Agammaglobulinemia Gene Set

Dataset DISEASES Text-mining Gene-Disease Association Evidence Scores 2025
Category disease or phenotype associations
Type disease
Description A B cell deficiency that is caused by a reduction in all types of gamma globulins. (Human Disease Ontology, DOID_2583)
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Genes

757 genes co-occuring with the disease Agammaglobulinemia in abstracts of biomedical publications from the DISEASES Text-mining Gene-Disease Assocation Evidence Scores 2025 dataset.

Symbol Name Standardized Value
BTK Bruton agammaglobulinemia tyrosine kinase 3.56
CD19 CD19 molecule 3.37
TNFRSF13B tumor necrosis factor receptor superfamily, member 13B 3.363
CD4 CD4 molecule 3.188
LRBA LPS-responsive vesicle trafficking, beach and anchor containing 3.159
CD27 CD27 molecule 3.138
CD8A CD8a molecule 3.069
TNFRSF13C tumor necrosis factor receptor superfamily, member 13C 3.04
CR2 complement component (3d/Epstein Barr virus) receptor 2 3.021
TNFSF13B tumor necrosis factor (ligand) superfamily, member 13b 2.868
ICOS inducible T-cell co-stimulator 2.838
CD40LG CD40 ligand 2.835
SH2D1A SH2 domain containing 1A 2.833
PLCG2 phospholipase C, gamma 2 (phosphatidylinositol-specific) 2.811
CD38 CD38 molecule 2.733
DOCK8 dedicator of cytokinesis 8 2.706
IFNG interferon, gamma 2.67
NFKB2 nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) 2.639
CTLA4 cytotoxic T-lymphocyte-associated protein 4 2.633
BLNK B-cell linker 2.627
CD40 CD40 molecule, TNF receptor superfamily member 5 2.621
ITK IL2-inducible T-cell kinase 2.618
IL2 interleukin 2 2.608
RAG1 recombination activating gene 1 2.597
CD28 CD28 molecule 2.593
LOC102723407 putative V-set and immunoglobulin domain-containing-like protein IGHV4OR15-8 2.554
TNF tumor necrosis factor 2.553
BCR breakpoint cluster region 2.52
IL10 interleukin 10 2.506
FCGR3A Fc fragment of IgG, low affinity IIIa, receptor (CD16a) 2.503
SYK spleen tyrosine kinase 2.493
IL6 interleukin 6 2.492
CXCR5 chemokine (C-X-C motif) receptor 5 2.485
CAMLG calcium modulating ligand 2.485
FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b) 2.478
CD79B CD79b molecule, immunoglobulin-associated beta 2.473
AICDA activation-induced cytidine deaminase 2.47
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.469
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.456
FOXP3 forkhead box P3 2.44
IGLL1 immunoglobulin lambda-like polypeptide 1 2.437
BMX BMX non-receptor tyrosine kinase 2.422
CD22 CD22 molecule 2.422
TXK TXK tyrosine kinase 2.418
NFKB1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 2.416
CD5 CD5 molecule 2.415
RAG2 recombination activating gene 2 2.41
PLEK pleckstrin 2.404
PLEK2 pleckstrin 2 2.4
ADA2 adenosine deaminase 2 2.395
ZBTB24 zinc finger and BTB domain containing 24 2.369
CXCR4 chemokine (C-X-C motif) receptor 4 2.367
PIK3R1 phosphoinositide-3-kinase, regulatory subunit 1 (alpha) 2.365
CD79A CD79a molecule, immunoglobulin-associated alpha 2.364
CSF3 colony stimulating factor 3 (granulocyte) 2.351
IL4 interleukin 4 2.351
DCLRE1C DNA cross-link repair 1C 2.349
STAT1 signal transducer and activator of transcription 1, 91kDa 2.346
STAT3 signal transducer and activator of transcription 3 (acute-phase response factor) 2.34
CD81 CD81 molecule 2.336
CARD11 caspase recruitment domain family, member 11 2.329
LYN LYN proto-oncogene, Src family tyrosine kinase 2.327
NCAM1 neural cell adhesion molecule 1 2.312
TLR9 toll-like receptor 9 2.307
CCR7 chemokine (C-C motif) receptor 7 2.298
TNFRSF9 tumor necrosis factor receptor superfamily, member 9 2.297
IL7R interleukin 7 receptor 2.293
CRP C-reactive protein, pentraxin-related 2.286
FCGRT Fc fragment of IgG, receptor, transporter, alpha 2.279
IL21R interleukin 21 receptor 2.278
IRF2BP2 interferon regulatory factor 2 binding protein 2 2.268
TNFRSF17 tumor necrosis factor receptor superfamily, member 17 2.265
WAS Wiskott-Aldrich syndrome 2.265
IL17A interleukin 17A 2.263
ALB albumin 2.251
B3GAT1 beta-1,3-glucuronyltransferase 1 2.247
AIRE autoimmune regulator 2.242
TTC7A tetratricopeptide repeat domain 7A 2.24
