| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in SNU-423 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_SNU-423 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| NAMPT | nicotinamide phosphoribosyltransferase | 0.102157 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0991857 |
| DCBLD2 | discoidin, CUB and LCCL domain containing 2 | 0.0942947 |
| CD44 | CD44 molecule (Indian blood group) | 0.0805695 |
| MYH9 | myosin, heavy chain 9, non-muscle | 0.0724954 |
| SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | 0.0665313 |
| HDAC9 | histone deacetylase 9 | 0.0612645 |
| MSN | moesin | 0.056265 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.0506645 |
| AKAP12 | A kinase (PRKA) anchor protein 12 | 0.0479662 |
| MKI67 | marker of proliferation Ki-67 | 0.0475306 |
| STAT1 | signal transducer and activator of transcription 1, 91kDa | 0.0467948 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0466121 |
| STC1 | stanniocalcin 1 | 0.0460206 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0454388 |
| SFTPA2 | surfactant protein A2 | 0.0448943 |
| IGFN1 | immunoglobulin-like and fibronectin type III domain containing 1 | 0.0445036 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0436792 |
| B2M | beta-2-microglobulin | 0.043596 |
| IFIT3 | interferon-induced protein with tetratricopeptide repeats 3 | 0.0406469 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.039978 |
| VCL | vinculin | 0.0388669 |
| IFIT2 | interferon-induced protein with tetratricopeptide repeats 2 | 0.0383006 |
| CDCP1 | CUB domain containing protein 1 | 0.0368047 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0360289 |
| TIMP2 | TIMP metallopeptidase inhibitor 2 | 0.0356351 |
| EIF2AK2 | eukaryotic translation initiation factor 2-alpha kinase 2 | 0.0349386 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0326592 |
| ATP2B1 | ATPase, Ca++ transporting, plasma membrane 1 | 0.0316353 |
| MLPH | melanophilin | 0.0307801 |
| C3 | complement component 3 | 0.0304621 |
| RPS12 | ribosomal protein S12 | 0.0296873 |
| CALD1 | caldesmon 1 | 0.0293537 |
| DDX60L | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like | 0.0287518 |
| PCBP2 | poly(rC) binding protein 2 | 0.0287498 |
| CENPF | centromere protein F, 350/400kDa | 0.0284225 |
| STC2 | stanniocalcin 2 | 0.0282521 |
| WWOX | WW domain containing oxidoreductase | 0.0281875 |
| TOP2A | topoisomerase (DNA) II alpha 170kDa | 0.0276581 |
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0275062 |
| NRP1 | neuropilin 1 | 0.0274232 |
| MT2A | metallothionein 2A | 0.0273132 |
| BNIP3 | BCL2/adenovirus E1B 19kDa interacting protein 3 | 0.0272936 |
| NAV2 | neuron navigator 2 | 0.027172 |
| MCL1 | myeloid cell leukemia 1 | 0.0268287 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0268186 |
| EGR1 | early growth response 1 | 0.0263638 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 0.0259162 |
| RPL3 | ribosomal protein L3 | 0.0251537 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0250714 |
| MX1 | MX dynamin-like GTPase 1 | 0.0249669 |
| FOXP1 | forkhead box P1 | 0.0247219 |
| GRN | granulin | 0.0245335 |
| TAPBP | TAP binding protein (tapasin) | 0.0242311 |
| HSPA8 | heat shock 70kDa protein 8 | 0.0241763 |
| SYNJ2 | synaptojanin 2 | 0.0237708 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | 0.0233637 |
| TPM3 | tropomyosin 3 | 0.023082 |
| CCNL1 | cyclin L1 | 0.0230501 |
| PLSCR1 | phospholipid scramblase 1 | 0.0229821 |
| DSTN | destrin (actin depolymerizing factor) | 0.0227388 |
| DUSP5 | dual specificity phosphatase 5 | 0.0224307 |
| APLP2 | amyloid beta (A4) precursor-like protein 2 | 0.022425 |
| ZBTB38 | zinc finger and BTB domain containing 38 | 0.0222735 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.0220051 |
| RPS2 | ribosomal protein S2 | 0.0218091 |
| OAS3 | 2'-5'-oligoadenylate synthetase 3, 100kDa | 0.0206707 |
