 131 | -0.0394753 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.0390913 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0390741 |
| MEF2D | myocyte enhancer factor 2D | -0.0385789 |
| USP34 | ubiquitin specific peptidase 34 | -0.03839 |
| COG5 | component of oligomeric golgi complex 5 | -0.038232 |
| RASAL2 | RAS protein activator like 2 | -0.0377754 |
| VPS13B | vacuolar protein sorting 13 homolog B (yeast) | -0.0371921 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0367319 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0365865 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | -0.0364285 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0352718 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0351712 |
| FLNA | filamin A, alpha | -0.0351445 |
| FTH1 | ferritin, heavy polypeptide 1 | -0.034707 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0339272 |
| WDR43 | WD repeat domain 43 | -0.0335317 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0332184 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.033218 |
| INO80 | INO80 complex subunit | -0.0330989 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.033045 |
| CDK2AP2 | cyclin-dependent kinase 2 associated protein 2 | -0.0330019 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | -0.0329768 |
| RPL13A | ribosomal protein L13a | -0.0328426 |
| RPL8 | ribosomal protein L8 | -0.0328047 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | -0.0325958 |
| RPL11 | ribosomal protein L11 | -0.0325643 |
| RACK1 | receptor for activated C kinase 1 | -0.0325192 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | -0.032307 |
| RLF | rearranged L-myc fusion | -0.0321448 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0316952 |
| ANKRD11 | ankyrin repeat domain 11 | -0.0312898 |
| RPL4 | ribosomal protein L4 | -0.0312886 |
| PRR16 | proline rich 16 | -0.0312596 |
| RTN4 | reticulon 4 | -0.0311712 |
| UBC | ubiquitin C | -0.0309072 |
| GPBP1 | GC-rich promoter binding protein 1 | -0.0308205 |
| BSG | basigin (Ok blood group) | -0.0307667 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0305083 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | -0.030181 |
| EIF5 | eukaryotic translation initiation factor 5 | -0.0298511 |
| CCNL1 | cyclin L1 | -0.0298323 |
| RPS5 | ribosomal protein S5 | -0.029686 |
| CAMK2D | calcium/calmodulin-dependent protein kinase II delta | -0.0296064 |
| CENPF | centromere protein F, 350/400kDa | -0.0294215 |
| TPX2 | TPX2, microtubule-associated | -0.0293921 |
| FBXO11 | F-box protein 11 | -0.0292536 |
| SFPQ | splicing factor proline/glutamine-rich | -0.0291105 |
| SERF2 | small EDRK-rich factor 2 | -0.0290038 |
| APP | amyloid beta (A4) precursor protein | -0.028834 |
| GLIS3 | GLIS family zinc finger 3 | -0.0287144 |
| TBC1D5 | TBC1 domain family, member 5 | -0.0287111 |
| UBAP2L | ubiquitin associated protein 2-like | -0.0284772 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0284678 |
| ARHGEF12 | Rho guanine nucleotide exchange factor (GEF) 12 | -0.0284351 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.02821 |
| AP1G1 | adaptor-related protein complex 1, gamma 1 subunit | -0.0282073 |
