| Dataset | Tahoe Therapeutics Tahoe 100M Perturbation Atlas |
| Category | transcriptomics |
| Type | cell type |
| Description | Afatinib perturbation in SW 1271 cell line (Tahoe Therapeutics) |
| Similar Terms | |
| Downloads & Tools |
200 genes differentially expressed following the Afatinib_SW 1271 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90AB1 | heat shock protein 90kDa alpha (cytosolic), class B member 1 | 0.0831181 |
| FTH1 | ferritin, heavy polypeptide 1 | 0.0801711 |
| FNDC3B | fibronectin type III domain containing 3B | 0.0628871 |
| PKM | pyruvate kinase, muscle | 0.0552454 |
| ENO1 | enolase 1, (alpha) | 0.0488087 |
| HSP90AA1 | heat shock protein 90kDa alpha (cytosolic), class A member 1 | 0.0459253 |
| LOC102724023 | ES1 protein homolog, mitochondrial | 0.0442314 |
| NPM1 | nucleophosmin (nucleolar phosphoprotein B23, numatrin) | 0.0427732 |
| RPL4 | ribosomal protein L4 | 0.0423003 |
| ZNF292 | zinc finger protein 292 | 0.0388683 |
| ZFAND3 | zinc finger, AN1-type domain 3 | 0.0383555 |
| EEF2 | eukaryotic translation elongation factor 2 | 0.0383011 |
| IMMP2L | IMP2 inner mitochondrial membrane peptidase-like (S. cerevisiae) | 0.0380689 |
| ANO6 | anoctamin 6 | 0.0367221 |
| PCBP2 | poly(rC) binding protein 2 | 0.0360555 |
| RORA | RAR-related orphan receptor A | 0.0353198 |
| HSPD1 | heat shock 60kDa protein 1 (chaperonin) | 0.0352613 |
| KTN1 | kinectin 1 (kinesin receptor) | 0.0351877 |
| TXNIP | thioredoxin interacting protein | 0.034927 |
| SRRM2 | serine/arginine repetitive matrix 2 | 0.0348755 |
| RTN4 | reticulon 4 | 0.0343058 |
| RPS12 | ribosomal protein S12 | 0.0329904 |
| EIF4G1 | eukaryotic translation initiation factor 4 gamma, 1 | 0.0329 |
| MBNL2 | muscleblind-like splicing regulator 2 | 0.0324279 |
| KIAA1958 | KIAA1958 | 0.0322684 |
| SET | SET nuclear proto-oncogene | 0.031951 |
| ATP6V1A | ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A | 0.0311764 |
| NFE2L1 | nuclear factor, erythroid 2-like 1 | 0.0308705 |
| CUL5 | cullin 5 | 0.0302405 |
| RALGAPA2 | Ral GTPase activating protein, alpha subunit 2 (catalytic) | 0.0299297 |
| JMJD1C | jumonji domain containing 1C | 0.0298673 |
| RPS3 | ribosomal protein S3 | 0.0295518 |
| BAZ2B | bromodomain adjacent to zinc finger domain, 2B | 0.0293625 |
| NAP1L1 | nucleosome assembly protein 1-like 1 | 0.0293324 |
| MPP2 | membrane protein, palmitoylated 2 (MAGUK p55 subfamily member 2) | 0.0292228 |
| BICD1 | bicaudal D homolog 1 (Drosophila) | 0.0290737 |
| BHLHE40 | basic helix-loop-helix family, member e40 | 0.0284415 |
| NPTN | neuroplastin | 0.0282602 |
| AXL | AXL receptor tyrosine kinase | 0.0282187 |
| SVIL | supervillin | 0.0279247 |
| PPP1R12A | protein phosphatase 1, regulatory subunit 12A | 0.027552 |
| ABL1 | ABL proto-oncogene 1, non-receptor tyrosine kinase | 0.0274884 |
| PLOD2 | procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 | 0.0271933 |
| DGKD | diacylglycerol kinase, delta 130kDa | 0.0270033 |
| GOLIM4 | golgi integral membrane protein 4 | 0.026885 |
| TPI1 | triosephosphate isomerase 1 | 0.0265302 |
| CDCP1 | CUB domain containing protein 1 | 0.0263861 |
