| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H596 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H596 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| ROBO2 | roundabout, axon guidance receptor, homolog 2 (Drosophila) | 0.193416 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.102768 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | 0.0997817 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.099284 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0975981 |
| EFNA5 | ephrin-A5 | 0.0965438 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | 0.095791 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0944407 |
| APP | amyloid beta (A4) precursor protein | 0.0923266 |
| PTPRG | protein tyrosine phosphatase, receptor type, G | 0.0899239 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0878096 |
| CTNNA1 | catenin (cadherin-associated protein), alpha 1, 102kDa | 0.0863826 |
| LPP | LIM domain containing preferred translocation partner in lipoma | 0.0846931 |
| WNK1 | WNK lysine deficient protein kinase 1 | 0.0791811 |
| COPA | coatomer protein complex, subunit alpha | 0.0777813 |
| MSI2 | musashi RNA-binding protein 2 | 0.0771398 |
| GPC6 | glypican 6 | 0.07659 |
| AKAP9 | A kinase (PRKA) anchor protein 9 | 0.0765541 |
| YWHAG | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma | 0.0751372 |
| FTL | ferritin, light polypeptide | 0.07287 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0724436 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | 0.0717476 |
| OXR1 | oxidation resistance 1 | 0.0707343 |
| DST | dystonin | 0.0669999 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 0.0668902 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0667503 |
| FAT1 | FAT atypical cadherin 1 | 0.0667401 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0661896 |
| RUNX1 | runt-related transcription factor 1 | 0.0644971 |
| ASPH | aspartate beta-hydroxylase | 0.0632988 |
| IGF2 | insulin-like growth factor 2 | 0.0631123 |
| MDM2 | MDM2 proto-oncogene, E3 ubiquitin protein ligase | 0.0628101 |
| MAML2 | mastermind-like 2 (Drosophila) | 0.0621533 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0621192 |
| KRT18 | keratin 18, type I | 0.0601837 |
| DENND1A | DENN/MADD domain containing 1A | 0.0580542 |
| NKTR | natural killer cell triggering receptor | 0.0568773 |
| TCF12 | transcription factor 12 | 0.0560332 |
| LOXL2 | lysyl oxidase-like 2 | 0.0559744 |
| SND1 | staphylococcal nuclease and tudor domain containing 1 | 0.0553861 |
| FLNB | filamin B, beta | 0.0549332 |
| BRWD3 | bromodomain and WD repeat domain containing 3 | 0.0542508 |
| ARHGAP26 | Rho GTPase activating protein 26 | 0.0538875 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.053275 |
| MGAT5 | mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase | 0.0522429 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0504403 |
| REV3L | REV3-like, polymerase (DNA directed), zeta, catalytic subunit | 0.0501482 |
| TOP1 | topoisomerase (DNA) I | 0.0497698 |
| SMYD3 | SET and MYND domain containing 3 | 0.049698 |
| DSPP | dentin sialophosphoprotein | 0.0494805 |
| LMO7 | LIM domain 7 | 0.0486183 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | 0.0483485 |
| PRKG1 | protein kinase, cGMP-dependent, type I | 0.0479386 |
| BCL2L1 | BCL2-like 1 | 0.0469888 |
| RTN4 | reticulon 4 | 0.0467177 |
| RICTOR | RPTOR independent companion of MTOR, complex 2 | 0.0464863 |
| USP34 | ubiquitin specific peptidase 34 | 0.0457893 |
| ENO1 | enolase 1, (alpha) | 0.0454337 |
| ZNF148 | zinc finger protein 148 | 0.0451664 |
| RBM39 | RNA binding motif protein 39 | 0.043533 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.043243 |
| COL6A3 | collagen, type VI, alpha 3 | 0.042352 |
| PCGF5 | polycomb group ring finger 5 | 0.0422722 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | 0.0420018 |
