| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in SW 1088 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_SW 1088 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| FTH1 | ferritin, heavy polypeptide 1 | 0.184506 |
| ERRFI1 | ERBB receptor feedback inhibitor 1 | 0.149561 |
| STC1 | stanniocalcin 1 | 0.103047 |
| ITGA2 | integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | 0.085685 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | 0.0776289 |
| MACF1 | microtubule-actin crosslinking factor 1 | 0.0734702 |
| NRXN3 | neurexin 3 | 0.0722619 |
| TGFBI | transforming growth factor, beta-induced, 68kDa | 0.0592047 |
| CD44 | CD44 molecule (Indian blood group) | 0.0571282 |
| ELL2 | elongation factor, RNA polymerase II, 2 | 0.0554374 |
| B2M | beta-2-microglobulin | 0.052426 |
| ZBTB20 | zinc finger and BTB domain containing 20 | 0.0507291 |
| ANTXR2 | anthrax toxin receptor 2 | 0.0494883 |
| HLA-A | major histocompatibility complex, class I, A | 0.049403 |
| ALK | anaplastic lymphoma receptor tyrosine kinase | 0.0477462 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0473145 |
| GOLGB1 | golgin B1 | 0.0471901 |
| SPTBN1 | spectrin, beta, non-erythrocytic 1 | 0.0464887 |
| KYNU | kynureninase | 0.0459415 |
| NDRG1 | N-myc downstream regulated 1 | 0.0445302 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | 0.0433326 |
| LRRFIP1 | leucine rich repeat (in FLII) interacting protein 1 | 0.0430051 |
| SFTPA2 | surfactant protein A2 | 0.0422716 |
| MYADM | myeloid-associated differentiation marker | 0.0416867 |
| RNF145 | ring finger protein 145 | 0.0409277 |
| IGFBP7 | insulin-like growth factor binding protein 7 | 0.0390859 |
| MT2A | metallothionein 2A | 0.0380072 |
| ASPH | aspartate beta-hydroxylase | 0.0375769 |
| PSD3 | pleckstrin and Sec7 domain containing 3 | 0.0369864 |
| PTK2 | protein tyrosine kinase 2 | 0.036436 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0362553 |
| KMT2E | lysine (K)-specific methyltransferase 2E | 0.0360694 |
| TMF1 | TATA element modulatory factor 1 | 0.0360636 |
| EFNA5 | ephrin-A5 | 0.0355637 |
| TPI1 | triosephosphate isomerase 1 | 0.0351936 |
| IL6 | interleukin 6 | 0.0339053 |
| RPS8 | ribosomal protein S8 | 0.0337049 |
| RPS2 | ribosomal protein S2 | 0.0335522 |
| PUM2 | pumilio RNA-binding family member 2 | 0.0328702 |
| TOP1 | topoisomerase (DNA) I | 0.0323787 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | 0.032164 |
| ARRDC3 | arrestin domain containing 3 | 0.0321163 |
| PDIA6 | protein disulfide isomerase family A, member 6 | 0.0320604 |
| ZSWIM6 | zinc finger, SWIM-type containing 6 | 0.031098 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0306461 |
| CAPN2 | calpain 2, (m/II) large subunit | 0.0306432 |
| ITPR1 | inositol 1,4,5-trisphosphate receptor, type 1 | 0.0305683 |
| EDIL3 | EGF-like repeats and discoidin I-like domains 3 | 0.0303494 |
| METTL15 | methyltransferase like 15 | 0.0299308 |
| TTC3 | tetratricopeptide repeat domain 3 | 0.0294045 |
| STK10 | serine/threonine kinase 10 | 0.0290985 |
| PRKRIP1 | PRKR interacting protein 1 (IL11 inducible) | 0.0290883 |
| ETS1 | v-ets avian erythroblastosis virus E26 oncogene homolog 1 | 0.0289494 |
| WWTR1 | WW domain containing transcription regulator 1 | 0.0285773 |
| DOCK1 | dedicator of cytokinesis 1 | 0.0285575 |
| WNT5A | wingless-type MMTV integration site family, member 5A | 0.0284728 |
| ACAP2 | ArfGAP with coiled-coil, ankyrin repeat and PH domains 2 | 0.0283942 |
| LHFPL2 | lipoma HMGIC fusion partner-like 2 | 0.028121 |
| CCDC14 | coiled-coil domain containing 14 | 0.0281169 |
| TMEM165 | transmembrane protein 165 | 0.0280088 |
| ANKRD36C | ankyrin repeat domain 36C | 0.0276777 |
| ARL6IP1 | ADP-ribosylation factor-like 6 interacting protein 1 | 0.0271331 |
| ATP2C1 | ATPase, Ca++ transporting, type 2C, member 1 | 0.0270369 |
| CD59 | CD59 molecule, complement regulatory protein | 0.0267342 |
| CA12 | carbonic anhydrase XII | 0.0265784 |
| PHLDA1 | pleckstrin homology-like domain, family A, member 1 | 0.0265277 |
| RND3 | Rho family GTPase 3 | 0.0262665 |