| IFIT1 | interferon-induced protein with tetratricopeptide repeats 1 | 0.0204465 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0204459 |
| RB1CC1 | RB1-inducible coiled-coil 1 | 0.0202804 |
| ITGB1 | integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) | 0.0202459 |
| ARRDC3 | arrestin domain containing 3 | 0.0201841 |
| PLIN2 | perilipin 2 | 0.019837 |
| IFI6 | interferon, alpha-inducible protein 6 | 0.0198325 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0197932 |
| MYADM | myeloid-associated differentiation marker | 0.0197466 |
| SNX3 | sorting nexin 3 | 0.0196986 |
| LGALS3BP | lectin, galactoside-binding, soluble, 3 binding protein | 0.0192502 |
| AXL | AXL receptor tyrosine kinase | 0.0188104 |
| SYAP1 | synapse associated protein 1 | 0.0184645 |
| FHIT | fragile histidine triad | 0.0184287 |
| JMJD1C | jumonji domain containing 1C | 0.018284 |
| PARP14 | poly (ADP-ribose) polymerase family, member 14 | 0.0179041 |
| CTSA | cathepsin A | 0.0176723 |
| VEGFA | vascular endothelial growth factor A | 0.0175162 |
| SOX9 | SRY (sex determining region Y)-box 9 | 0.0173949 |
| TBC1D5 | TBC1 domain family, member 5 | 0.0173748 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0171953 |
| ZNF148 | zinc finger protein 148 | 0.016709 |
| LAMP2 | lysosomal-associated membrane protein 2 | 0.0167052 |
| PMP22 | peripheral myelin protein 22 | 0.0164393 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0161816 |
| ZC3H12B | zinc finger CCCH-type containing 12B | 0.0161518 |
| MAGI2 | membrane associated guanylate kinase, WW and PDZ domain containing 2 | 0.0161273 |
| FOSL1 | FOS-like antigen 1 | 0.0161151 |
| TRAF3IP2 | TRAF3 interacting protein 2 | 0.0160423 |
| SH3RF2 | SH3 domain containing ring finger 2 | 0.015956 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0157646 |
| CAMK1D | calcium/calmodulin-dependent protein kinase ID | 0.015689 |
| CTSB | cathepsin B | 0.0156299 |
| Symbol | Name | Standardized Value |
|---|---|---|
| FN1 | fibronectin 1 | -0.179865 |
| IER3 | immediate early response 3 | -0.155166 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.152137 |
| FRMD4A | FERM domain containing 4A | -0.127497 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.123745 |
| IQCJ-SCHIP1 | IQCJ-SCHIP1 readthrough | -0.121069 |
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.121048 |
| PDE10A | phosphodiesterase 10A | -0.119469 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.115717 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.11077 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0924651 |
| PGK1 | phosphoglycerate kinase 1 | -0.088489 |
| COL6A3 | collagen, type VI, alpha 3 | -0.0867386 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0866385 |
| CADM1 | cell adhesion molecule 1 | -0.0813236 |
| RPS24 | ribosomal protein S24 | -0.079229 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0743508 |
| KDM3A | lysine (K)-specific demethylase 3A | -0.0733231 |
| GLIS3 | GLIS family zinc finger 3 | -0.0716439 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.0690592 |
| CANX | calnexin | -0.0673923 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | -0.0663257 |
| MORF4L2 | mortality factor 4 like 2 | -0.0654601 |
| OGA | O-GlcNAcase | -0.0640007 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.058455 |
| ZFAND3 | zinc finger, AN1-type domain 3 | -0.0574258 |
| FRMPD4 | FERM and PDZ domain containing 4 | -0.0548904 |
| INTS6 | integrator complex subunit 6 | -0.0528288 |
| HMGA2 | high mobility group AT-hook 2 | -0.0524289 |
| ANXA2 | annexin A2 | -0.0512969 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | -0.0478069 |
| RBM39 | RNA binding motif protein 39 | -0.0469034 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0462671 |
| AGAP1 | ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 | -0.0459264 |
| COL5A1 | collagen, type V, alpha 1 | -0.0456528 |