| MSI2 | musashi RNA-binding protein 2 | 0.0263574 |
| NFE2L2 | nuclear factor, erythroid 2-like 2 | 0.0261986 |
| MACROD2 | MACRO domain containing 2 | 0.0256162 |
| BBS9 | Bardet-Biedl syndrome 9 | 0.0254888 |
| PABPC1 | poly(A) binding protein, cytoplasmic 1 | 0.025384 |
| CCT5 | chaperonin containing TCP1, subunit 5 (epsilon) | 0.0252493 |
| SLC25A3 | solute carrier family 25 (mitochondrial carrier; phosphate carrier), member 3 | 0.0250984 |
| RNF145 | ring finger protein 145 | 0.0250703 |
| PHF21A | PHD finger protein 21A | 0.0250529 |
| PPP1R15A | protein phosphatase 1, regulatory subunit 15A | 0.0249902 |
| RNF24 | ring finger protein 24 | 0.0249726 |
| SLC38A2 | solute carrier family 38, member 2 | 0.0248997 |
| TGFBR2 | transforming growth factor, beta receptor II (70/80kDa) | 0.0240769 |
| STAT3 | signal transducer and activator of transcription 3 (acute-phase response factor) | 0.0238848 |
| BNIP3L | BCL2/adenovirus E1B 19kDa interacting protein 3-like | 0.0238232 |
| UST | uronyl-2-sulfotransferase | 0.0234496 |
| PPIG | peptidylprolyl isomerase G (cyclophilin G) | 0.0234005 |
| RPL37A | ribosomal protein L37a | 0.0232788 |
| SIN3A | SIN3 transcription regulator family member A | 0.0231842 |
| PRKD1 | protein kinase D1 | 0.0229251 |
| RPL23 | ribosomal protein L23 | 0.022688 |
| AHR | aryl hydrocarbon receptor | 0.0226545 |
| PNISR | PNN-interacting serine/arginine-rich protein | 0.0225512 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | 0.0224843 |
| BRD4 | bromodomain containing 4 | 0.0223441 |
| EXOC4 | exocyst complex component 4 | 0.0223062 |
| TNIP1 | TNFAIP3 interacting protein 1 | 0.0219765 |
| AKAP11 | A kinase (PRKA) anchor protein 11 | 0.0219728 |
| RPS17 | ribosomal protein S17 | 0.0218491 |
| RPL17-C18ORF32 | RPL17-C18orf32 readthrough | 0.0217781 |
| ERGIC3 | ERGIC and golgi 3 | 0.0216988 |
| PA2G4 | proliferation-associated 2G4, 38kDa | 0.0216517 |
| OSBPL9 | oxysterol binding protein-like 9 | 0.0215376 |
| TTC1 | tetratricopeptide repeat domain 1 | 0.0214196 |
| GPRC5A | G protein-coupled receptor, class C, group 5, member A | 0.0213418 |
| ATF3 | activating transcription factor 3 | 0.021331 |
| CWC15 | CWC15 spliceosome-associated protein | 0.0212944 |
| HECTD4 | HECT domain containing E3 ubiquitin protein ligase 4 | 0.0211854 |
| SNX2 | sorting nexin 2 | 0.0211784 |
| INTS13 | integrator complex subunit 13 | 0.0210282 |
| RACK1 | receptor for activated C kinase 1 | 0.0210212 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | 0.0209148 |
| ROCK1 | Rho-associated, coiled-coil containing protein kinase 1 | 0.0209109 |
| GARS1 | glycyl-tRNA synthetase 1 | 0.0208807 |
| HSDL2 | hydroxysteroid dehydrogenase like 2 | 0.0208198 |
| RBM26 | RNA binding motif protein 26 | 0.0208123 |
| CRY1 | cryptochrome circadian clock 1 | 0.0207893 |
| DSTN | destrin (actin depolymerizing factor) | 0.0207024 |
| ANKRD28 | ankyrin repeat domain 28 | 0.0206638 |
| SMC1A | structural maintenance of chromosomes 1A | 0.0206545 |
| ANP32A | acidic (leucine-rich) nuclear phosphoprotein 32 family, member A | 0.0204172 |
