| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H2347 cell line (Tahoe Therapeutics) |
| Similar Terms | |
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200 genes differentially expressed following the Afatinib_NCI-H2347 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.166741 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.120703 |
| FTL | ferritin, light polypeptide | 0.0862826 |
| RACK1 | receptor for activated C kinase 1 | 0.0760786 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0734318 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0641119 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0626997 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0524538 |
| RPS3 | ribosomal protein S3 | 0.0509643 |
| RPS12 | ribosomal protein S12 | 0.0461057 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0397697 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0363631 |
| RPS17 | ribosomal protein S17 | 0.035548 |
| YBX1 | Y box binding protein 1 | 0.0351706 |
| TPM3 | tropomyosin 3 | 0.0336831 |
| RPS8 | ribosomal protein S8 | 0.0332234 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0331507 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0331347 |
| RPL3 | ribosomal protein L3 | 0.0328074 |
| PCBP2 | poly(rC) binding protein 2 | 0.0312164 |
| EEF1G | eukaryotic translation elongation factor 1 gamma | 0.0309528 |
| RPL23 | ribosomal protein L23 | 0.0304323 |
| RPL4 | ribosomal protein L4 | 0.0298685 |
| DSPP | dentin sialophosphoprotein | 0.0296193 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0287854 |
| SET | SET nuclear proto-oncogene | 0.0284023 |
| ZFP36L1 | ZFP36 ring finger protein-like 1 | 0.0279394 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.026011 |
| RPL12 | ribosomal protein L12 | 0.0251852 |
| ENO1 | enolase 1, (alpha) | 0.0248622 |
| HDGF | hepatoma-derived growth factor | 0.0242917 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0242483 |
| RPS27 | ribosomal protein S27 | 0.0242458 |
| RPS6 | ribosomal protein S6 | 0.0235033 |
| TPI1 | triosephosphate isomerase 1 | 0.0233763 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | 0.0233222 |
| RPLP0 | ribosomal protein, large, P0 | 0.0228358 |
| RPL7 | ribosomal protein L7 | 0.0227464 |
| RPS14 | ribosomal protein S14 | 0.0225588 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0219212 |
| VIM | vimentin | 0.0218739 |
| TMBIM6 | transmembrane BAX inhibitor motif containing 6 | 0.0218646 |
| LDHB | lactate dehydrogenase B | 0.0214929 |
| RPL37A | ribosomal protein L37a | 0.0205086 |
| ARRDC3 | arrestin domain containing 3 | 0.0197913 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0192382 |
| RPS2 | ribosomal protein S2 | 0.0192381 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0184495 |
| DSTN | destrin (actin depolymerizing factor) | 0.0176442 |
| RPL18 | ribosomal protein L18 | 0.0175862 |
| RPS19 | ribosomal protein S19 | 0.0173858 |
| CBX3 | chromobox homolog 3 | 0.0173553 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.0171071 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0161482 |
| RPL37 | ribosomal protein L37 | 0.0159918 |
| RPS4X | ribosomal protein S4, X-linked | 0.0157938 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.0154601 |
| HNRNPDL | heterogeneous nuclear ribonucleoprotein D-like | 0.015128 |
| GPX4 | glutathione peroxidase 4 | 0.0151246 |
| CD9 | CD9 molecule | 0.0148005 |
| AHNAK | AHNAK nucleoprotein | 0.0145795 |
| RPL5 | ribosomal protein L5 | 0.0142334 |
| RPL10A | ribosomal protein L10a | 0.0139679 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.013857 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0135725 |
| TMA7 | translation machinery associated 7 homolog (S. cerevisiae) | 0.0135534 |
| HMGA1 | high mobility group AT-hook 1 | 0.0135235 |
| AP2M1 | adaptor-related protein complex 2, mu 1 subunit | 0.0135097 |
| NACA | nascent polypeptide-associated complex alpha subunit | 0.0133736 |
| SSRP1 | structure specific recognition protein 1 | 0.0133449 |
| RPL8 | ribosomal protein L8 | 0.0133436 |
| HMGN2 | high mobility group nucleosomal binding domain 2 | 0.0129969 |
| PSMA7 | proteasome (prosome, macropain) subunit, alpha type, 7 | 0.0129881 |
| RPLP1 | ribosomal protein, large, P1 | 0.0129646 |
| RPL21 | ribosomal protein L21 | 0.0128511 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.012828 |
| TUBA1B | tubulin, alpha 1b | 0.0127285 |
| SLC25A5 | solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 5 | 0.0127236 |
| YWHAH | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta | 0.0126936 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0126211 |
| RPL11 | ribosomal protein L11 | 0.0125253 |
| MSN | moesin | 0.0124772 |
| RPL9 | ribosomal protein L9 | 0.0124506 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0123337 |
| PGAM4 | phosphoglycerate mutase family member 4 | 0.0122383 |
| HMGB2 | high mobility group box 2 | 0.0121146 |
| EPCAM | epithelial cell adhesion molecule | 0.0121022 |
| RPS7 | ribosomal protein S7 | 0.0118187 |
| PRKDC | protein kinase, DNA-activated, catalytic polypeptide | 0.0117789 |
| PKM | pyruvate kinase, muscle | 0.0117474 |
| PTGES3 | prostaglandin E synthase 3 (cytosolic) | 0.0117445 |
| RPL36 | ribosomal protein L36 | 0.0117021 |
| RPS27A | ribosomal protein S27a | 0.0117 |
| RPL27 | ribosomal protein L27 | 0.0116515 |
| SUPT16H | suppressor of Ty 16 homolog (S. cerevisiae) | 0.0115765 |
| MKI67 | marker of proliferation Ki-67 | 0.0114642 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | 0.0113127 |
| CENPF | centromere protein F, 350/400kDa | 0.0111392 |
| COX6C | cytochrome c oxidase subunit VIc | 0.0109723 |
| ANP32E | acidic (leucine-rich) nuclear phosphoprotein 32 family, member E | 0.0109305 |