PTPRC protein tyrosine phosphatase, receptor type, C 2.238
MAGT1 magnesium transporter 1 2.236
CD86 CD86 molecule 2.234
STXBP2 syntaxin binding protein 2 2.22
IL2RG interleukin 2 receptor, gamma 2.217
XIAP X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase 2.216
CD70 CD70 molecule 2.215
CD80 CD80 molecule 2.209
PIK3CD phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta 2.208
PRF1 perforin 1 (pore forming protein) 2.197
IL7 interleukin 7 2.194
IL1B interleukin 1, beta 2.191
IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 2.18
CD247 CD247 molecule 2.173
UNC13D unc-13 homolog D (C. elegans) 2.172
MYD88 myeloid differentiation primary response 88 2.171
LOC102723996 ICOS ligand 2.171
JAK3 Janus kinase 3 2.17
CD69 CD69 molecule 2.166
GATA2 GATA binding protein 2 2.156
LRRC8A leucine rich repeat containing 8 family, member A 2.146
FAS Fas cell surface death receptor 2.145
MSH5 mutS homolog 5 2.137
IFNA1 interferon, alpha 1 2.131
CXCL12 chemokine (C-X-C motif) ligand 12 2.126
SDC1 syndecan 1 2.126
CARMIL2 capping protein regulator and myosin 1 linker 2 2.125
TLR7 toll-like receptor 7 2.118
VPREB1 pre-B lymphocyte 1 2.098
SELL selectin L 2.089
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.088
CD52 CD52 molecule 2.088
IRAK4 interleukin-1 receptor-associated kinase 4 2.088
ADA adenosine deaminase 2.082
BCL6 B-cell CLL/lymphoma 6 2.076
FCRL5 Fc receptor-like 5 2.074
CEL carboxyl ester lipase 2.07
TRNT1 tRNA nucleotidyl transferase, CCA-adding, 1 2.07
VAV1 vav 1 guanine nucleotide exchange factor 2.067
ICOSLG inducible T-cell co-stimulator ligand 2.063
SLAMF1 signaling lymphocytic activation molecule family member 1 2.058
CSF2 colony stimulating factor 2 (granulocyte-macrophage) 2.056
IL15 interleukin 15 2.04
CXCR3 chemokine (C-X-C motif) receptor 3 2.04
TBX21 T-box 21 2.038
MME membrane metallo-endopeptidase 2.032
PRDM1 PR domain containing 1, with ZNF domain 2.025
STAT5B signal transducer and activator of transcription 5B 2.025
SPN sialophorin 2.024
TOR1A torsin family 1, member A (torsin A) 2.021
FCGR2B Fc fragment of IgG, low affinity IIb, receptor (CD32) 2.011
GPRC5D G protein-coupled receptor, class C, group 5, member D 2.003
NHEJ1 nonhomologous end-joining factor 1 2.002
TNFSF13 tumor necrosis factor (ligand) superfamily, member 13 1.994
IL1A interleukin 1, alpha 1.989
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 1.982
LCK LCK proto-oncogene, Src family tyrosine kinase 1.981
FCRL4 Fc receptor-like 4 1.978
CD276 CD276 molecule 1.974
FASLG Fas ligand (TNF superfamily, member 6) 1.972
CD34 CD34 molecule 1.969
IL2RA interleukin 2 receptor, alpha 1.966
IL5 interleukin 5 1.966
ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) 1.964
LIG4 ligase IV, DNA, ATP-dependent 1.963
MOGS mannosyl-oligosaccharide glucosidase 1.961
IL12RB1 interleukin 12 receptor, beta 1 1.959
PRKCD protein kinase C, delta 1.956
TLR3 toll-like receptor 3 1.951
MTOR mechanistic target of rapamycin (serine/threonine kinase) 1.949
RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated) 1.948
PAX5 paired box 5 1.948
IFNB1 interferon, beta 1, fibroblast 1.946
PIK3CG phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma 1.938
STX11 syntaxin 11 1.935
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 1.934
AKT1 v-akt murine thymoma viral oncogene homolog 1 1.93
FCGR2A Fc fragment of IgG, low affinity IIa, receptor (CD32) 1.927
IL10RA interleukin 10 receptor, alpha 1.923
CACNA1B calcium channel, voltage-dependent, N type, alpha 1B subunit 1.919
LYST lysosomal trafficking regulator 1.918
IRF4 interferon regulatory factor 4 1.917
PGM3 phosphoglucomutase 3 1.916
C3 complement component 3 1.908
B2M beta-2-microglobulin 1.907
CXCL8 chemokine (C-X-C motif) ligand 8 1.905
TLR4 toll-like receptor 4 1.905
PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 1.904
PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 1.902
UNC93B1 unc-93 homolog B1 (C. elegans) 1.887
BACH2 BTB and CNC homology 1, basic leucine zipper transcription factor 2 1.884
TNFRSF8 tumor necrosis factor receptor superfamily, member 8 1.875
NOD2 nucleotide-binding oligomerization domain containing 2 1.869
