| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in SNU-1 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_SNU-1 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| RPL3 | ribosomal protein L3 | 0.0520916 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0454486 |
| SAMD4A | sterile alpha motif domain containing 4A | 0.0252083 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0234641 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0225026 |
| ANK2 | ankyrin 2, neuronal | 0.0223371 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0204016 |
| CCNL1 | cyclin L1 | 0.0201656 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0194812 |
| NAMPT | nicotinamide phosphoribosyltransferase | 0.0194668 |
| BACH2 | BTB and CNC homology 1, basic leucine zipper transcription factor 2 | 0.018244 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0177606 |
| RPS12 | ribosomal protein S12 | 0.0162929 |
| PCBP2 | poly(rC) binding protein 2 | 0.016141 |
| PSAT1 | phosphoserine aminotransferase 1 | 0.0160032 |
| ATF4 | activating transcription factor 4 | 0.0154682 |
| MT2A | metallothionein 2A | 0.0146337 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0144806 |
| RPS3 | ribosomal protein S3 | 0.0142198 |
| NCKAP1 | NCK-associated protein 1 | 0.0141698 |
| HIVEP2 | human immunodeficiency virus type I enhancer binding protein 2 | 0.0140237 |
| HDGF | hepatoma-derived growth factor | 0.0138388 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0137141 |
| SLC7A11 | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 | 0.0133894 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | 0.0133802 |
| CABIN1 | calcineurin binding protein 1 | 0.0132343 |
| OGT | O-linked N-acetylglucosamine (GlcNAc) transferase | 0.0132 |
| ITSN1 | intersectin 1 (SH3 domain protein) | 0.013162 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0128484 |
| SESN2 | sestrin 2 | 0.0128187 |
| RPS2 | ribosomal protein S2 | 0.0126111 |
| PLXNA1 | plexin A1 | 0.012604 |
| EFNA5 | ephrin-A5 | 0.0125465 |
| CTNND1 | catenin (cadherin-associated protein), delta 1 | 0.0125249 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0124772 |
| HNRNPA1 | heterogeneous nuclear ribonucleoprotein A1 | 0.0124435 |
| CSF1 | colony stimulating factor 1 (macrophage) | 0.0124038 |
| CREB5 | cAMP responsive element binding protein 5 | 0.0123776 |
| DUSP16 | dual specificity phosphatase 16 | 0.0122055 |
| B2M | beta-2-microglobulin | 0.0121808 |
| ABTB2 | ankyrin repeat and BTB (POZ) domain containing 2 | 0.0121177 |
| ANKRD36 | ankyrin repeat domain 36 | 0.0120833 |
| ARRDC3 | arrestin domain containing 3 | 0.0118813 |
| PPFIBP1 | PTPRF interacting protein, binding protein 1 (liprin beta 1) | 0.0117712 |
| NDRG1 | N-myc downstream regulated 1 | 0.0116924 |
| UBE2H | ubiquitin-conjugating enzyme E2H | 0.0114604 |
| MIDEAS | mitotic deacetylase associated SANT domain protein | 0.0112046 |
| RPS3A | ribosomal protein S3A | 0.011178 |
| VMP1 | vacuole membrane protein 1 | 0.0111119 |
| PHC3 | polyhomeotic homolog 3 (Drosophila) | 0.0107969 |
| SPTAN1 | spectrin, alpha, non-erythrocytic 1 | 0.0107588 |
| CLIP1 | CAP-GLY domain containing linker protein 1 | 0.0106452 |
| RPL21 | ribosomal protein L21 | 0.0104403 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0103628 |
| ANP32B | acidic (leucine-rich) nuclear phosphoprotein 32 family, member B | 0.0102616 |
| ZBTB10 | zinc finger and BTB domain containing 10 | 0.0102123 |
| CD46 | CD46 molecule, complement regulatory protein | 0.00999424 |
| HDAC9 | histone deacetylase 9 | 0.00996097 |
| PLEKHA1 | pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 | 0.00995312 |
| RPS18 | ribosomal protein S18 | 0.00982784 |
| EIF5B | eukaryotic translation initiation factor 5B | 0.00972433 |
| PNN | pinin, desmosome associated protein | 0.00954354 |
| CHORDC1 | cysteine and histidine-rich domain (CHORD) containing 1 | 0.00938359 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.00897035 |
| DDIT4 | DNA-damage-inducible transcript 4 | 0.00873588 |
