| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in NCI-H661 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_NCI-H661 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.118537 |
| PCLO | piccolo presynaptic cytomatrix protein | 0.113327 |
| CADM2 | cell adhesion molecule 2 | 0.0748915 |
| COL3A1 | collagen, type III, alpha 1 | 0.0729148 |
| FOXP2 | forkhead box P2 | 0.0573102 |
| PTMA | prothymosin, alpha | 0.0572217 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0569421 |
| ENAH | enabled homolog (Drosophila) | 0.045771 |
| CTNNA2 | catenin (cadherin-associated protein), alpha 2 | 0.0436467 |
| SET | SET nuclear proto-oncogene | 0.0419675 |
| DNAH14 | dynein, axonemal, heavy chain 14 | 0.0402991 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.040086 |
| GPC3 | glypican 3 | 0.0400208 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0398473 |
| RPL37 | ribosomal protein L37 | 0.039641 |
| KCTD16 | potassium channel tetramerization domain containing 16 | 0.0393711 |
| COL1A2 | collagen, type I, alpha 2 | 0.0388063 |
| NCKAP1 | NCK-associated protein 1 | 0.0369843 |
| NCAM2 | neural cell adhesion molecule 2 | 0.0364192 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.033286 |
| DNAJC5 | DnaJ (Hsp40) homolog, subfamily C, member 5 | 0.0326856 |
| NBEA | neurobeachin | 0.032328 |
| EXOC4 | exocyst complex component 4 | 0.0315665 |
| RIMS2 | regulating synaptic membrane exocytosis 2 | 0.0315001 |
| MBD5 | methyl-CpG binding domain protein 5 | 0.0314133 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.0312064 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 0.0306165 |
| WDPCP | WD repeat containing planar cell polarity effector | 0.0301605 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0301073 |
| MACROD2 | MACRO domain containing 2 | 0.0298795 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.0297407 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0294821 |
| RPL7A | ribosomal protein L7a | 0.0290695 |
| BMPR2 | bone morphogenetic protein receptor, type II (serine/threonine kinase) | 0.0283748 |
| CABLES1 | Cdk5 and Abl enzyme substrate 1 | 0.0281056 |
| TNFRSF19 | tumor necrosis factor receptor superfamily, member 19 | 0.0280475 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0275993 |
| WWOX | WW domain containing oxidoreductase | 0.0272226 |
| MED12L | mediator complex subunit 12-like | 0.0270376 |
| HCN1 | hyperpolarization activated cyclic nucleotide gated potassium channel 1 | 0.0267269 |
| CUL4B | cullin 4B | 0.0266125 |
| SEMA3C | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | 0.0263979 |
| GPC4 | glypican 4 | 0.0263092 |
| IFIH1 | interferon induced with helicase C domain 1 | 0.0260952 |
| USP25 | ubiquitin specific peptidase 25 | 0.026019 |
| XPO1 | exportin 1 | 0.0257704 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0257543 |
| RPS12 | ribosomal protein S12 | 0.025722 |
| SERINC1 | serine incorporator 1 | 0.0255847 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0255555 |
| IVNS1ABP | influenza virus NS1A binding protein | 0.0243709 |
| EPB41L3 | erythrocyte membrane protein band 4.1-like 3 | 0.0241271 |
| GSE1 | Gse1 coiled-coil protein | 0.0240695 |
| KCNQ5 | potassium channel, voltage gated KQT-like subfamily Q, member 5 | 0.0239531 |
| DDX1 | DEAD (Asp-Glu-Ala-Asp) box helicase 1 | 0.0238529 |
| CNTN6 | contactin 6 | 0.0238146 |
| ZNF292 | zinc finger protein 292 | 0.0237645 |
| TXNRD1 | thioredoxin reductase 1 | 0.0234441 |
| HMCN1 | hemicentin 1 | 0.023438 |
| KIF1C | kinesin family member 1C | 0.0229822 |
| SNX6 | sorting nexin 6 | 0.0229147 |
| MBOAT2 | membrane bound O-acyltransferase domain containing 2 | 0.0228391 |
| HSPA9 | heat shock 70kDa protein 9 (mortalin) | 0.02269 |
| FARS2 | phenylalanyl-tRNA synthetase 2, mitochondrial | 0.0225429 |