| Symbol | Name | Standardized Value |
|---|---|---|
| NDRG1 | N-myc downstream regulated 1 | -0.195737 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.145496 |
| FN1 | fibronectin 1 | -0.138966 |
| ACTG1 | actin gamma 1 | -0.138782 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | -0.130653 |
| FNDC3B | fibronectin type III domain containing 3B | -0.126137 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.116151 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.107539 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.102253 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0897226 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0889166 |
| TSC22D2 | TSC22 domain family, member 2 | -0.085534 |
| PTK2 | protein tyrosine kinase 2 | -0.0829914 |
| LMO7 | LIM domain 7 | -0.0794525 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0784277 |
| CD2AP | CD2-associated protein | -0.0775491 |
| ERBIN | erbb2 interacting protein | -0.0761689 |
| MYO6 | myosin VI | -0.0761523 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0727033 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0702631 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0685094 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0656346 |
| GOLGA4 | golgin A4 | -0.0645706 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0638367 |
| LPP | LIM domain containing preferred translocation partner in lipoma | -0.0638049 |
| GRB10 | growth factor receptor-bound protein 10 | -0.0621389 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.060847 |
| RBM39 | RNA binding motif protein 39 | -0.0599801 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0586424 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | -0.0578449 |
| FHIP1A | FHF complex subunit HOOK interacting protein 1A | -0.0578193 |
| DTNA | dystrobrevin, alpha | -0.0577399 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0574706 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0570916 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0569712 |
| ASPH | aspartate beta-hydroxylase | -0.0564954 |
| FAM3C | family with sequence similarity 3, member C | -0.0554188 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0549246 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | -0.0548255 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0532111 |
| DSCAM | Down syndrome cell adhesion molecule | -0.0530868 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0524628 |
| EFNA5 | ephrin-A5 | -0.0524388 |
| KMT2E | lysine (K)-specific methyltransferase 2E | -0.051269 |
| SPAG9 | sperm associated antigen 9 | -0.0497661 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0495509 |
| RASA2 | RAS p21 protein activator 2 | -0.0491406 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0488073 |
| RCOR1 | REST corepressor 1 | -0.0485716 |
| JMJD1C | jumonji domain containing 1C | -0.04802 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.0478187 |
| NRIP1 | nuclear receptor interacting protein 1 | -0.0466897 |
| FBXO32 | F-box protein 32 | -0.0464908 |
| TMEM263 | transmembrane protein 263 | -0.0464562 |
| OGA | O-GlcNAcase | -0.0458518 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0453705 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0452317 |
| SDC4 | syndecan 4 | -0.0448147 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.044787 |
| LAMB3 | laminin, beta 3 | -0.044783 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0444043 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.0442709 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.0438061 |
| LAMC2 | laminin, gamma 2 | -0.0434237 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0423683 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0423218 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0422959 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0422564 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0420931 |
| RALGPS2 | Ral GEF with PH domain and SH3 binding motif 2 | -0.0420449 |
| NEK7 | NIMA-related kinase 7 | -0.041841 |
| RLF | rearranged L-myc fusion | -0.0411387 |
| SBF2 | SET binding factor 2 | -0.0404271 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0400193 |
| TMSB10 | thymosin beta 10 | -0.039901 |
| NFKBIZ | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta | -0.0395489 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0393873 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | -0.0391568 |
| ZFAND6 | zinc finger, AN1-type domain 6 | -0.0390675 |
| FLNB | filamin B, beta | -0.0389189 |
| MYO1E | myosin IE | -0.0387894 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0386944 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | -0.0384417 |
| MEF2A | myocyte enhancer factor 2A | -0.0383246 |
| CDC73 | cell division cycle 73 | -0.0382998 |
| NF1 | neurofibromin 1 | -0.0382833 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0378666 |
| ALCAM | activated leukocyte cell adhesion molecule | -0.0375707 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | -0.0374586 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -0.0372888 |
| CDCP1 | CUB domain containing protein 1 | -0.0369868 |
| RUNX1 | runt-related transcription factor 1 | -0.0368197 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0367952 |
| ZNF292 | zinc finger protein 292 | -0.0363592 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.0362414 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | -0.0360612 |
| UBE2E1 | ubiquitin-conjugating enzyme E2E 1 | -0.0360246 |
| TMEM165 | transmembrane protein 165 | -0.0357752 |
| ANKRD28 | ankyrin repeat domain 28 | -0.0356157 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.03547 |