CTPS1 CTP synthase 1 1.866
CD24 CD24 molecule 1.862
CXCL13 chemokine (C-X-C motif) ligand 13 1.858
ATM ATM serine/threonine kinase 1.857
CEP70 centrosomal protein 70kDa 1.857
IL18 interleukin 18 1.857
SERPINA1 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1 1.849
LRRC8B leucine rich repeat containing 8 family, member B 1.849
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 1.847
IL22 interleukin 22 1.844
LCP2 lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) 1.842
MALT1 MALT1 paracaspase 1.839
TLR2 toll-like receptor 2 1.838
BLK BLK proto-oncogene, Src family tyrosine kinase 1.838
MS4A1 membrane-spanning 4-domains, subfamily A, member 1 1.835
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) 1.834
IFNGR1 interferon gamma receptor 1 1.829
IL13 interleukin 13 1.829
BCL2 B-cell CLL/lymphoma 2 1.826
CD1D CD1d molecule 1.826
RFXANK regulatory factor X-associated ankyrin-containing protein 1.824
CCR6 chemokine (C-C motif) receptor 6 1.824
PLCG1 phospholipase C, gamma 1 1.824
CYBB cytochrome b-245, beta polypeptide 1.821
INSM2 insulinoma-associated 2 1.819
CORO1A coronin, actin binding protein, 1A 1.819
TNFSF12 tumor necrosis factor (ligand) superfamily, member 12 1.817
MBL2 mannose-binding lectin (protein C) 2, soluble 1.816
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 1.813
TMC8 transmembrane channel-like 8 1.812
PRTN3 proteinase 3 1.811
TGFB1 transforming growth factor, beta 1 1.8
AK2 adenylate kinase 2 1.8
SLAMF7 SLAM family member 7 1.798
BCL10 B-cell CLL/lymphoma 10 1.798
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 1.795
IKZF3 IKAROS family zinc finger 3 (Aiolos) 1.789
CCRL2 chemokine (C-C motif) receptor-like 2 1.789
ITGB2 integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) 1.788
ACE2 angiotensin I converting enzyme 2 1.787
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 1.779
MYOM2 myomesin 2 1.778
CXCL10 chemokine (C-X-C motif) ligand 10 1.777
KLRK1 killer cell lectin-like receptor subfamily K, member 1 1.773
NBAS neuroblastoma amplified sequence 1.772
JAK1 Janus kinase 1 1.77
TLR8 toll-like receptor 8 1.77
ARPC1B actin related protein 2/3 complex, subunit 1B, 41kDa 1.766
TYK2 tyrosine kinase 2 1.763
REL v-rel avian reticuloendotheliosis viral oncogene homolog 1.755
CD274 CD274 molecule 1.754
PNP purine nucleoside phosphorylase 1.752
PIGR polymeric immunoglobulin receptor 1.744
STAT5A signal transducer and activator of transcription 5A 1.744
FYN FYN proto-oncogene, Src family tyrosine kinase 1.742
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 1.737
IL21 interleukin 21 1.735
TCF3 transcription factor 3 1.732
MPO myeloperoxidase 1.728
NCF1 neutrophil cytosolic factor 1 1.723
MS4A2 membrane-spanning 4-domains, subfamily A, member 2 1.723
LAMP1 lysosomal-associated membrane protein 1 1.722
DOCK2 dedicator of cytokinesis 2 1.721
IRF8 interferon regulatory factor 8 1.719
CD2 CD2 molecule 1.716
DNMT3B DNA (cytosine-5-)-methyltransferase 3 beta 1.713
CCR5 chemokine (C-C motif) receptor 5 (gene/pseudogene) 1.71
MPL MPL proto-oncogene, thrombopoietin receptor 1.706
HLA-A major histocompatibility complex, class I, A 1.699
IRF7 interferon regulatory factor 7 1.699
CHUK conserved helix-loop-helix ubiquitous kinase 1.697
KMT2D lysine (K)-specific methyltransferase 2D 1.696
IL9 interleukin 9 1.694
TNFRSF25 tumor necrosis factor receptor superfamily, member 25 1.692
CARD9 caspase recruitment domain family, member 9 1.691
TRAF3 TNF receptor-associated factor 3 1.691
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) 1.69
GPT glutamic-pyruvate transaminase (alanine aminotransferase) 1.688
TGM2 transglutaminase 2 1.687
PRKCB protein kinase C, beta 1.684
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 1.681
PDCD1 programmed cell death 1 1.68
CDCA7 cell division cycle associated 7 1.68
IL3RA interleukin 3 receptor, alpha (low affinity) 1.68
TP53 tumor protein p53 1.679
TNFRSF1A tumor necrosis factor receptor superfamily, member 1A 1.679
NLRP3 NLR family, pyrin domain containing 3 1.677
IFNAR1 interferon (alpha, beta and omega) receptor 1 1.676
IRAK1 interleukin-1 receptor-associated kinase 1 1.673
