Afatinib_SW 900 Gene Set

Dataset Tahoe Therapeutics Tahoe 100M Perturbation Atlas
Category transcriptomics
Type cell type
Description Afatinib perturbation in SW 900 cell line (Tahoe Therapeutics)
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Genes

200 genes differentially expressed following the Afatinib_SW 900 drug perturbation from the Tahoe Therapeutics Tahoe 100M Perturbation Atlas dataset.

increased expression

Symbol Name Standardized Value
FTH1 ferritin, heavy polypeptide 1 0.189213
MT2A metallothionein 2A 0.14348
HSP90AA1 heat shock protein 90kDa alpha (cytosolic), class A member 1 0.0857743
RACK1 receptor for activated C kinase 1 0.0767273
HSP90AB1 heat shock protein 90kDa alpha (cytosolic), class B member 1 0.0727527
TPI1 triosephosphate isomerase 1 0.060516
B2M beta-2-microglobulin 0.0569562
RPS12 ribosomal protein S12 0.0557774
STC2 stanniocalcin 2 0.0552343
TMSB4X thymosin beta 4, X-linked 0.0538485
PLOD2 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 2 0.0531582
RPL26 ribosomal protein L26 0.0530337
NPM1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) 0.050986
TXNIP thioredoxin interacting protein 0.0502363
SFTPA2 surfactant protein A2 0.0486295
NAMPT nicotinamide phosphoribosyltransferase 0.0461856
FAM13A family with sequence similarity 13, member A 0.0457389
PLIN2 perilipin 2 0.0434158
MKI67 marker of proliferation Ki-67 0.0398661
CYP1B1 cytochrome P450, family 1, subfamily B, polypeptide 1 0.0393809
AKAP12 A kinase (PRKA) anchor protein 12 0.0392408
PRRC2C proline-rich coiled-coil 2C 0.0391578
SLC5A3 solute carrier family 5 (sodium/myo-inositol cotransporter), member 3 0.0383593
FTL ferritin, light polypeptide 0.0359525
SOX4 SRY (sex determining region Y)-box 4 0.0358037
EEF2 eukaryotic translation elongation factor 2 0.0352194
PPP1R15A protein phosphatase 1, regulatory subunit 15A 0.0346033
RPL12 ribosomal protein L12 0.034474
RPL37A ribosomal protein L37a 0.0326295
ERRFI1 ERBB receptor feedback inhibitor 1 0.0320964
SRRM2 serine/arginine repetitive matrix 2 0.0312279
RPL18 ribosomal protein L18 0.0311212
RPS27 ribosomal protein S27 0.0308494
RPS3 ribosomal protein S3 0.0302088
RPL36 ribosomal protein L36 0.0295401
HSPA8 heat shock 70kDa protein 8 0.0293792
RPS19 ribosomal protein S19 0.0293552
H1-0 H1.0 linker histone 0.0282717
DDIT4 DNA-damage-inducible transcript 4 0.0281797
LMNA lamin A/C 0.0280201
NFE2L1 nuclear factor, erythroid 2-like 1 0.0280121
ENO1 enolase 1, (alpha) 0.0278373
IRF2BP2 interferon regulatory factor 2 binding protein 2 0.0269123
ARL6IP1 ADP-ribosylation factor-like 6 interacting protein 1 0.0267306
BNIP3 BCL2/adenovirus E1B 19kDa interacting protein 3 0.0265926
RFX2 regulatory factor X, 2 (influences HLA class II expression) 0.0265867
YBX3 Y box binding protein 3 0.0259465
CALM2 calmodulin 2 (phosphorylase kinase, delta) 0.0252574
EREG epiregulin 0.0250141
MYADM myeloid-associated differentiation marker 0.0247945
ITGA1 integrin, alpha 1 0.0246436
TPM3 tropomyosin 3 0.0245223
ATP2B4 ATPase, Ca++ transporting, plasma membrane 4 0.0243718
DSTN destrin (actin depolymerizing factor) 0.0242101
RPS2 ribosomal protein S2 0.0232894
BASP1 brain abundant, membrane attached signal protein 1 0.023207
NAP1L1 nucleosome assembly protein 1-like 1 0.0230685
ANKRD28 ankyrin repeat domain 28 0.0228044
DUSP6 dual specificity phosphatase 6 0.0222745
CFB complement factor B 0.0219941
HDGF hepatoma-derived growth factor 0.0219248
RPS8 ribosomal protein S8 0.0217981
ATP1B1 ATPase, Na+/K+ transporting, beta 1 polypeptide 0.0213457
SOX9 SRY (sex determining region Y)-box 9 0.0213391
BZW1 basic leucine zipper and W2 domains 1 0.0212413
YBX1 Y box binding protein 1 0.0208193
PARP14 poly (ADP-ribose) polymerase family, member 14 0.0207565
ANGPTL4 angiopoietin-like 4 0.0206352
HSPD1 heat shock 60kDa protein 1 (chaperonin) 0.0204166
PGAM4 phosphoglycerate mutase family member 4 0.0203456
SH3KBP1 SH3-domain kinase binding protein 1 0.0202079
BHLHE40 basic helix-loop-helix family, member e40 0.0199127
ASPH aspartate beta-hydroxylase 0.0197169
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 0.0196739
CAPN2 calpain 2, (m/II) large subunit 0.0196521
RPL30 ribosomal protein L30 0.0189891
AHNAK AHNAK nucleoprotein 0.0187382
PRPF4B pre-mRNA processing factor 4B 0.0186869
MMP13 matrix metallopeptidase 13 0.0184185
KLF6 Kruppel-like factor 6 0.0182973
RPL4 ribosomal protein L4 0.0182916
LOC102724023 ES1 protein homolog, mitochondrial 0.0181577
CRIM1 cysteine rich transmembrane BMP regulator 1 (chordin-like) 0.0179338
LAMB3 laminin, beta 3 0.0179071
EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 0.0174356
FOS FBJ murine osteosarcoma viral oncogene homolog 0.0172858
EZR ezrin 0.0170285
RPL21 ribosomal protein L21 0.0169562
YWHAE tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon 0.0168883
NFATC2 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2 0.0168747
HLA-A major histocompatibility complex, class I, A 0.0167278
RPL3 ribosomal protein L3 0.0167018
TCIM transcriptional and immune response regulator 0.0166983
TXNRD1 thioredoxin reductase 1 0.0166184
S100A6 S100 calcium binding protein A6 0.0166134
EMP1 epithelial membrane protein 1 0.0165712
FBXO32 F-box protein 32 0.0165337
MXI1 MAX interactor 1, dimerization protein 0.0164556
RPLP1 ribosomal protein, large, P1 0.0161953
VIM vimentin 0.0161135