| EHBP1 | EH domain binding protein 1 | 0.0418295 |
| ATRX | alpha thalassemia/mental retardation syndrome X-linked | 0.0405539 |
| PRRC2C | proline-rich coiled-coil 2C | 0.0402098 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | 0.039886 |
| NALF1 | NALCN channel auxiliary factor 1 | 0.0392577 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.039151 |
| HELZ | helicase with zinc finger | 0.0389866 |
| SYT1 | synaptotagmin I | 0.0380647 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0376924 |
| SH3D19 | SH3 domain containing 19 | 0.0376616 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 0.0374271 |
| PCBP2 | poly(rC) binding protein 2 | 0.0374173 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0373897 |
| DTNA | dystrobrevin, alpha | 0.0373158 |
| CSNK1A1 | casein kinase 1, alpha 1 | 0.0370498 |
| NAV2 | neuron navigator 2 | 0.0366717 |
| KDM2A | lysine (K)-specific demethylase 2A | 0.0350618 |
| H1-0 | H1.0 linker histone | 0.0340964 |
| AFF1 | AF4/FMR2 family, member 1 | 0.0332052 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | 0.0300878 |
| INHBA | inhibin, beta A | 0.0292664 |
| EXOC4 | exocyst complex component 4 | 0.0291602 |
| DSCAM | Down syndrome cell adhesion molecule | 0.0286166 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | 0.0278415 |
| NCEH1 | neutral cholesterol ester hydrolase 1 | 0.0270523 |
| ALCAM | activated leukocyte cell adhesion molecule | 0.0270123 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0269951 |
| RPL23 | ribosomal protein L23 | 0.0267533 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0262631 |
| TBC1D22A | TBC1 domain family, member 22A | 0.0257244 |
| RPS25 | ribosomal protein S25 | 0.0256778 |
| PSME4 | proteasome (prosome, macropain) activator subunit 4 | 0.0246253 |
| NAV1 | neuron navigator 1 | 0.0242709 |
| RPL37 | ribosomal protein L37 | 0.0241458 |
| ARID1B | AT rich interactive domain 1B (SWI1-like) | 0.0229694 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0228462 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.212847 |
| VIM | vimentin | -0.184124 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.167884 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.133449 |
| CXCL8 | chemokine (C-X-C motif) ligand 8 | -0.130019 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.126496 |
| LAMA4 | laminin, alpha 4 | -0.1239 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.1069 |
| EGFR | epidermal growth factor receptor | -0.102901 |
| RBPJ | recombination signal binding protein for immunoglobulin kappa J region | -0.100877 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0970736 |
| PDE10A | phosphodiesterase 10A | -0.0903697 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0890968 |
| RPL15 | ribosomal protein L15 | -0.0881261 |
| PITPNC1 | phosphatidylinositol transfer protein, cytoplasmic 1 | -0.0843459 |
| RPL19 | ribosomal protein L19 | -0.0831169 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0810859 |
| TXNRD1 | thioredoxin reductase 1 | -0.0761291 |
| MCL1 | myeloid cell leukemia 1 | -0.0743636 |
| EIF4G3 | eukaryotic translation initiation factor 4 gamma, 3 | -0.0733791 |
| KTN1 | kinectin 1 (kinesin receptor) | -0.0726096 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.0721982 |
| ATF6 | activating transcription factor 6 | -0.0717013 |
| SLTM | SAFB-like, transcription modulator | -0.0689207 |
| CDH13 | cadherin 13 | -0.0688782 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | -0.0679137 |
| ELL2 | elongation factor, RNA polymerase II, 2 | -0.0671403 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0670622 |
| EIF1 | eukaryotic translation initiation factor 1 | -0.0636538 |
| HERC4 | HECT and RLD domain containing E3 ubiquitin protein ligase 4 | -0.0590399 |
| CCNI | cyclin I | -0.0590263 |
| NF1 | neurofibromin 1 | -0.0573212 |