STK4 serine/threonine kinase 4 1.672
SEC61A1 Sec61 alpha 1 subunit (S. cerevisiae) 1.663
SLAMF6 SLAM family member 6 1.662
ZNF341 zinc finger protein 341 1.655
TIMM8A translocase of inner mitochondrial membrane 8 homolog A (yeast) 1.655
CFP complement factor properdin 1.651
NCF4 neutrophil cytosolic factor 4, 40kDa 1.65
CD84 CD84 molecule 1.649
CCL3 chemokine (C-C motif) ligand 3 1.648
LRRC8C leucine rich repeat containing 8 family, member C 1.645
CLEC16A C-type lectin domain family 16, member A 1.645
IRF3 interferon regulatory factor 3 1.643
IFIH1 interferon induced with helicase C domain 1 1.638
NCF2 neutrophil cytosolic factor 2 1.636
IFNA2 interferon, alpha 2 1.632
POU2AF1 POU class 2 associating factor 1 1.631
TEC tec protein tyrosine kinase 1.629
JAGN1 jagunal homolog 1 (Drosophila) 1.629
RNF31 ring finger protein 31 1.628
CD33 CD33 molecule 1.625
CCL2 chemokine (C-C motif) ligand 2 1.623
STIM1 stromal interaction molecule 1 1.621
CXCL9 chemokine (C-X-C motif) ligand 9 1.615
LRRC8E leucine rich repeat containing 8 family, member E 1.614
CASP10 caspase 10, apoptosis-related cysteine peptidase 1.613
SPI1 Spi-1 proto-oncogene 1.611
AP3B1 adaptor-related protein complex 3, beta 1 subunit 1.61
ELANE elastase, neutrophil expressed 1.61
CD55 CD55 molecule, decay accelerating factor for complement (Cromer blood group) 1.608
IKZF5 IKAROS family zinc finger 5 (Pegasus) 1.604
IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 1.603
C4A complement component 4A (Rodgers blood group) 1.603
CSK c-src tyrosine kinase 1.602
CLEC7A C-type lectin domain family 7, member A 1.601
TLR5 toll-like receptor 5 1.6
CYBA cytochrome b-245, alpha polypeptide 1.6
THPO thrombopoietin 1.597
FCGR1A Fc fragment of IgG, high affinity Ia, receptor (CD64) 1.593
TFRC transferrin receptor 1.593
UNG uracil-DNA glycosylase 1.591
FNIP1 folliculin interacting protein 1 1.59
MYC v-myc avian myelocytomatosis viral oncogene homolog 1.59
CD1C CD1c molecule 1.59
PECAM1 platelet/endothelial cell adhesion molecule 1 1.587
HCK HCK proto-oncogene, Src family tyrosine kinase 1.587
MOG myelin oligodendrocyte glycoprotein 1.586
RAB27A RAB27A, member RAS oncogene family 1.585
CCL19 chemokine (C-C motif) ligand 19 1.583
MEFV Mediterranean fever 1.582
JCHAIN joining chain of multimeric IgA and IgM 1.581
ALG12 ALG12, alpha-1,6-mannosyltransferase 1.58
JAK2 Janus kinase 2 1.58
IKZF2 IKAROS family zinc finger 2 (Helios) 1.579
CD7 CD7 molecule 1.572
PSTPIP1 proline-serine-threonine phosphatase interacting protein 1 1.571
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 1.57
LY9 lymphocyte antigen 9 1.567
ZNF274 zinc finger protein 274 1.567
HELLS helicase, lymphoid-specific 1.565
SERPING1 serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 1.565
HP haptoglobin 1.564
IL10RB interleukin 10 receptor, beta 1.56
IL17F interleukin 17F 1.55
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 1.549
ACE angiotensin I converting enzyme 1.544
TPP2 tripeptidyl peptidase II 1.541
PTPN22 protein tyrosine phosphatase, non-receptor type 22 (lymphoid) 1.535
CD83 CD83 molecule 1.534
MVK mevalonate kinase 1.529
LRRC8D leucine rich repeat containing 8 family, member D 1.527
INPP5D inositol polyphosphate-5-phosphatase, 145kDa 1.525
HAVCR2 hepatitis A virus cellular receptor 2 1.524
CD46 CD46 molecule, complement regulatory protein 1.523
CD72 CD72 molecule 1.523
BCL2L1 BCL2-like 1 1.522
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 1.522
IGLL5 immunoglobulin lambda-like polypeptide 5 1.52
CD3G CD3g molecule, gamma (CD3-TCR complex) 1.519
IFNA17 interferon, alpha 17 1.517
ORC4 origin recognition complex, subunit 4 1.517
CIITA class II, major histocompatibility complex, transactivator 1.515
STAT2 signal transducer and activator of transcription 2, 113kDa 1.512
PRKDC protein kinase, DNA-activated, catalytic polypeptide 1.507
HLA-B major histocompatibility complex, class I, B 1.506
TLR1 toll-like receptor 1 1.504
ACTB actin, beta 1.503
NLRP12 NLR family, pyrin domain containing 12 1.501
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 1.501
IL6R interleukin 6 receptor 1.496