decreased expression

Symbol Name Standardized Value
GAPDH glyceraldehyde-3-phosphate dehydrogenase -0.245692
P4HB prolyl 4-hydroxylase, beta polypeptide -0.126828
NRG1 neuregulin 1 -0.11209
FN1 fibronectin 1 -0.10442
VCL vinculin -0.101993
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -0.0917627
EXT1 exostosin glycosyltransferase 1 -0.0845635
INTS6 integrator complex subunit 6 -0.070755
HMGA2 high mobility group AT-hook 2 -0.0694786
RBPJ recombination signal binding protein for immunoglobulin kappa J region -0.0644441
POLR2A polymerase (RNA) II (DNA directed) polypeptide A, 220kDa -0.0588028
CXCL8 chemokine (C-X-C motif) ligand 8 -0.0587042
AEBP2 AE binding protein 2 -0.0586914
HSPA5 heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) -0.0554786
SEC31A SEC31 homolog A (S. cerevisiae) -0.0538073
SOD2 superoxide dismutase 2, mitochondrial -0.051408
NRIP1 nuclear receptor interacting protein 1 -0.0504077
HNRNPH1 heterogeneous nuclear ribonucleoprotein H1 (H) -0.0492563
ZCCHC7 zinc finger, CCHC domain containing 7 -0.0486083
TAS2R14 taste receptor, type 2, member 14 -0.0482255
PABPC1 poly(A) binding protein, cytoplasmic 1 -0.0471327
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 -0.0462501
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -0.0460555
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -0.0459523
COG5 component of oligomeric golgi complex 5 -0.0455464
ARID4B AT rich interactive domain 4B (RBP1-like) -0.0449669
GFPT1 glutamine--fructose-6-phosphate transaminase 1 -0.0446263
FNDC3B fibronectin type III domain containing 3B -0.0442076
BIRC6 baculoviral IAP repeat containing 6 -0.0441157
MON2 MON2 homolog (S. cerevisiae) -0.0441066
ACTG1 actin gamma 1 -0.0437061
COPA coatomer protein complex, subunit alpha -0.0430303
HSP90B1 heat shock protein 90kDa beta (Grp94), member 1 -0.0428329
TBC1D22A TBC1 domain family, member 22A -0.0422954
RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1 -0.0417857
GLIS3 GLIS family zinc finger 3 -0.0416864
SPAG9 sperm associated antigen 9 -0.0406359
PTK2 protein tyrosine kinase 2 -0.0405559
KCNMA1 potassium channel, calcium activated large conductance subfamily M alpha, member 1 -0.0405432
RICTOR RPTOR independent companion of MTOR, complex 2 -0.0403425
VMP1 vacuole membrane protein 1 -0.0399547
ZC3HAV1 zinc finger CCCH-type, antiviral 1 -0.0399358
ZSWIM6 zinc finger, SWIM-type containing 6 -0.0396586
FBXO11 F-box protein 11 -0.039578
HNRNPA2B1 heterogeneous nuclear ribonucleoprotein A2/B1 -0.0391409
TPT1 tumor protein, translationally-controlled 1 -0.0388439
RAB7A RAB7A, member RAS oncogene family -0.0386366
RCOR1 REST corepressor 1 -0.0385717
RPL38 ribosomal protein L38 -0.0384173
OGA O-GlcNAcase -0.0371543