| EIF4G2 | eukaryotic translation initiation factor 4 gamma, 2 | 0.0225023 |
| SLIT2 | slit homolog 2 (Drosophila) | 0.0224303 |
| RPL21 | ribosomal protein L21 | 0.0223362 |
| VAPA | VAMP (vesicle-associated membrane protein)-associated protein A, 33kDa | 0.0220947 |
| TIAM2 | T-cell lymphoma invasion and metastasis 2 | 0.0220194 |
| GNL3L | guanine nucleotide binding protein-like 3 (nucleolar)-like | 0.0218875 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0218508 |
| ISG15 | ISG15 ubiquitin-like modifier | 0.0215753 |
| SPIRE1 | spire-type actin nucleation factor 1 | 0.0211661 |
| RPL27 | ribosomal protein L27 | 0.0209856 |
| LBR | lamin B receptor | 0.0206436 |
| UNC5C | unc-5 homolog C (C. elegans) | 0.0205025 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.020485 |
| ZNF518A | zinc finger protein 518A | 0.0203957 |
| AUTS2 | autism susceptibility candidate 2 | 0.0201942 |
| WDR3 | WD repeat domain 3 | 0.0201881 |
| MTX2 | metaxin 2 | 0.0200807 |
| USP22 | ubiquitin specific peptidase 22 | 0.0199121 |
| GLS2 | glutaminase 2 (liver, mitochondrial) | 0.0197261 |
| AKT2 | v-akt murine thymoma viral oncogene homolog 2 | 0.0197088 |
| TMSB4X | thymosin beta 4, X-linked | 0.0196765 |
| POU2F1 | POU class 2 homeobox 1 | 0.0196363 |
| ACTR3 | ARP3 actin-related protein 3 homolog (yeast) | 0.0196114 |
| CHML | choroideremia-like (Rab escort protein 2) | 0.0192896 |
| DAG1 | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 0.0192419 |
| CCNL1 | cyclin L1 | 0.0192339 |
| TUBA1A | tubulin, alpha 1a | 0.0192259 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0191716 |
| RPL9 | ribosomal protein L9 | 0.0191189 |
| RPRD2 | regulation of nuclear pre-mRNA domain containing 2 | 0.0189276 |
| LRBA | LPS-responsive vesicle trafficking, beach and anchor containing | 0.0188163 |
| FMR1 | fragile X mental retardation 1 | 0.0185468 |
| WSB1 | WD repeat and SOCS box containing 1 | 0.0184728 |
| TTC28 | tetratricopeptide repeat domain 28 | 0.0184621 |
| CNN3 | calponin 3, acidic | 0.0184591 |
| DDAH1 | dimethylarginine dimethylaminohydrolase 1 | 0.0184507 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.181696 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.127373 |
| FNDC3B | fibronectin type III domain containing 3B | -0.120226 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.112846 |
| ERBB4 | erb-b2 receptor tyrosine kinase 4 | -0.110008 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.103147 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0967377 |
| ANKRD33B | ankyrin repeat domain 33B | -0.0789175 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0763774 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | -0.07597 |
| NIPBL | Nipped-B homolog (Drosophila) | -0.0739569 |
| AHNAK | AHNAK nucleoprotein | -0.0695053 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0669016 |
| ZFPM2 | zinc finger protein, FOG family member 2 | -0.0668951 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.0656999 |
| ARHGAP15 | Rho GTPase activating protein 15 | -0.0591082 |
| RALGAPA1 | Ral GTPase activating protein, alpha subunit 1 (catalytic) | -0.0580276 |
| SEC31A | SEC31 homolog A (S. cerevisiae) | -0.056893 |
| EMP1 | epithelial membrane protein 1 | -0.0550767 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0540988 |
| ARID2 | AT rich interactive domain 2 (ARID, RFX-like) | -0.0530623 |
| HDAC9 | histone deacetylase 9 | -0.0529198 |
| TMSB10 | thymosin beta 10 | -0.0521557 |
| NRG1 | neuregulin 1 | -0.0512886 |
| RPLP1 | ribosomal protein, large, P1 | -0.0511804 |
| SRP54 | signal recognition particle 54kDa | -0.0509495 |
| STRN3 | striatin, calmodulin binding protein 3 | -0.0507101 |
| SHROOM3 | shroom family member 3 | -0.0501894 |
| PRKD1 | protein kinase D1 | -0.0500169 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0486374 |
| RPL23 | ribosomal protein L23 | -0.0485955 |