MAP3K14 mitogen-activated protein kinase kinase kinase 14 1.494
DUSP5 dual specificity phosphatase 5 1.493
CCL4 chemokine (C-C motif) ligand 4 1.493
NLRC4 NLR family, CARD domain containing 4 1.492
TAF7L TAF7-like RNA polymerase II, TATA box binding protein (TBP)-associated factor, 50kDa 1.488
LAG3 lymphocyte-activation gene 3 1.485
SBDS Shwachman-Bodian-Diamond syndrome 1.484
SLC39A7 solute carrier family 39 (zinc transporter), member 7 1.483
GP6 glycoprotein VI (platelet) 1.48
HAX1 HCLS1 associated protein X-1 1.479
IL4R interleukin 4 receptor 1.479
IFNA8 interferon, alpha 8 1.474
IFNA4 interferon, alpha 4 1.474
RBCK1 RanBP-type and C3HC4-type zinc finger containing 1 1.473
IFNA10 interferon, alpha 10 1.47
IFNA6 interferon, alpha 6 1.469
ERVW-1 endogenous retrovirus group W, member 1 1.468
ITGA4 integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor) 1.468
IFNA13 interferon, alpha 13 1.467
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 1.467
IFNA21 interferon, alpha 21 1.466
CD180 CD180 molecule 1.465
IFNA5 interferon, alpha 5 1.464
CTNNBL1 catenin, beta like 1 1.463
IFNA16 interferon, alpha 16 1.462
CD3D CD3d molecule, delta (CD3-TCR complex) 1.462
IFNA14 interferon, alpha 14 1.461
IFNA7 interferon, alpha 7 1.461
TCL1A T-cell leukemia/lymphoma 1A 1.459
TBK1 TANK-binding kinase 1 1.456
OR10X1 olfactory receptor, family 10, subfamily X, member 1 (gene/pseudogene) 1.455
INS insulin 1.451
ORAI1 ORAI calcium release-activated calcium modulator 1 1.45
FCRLA Fc receptor-like A 1.448
LAT linker for activation of T cells 1.448
IL2RB interleukin 2 receptor, beta 1.447
EGFR epidermal growth factor receptor 1.445
DEF6 differentially expressed in FDCP 6 homolog (mouse) 1.445
DBR1 debranching RNA lariats 1 1.44
DKC1 dyskeratosis congenita 1, dyskerin 1.439
TET2 tet methylcytosine dioxygenase 2 1.437
TCL1B T-cell leukemia/lymphoma 1B 1.437
GTF2I general transcription factor IIi 1.436
NCR1 natural cytotoxicity triggering receptor 1 1.435
IL17RA interleukin 17 receptor A 1.432
NFKBID nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, delta 1.431
PTEN phosphatase and tensin homolog 1.426
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 1.426
TBX1 T-box 1 1.424
DNTT DNA nucleotidylexotransferase 1.423
PIDD1 p53-induced death domain protein 1 1.423
ERVFRD-1 endogenous retrovirus group FRD, member 1 1.422
TIRAP toll-interleukin 1 receptor (TIR) domain containing adaptor protein 1.422
ERV3-1 endogenous retrovirus group 3, member 1 1.422
CXCR2 chemokine (C-X-C motif) receptor 2 1.422
GINS1 GINS complex subunit 1 (Psf1 homolog) 1.42
XBP1 X-box binding protein 1 1.417
FLT3 fms-related tyrosine kinase 3 1.417
ACKR2 atypical chemokine receptor 2 1.416
ITPKB inositol-trisphosphate 3-kinase B 1.415
CD200 CD200 molecule 1.414
IFITM1 interferon induced transmembrane protein 1 1.411
IFNAR2 interferon (alpha, beta and omega) receptor 2 1.409
SPINK5 serine peptidase inhibitor, Kazal type 5 1.406
FCN3 ficolin (collagen/fibrinogen domain containing) 3 1.406
IL1R1 interleukin 1 receptor, type I 1.405
GRK3 G protein-coupled receptor kinase 3 1.405
CD1B CD1b molecule 1.405
CD244 CD244 molecule, natural killer cell receptor 2B4 1.4
GRB2 growth factor receptor-bound protein 2 1.4
GAPDH glyceraldehyde-3-phosphate dehydrogenase 1.399
LTA lymphotoxin alpha 1.398
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) 1.397
SOCS1 suppressor of cytokine signaling 1 1.396
TCN2 transcobalamin II 1.392
KLRB1 killer cell lectin-like receptor subfamily B, member 1 1.392
FCER1G Fc fragment of IgE, high affinity I, receptor for; gamma polypeptide 1.391
RUNX1 runt-related transcription factor 1 1.39
ZNF587 zinc finger protein 587 1.389
PREB prolactin regulatory element binding 1.387
RFXAP regulatory factor X-associated protein 1.386
RFX5 regulatory factor X, 5 (influences HLA class II expression) 1.385
MCM4 minichromosome maintenance complex component 4 1.384
TPO thyroid peroxidase 1.384
ISG15 ISG15 ubiquitin-like modifier 1.382
F2 coagulation factor II (thrombin) 1.382
IRF9 interferon regulatory factor 9 1.381
STING1 stimulator of interferon response cGAMP interactor 1 1.377