| RABGAP1 | RAB GTPase activating protein 1 | 0.0260413 |
| PARD3 | par-3 family cell polarity regulator | 0.0259093 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0258252 |
| TLN1 | talin 1 | 0.0256815 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | 0.025657 |
| PRPF40A | PRP40 pre-mRNA processing factor 40 homolog A (S. cerevisiae) | 0.0255873 |
| PRKN | parkin RBR E3 ubiquitin protein ligase | 0.0255024 |
| EEF1A1 | eukaryotic translation elongation factor 1 alpha 1 | 0.0254221 |
| PLAUR | plasminogen activator, urokinase receptor | 0.0253002 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0249626 |
| IRAK2 | interleukin-1 receptor-associated kinase 2 | 0.0249455 |
| PTGES2 | prostaglandin E synthase 2 | 0.0248485 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0246727 |
| PDXDC1 | pyridoxal-dependent decarboxylase domain containing 1 | 0.024491 |
| SLC4A7 | solute carrier family 4, sodium bicarbonate cotransporter, member 7 | 0.0244395 |
| TBC1D8 | TBC1 domain family, member 8 (with GRAM domain) | 0.0244239 |
| HUWE1 | HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase | 0.024415 |
| PCBP2 | poly(rC) binding protein 2 | 0.024317 |
| MYL6 | myosin, light chain 6, alkali, smooth muscle and non-muscle | 0.0240764 |
| SLC25A37 | solute carrier family 25 (mitochondrial iron transporter), member 37 | 0.0239834 |
| COPA | coatomer protein complex, subunit alpha | 0.0238078 |
| PGM3 | phosphoglucomutase 3 | 0.0237178 |
| PHF14 | PHD finger protein 14 | 0.0231934 |
| KDM5C | lysine (K)-specific demethylase 5C | 0.02314 |
| COG5 | component of oligomeric golgi complex 5 | 0.02313 |
| LYSMD3 | LysM, putative peptidoglycan-binding, domain containing 3 | 0.0231291 |
| USP47 | ubiquitin specific peptidase 47 | 0.0228018 |
| PTPN12 | protein tyrosine phosphatase, non-receptor type 12 | 0.0227831 |
| RAP1A | RAP1A, member of RAS oncogene family | 0.0226913 |
| ITGA5 | integrin, alpha 5 (fibronectin receptor, alpha polypeptide) | 0.0226112 |
| GLIS3 | GLIS family zinc finger 3 | 0.0224285 |
| MICAL3 | microtubule associated monooxygenase, calponin and LIM domain containing 3 | 0.0223678 |
| USPL1 | ubiquitin specific peptidase like 1 | 0.0223637 |
| Symbol | Name | Standardized Value |
|---|---|---|
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.25598 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.144344 |
| HLA-B | major histocompatibility complex, class I, B | -0.0914729 |
| ERO1A | endoplasmic reticulum oxidoreductase 1 alpha | -0.0884667 |
| FN1 | fibronectin 1 | -0.0834219 |
| TMSB10 | thymosin beta 10 | -0.0805503 |
| VIM | vimentin | -0.0742534 |
| TENT5A | terminal nucleotidyltransferase 5A | -0.0737925 |
| CALD1 | caldesmon 1 | -0.0730538 |
| COL6A3 | collagen, type VI, alpha 3 | -0.067952 |
| CALU | calumenin | -0.066825 |
| POTEF | POTE ankyrin domain family, member F | -0.0656378 |
| ROBO1 | roundabout, axon guidance receptor, homolog 1 (Drosophila) | -0.0635283 |
| F3 | coagulation factor III (thromboplastin, tissue factor) | -0.0631594 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0602244 |
| RBM39 | RNA binding motif protein 39 | -0.0600857 |
| YWHAZ | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta | -0.0599774 |
| VCL | vinculin | -0.0598669 |
| SDC4 | syndecan 4 | -0.0581506 |
| HIBADH | 3-hydroxyisobutyrate dehydrogenase | -0.0578618 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0565683 |
| TRIO | trio Rho guanine nucleotide exchange factor | -0.0553367 |
| ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | -0.0549235 |
| ARF4 | ADP-ribosylation factor 4 | -0.0548189 |
| HYCC1 | hyccin PI4KA lipid kinase complex subunit 1 | -0.052176 |
| CAV1 | caveolin 1, caveolae protein, 22kDa | -0.051912 |
| UBE2D3 | ubiquitin-conjugating enzyme E2D 3 | -0.0511675 |
| WTAP | Wilms tumor 1 associated protein | -0.0491926 |
| MYH9 | myosin, heavy chain 9, non-muscle | -0.0490407 |
| FUS | FUS RNA binding protein | -0.0487765 |
| HLA-C | major histocompatibility complex, class I, C | -0.0460242 |
| P4HB | prolyl 4-hydroxylase, beta polypeptide | -0.0454808 |
