| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H2122 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H2122 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ZNF292 | zinc finger protein 292 | 0.104964 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0873824 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | 0.0840187 |
| YTHDC1 | YTH domain containing 1 | 0.0748714 |
| RPS12 | ribosomal protein S12 | 0.0737068 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.070386 |
| CNOT2 | CCR4-NOT transcription complex, subunit 2 | 0.0702178 |
| MTUS1 | microtubule associated tumor suppressor 1 | 0.0636091 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0635863 |
| TBL1XR1 | transducin (beta)-like 1 X-linked receptor 1 | 0.0635313 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0614403 |
| GDNF | glial cell derived neurotrophic factor | 0.0602545 |
| NPEPPS | aminopeptidase puromycin sensitive | 0.0596885 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0569364 |
| NPAS3 | neuronal PAS domain protein 3 | 0.056386 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0560441 |
| RAB7A | RAB7A, member RAS oncogene family | 0.0550427 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0550357 |
| DSPP | dentin sialophosphoprotein | 0.0545553 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0544329 |
| LAMA4 | laminin, alpha 4 | 0.0542793 |
| CEP170 | centrosomal protein 170kDa | 0.0515474 |
| SMOC1 | SPARC related modular calcium binding 1 | 0.0509773 |
| RRAS2 | related RAS viral (r-ras) oncogene homolog 2 | 0.0505762 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0494302 |
| ATG14 | autophagy related 14 | 0.0477272 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0476877 |
| RSRC2 | arginine/serine-rich coiled-coil 2 | 0.0470392 |
| FER | fer (fps/fes related) tyrosine kinase | 0.0466377 |
| WDR43 | WD repeat domain 43 | 0.0464453 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | 0.046091 |
| PTPN14 | protein tyrosine phosphatase, non-receptor type 14 | 0.0459073 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0453434 |
| PPFIA1 | protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 1 | 0.0448983 |
| MAML3 | mastermind-like 3 (Drosophila) | 0.0448004 |
| CLINT1 | clathrin interactor 1 | 0.0447187 |
| ECT2 | epithelial cell transforming 2 | 0.0440701 |
| HELZ | helicase with zinc finger | 0.0433607 |
| ZNF654 | zinc finger protein 654 | 0.0430861 |
| RPL6 | ribosomal protein L6 | 0.0430118 |
| YBX3 | Y box binding protein 3 | 0.0428196 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | 0.0421897 |
| NCKAP1 | NCK-associated protein 1 | 0.0421773 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0420349 |
| MKLN1 | muskelin 1, intracellular mediator containing kelch motifs | 0.040942 |
| CTBP2 | C-terminal binding protein 2 | 0.0408299 |
| PTK2 | protein tyrosine kinase 2 | 0.0407065 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0404475 |
| DICER1 | dicer 1, ribonuclease type III | 0.0403866 |
| ZNF207 | zinc finger protein 207 | 0.0403766 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | 0.0403727 |
| BCLAF1 | BCL2-associated transcription factor 1 | 0.0401574 |
| RPL34 | ribosomal protein L34 | 0.0399512 |
| NUP153 | nucleoporin 153kDa | 0.0397331 |
| HNRNPU | heterogeneous nuclear ribonucleoprotein U (scaffold attachment factor A) | 0.0395439 |
| KLF6 | Kruppel-like factor 6 | 0.0394376 |
| AP3S1 | adaptor-related protein complex 3, sigma 1 subunit | 0.0392242 |
| RPLP2 | ribosomal protein, large, P2 | 0.0391177 |
| TSC22D2 | TSC22 domain family, member 2 | 0.038742 |
| ZNRF2 | zinc and ring finger 2, E3 ubiquitin protein ligase | 0.0386318 |
| ANK2 | ankyrin 2, neuronal | 0.0385528 |
| WIPF2 | WAS/WASL interacting protein family, member 2 | 0.0382493 |
| TJP1 | tight junction protein 1 | 0.0381617 |
| HDAC4 | histone deacetylase 4 | 0.0379058 |
| LIMCH1 | LIM and calponin homology domains 1 | 0.0376023 |
| KDM6A | lysine (K)-specific demethylase 6A | 0.0374489 |
| PPP4R2 | protein phosphatase 4, regulatory subunit 2 | 0.0373648 |
| RPS29 | ribosomal protein S29 | 0.0372814 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0370548 |
| CARD16 | caspase recruitment domain family, member 16 | 0.036958 |
| VGLL3 | vestigial-like family member 3 | 0.0369114 |
| SLTM | SAFB-like, transcription modulator | 0.0369061 |
| XRN1 | 5'-3' exoribonuclease 1 | 0.0366063 |
| RBM6 | RNA binding motif protein 6 | 0.0362949 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0361729 |
| RPL37A | ribosomal protein L37a | 0.036023 |
| CEP95 | centrosomal protein 95kDa | 0.0359284 |
| H3-3B | H3.3 histone B | 0.0359269 |
| GPBP1 | GC-rich promoter binding protein 1 | 0.0358071 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | 0.0358017 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.035741 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.035506 |
| YY1 | YY1 transcription factor | 0.0354741 |
| WWOX | WW domain containing oxidoreductase | 0.0354384 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | 0.0350822 |
| AGO3 | argonaute RISC catalytic component 3 | 0.0349629 |
| SBF2 | SET binding factor 2 | 0.0342315 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0341559 |
| MUC13 | mucin 13, cell surface associated | 0.0339814 |
| UBQLN1 | ubiquilin 1 | 0.0339145 |
| FMN1 | formin 1 | 0.0338744 |
| TFG | TRK-fused gene | 0.0338053 |
| STT3B | STT3B, subunit of the oligosaccharyltransferase complex (catalytic) | 0.0337222 |
| GLCCI1 | glucocorticoid induced 1 | 0.0335787 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0335691 |
| THOC2 | THO complex 2 | 0.0334692 |