| FAM13A | family with sequence similarity 13, member A | -0.0569936 |
| CADM2 | cell adhesion molecule 2 | -0.0564776 |
| FNDC3A | fibronectin type III domain containing 3A | -0.0558721 |
| SMC5 | structural maintenance of chromosomes 5 | -0.0552662 |
| RPS8 | ribosomal protein S8 | -0.0543115 |
| PKM | pyruvate kinase, muscle | -0.0538434 |
| GSK3B | glycogen synthase kinase 3 beta | -0.0518786 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.0511328 |
| HNRNPC | heterogeneous nuclear ribonucleoprotein C (C1/C2) | -0.0510649 |
| ZNF608 | zinc finger protein 608 | -0.0508566 |
| FN1 | fibronectin 1 | -0.0507073 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | -0.0506572 |
| ARRDC3 | arrestin domain containing 3 | -0.0490289 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0454624 |
| PRELID2 | PRELI domain containing 2 | -0.0452524 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0448728 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | -0.0439401 |
| SEMA3D | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3D | -0.0431817 |
| POTEF | POTE ankyrin domain family, member F | -0.0428639 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0428425 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0427906 |
| PEG10 | paternally expressed 10 | -0.0427157 |
| MAML3 | mastermind-like 3 (Drosophila) | -0.0422601 |
| CEP170 | centrosomal protein 170kDa | -0.0420936 |
| ATP11A | ATPase, class VI, type 11A | -0.0420195 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | -0.0416429 |
| RSF1 | remodeling and spacing factor 1 | -0.0412432 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | -0.03992 |
| PDLIM5 | PDZ and LIM domain 5 | -0.039208 |
| ANXA2 | annexin A2 | -0.0372512 |
| RPL11 | ribosomal protein L11 | -0.0367353 |
| TMEM165 | transmembrane protein 165 | -0.0367126 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0366794 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | -0.0365711 |
| SRRM2 | serine/arginine repetitive matrix 2 | -0.0358735 |
| RORA | RAR-related orphan receptor A | -0.0357256 |
| MED13L | mediator complex subunit 13-like | -0.0356116 |
| PTMA | prothymosin, alpha | -0.0353203 |
| OGA | O-GlcNAcase | -0.035089 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | -0.0348178 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0347782 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0346487 |
| MAP4 | microtubule-associated protein 4 | -0.0336024 |
| PDE3A | phosphodiesterase 3A, cGMP-inhibited | -0.0334027 |
| MAP1B | microtubule-associated protein 1B | -0.03113 |
| TAF1B | TATA box binding protein (TBP)-associated factor, RNA polymerase I, B, 63kDa | -0.0306543 |
| RPS6 | ribosomal protein S6 | -0.0304471 |
| RPL34 | ribosomal protein L34 | -0.02885 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | -0.0282133 |
| ANKRD12 | ankyrin repeat domain 12 | -0.0281802 |
| SEPTIN9 | septin 9 | -0.0259963 |
| KDM4C | lysine (K)-specific demethylase 4C | -0.0258812 |
| GREM1 | gremlin 1, DAN family BMP antagonist | -0.0256058 |
| PGK1 | phosphoglycerate kinase 1 | -0.0249402 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | -0.0249315 |
| ARIH1 | ariadne RBR E3 ubiquitin protein ligase 1 | -0.0248157 |
| LTBP1 | latent transforming growth factor beta binding protein 1 | -0.0241908 |
| NDRG1 | N-myc downstream regulated 1 | -0.0239515 |
| TUT7 | terminal uridylyl transferase 7 | -0.0234251 |
| NRXN3 | neurexin 3 | -0.0233882 |
| RPLP1 | ribosomal protein, large, P1 | -0.0232143 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0228707 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.022246 |
| JARID2 | jumonji, AT rich interactive domain 2 | -0.0222163 |
| DPP10 | dipeptidyl-peptidase 10 (non-functional) | -0.0222075 |
| VMP1 | vacuole membrane protein 1 | -0.0219576 |
| RPS12 | ribosomal protein S12 | -0.0215869 |
| INTS6 | integrator complex subunit 6 | -0.0215545 |
