Afatinib_NCI-H23 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Afatinib perturbation in NCI-H23 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Afatinib_NCI-H23 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
AKAP12 A kinase (PRKA) anchor protein 12 0.165759
TXNRD1 thioredoxin reductase 1 0.144018
KTN1 kinectin 1 (kinesin receptor) 0.10074
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0726843
SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 0.0670416
TPI1 triosephosphate isomerase 1 0.0654733
GRAMD1B GRAM domain containing 1B 0.0590808
RPS6 ribosomal protein S6 0.0580056
PABPC1 poly(A) binding protein, cytoplasmic 1 0.0550061
ERRFI1 ERBB receptor feedback inhibitor 1 0.052676
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 0.0472537
IFI6 interferon, alpha-inducible protein 6 0.0469216
RNF145 ring finger protein 145 0.0462841
RPS2 ribosomal protein S2 0.0462708
FTH1 ferritin, heavy polypeptide 1 0.0457057
ADAR adenosine deaminase, RNA-specific 0.0455336
ATP1B3 ATPase, Na+/K+ transporting, beta 3 polypeptide 0.0432612
GAPDH glyceraldehyde-3-phosphate dehydrogenase 0.0423529
LATS2 large tumor suppressor kinase 2 0.0414589
BASP1 brain abundant, membrane attached signal protein 1 0.0380087
MT2A metallothionein 2A 0.0379784
DENND5B DENN/MADD domain containing 5B 0.0373462
PFN1 profilin 1 0.0365213
BMP5 bone morphogenetic protein 5 0.0358175
RPS27 ribosomal protein S27 0.0350608
RPS12 ribosomal protein S12 0.0345444
STAT1 signal transducer and activator of transcription 1, 91kDa 0.0325311
SNAP25 synaptosomal-associated protein, 25kDa 0.0324324
PDE10A phosphodiesterase 10A 0.0321591
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0309936
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0300602
LOC102724023 ES1 protein homolog, mitochondrial 0.0286027
RPL36A ribosomal protein L36a 0.0283448
EEF1A1 eukaryotic translation elongation factor 1 alpha 1 0.0279774
ATP11A ATPase, class VI, type 11A 0.0275681
PNN pinin, desmosome associated protein 0.0274911
RPS19 ribosomal protein S19 0.0270388
RPL37 ribosomal protein L37 0.0268137
RTN4 reticulon 4 0.0267036
MKI67 marker of proliferation Ki-67 0.0266964
RPS21 ribosomal protein S21 0.026518
FTL ferritin, light polypeptide 0.026142
B2M beta-2-microglobulin 0.0258881
SRRM2 serine/arginine repetitive matrix 2 0.0256334
PTMS parathymosin 0.0256043
NFE2L2 nuclear factor, erythroid 2-like 2 0.0246237
HNRNPA1 heterogeneous nuclear ribonucleoprotein A1 0.0243594
SLC2A3 solute carrier family 2 (facilitated glucose transporter), member 3 0.0241798
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0239962
PPIG peptidylprolyl isomerase G (cyclophilin G) 0.0237446
PDE4B phosphodiesterase 4B, cAMP-specific 0.0234607
RPS17 ribosomal protein S17 0.0234363
HLA-B major histocompatibility complex, class I, B 0.0233779
SRSF11 serine/arginine-rich splicing factor 11 0.0233638
RPS8 ribosomal protein S8 0.0233043
MBNL2 muscleblind-like splicing regulator 2 0.0233006
FOXP1 forkhead box P1 0.0226692
PNPT1 polyribonucleotide nucleotidyltransferase 1 0.0226572
RPS14 ribosomal protein S14 0.0224633
HSPA8 heat shock 70kDa protein 8 0.0224309
LRP1B low density lipoprotein receptor-related protein 1B 0.021822
LUC7L3 LUC7-like 3 (S. cerevisiae) 0.0216859
TFDP2 transcription factor Dp-2 (E2F dimerization partner 2) 0.0215468
ADARB2 adenosine deaminase, RNA-specific, B2 (non-functional) 0.0208547
ARID1A AT rich interactive domain 1A (SWI-like) 0.0208525
RPS7 ribosomal protein S7 0.0202936