FBXW11 F-box and WD repeat domain containing 11 -0.0370323
ZFAND3 zinc finger, AN1-type domain 3 -0.0364843
MBD5 methyl-CpG binding domain protein 5 -0.0364266
LRRC23 leucine rich repeat containing 23 -0.0364228
CPEB4 cytoplasmic polyadenylation element binding protein 4 -0.0356838
SPDYA speedy/RINGO cell cycle regulator family member A -0.0356175
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -0.0355851
SUCO SUN domain containing ossification factor -0.035429
AP3B1 adaptor-related protein complex 3, beta 1 subunit -0.0347699
ANKHD1 ankyrin repeat and KH domain containing 1 -0.0346419
GBE1 glucan (1,4-alpha-), branching enzyme 1 -0.0345952
ARF4 ADP-ribosylation factor 4 -0.0344296
NAV1 neuron navigator 1 -0.034335
MKLN1 muskelin 1, intracellular mediator containing kelch motifs -0.0341923
POTEF POTE ankyrin domain family, member F -0.0341767
TUFT1 tuftelin 1 -0.0341024
TRIO trio Rho guanine nucleotide exchange factor -0.0339455
CUL3 cullin 3 -0.0334723
HLA-B major histocompatibility complex, class I, B -0.0331719
DNAJC3 DnaJ (Hsp40) homolog, subfamily C, member 3 -0.0325393
CCDC138 coiled-coil domain containing 138 -0.0319223
SQSTM1 sequestosome 1 -0.0318258
TMEM165 transmembrane protein 165 -0.0314325
FAM20C family with sequence similarity 20, member C -0.0314177
NFAT5 nuclear factor of activated T-cells 5, tonicity-responsive -0.0310628
BLZF1 basic leucine zipper nuclear factor 1 -0.03071
ETNK1 ethanolamine kinase 1 -0.0306508
CNOT1 CCR4-NOT transcription complex, subunit 1 -0.0305913
GNB1 guanine nucleotide binding protein (G protein), beta polypeptide 1 -0.0305627
RAB1A RAB1A, member RAS oncogene family -0.0305337
KDM5B lysine (K)-specific demethylase 5B -0.0304598
FRYL FRY-like -0.0302422
RUNX1 runt-related transcription factor 1 -0.0301961
RERE arginine-glutamic acid dipeptide (RE) repeats -0.0301925
CTBP2 C-terminal binding protein 2 -0.0301691
MCTP2 multiple C2 domains, transmembrane 2 -0.0294373
RPS24 ribosomal protein S24 -0.0293039
RBM39 RNA binding motif protein 39 -0.0289811
HUWE1 HECT, UBA and WWE domain containing 1, E3 ubiquitin protein ligase -0.0289684
HM13 histocompatibility (minor) 13 -0.028769
SHB Src homology 2 domain containing adaptor protein B -0.0286242
ASH1L ash1 (absent, small, or homeotic)-like (Drosophila) -0.0283259
DNM1L dynamin 1-like -0.0283214
ABL2 ABL proto-oncogene 2, non-receptor tyrosine kinase -0.0282659
GLG1 golgi glycoprotein 1 -0.0281893
CEP350 centrosomal protein 350kDa -0.0279264
MARK3 MAP/microtubule affinity-regulating kinase 3 -0.027917
SMYD3 SET and MYND domain containing 3 -0.0278195
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 -0.0277243
TENT2 terminal nucleotidyltransferase 2 -0.0276899