| PFN1 | profilin 1 | -0.0480257 |
| NTM | neurotrimin | -0.047987 |
| TPR | translocated promoter region, nuclear basket protein | -0.0476028 |
| LHFPL6 | LHFPL tetraspan subfamily member 6 | -0.047275 |
| NHSL1 | NHS-like 1 | -0.0467149 |
| POTEF | POTE ankyrin domain family, member F | -0.0466671 |
| NFIA | nuclear factor I/A | -0.0464237 |
| NOP58 | NOP58 ribonucleoprotein | -0.0455552 |
| MORF4L2 | mortality factor 4 like 2 | -0.0455121 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0454078 |
| ADGRL2 | adhesion G protein-coupled receptor L2 | -0.0453558 |
| RPL19 | ribosomal protein L19 | -0.0444151 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | -0.0439576 |
| ANXA2 | annexin A2 | -0.043717 |
| COPA | coatomer protein complex, subunit alpha | -0.0435363 |
| PGAP1 | post-GPI attachment to proteins 1 | -0.0429152 |
| RTN4 | reticulon 4 | -0.0428033 |
| RERE | arginine-glutamic acid dipeptide (RE) repeats | -0.0422715 |
| G2E3 | G2/M-phase specific E3 ubiquitin protein ligase | -0.0421961 |
| SETD5 | SET domain containing 5 | -0.0417347 |
| UBR5 | ubiquitin protein ligase E3 component n-recognin 5 | -0.0414798 |
| RAI1 | retinoic acid induced 1 | -0.040848 |
| SGO2 | shugoshin 2 | -0.0408285 |
| ZBTB35 | zinc finger and BTB domain containing 35 | -0.0402725 |
| MED13L | mediator complex subunit 13-like | -0.0393889 |
| PHIP | pleckstrin homology domain interacting protein | -0.0393199 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0390985 |
| THOC2 | THO complex 2 | -0.038996 |
| HDLBP | high density lipoprotein binding protein | -0.038548 |
| GOLGA4 | golgin A4 | -0.0384722 |
| CALR | calreticulin | -0.0380472 |
| MRPS6 | mitochondrial ribosomal protein S6 | -0.0378404 |
| PTK2 | protein tyrosine kinase 2 | -0.0374927 |
| TENM3 | teneurin transmembrane protein 3 | -0.0373995 |
| NEBL | nebulette | -0.03736 |
| NCOR2 | nuclear receptor corepressor 2 | -0.0373137 |
| FNIP1 | folliculin interacting protein 1 | -0.0373113 |
| TRPS1 | trichorhinophalangeal syndrome I | -0.0371395 |
| HMGB1 | high mobility group box 1 | -0.0368351 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0365817 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | -0.0365735 |
| CKAP2 | cytoskeleton associated protein 2 | -0.0363619 |
| MARCHF6 | membrane associated ring-CH-type finger 6 | -0.0363568 |
| RHOA | ras homolog family member A | -0.0361022 |
| DENND1A | DENN/MADD domain containing 1A | -0.0358821 |
| FBL | fibrillarin | -0.03572 |
| SEMA3A | sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A | -0.0355498 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0352231 |
| NR6A1 | nuclear receptor subfamily 6, group A, member 1 | -0.0349791 |
| RAD51B | RAD51 paralog B | -0.0347501 |
| RSF1 | remodeling and spacing factor 1 | -0.0346438 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0344438 |
| JMJD1C | jumonji domain containing 1C | -0.0340398 |
| SCFD1 | sec1 family domain containing 1 | -0.0338964 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.0334056 |
| NXN | nucleoredoxin | -0.0333539 |
| DENND4C | DENN/MADD domain containing 4C | -0.0332464 |
| ERC2 | ELKS/RAB6-interacting/CAST family member 2 | -0.033234 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0331079 |
| DNAJC1 | DnaJ (Hsp40) homolog, subfamily C, member 1 | -0.0330526 |
| VIM | vimentin | -0.0330077 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0329643 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0328052 |
| TAOK1 | TAO kinase 1 | -0.032646 |
| EZH2 | enhancer of zeste 2 polycomb repressive complex 2 subunit | -0.032627 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0324779 |
| LSM14A | LSM14A, SCD6 homolog A (S. cerevisiae) | -0.0321906 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0321139 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | -0.032094 |