MED13L mediator complex subunit 13-like 0.0198417
ZFP36L1 ZFP36 ring finger protein-like 1 0.0198304
OAS3 2'-5'-oligoadenylate synthetase 3, 100kDa 0.0197218
CENPF centromere protein F, 350/400kDa 0.0192365
SINHCAF SIN3-HDAC complex associated factor 0.019002
SIN3A SIN3 transcription regulator family member A 0.018941
HDGF hepatoma-derived growth factor 0.0189319
TAPBP TAP binding protein (tapasin) 0.0188381
SSH2 slingshot protein phosphatase 2 0.018649
KPNA4 karyopherin alpha 4 (importin alpha 3) 0.0185966
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 0.018572
RPS10 ribosomal protein S10 0.0181874
MAP7 microtubule-associated protein 7 0.0180312
MACROD2 MACRO domain containing 2 0.0178835
REL v-rel avian reticuloendotheliosis viral oncogene homolog 0.0177503
GNAS GNAS complex locus 0.017712
SFTPA2 surfactant protein A2 0.0177064
CCDC88A coiled-coil domain containing 88A 0.0176064
EIF5B eukaryotic translation initiation factor 5B 0.017573
YWHAZ tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta 0.0174975
RPS26 ribosomal protein S26 0.0174551
GPX4 glutathione peroxidase 4 0.0173445
RPL37A ribosomal protein L37a 0.0173073
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0172078
DSPP dentin sialophosphoprotein 0.0171623
AXL AXL receptor tyrosine kinase 0.0170615
PA2G4 proliferation-associated 2G4, 38kDa 0.0170068
RPL11 ribosomal protein L11 0.0169234
RPLP2 ribosomal protein, large, P2 0.0166711
KMT2E lysine (K)-specific methyltransferase 2E 0.0166629
RASSF8 Ras association (RalGDS/AF-6) domain family (N-terminal) member 8 0.0165311
COL5A2 collagen, type V, alpha 2 0.0164795
VIM vimentin 0.0164622
PGAM4 phosphoglycerate mutase family member 4 0.0163036

decreased expression

Symbol Name Standardized Value
MCL1 myeloid cell leukemia 1 -0.179684
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.173497
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.16085
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.152942
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 -0.108438
UBC ubiquitin C -0.0990045
RAD51B RAD51 paralog B -0.0903182
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0862348
AFF3 AF4/FMR2 family, member 3 -0.0804995
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0793896
SHANK2 SH3 and multiple ankyrin repeat domains 2 -0.0739919
NABP1 nucleic acid binding protein 1 -0.073301
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0673915
INTS6 integrator complex subunit 6 -0.0635953
MTHFD1L methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like -0.0621498
TFPI2 tissue factor pathway inhibitor 2 -0.0620942
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) -0.0620105
AEBP2 AE binding protein 2 -0.0615395
USP34 ubiquitin specific peptidase 34 -0.0611312
NF1 neurofibromin 1 -0.0591742
HMGA2 high mobility group AT-hook 2 -0.0589214
LRPPRC leucine-rich pentatricopeptide repeat containing -0.0583559
ERO1A endoplasmic reticulum oxidoreductase 1 alpha -0.057307
TAS2R14 taste receptor, type 2, member 14 -0.0569052
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0568652
FMNL2 formin-like 2 -0.0541598
EGR1 early growth response 1 -0.0537561
COPA coatomer protein complex, subunit alpha -0.0530062
THSD4 thrombospondin, type I, domain containing 4 -0.0522202
ATXN1 ataxin 1 -0.0508736
CSDE1 cold shock domain containing E1, RNA-binding -0.0508634
DDX5 DEAD (Asp-Glu-Ala-Asp) box helicase 5 -0.0503825
WNT2B wingless-type MMTV integration site family, member 2B -0.0498394
MACF1 microtubule-actin crosslinking factor 1 -0.0487367