| SMARCA2 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 | 0.00872636 |
| LPIN1 | lipin 1 | 0.00872407 |
| SREBF1 | sterol regulatory element binding transcription factor 1 | 0.00868404 |
| DAPK3 | death-associated protein kinase 3 | 0.00866943 |
| ANKRD36C | ankyrin repeat domain 36C | 0.00863454 |
| VEGFA | vascular endothelial growth factor A | 0.00858003 |
| ABCA5 | ATP-binding cassette, sub-family A (ABC1), member 5 | 0.00854611 |
| ETNK1 | ethanolamine kinase 1 | 0.00846887 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.00846244 |
| TRIO | trio Rho guanine nucleotide exchange factor | 0.00834862 |
| HILPDA | hypoxia inducible lipid droplet-associated | 0.00833387 |
| POLR2B | polymerase (RNA) II (DNA directed) polypeptide B, 140kDa | 0.00831905 |
| PRRC2C | proline-rich coiled-coil 2C | 0.00831714 |
| MCL1 | myeloid cell leukemia 1 | 0.00824956 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.00818048 |
| FGD4 | FYVE, RhoGEF and PH domain containing 4 | 0.00814899 |
| COX16 | COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) | 0.00808901 |
| NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 0.00799532 |
| REL | v-rel avian reticuloendotheliosis viral oncogene homolog | 0.00794432 |
| KCTD3 | potassium channel tetramerization domain containing 3 | 0.00793262 |
| ITSN2 | intersectin 2 | 0.0079249 |
| CASC3 | cancer susceptibility candidate 3 | 0.00780811 |
| RUSC2 | RUN and SH3 domain containing 2 | 0.00777116 |
| ANXA4 | annexin A4 | 0.00770631 |
| TUFT1 | tuftelin 1 | 0.00769102 |
| SLC3A2 | solute carrier family 3 (amino acid transporter heavy chain), member 2 | 0.00761201 |
| RELA | v-rel avian reticuloendotheliosis viral oncogene homolog A | 0.00761011 |
| ZDHHC21 | zinc finger, DHHC-type containing 21 | 0.00755548 |
| PSMF1 | proteasome (prosome, macropain) inhibitor subunit 1 (PI31) | 0.00752773 |
| PPID | peptidylprolyl isomerase D | 0.00738297 |
| RPS26 | ribosomal protein S26 | 0.00730805 |
| CEP83 | centrosomal protein 83kDa | 0.00727906 |
| MB21D2 | Mab-21 domain containing 2 | 0.00720405 |
| RPL37A | ribosomal protein L37a | 0.00720021 |
| MAST2 | microtubule associated serine/threonine kinase 2 | 0.0071894 |
| Symbol | Name | Standardized Value |
|---|---|---|
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.329085 |
| VCL | vinculin | -0.215752 |
| NFAT5 | nuclear factor of activated T-cells 5, tonicity-responsive | -0.156578 |
| PTMA | prothymosin, alpha | -0.141397 |
| FOXP1 | forkhead box P1 | -0.138371 |
| B3GALT1 | UDP-Gal:betaGlcNAc beta 1,3-galactosyltransferase, polypeptide 1 | -0.126658 |
| ADAM10 | ADAM metallopeptidase domain 10 | -0.121051 |
| SOX6 | SRY (sex determining region Y)-box 6 | -0.11908 |
| BMP10 | bone morphogenetic protein 10 | -0.114702 |
| RBMS3 | RNA binding motif, single stranded interacting protein 3 | -0.111776 |
| CPED1 | cadherin-like and PC-esterase domain containing 1 | -0.108902 |
| AHNAK | AHNAK nucleoprotein | -0.103823 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0948339 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0926144 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.088982 |
| PKM | pyruvate kinase, muscle | -0.0860442 |
| PDE4D | phosphodiesterase 4D, cAMP-specific | -0.0842303 |
| MINDY2 | MINDY lysine 48 deubiquitinase 2 | -0.0821717 |
| ACTG1 | actin gamma 1 | -0.078543 |
| NBEA | neurobeachin | -0.0717501 |
| GLI3 | GLI family zinc finger 3 | -0.0710425 |
| CACNB4 | calcium channel, voltage-dependent, beta 4 subunit | -0.0657142 |
| TMSB4X | thymosin beta 4, X-linked | -0.0653751 |
| TJP1 | tight junction protein 1 | -0.0652023 |
| CCND1 | cyclin D1 | -0.0638715 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.0622509 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | -0.0620325 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | -0.0616961 |
| FLNB | filamin B, beta | -0.061579 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0614175 |
| NPAS2 | neuronal PAS domain protein 2 | -0.0611069 |