| MYOF | myoferlin | 0.0331796 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0328022 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0326716 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0326011 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.139268 |
| FN1 | fibronectin 1 | -0.126244 |
| MYO1E | myosin IE | -0.111408 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.109899 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | -0.096144 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0960333 |
| ATOSA | atos homolog A | -0.0955558 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0911605 |
| CEMIP | cell migration inducing protein, hyaluronan binding | -0.0899094 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0898173 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0858655 |
| STC1 | stanniocalcin 1 | -0.0844377 |
| NDRG1 | N-myc downstream regulated 1 | -0.0830888 |
| KRT17 | keratin 17, type I | -0.0822349 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0812242 |
| POTEF | POTE ankyrin domain family, member F | -0.079266 |
| ELF3 | E74-like factor 3 (ets domain transcription factor, epithelial-specific ) | -0.0768334 |
| ZBTB20 | zinc finger and BTB domain containing 20 | -0.0766849 |
| MUC16 | mucin 16, cell surface associated | -0.0743505 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0709678 |
| EGR1 | early growth response 1 | -0.0702645 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.06943 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0688051 |
| PARD3 | par-3 family cell polarity regulator | -0.068764 |
| APBB2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | -0.0685366 |
| BAIAP2L1 | BAI1-associated protein 2-like 1 | -0.0685087 |
| VIM | vimentin | -0.0672923 |
| TXNRD1 | thioredoxin reductase 1 | -0.0672215 |
| UBA6 | ubiquitin-like modifier activating enzyme 6 | -0.0657099 |
| ACTG1 | actin gamma 1 | -0.0651199 |
| TMSB10 | thymosin beta 10 | -0.0643175 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0641425 |
| ANXA2 | annexin A2 | -0.062881 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0628809 |
| LAMB3 | laminin, beta 3 | -0.0610902 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0603904 |
| LMO7 | LIM domain 7 | -0.0576471 |
| UBC | ubiquitin C | -0.0572233 |
| ATP2C2 | ATPase, Ca++ transporting, type 2C, member 2 | -0.0570325 |
| EZR | ezrin | -0.056958 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0567805 |
| ESYT2 | extended synaptotagmin-like protein 2 | -0.055901 |
| INHBA | inhibin, beta A | -0.0541613 |
| SPAG9 | sperm associated antigen 9 | -0.0527474 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | -0.0524252 |
| FLNB | filamin B, beta | -0.0509888 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0501665 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | -0.0492139 |
| CUX1 | cut-like homeobox 1 | -0.049121 |
| ARPC2 | actin related protein 2/3 complex, subunit 2, 34kDa | -0.0487917 |
| RAI14 | retinoic acid induced 14 | -0.0487371 |
| JUN | jun proto-oncogene | -0.0485952 |
| ERBIN | erbb2 interacting protein | -0.048082 |
| NBAS | neuroblastoma amplified sequence | -0.0464006 |
| OSMR | oncostatin M receptor | -0.0463095 |
| S100A10 | S100 calcium binding protein A10 | -0.045164 |
| RAB2A | RAB2A, member RAS oncogene family | -0.0449745 |
| KLHL24 | kelch-like family member 24 | -0.0449575 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0441797 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0437595 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | -0.0436687 |
| ENO1 | enolase 1, (alpha) | -0.0430396 |
| BMAL2 | basic helix-loop-helix ARNT like 2 | -0.0426418 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | -0.0425326 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | -0.0424079 |
| KPNB1 | karyopherin (importin) beta 1 | -0.042345 |
| SLMAP | sarcolemma associated protein | -0.0420926 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | -0.0415067 |
| KIF13B | kinesin family member 13B | -0.0415025 |
| JUP | junction plakoglobin | -0.0412233 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0410311 |
| PELI1 | pellino E3 ubiquitin protein ligase 1 | -0.0408003 |
| RRBP1 | ribosome binding protein 1 | -0.0405849 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0404713 |
| TPM4 | tropomyosin 4 | -0.040342 |
| MAP3K20 | mitogen-activated protein kinase kinase kinase 20 | -0.0402724 |
| FBXW7 | F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase | -0.0401012 |
| MMAB | methylmalonic aciduria (cobalamin deficiency) cblB type | -0.0400989 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0397482 |
| GNAQ | guanine nucleotide binding protein (G protein), q polypeptide | -0.0396242 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0393731 |
| GPC6 | glypican 6 | -0.0393197 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0390046 |
| FOXO3 | forkhead box O3 | -0.0389575 |
| DGKD | diacylglycerol kinase, delta 130kDa | -0.0387074 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | -0.0378645 |
| RAB5A | RAB5A, member RAS oncogene family | -0.0377604 |
| CATSPERB | catsper channel auxiliary subunit beta | -0.0377388 |
| CFDP1 | craniofacial development protein 1 | -0.0376715 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0370364 |
| RPL19 | ribosomal protein L19 | -0.0369725 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0363832 |
| GNPDA1 | glucosamine-6-phosphate deaminase 1 | -0.0363033 |
| ATXN1 | ataxin 1 | -0.0362787 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | -0.0361409 |
| MBD5 | methyl-CpG binding domain protein 5 | -0.0360774 |
| PRKCSH | protein kinase C substrate 80K-H | -0.0360251 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0359775 |
| IGF2 | insulin-like growth factor 2 | -0.0359435 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0359211 |