| SMAD3 | SMAD family member 3 | 0.0203474 |
| FEM1B | fem-1 homolog b (C. elegans) | 0.0201905 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HSP90B1 | heat shock protein 90kDa beta (Grp94), member 1 | -0.128044 |
| ZC3HAV1 | zinc finger CCCH-type, antiviral 1 | -0.121934 |
| PHLDB2 | pleckstrin homology-like domain, family B, member 2 | -0.11269 |
| GAPDH | glyceraldehyde-3-phosphate dehydrogenase | -0.106447 |
| PALM2AKAP2 | PALM2 and AKAP2 fusion | -0.0893767 |
| TMSB10 | thymosin beta 10 | -0.0816884 |
| HSPA5 | heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | -0.0776583 |
| HMGA2 | high mobility group AT-hook 2 | -0.0751378 |
| ATM | ATM serine/threonine kinase | -0.074691 |
| GOLGA4 | golgin A4 | -0.0744945 |
| POTEF | POTE ankyrin domain family, member F | -0.0720369 |
| COPB1 | coatomer protein complex, subunit beta 1 | -0.0665436 |
| N4BP2L2 | NEDD4 binding protein 2-like 2 | -0.0664267 |
| SPAG9 | sperm associated antigen 9 | -0.0647179 |
| KCNMA1 | potassium channel, calcium activated large conductance subfamily M alpha, member 1 | -0.0620791 |
| SAMD4A | sterile alpha motif domain containing 4A | -0.0602304 |
| HNRNPA2B1 | heterogeneous nuclear ribonucleoprotein A2/B1 | -0.0594798 |
| RIGI | RNA sensor RIG-I | -0.0591212 |
| PCNX4 | pecanex 4 | -0.0547118 |
| TPT1 | tumor protein, translationally-controlled 1 | -0.0542326 |
| CD55 | CD55 molecule, decay accelerating factor for complement (Cromer blood group) | -0.052647 |
| LDHA | lactate dehydrogenase A | -0.0523008 |
| TAS2R14 | taste receptor, type 2, member 14 | -0.0521444 |
| ANKHD1 | ankyrin repeat and KH domain containing 1 | -0.0516629 |
| BIRC6 | baculoviral IAP repeat containing 6 | -0.0516027 |
| DOCK4 | dedicator of cytokinesis 4 | -0.0506264 |
| AP3B1 | adaptor-related protein complex 3, beta 1 subunit | -0.0505297 |
| RAB7A | RAB7A, member RAS oncogene family | -0.0503137 |
| CDH4 | cadherin 4, type 1, R-cadherin (retinal) | -0.049965 |
| NEDD4L | neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase | -0.0489115 |
| MTHFD1L | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1-like | -0.0483461 |
| ARHGAP5 | Rho GTPase activating protein 5 | -0.0476383 |
| PTMA | prothymosin, alpha | -0.0466743 |
| RALY | RALY heterogeneous nuclear ribonucleoprotein | -0.0465439 |
| VCL | vinculin | -0.0457214 |
| RABGEF1 | RAB guanine nucleotide exchange factor (GEF) 1 | -0.0456065 |
| IARS1 | isoleucyl-tRNA synthetase 1 | -0.0455751 |
| AKAP13 | A kinase (PRKA) anchor protein 13 | -0.0455269 |
| GOLGA3 | golgin A3 | -0.0444493 |
| TANC2 | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | -0.0444249 |
| ELOF1 | elongation factor 1 homolog (S. cerevisiae) | -0.0443956 |
| NDRG1 | N-myc downstream regulated 1 | -0.0439135 |
| KPNA4 | karyopherin alpha 4 (importin alpha 3) | -0.0437855 |
| SRGAP1 | SLIT-ROBO Rho GTPase activating protein 1 | -0.0435248 |
| NALCN | sodium leak channel, non selective | -0.0423703 |
| SMURF2 | SMAD specific E3 ubiquitin protein ligase 2 | -0.0423527 |
| GNAS | GNAS complex locus | -0.0412219 |
| GPC6 | glypican 6 | -0.0406564 |
