| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H460 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H460 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPS6 | ribosomal protein S6 | 0.118282 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.110687 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | 0.0888935 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0789514 |
| RPS2 | ribosomal protein S2 | 0.076925 |
| CDH11 | cadherin 11, type 2, OB-cadherin (osteoblast) | 0.0679975 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0658803 |
| SLC39A8 | solute carrier family 39 (zinc transporter), member 8 | 0.0646218 |
| GDA | guanine deaminase | 0.0643899 |
| RPS12 | ribosomal protein S12 | 0.0562724 |
| GRAMD1B | GRAM domain containing 1B | 0.0548123 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0515812 |
| VIM | vimentin | 0.0499239 |
| CTSL | cathepsin L | 0.0470497 |
| ADAMTS6 | ADAM metallopeptidase with thrombospondin type 1 motif, 6 | 0.0463323 |
| TMX4 | thioredoxin-related transmembrane protein 4 | 0.0450181 |
| MFF | mitochondrial fission factor | 0.0425707 |
| CD109 | CD109 molecule | 0.0424517 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0416016 |
| RPL37A | ribosomal protein L37a | 0.0414244 |
| RPL26 | ribosomal protein L26 | 0.0411007 |
| RACK1 | receptor for activated C kinase 1 | 0.0400603 |
| RPS8 | ribosomal protein S8 | 0.0394099 |
| RAB3B | RAB3B, member RAS oncogene family | 0.0389385 |
| STC1 | stanniocalcin 1 | 0.0377447 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | 0.0361753 |
| B2M | beta-2-microglobulin | 0.0360863 |
| CENPF | centromere protein F, 350/400kDa | 0.0360847 |
| RPS19 | ribosomal protein S19 | 0.0352814 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0350065 |
| IGFBP3 | insulin-like growth factor binding protein 3 | 0.0346826 |
| PYGL | phosphorylase, glycogen, liver | 0.0343683 |
| LAMB1 | laminin, beta 1 | 0.0336577 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0335807 |
| SOX4 | SRY (sex determining region Y)-box 4 | 0.0334292 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0330837 |
| MSN | moesin | 0.0324605 |
| RPS27 | ribosomal protein S27 | 0.0324218 |
| SH3KBP1 | SH3-domain kinase binding protein 1 | 0.0319043 |
| SERPINB2 | serpin peptidase inhibitor, clade B (ovalbumin), member 2 | 0.0311883 |
| SLC7A2 | solute carrier family 7 (cationic amino acid transporter, y+ system), member 2 | 0.0309384 |
| MKI67 | marker of proliferation Ki-67 | 0.0308646 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0307818 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0304873 |
| RPS17 | ribosomal protein S17 | 0.030391 |
| RPL3 | ribosomal protein L3 | 0.0302413 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0300906 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0299885 |
| RPL36A | ribosomal protein L36a | 0.0299597 |
| HLA-A | major histocompatibility complex, class I, A | 0.0297246 |
| SFTPA2 | surfactant protein A2 | 0.0291671 |
| TBXT | T-box transcription factor T | 0.0284258 |
| RPL11 | ribosomal protein L11 | 0.0282346 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0273935 |
| COL8A1 | collagen, type VIII, alpha 1 | 0.0273376 |
| RPL37 | ribosomal protein L37 | 0.0270951 |
| RPS14 | ribosomal protein S14 | 0.0269036 |
| NTN4 | netrin 4 | 0.0268163 |
| RPS3 | ribosomal protein S3 | 0.0267712 |
| RPL31 | ribosomal protein L31 | 0.0265893 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0261546 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.025651 |
| RPL7 | ribosomal protein L7 | 0.0252109 |
| EIF1 | eukaryotic translation initiation factor 1 | 0.0247875 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0247111 |
| TMSB4X | thymosin beta 4, X-linked | 0.0240244 |
| ESM1 | endothelial cell-specific molecule 1 | 0.0238173 |
| RPS23 | ribosomal protein S23 | 0.0236863 |
| RPL9 | ribosomal protein L9 | 0.0236674 |
| INHBA | inhibin, beta A | 0.0235982 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0234637 |
| DISP1 | dispatched homolog 1 (Drosophila) | 0.0232973 |
| RPL21 | ribosomal protein L21 | 0.0232913 |
| GPRIN3 | GPRIN family member 3 | 0.0227555 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0226582 |
| RPL35A | ribosomal protein L35a | 0.0223371 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0222894 |
| SLK | STE20-like kinase | 0.0222674 |
| RPL7A | ribosomal protein L7a | 0.0217532 |
| TNFAIP3 | tumor necrosis factor, alpha-induced protein 3 | 0.0216152 |
| TPI1 | triosephosphate isomerase 1 | 0.0215908 |
| RPL36 | ribosomal protein L36 | 0.0205745 |
| CDC42BPA | CDC42 binding protein kinase alpha (DMPK-like) | 0.0204426 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0204046 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0201646 |
| CD44 | CD44 molecule (Indian blood group) | 0.0196738 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.0193326 |
| RPS13 | ribosomal protein S13 | 0.0192391 |
| CLU | clusterin | 0.0191438 |
| STC2 | stanniocalcin 2 | 0.0187651 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0187546 |
| UBXN4 | UBX domain protein 4 | 0.0187165 |
| TXNIP | thioredoxin interacting protein | 0.0187151 |
| PDLIM5 | PDZ and LIM domain 5 | 0.0186819 |
| NRCAM | neuronal cell adhesion molecule | 0.0186493 |
| HADHA | hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA thiolase/enoyl-CoA hydratase (trifunctional protein), alpha subunit | 0.0181653 |
| ATF4 | activating transcription factor 4 | 0.0181166 |
| VPS13C | vacuolar protein sorting 13 homolog C (S. cerevisiae) | 0.0177975 |