| PDE4B | phosphodiesterase 4B, cAMP-specific | -0.0610972 |
| TNFRSF11B | tumor necrosis factor receptor superfamily, member 11b | -0.0591941 |
| MYO5C | myosin VC | -0.0553606 |
| MKI67 | marker of proliferation Ki-67 | -0.0550732 |
| CAMKMT | calmodulin-lysine N-methyltransferase | -0.0541617 |
| SLC38A2 | solute carrier family 38, member 2 | -0.0535608 |
| CITED2 | Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 2 | -0.0520217 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.0502348 |
| CALM2 | calmodulin 2 (phosphorylase kinase, delta) | -0.0501803 |
| TM4SF1 | transmembrane 4 L six family member 1 | -0.048706 |
| ARL4C | ADP-ribosylation factor-like 4C | -0.0480876 |
| ANXA1 | annexin A1 | -0.0464748 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0462272 |
| RPS6 | ribosomal protein S6 | -0.0447428 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0445857 |
| EGFR | epidermal growth factor receptor | -0.0444871 |
| EML4 | echinoderm microtubule associated protein like 4 | -0.0431789 |
| SPATS2L | spermatogenesis associated, serine-rich 2-like | -0.0430362 |
| LOC112694756 | uncharaterized LOC112694756 | -0.0427182 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | -0.0426308 |
| TTC28 | tetratricopeptide repeat domain 28 | -0.0424898 |
| EZR | ezrin | -0.0416446 |
| CYB5B | cytochrome b5 type B (outer mitochondrial membrane) | -0.041301 |
| NAV2 | neuron navigator 2 | -0.0397708 |
| ENOX1 | ecto-NOX disulfide-thiol exchanger 1 | -0.0386794 |
| KPNB1 | karyopherin (importin) beta 1 | -0.0385173 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0384404 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | -0.0382896 |
| RPL34 | ribosomal protein L34 | -0.037821 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0375135 |
| NFIA | nuclear factor I/A | -0.0371492 |
| PYGB | phosphorylase, glycogen; brain | -0.036933 |
| RPLP0 | ribosomal protein, large, P0 | -0.0366105 |
| ENO1 | enolase 1, (alpha) | -0.0365795 |
| ALDH3A2 | aldehyde dehydrogenase 3 family, member A2 | -0.0364114 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | -0.0363661 |
| S100A6 | S100 calcium binding protein A6 | -0.0358347 |
| PRUNE2 | prune homolog 2 (Drosophila) | -0.0356567 |
| LDHA | lactate dehydrogenase A | -0.0352641 |
| EVI5 | ecotropic viral integration site 5 | -0.0351469 |
| BMP2K | BMP2 inducible kinase | -0.0351368 |
| POTEF | POTE ankyrin domain family, member F | -0.0340794 |
| UNC13A | unc-13 homolog A (C. elegans) | -0.0340337 |
| RPLP1 | ribosomal protein, large, P1 | -0.0339222 |
| FUS | FUS RNA binding protein | -0.0338956 |
| EIF4A2 | eukaryotic translation initiation factor 4A2 | -0.0338443 |
| HSPB1 | heat shock 27kDa protein 1 | -0.0337472 |
| GCNT1 | glucosaminyl (N-acetyl) transferase 1, core 2 | -0.0336542 |
| DUSP4 | dual specificity phosphatase 4 | -0.0332824 |
| SMC4 | structural maintenance of chromosomes 4 | -0.0331404 |
| TCF7L2 | transcription factor 7-like 2 (T-cell specific, HMG-box) | -0.0330546 |
| NUCKS1 | nuclear casein kinase and cyclin-dependent kinase substrate 1 | -0.0325774 |
| TPM4 | tropomyosin 4 | -0.0324572 |
| DUSP6 | dual specificity phosphatase 6 | -0.0323263 |
| ECT2 | epithelial cell transforming 2 | -0.0319215 |
| NF1 | neurofibromin 1 | -0.0319138 |
| RBM39 | RNA binding motif protein 39 | -0.0318354 |
| DENND1A | DENN/MADD domain containing 1A | -0.0314487 |
| S100A4 | S100 calcium binding protein A4 | -0.0313234 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0311838 |
| MICAL2 | microtubule associated monooxygenase, calponin and LIM domain containing 2 | -0.0311407 |
| SMNDC1 | survival motor neuron domain containing 1 | -0.0307133 |
| EBNA1BP2 | EBNA1 binding protein 2 | -0.0303062 |
| ANKRD17 | ankyrin repeat domain 17 | -0.0301385 |
| SP100 | SP100 nuclear antigen | -0.0300112 |
| HEG1 | heart development protein with EGF-like domains 1 | -0.0297702 |
| GLI2 | GLI family zinc finger 2 | -0.0297671 |
| RPS23 | ribosomal protein S23 | -0.0296445 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0293056 |