ICAM1 intercellular adhesion molecule 1 1.376
TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 1.376
NBN nibrin 1.376
HLA-DQA1 major histocompatibility complex, class II, DQ alpha 1 1.374
WIPF1 WAS/WASL interacting protein family, member 1 1.373
CCL5 chemokine (C-C motif) ligand 5 1.37
CD44 CD44 molecule (Indian blood group) 1.37
CFTR cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) 1.37
EPO erythropoietin 1.368
FOXN1 forkhead box N1 1.367
EBF1 early B-cell factor 1 1.367
F3 coagulation factor III (thromboplastin, tissue factor) 1.366
ATP4A ATPase, H+/K+ exchanging, alpha polypeptide 1.366
IL3 interleukin 3 1.366
CDC42 cell division cycle 42 1.363
CASP8 caspase 8, apoptosis-related cysteine peptidase 1.363
FUT4 fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific) 1.361
CCL21 chemokine (C-C motif) ligand 21 1.359
STX19 syntaxin 19 1.353
ATP12A ATPase, H+/K+ transporting, nongastric, alpha polypeptide 1.352
STAT4 signal transducer and activator of transcription 4 1.347
C4B complement component 4B (Chido blood group) 1.347
CASP1 caspase 1, apoptosis-related cysteine peptidase 1.344
HLA-DRB1 major histocompatibility complex, class II, DR beta 1 1.343
SPPL2A signal peptide peptidase like 2A 1.343
STAT6 signal transducer and activator of transcription 6, interleukin-4 induced 1.342
RTEL1 regulator of telomere elongation helicase 1 1.342
CLEC1B C-type lectin domain family 1, member B 1.339
CD1A CD1a molecule 1.337
GATA3 GATA binding protein 3 1.335
IL23R interleukin 23 receptor 1.334
CD1E CD1e molecule 1.332
RABIF RAB interacting factor 1.331
KCNN3 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 3 1.33
FCAR Fc fragment of IgA receptor 1.327
RORC RAR-related orphan receptor C 1.326
ENTPD1 ectonucleoside triphosphate diphosphohydrolase 1 1.326
CD58 CD58 molecule 1.324
PXDN peroxidasin 1.324
LTBR lymphotoxin beta receptor (TNFR superfamily, member 3) 1.32
PXDNL peroxidasin-like 1.319
ZBTB14 zinc finger and BTB domain containing 14 1.319
TLR6 toll-like receptor 6 1.318
IL12RB2 interleukin 12 receptor, beta 2 1.317
CD37 CD37 molecule 1.317
SPIB Spi-B transcription factor (Spi-1/PU.1 related) 1.316
ARRB1 arrestin, beta 1 1.313
KLRC1 killer cell lectin-like receptor subfamily C, member 1 1.309
JUN jun proto-oncogene 1.307
IL1RN interleukin 1 receptor antagonist 1.306
C1S complement component 1, s subcomponent 1.304
NT5E 5'-nucleotidase, ecto (CD73) 1.302
RHOH ras homolog family member H 1.302
ERBB2 erb-b2 receptor tyrosine kinase 2 1.302
SH3KBP1 SH3-domain kinase binding protein 1 1.3
PTPN11 protein tyrosine phosphatase, non-receptor type 11 1.299
TIGIT T cell immunoreceptor with Ig and ITIM domains 1.298
TMPRSS2 transmembrane protease, serine 2 1.296
VWF von Willebrand factor 1.296
CD68 CD68 molecule 1.294
MAF v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog 1.294
MUSK muscle, skeletal, receptor tyrosine kinase 1.292
CHD7 chromodomain helicase DNA binding protein 7 1.292
VCAM1 vascular cell adhesion molecule 1 1.291
RC3H1 ring finger and CCCH-type domains 1 1.29
TG thyroglobulin 1.286
POMC proopiomelanocortin 1.286
KLRD1 killer cell lectin-like receptor subfamily D, member 1 1.285
PDCD1LG2 programmed cell death 1 ligand 2 1.285
C1R complement component 1, r subcomponent 1.283
MAPK3 mitogen-activated protein kinase 3 1.283
EOMES eomesodermin 1.281
DNAJC21 DnaJ (Hsp40) homolog, subfamily C, member 21 1.279
ROR1 receptor tyrosine kinase-like orphan receptor 1 1.276
LTB lymphotoxin beta (TNF superfamily, member 3) 1.276
TNFRSF18 tumor necrosis factor receptor superfamily, member 18 1.275
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) 1.273
FOXO1 forkhead box O1 1.273
BANK1 B-cell scaffold protein with ankyrin repeats 1 1.27
OAS1 2'-5'-oligoadenylate synthetase 1, 40/46kDa 1.267
CSF3R colony stimulating factor 3 receptor (granulocyte) 1.265
CSF1 colony stimulating factor 1 (macrophage) 1.264
FCER2 Fc fragment of IgE, low affinity II, receptor for (CD23) 1.262
BCL2L11 BCL2-like 11 (apoptosis facilitator) 1.261
TNFSF11 tumor necrosis factor (ligand) superfamily, member 11 1.26
CD59 CD59 molecule, complement regulatory protein 1.26