| BCAR3 | breast cancer anti-estrogen resistance 3 | 0.0175843 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0174688 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.356153 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.229754 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.13779 |
| FN1 | fibronectin 1 | -0.128742 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.124326 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.123677 |
| UBC | ubiquitin C | -0.111588 |
| LIMCH1 | LIM and calponin homology domains 1 | -0.104078 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.10361 |
| CANX | calnexin | -0.0917018 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.0850105 |
| VCL | vinculin | -0.0782567 |
| TMSB10 | thymosin beta 10 | -0.0760867 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0699139 |
| SPAG9 | sperm associated antigen 9 | -0.0685305 |
| OGA | O-GlcNAcase | -0.065861 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0656916 |
| EFNA5 | ephrin-A5 | -0.0647446 |
| EIF4A1 | eukaryotic translation initiation factor 4A1 | -0.0642066 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.063724 |
| PDIA4 | protein disulfide isomerase family A, member 4 | -0.063155 |
| CRIM1 | cysteine rich transmembrane BMP regulator 1 (chordin-like) | -0.0630985 |
| RPS27A | ribosomal protein S27a | -0.0630355 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0627071 |
| CDH13 | cadherin 13 | -0.059813 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0582774 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0572497 |
| DST | dystonin | -0.056736 |
| PDE10A | phosphodiesterase 10A | -0.0555754 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0548172 |
| ASPH | aspartate beta-hydroxylase | -0.0514389 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0506208 |
| ATP1B3 | ATPase, Na+/K+ transporting, beta 3 polypeptide | -0.0499163 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | -0.0497144 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.047621 |
| ACTG1 | actin gamma 1 | -0.0463041 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0457039 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0454076 |
| AHNAK | AHNAK nucleoprotein | -0.0452686 |
| MARCHF1 | membrane associated ring-CH-type finger 1 | -0.0450642 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0449716 |
| FNDC3B | fibronectin type III domain containing 3B | -0.0448801 |
| MORF4L2 | mortality factor 4 like 2 | -0.0440983 |
| TGFBR1 | transforming growth factor, beta receptor 1 | -0.043224 |
| INTS6 | integrator complex subunit 6 | -0.0424848 |
| COPA | coatomer protein complex, subunit alpha | -0.041868 |
| NT5C2 | 5'-nucleotidase, cytosolic II | -0.0418176 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0415079 |
| PRELID2 | PRELI domain containing 2 | -0.0414137 |
| DENND1A | DENN/MADD domain containing 1A | -0.041273 |
| MYOF | myoferlin | -0.0403448 |
| PTPRM | protein tyrosine phosphatase, receptor type, M | -0.0403187 |
| ADGRD1 | adhesion G protein-coupled receptor D1 | -0.0402127 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0396797 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.0396269 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0394928 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0393223 |
| PGK1 | phosphoglycerate kinase 1 | -0.0392764 |
| LDHA | lactate dehydrogenase A | -0.0391601 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | -0.0382877 |
| CTBP2 | C-terminal binding protein 2 | -0.0377608 |
| ENO1 | enolase 1, (alpha) | -0.0377543 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0370393 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.036413 |
| LRPPRC | leucine-rich pentatricopeptide repeat containing | -0.0360533 |
| DYNC1H1 | dynein, cytoplasmic 1, heavy chain 1 | -0.0357986 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.035287 |
| PDIA6 | protein disulfide isomerase family A, member 6 | -0.0351478 |
| LSAMP | limbic system-associated membrane protein | -0.0347341 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.0344734 |
| PDIA3 | protein disulfide isomerase family A, member 3 | -0.0342318 |
| HDLBP | high density lipoprotein binding protein | -0.0341961 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0339654 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0337378 |
| CALR | calreticulin | -0.0337208 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0337004 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.033516 |
| NCOA7 | nuclear receptor coactivator 7 | -0.0334396 |
| RBM39 | RNA binding motif protein 39 | -0.0329595 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0327875 |
| HELZ | helicase with zinc finger | -0.0326504 |
| WDR45B | WD repeat domain 45B | -0.0324245 |
| USP34 | ubiquitin specific peptidase 34 | -0.0320698 |
| NBAS | neuroblastoma amplified sequence | -0.0319884 |
| EPHA4 | EPH receptor A4 | -0.0318513 |
| CALU | calumenin | -0.0318226 |
| LMAN1 | lectin, mannose-binding, 1 | -0.0317122 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0317072 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0316373 |
| KMT2C | lysine (K)-specific methyltransferase 2C | -0.0312723 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0309853 |
| STARD4 | StAR-related lipid transfer (START) domain containing 4 | -0.0307582 |
| PLCB4 | phospholipase C, beta 4 | -0.0305114 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0300625 |
| RAP1B | RAP1B, member of RAS oncogene family | -0.0300188 |
| NUFIP2 | nuclear fragile X mental retardation protein interacting protein 2 | -0.0299336 |
| RPS24 | ribosomal protein S24 | -0.0298025 |
| SRPK2 | SRSF protein kinase 2 | -0.0295882 |
| LAMA1 | laminin, alpha 1 | -0.0294305 |
| PSMD14 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 14 | -0.0293852 |