| TPX2 | TPX2, microtubule-associated | -0.0401883 |
| CLINT1 | clathrin interactor 1 | -0.040167 |
| ZEB1 | zinc finger E-box binding homeobox 1 | -0.0400238 |
| PDCD6IP | programmed cell death 6 interacting protein | -0.0398266 |
| RAI14 | retinoic acid induced 14 | -0.0397652 |
| SDC4 | syndecan 4 | -0.0395586 |
| MACF1 | microtubule-actin crosslinking factor 1 | -0.0390826 |
| CBFA2T2 | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 | -0.0387725 |
| MON2 | MON2 homolog (S. cerevisiae) | -0.0384434 |
| DNER | delta/notch-like EGF repeat containing | -0.038093 |
| MAPKAP1 | mitogen-activated protein kinase associated protein 1 | -0.0378566 |
| GBE1 | glucan (1,4-alpha-), branching enzyme 1 | -0.0377559 |
| NSD2 | nuclear receptor binding SET domain protein 2 | -0.0374288 |
| TPM4 | tropomyosin 4 | -0.0370155 |
| DPYD | dihydropyrimidine dehydrogenase | -0.0364185 |
| PICALM | phosphatidylinositol binding clathrin assembly protein | -0.036339 |
| WARS1 | tryptophanyl-tRNA synthetase 1 | -0.0360841 |
| ITCH | itchy E3 ubiquitin protein ligase | -0.0353794 |
| FUS | FUS RNA binding protein | -0.0351382 |
| PPP6R3 | protein phosphatase 6, regulatory subunit 3 | -0.035035 |
| IGFBP3 | insulin-like growth factor binding protein 3 | -0.0349479 |
| RBM39 | RNA binding motif protein 39 | -0.0348224 |
| ABL2 | ABL proto-oncogene 2, non-receptor tyrosine kinase | -0.0347577 |
| ZC3H13 | zinc finger CCCH-type containing 13 | -0.0347275 |
| PIBF1 | progesterone immunomodulatory binding factor 1 | -0.0346737 |
| STARD13 | StAR-related lipid transfer (START) domain containing 13 | -0.0346684 |
| NF1 | neurofibromin 1 | -0.0346431 |
| SETX | senataxin | -0.0346193 |
| SNX14 | sorting nexin 14 | -0.0345723 |
| DTNA | dystrobrevin, alpha | -0.0341073 |
| HILPDA | hypoxia inducible lipid droplet-associated | -0.033978 |
| COPB2 | coatomer protein complex, subunit beta 2 (beta prime) | -0.0337822 |
| HNRNPK | heterogeneous nuclear ribonucleoprotein K | -0.0337526 |
| SOD2 | superoxide dismutase 2, mitochondrial | -0.0331419 |
| ATG7 | autophagy related 7 | -0.0325253 |
| ERBIN | erbb2 interacting protein | -0.0325197 |
| SDCCAG8 | serologically defined colon cancer antigen 8 | -0.0321466 |
| SMURF1 | SMAD specific E3 ubiquitin protein ligase 1 | -0.0320475 |
| FRMD6 | FERM domain containing 6 | -0.0319229 |
| AP2B1 | adaptor-related protein complex 2, beta 1 subunit | -0.0316375 |
| SETD5 | SET domain containing 5 | -0.0316369 |
| UACA | uveal autoantigen with coiled-coil domains and ankyrin repeats | -0.0314934 |
| TMEM263 | transmembrane protein 263 | -0.0314644 |
| GFPT1 | glutamine--fructose-6-phosphate transaminase 1 | -0.0314579 |
| FNIP1 | folliculin interacting protein 1 | -0.0313979 |
| FBXO11 | F-box protein 11 | -0.0310357 |
| MAP4K4 | mitogen-activated protein kinase kinase kinase kinase 4 | -0.0309755 |
| RAB1A | RAB1A, member RAS oncogene family | -0.0309725 |
| USP34 | ubiquitin specific peptidase 34 | -0.0309559 |
| AKAP10 | A kinase (PRKA) anchor protein 10 | -0.0308933 |
| CALU | calumenin | -0.030799 |
| ERC1 | ELKS/RAB6-interacting/CAST family member 1 | -0.0307798 |