| RAI14 | retinoic acid induced 14 | -0.0455815 |
| EXT1 | exostosin glycosyltransferase 1 | -0.0455312 |
| SPAG9 | sperm associated antigen 9 | -0.044782 |
| ACTG1 | actin gamma 1 | -0.0441948 |
| UBE2E2 | ubiquitin-conjugating enzyme E2E 2 | -0.0435341 |
| ACSL4 | acyl-CoA synthetase long-chain family member 4 | -0.0431028 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0429488 |
| FAM20C | family with sequence similarity 20, member C | -0.0428156 |
| TSC22D2 | TSC22 domain family, member 2 | -0.0428126 |
| DLG1 | discs, large homolog 1 (Drosophila) | -0.0426201 |
| TMEM263 | transmembrane protein 263 | -0.0419244 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0410635 |
| NPEPPS | aminopeptidase puromycin sensitive | -0.0408926 |
| PFKFB4 | 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 | -0.0404332 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | -0.0396756 |
| TMSB10 | thymosin beta 10 | -0.0396565 |
| CCBE1 | collagen and calcium binding EGF domains 1 | -0.0390455 |
| FUS | FUS RNA binding protein | -0.0390158 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0389181 |
| GNAS | GNAS complex locus | -0.0388645 |
| HELZ | helicase with zinc finger | -0.0387512 |
| HDLBP | high density lipoprotein binding protein | -0.0387478 |
| AHNAK | AHNAK nucleoprotein | -0.0386495 |
| BTG1 | B-cell translocation gene 1, anti-proliferative | -0.0382912 |
| AFF4 | AF4/FMR2 family, member 4 | -0.0375922 |
| WDR45B | WD repeat domain 45B | -0.0373704 |
| COL1A1 | collagen, type I, alpha 1 | -0.0370937 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0368449 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0368231 |
| AKT3 | v-akt murine thymoma viral oncogene homolog 3 | -0.0364193 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0361646 |
| CAVIN1 | caveolae associated protein 1 | -0.0359743 |
| LOC112694756 | uncharaterized LOC112694756 | -0.035722 |
| QKI | QKI, KH domain containing, RNA binding | -0.0355694 |
| RPLP1 | ribosomal protein, large, P1 | -0.0353678 |
| RPL35A | ribosomal protein L35a | -0.0352094 |
| P4HA1 | prolyl 4-hydroxylase, alpha polypeptide I | -0.0347595 |
| NDRG1 | N-myc downstream regulated 1 | -0.0346232 |
| PIK3C2A | phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 alpha | -0.0346009 |
| RLF | rearranged L-myc fusion | -0.0341312 |
| TAOK1 | TAO kinase 1 | -0.0336031 |
| RPL38 | ribosomal protein L38 | -0.033575 |
| PTMA | prothymosin, alpha | -0.0334032 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0332365 |
| AFF3 | AF4/FMR2 family, member 3 | -0.0330965 |
| MXI1 | MAX interactor 1, dimerization protein | -0.0324727 |
| GRIN2A | glutamate receptor, ionotropic, N-methyl D-aspartate 2A | -0.0321851 |
| VDAC1 | voltage-dependent anion channel 1 | -0.0321623 |
| SDCBP | syndecan binding protein (syntenin) | -0.0319239 |
| ZCCHC7 | zinc finger, CCHC domain containing 7 | -0.0312974 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0311138 |
| GNB1 | guanine nucleotide binding protein (G protein), beta polypeptide 1 | -0.0307605 |
| CDH13 | cadherin 13 | -0.030725 |
| COL4A2 | collagen, type IV, alpha 2 | -0.0306557 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | -0.0306524 |
| WTAP | Wilms tumor 1 associated protein | -0.0304766 |
| MARCKS | myristoylated alanine-rich protein kinase C substrate | -0.0304595 |
| GOLGA4 | golgin A4 | -0.030431 |
| SFRP1 | secreted frizzled-related protein 1 | -0.0302996 |
| TMSB4X | thymosin beta 4, X-linked | -0.0302359 |
| HBP1 | HMG-box transcription factor 1 | -0.0301737 |
| VIM | vimentin | -0.0301395 |
| PAPPA | pregnancy-associated plasma protein A, pappalysin 1 | -0.0301267 |
| TRPC4AP | transient receptor potential cation channel, subfamily C, member 4 associated protein | -0.0299498 |
| TAF1D | TATA box binding protein (TBP)-associated factor, RNA polymerase I, D, 41kDa | -0.0298983 |