MDGA2 MAM domain containing glycosylphosphatidylinositol anchor 2 -0.0484666
TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 -0.0482272
PRELID2 PRELI domain containing 2 -0.0477261
RAB7A RAB7A, member RAS oncogene family -0.0474246
RYR3 ryanodine receptor 3 -0.0464888
IMMP2L IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) -0.0452514
SPDYA speedy/RINGO cell cycle regulator family member A -0.0440443
PTPRN2 protein tyrosine phosphatase, receptor type, N polypeptide 2 -0.0438614
DENND1A DENN/MADD domain containing 1A -0.0438182
BIRC6 baculoviral IAP repeat containing 6 -0.0429441
GNAI3 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 3 -0.0424863
CANX calnexin -0.0423821
HNRNPC heterogeneous nuclear ribonucleoprotein C (C1/C2) -0.0419782
RAB1A RAB1A, member RAS oncogene family -0.0418822
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.041589
MCTP1 multiple C2 domains, transmembrane 1 -0.0413187
EIF4A1 eukaryotic translation initiation factor 4A1 -0.0405631
AHNAK AHNAK nucleoprotein -0.040044
PDIA4 protein disulfide isomerase family A, member 4 -0.0389304
CAMTA1 calmodulin binding transcription activator 1 -0.0373749
PPP6R3 protein phosphatase 6, regulatory subunit 3 -0.0367925
NEK10 NIMA-related kinase 10 -0.0363924
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.036142
PDLIM5 PDZ and LIM domain 5 -0.0359901
P4HB prolyl 4-hydroxylase, beta polypeptide -0.0357104
PPP1R10 protein phosphatase 1, regulatory subunit 10 -0.035474
GPATCH2L G patch domain containing 2-like -0.0353338
EGFR epidermal growth factor receptor -0.0352558
PRH1 proline-rich protein HaeIII subfamily 1 -0.0342585
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0340406
ACTN1 actinin, alpha 1 -0.033901
SUPT3H suppressor of Ty 3 homolog (S. cerevisiae) -0.0328568
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.032597
PDIA6 protein disulfide isomerase family A, member 6 -0.0321614
RPL23 ribosomal protein L23 -0.031927
ZNF217 zinc finger protein 217 -0.0316804
SRP72 signal recognition particle 72kDa -0.0316798
RPS27A ribosomal protein S27a -0.031671
TAOK1 TAO kinase 1 -0.0310318
CALU calumenin -0.0308132
VCL vinculin -0.0307022
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0303572
FMN1 formin 1 -0.0301858
SND1 staphylococcal nuclease and tudor domain containing 1 -0.0301599
TMEM263 transmembrane protein 263 -0.0299228
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0295927
HDLBP high density lipoprotein binding protein -0.0295576
MYL12A myosin, light chain 12A, regulatory, non-sarcomeric -0.0294363
SLC4A7 solute carrier family 4, sodium bicarbonate cotransporter, member 7 -0.029251
ACTR3 ARP3 actin-related protein 3 homolog (yeast) -0.0290882
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 -0.0289819
PDIA3 protein disulfide isomerase family A, member 3 -0.0285579
MON2 MON2 homolog (S. cerevisiae) -0.0282072
SETX senataxin -0.0280955
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) -0.0280919
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0279486
PRKCE protein kinase C, epsilon -0.0278949
PTK2 protein tyrosine kinase 2 -0.0277838
NBAS neuroblastoma amplified sequence -0.0277622
CALR calreticulin -0.027629
TRIP12 thyroid hormone receptor interactor 12 -0.0276039
SFPQ splicing factor proline/glutamine-rich -0.0274028
DDIT3 DNA-damage-inducible transcript 3 -0.0272894
CDK12 cyclin-dependent kinase 12 -0.0272279
BLTP2 bridge-like lipid transfer protein family member 2 -0.0272128
SAMD4A sterile alpha motif domain containing 4A -0.0269765