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B 1.259
RIPK1 receptor (TNFRSF)-interacting serine-threonine kinase 1 1.258
TNFSF4 tumor necrosis factor (ligand) superfamily, member 4 1.258
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 1.254
HLA-DQB1 major histocompatibility complex, class II, DQ beta 1 1.254
PLA2R1 phospholipase A2 receptor 1, 180kDa 1.251
PSMA7 proteasome (prosome, macropain) subunit, alpha type, 7 1.25
SLC35C1 solute carrier family 35 (GDP-fucose transporter), member C1 1.249
TSLP thymic stromal lymphopoietin 1.247
CD163 CD163 molecule 1.24
GRAP2 GRB2-related adaptor protein 2 1.24
IRF5 interferon regulatory factor 5 1.239
IDO1 indoleamine 2,3-dioxygenase 1 1.239
DUSP1 dual specificity phosphatase 1 1.239
CCL20 chemokine (C-C motif) ligand 20 1.237
HLA-C major histocompatibility complex, class I, C 1.236
CRBN cereblon 1.231
CXCL1 chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha) 1.231
CD160 CD160 molecule 1.227
FN1 fibronectin 1 1.227
NRAS neuroblastoma RAS viral (v-ras) oncogene homolog 1.226
ARRB2 arrestin, beta 2 1.224
NCKAP1L NCK-associated protein 1-like 1.222
WDR1 WD repeat domain 1 1.221
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 1.22
TMEM199 transmembrane protein 199 1.22
ANXA5 annexin A5 1.219
POLA1 polymerase (DNA directed), alpha 1, catalytic subunit 1.218
CARD14 caspase recruitment domain family, member 14 1.216
IL33 interleukin 33 1.214
SASH3 SAM and SH3 domain containing 3 1.212
MCL1 myeloid cell leukemia 1 1.211
FCN2 ficolin (collagen/fibrinogen domain containing lectin) 2 1.211
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 1.211
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 1.209
AOC3 amine oxidase, copper containing 3 1.209
CD209 CD209 molecule 1.206
CCR9 chemokine (C-C motif) receptor 9 1.203
NELFCD negative elongation factor complex member C/D 1.202
TRIM21 tripartite motif containing 21 1.198
DAPP1 dual adaptor of phosphotyrosine and 3-phosphoinositides 1.196
CR1 complement component (3b/4b) receptor 1 (Knops blood group) 1.196
CGAS cyclic GMP-AMP synthase 1.191
KLRG1 killer cell lectin-like receptor subfamily G, member 1 1.191
CCDC115 coiled-coil domain containing 115 1.19
MASP2 mannan-binding lectin serine peptidase 2 1.189
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 1.188
EXTL3 exostosin-like glycosyltransferase 3 1.187
CLEC12A C-type lectin domain family 12, member A 1.186
TK2 thymidine kinase 2, mitochondrial 1.185
RNASEH2A ribonuclease H2, subunit A 1.184
BTLA B and T lymphocyte associated 1.183
MSN moesin 1.183
XRCC4 X-ray repair complementing defective repair in Chinese hamster cells 4 1.181
SAMD9L sterile alpha motif domain containing 9-like 1.181
MADCAM1 mucosal vascular addressin cell adhesion molecule 1 1.179
RAD50 RAD50 homolog (S. cerevisiae) 1.178
CCBE1 collagen and calcium binding EGF domains 1 1.176
KMT2A lysine (K)-specific methyltransferase 2A 1.175
ELF4 E74-like factor 4 (ets domain transcription factor) 1.175
SH3BP5 SH3-domain binding protein 5 (BTK-associated) 1.175
MICB MHC class I polypeptide-related sequence B 1.175
IFNW1 interferon, omega 1 1.175
G6PC3 glucose 6 phosphatase, catalytic, 3 1.172
GPT2 glutamic pyruvate transaminase (alanine aminotransferase) 2 1.171
SIGLEC6 sialic acid binding Ig-like lectin 6 1.17
FLT3LG fms-related tyrosine kinase 3 ligand 1.169
TNFSF9 tumor necrosis factor (ligand) superfamily, member 9 1.168
LMO2 LIM domain only 2 (rhombotin-like 1) 1.168
GFI1 growth factor independent 1 transcription repressor 1.168
FGR FGR proto-oncogene, Src family tyrosine kinase 1.167
SLC46A1 solute carrier family 46 (folate transporter), member 1 1.163
CASP9 caspase 9, apoptosis-related cysteine peptidase 1.163
ARHGEF1 Rho guanine nucleotide exchange factor (GEF) 1 1.161
CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon 1.158
NBEAL2 neurobeachin-like 2 1.157
TMC6 transmembrane channel-like 6 1.153
NFATC1 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1 1.153
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 1.151
NOTCH1 notch 1 1.151
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 1.15