| S100A6 | S100 calcium binding protein A6 | -0.0451231 |
| UBE2H | ubiquitin-conjugating enzyme E2H | -0.0448526 |
| LUC7L2 | LUC7-like 2 (S. cerevisiae) | -0.0445881 |
| HIF1A | hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) | -0.0436046 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0434285 |
| PRRC1 | proline-rich coiled-coil 1 | -0.0428861 |
| LDHA | lactate dehydrogenase A | -0.0425411 |
| SLC8A1 | solute carrier family 8 (sodium/calcium exchanger), member 1 | -0.0421777 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.042083 |
| BBX | bobby sox homolog (Drosophila) | -0.0415696 |
| ZMYND8 | zinc finger, MYND-type containing 8 | -0.041469 |
| TRA2A | transformer 2 alpha homolog (Drosophila) | -0.0411211 |
| FBXO11 | F-box protein 11 | -0.0408706 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0400609 |
| PGK1 | phosphoglycerate kinase 1 | -0.0391338 |
| ACTG1 | actin gamma 1 | -0.0389164 |
| ADM | adrenomedullin | -0.0386112 |
| COL1A1 | collagen, type I, alpha 1 | -0.0385833 |
| POLR2A | polymerase (RNA) II (DNA directed) polypeptide A, 220kDa | -0.0384912 |
| NAMPT | nicotinamide phosphoribosyltransferase | -0.0384443 |
| KDM5B | lysine (K)-specific demethylase 5B | -0.0382629 |
| FTL | ferritin, light polypeptide | -0.037923 |
| SCD | stearoyl-CoA desaturase (delta-9-desaturase) | -0.0377199 |
| MAP4K5 | mitogen-activated protein kinase kinase kinase kinase 5 | -0.0375775 |
| SERPINE2 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 | -0.0374067 |
| CD109 | CD109 molecule | -0.0371611 |
| PNRC1 | proline-rich nuclear receptor coactivator 1 | -0.0370596 |
| EPS8 | epidermal growth factor receptor pathway substrate 8 | -0.0365208 |
| SLC2A1 | solute carrier family 2 (facilitated glucose transporter), member 1 | -0.0357149 |
| SLC16A1 | solute carrier family 16 (monocarboxylate transporter), member 1 | -0.0356131 |
| QKI | QKI, KH domain containing, RNA binding | -0.0355697 |
| GPCPD1 | glycerophosphocholine phosphodiesterase GDE1 homolog (S. cerevisiae) | -0.0355298 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0354204 |
| SPAG9 | sperm associated antigen 9 | -0.0353767 |
| MYCBP2 | MYC binding protein 2, E3 ubiquitin protein ligase | -0.0347534 |
| TUBB | tubulin, beta class I | -0.0344107 |
| UBC | ubiquitin C | -0.0339245 |
| NOP58 | NOP58 ribonucleoprotein | -0.0339101 |
| CYP1B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 | -0.0336014 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | -0.0333463 |
| SOCS5 | suppressor of cytokine signaling 5 | -0.0330395 |
| PPP1CB | protein phosphatase 1, catalytic subunit, beta isozyme | -0.0330113 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0328707 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0328447 |
| TM9SF3 | transmembrane 9 superfamily member 3 | -0.0327621 |
| IFRD1 | interferon-related developmental regulator 1 | -0.0326774 |
| TPM4 | tropomyosin 4 | -0.0326204 |
| LUC7L3 | LUC7-like 3 (S. cerevisiae) | -0.0325575 |
| CAMTA1 | calmodulin binding transcription activator 1 | -0.0325155 |
| TIMP3 | TIMP metallopeptidase inhibitor 3 | -0.0323377 |
| WSB1 | WD repeat and SOCS box containing 1 | -0.0322756 |
| SEPTIN2 | septin 2 | -0.0322603 |
| FAM20C | family with sequence similarity 20, member C | -0.032228 |
| MATR3 | matrin 3 | -0.0322128 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0321735 |
| TCF12 | transcription factor 12 | -0.0321131 |
| HPCAL1 | hippocalcin-like 1 | -0.0320282 |
| TPD52 | tumor protein D52 | -0.0319294 |
| PKM | pyruvate kinase, muscle | -0.0319198 |
| NRG1 | neuregulin 1 | -0.0318517 |
| RPS12 | ribosomal protein S12 | -0.0318215 |
| GNAS | GNAS complex locus | -0.0316087 |
| TFPI2 | tissue factor pathway inhibitor 2 | -0.0315022 |
| PAN3 | PAN3 poly(A) specific ribonuclease subunit | -0.0314466 |
| PNISR | PNN-interacting serine/arginine-rich protein | -0.0313619 |
| GLIPR1 | GLI pathogenesis-related 1 | -0.0313323 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | -0.0312869 |
| SPDYA | speedy/RINGO cell cycle regulator family member A | -0.0309365 |