S1PR1 sphingosine-1-phosphate receptor 1 1.148
FCRL3 Fc receptor-like 3 1.148
IL17RC interleukin 17 receptor C 1.148
ANKRD26 ankyrin repeat domain 26 1.147
ITIH4 inter-alpha-trypsin inhibitor heavy chain family, member 4 1.145
EDAR ectodysplasin A receptor 1.141
SAMD9 sterile alpha motif domain containing 9 1.141
FURIN furin (paired basic amino acid cleaving enzyme) 1.141
ADAR adenosine deaminase, RNA-specific 1.14
CD3E CD3e molecule, epsilon (CD3-TCR complex) 1.139
KCNN4 potassium channel, calcium activated intermediate/small conductance subfamily N alpha, member 4 1.139
PIK3R2 phosphoinositide-3-kinase, regulatory subunit 2 (beta) 1.137
TNFRSF10A tumor necrosis factor receptor superfamily, member 10a 1.136
NCK1 NCK adaptor protein 1 1.134
CDR2 cerebellar degeneration-related protein 2, 62kDa 1.133
CCR1 chemokine (C-C motif) receptor 1 1.132
IRF1 interferon regulatory factor 1 1.131
LAMTOR2 late endosomal/lysosomal adaptor, MAPK and MTOR activator 2 1.126
SMARCAL1 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a-like 1 1.125
POMP proteasome maturation protein 1.12
EZR ezrin 1.119
COLEC10 collectin sub-family member 10 (C-type lectin) 1.119
CXCR6 chemokine (C-X-C motif) receptor 6 1.117
DDX41 DEAD (Asp-Glu-Ala-Asp) box polypeptide 41 1.116
RIPK2 receptor-interacting serine-threonine kinase 2 1.115
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) 1.115
MUC1 mucin 1, cell surface associated 1.114
MYSM1 Myb-like, SWIRM and MPN domains 1 1.114
CD93 CD93 molecule 1.113
SEC61B Sec61 beta subunit 1.113
ITCH itchy E3 ubiquitin protein ligase 1.112
GPR183 G protein-coupled receptor 183 1.112
MX1 MX dynamin-like GTPase 1 1.112
TNFRSF11A tumor necrosis factor receptor superfamily, member 11a, NFKB activator 1.111
CAV2 caveolin 2 1.109
CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 1.108
DSG1 desmoglein 1 1.108
ZBTB32 zinc finger and BTB domain containing 32 1.107
OTULIN OTU deubiquitinase with linear linkage specificity 1.104
C5AR1 complement component 5a receptor 1 1.104
KLRC2 killer cell lectin-like receptor subfamily C, member 2 1.104
DNMT3A DNA (cytosine-5-)-methyltransferase 3 alpha 1.103
MASP1 mannan-binding lectin serine peptidase 1 (C4/C2 activating component of Ra-reactive factor) 1.103
LTF lactotransferrin 1.099
ETV6 ets variant 6 1.099
NFKBIB nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta 1.098
KRAS Kirsten rat sarcoma viral oncogene homolog 1.097
CXCL11 chemokine (C-X-C motif) ligand 11 1.097
HLA-E major histocompatibility complex, class I, E 1.096
EGF epidermal growth factor 1.094
CYBC1 cytochrome b-245 chaperone 1 1.093
CYP3A4 cytochrome P450, family 3, subfamily A, polypeptide 4 1.091
CSF2RA colony stimulating factor 2 receptor, alpha, low-affinity (granulocyte-macrophage) 1.091
TPMT thiopurine S-methyltransferase 1.09
NCR2 natural cytotoxicity triggering receptor 2 1.087
CCR2 chemokine (C-C motif) receptor 2 1.086
NIPAL3 NIPA-like domain containing 3 1.083
FADD Fas (TNFRSF6)-associated via death domain 1.083
TICAM1 toll-like receptor adaptor molecule 1 1.081
RNASEH2C ribonuclease H2, subunit C 1.081
MSLN mesothelin 1.08
PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (gamma) 1.079
BATF basic leucine zipper transcription factor, ATF-like 1.079
KCNRG potassium channel regulator 1.078
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) 1.078
IL11 interleukin 11 1.077
TYROBP TYRO protein tyrosine kinase binding protein 1.077
TCIRG1 T-cell, immune regulator 1, ATPase, H+ transporting, lysosomal V0 subunit A3 1.076
IL6ST interleukin 6 signal transducer 1.076
CXCR1 chemokine (C-X-C motif) receptor 1 1.076
PCSK7 proprotein convertase subtilisin/kexin type 7 1.076
KRTAP1-3 keratin associated protein 1-3 1.075
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 1.074
ITGB1 integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12) 1.074
DNAH8 dynein, axonemal, heavy chain 8 1.073
NLRP1 NLR family, pyrin domain containing 1 1.073
IKZF4 IKAROS family zinc finger 4 (Eos) 1.072
WAC WW domain containing adaptor with coiled-coil 1.072
AIM2 absent in melanoma 2 1.071
NCR3 natural cytotoxicity triggering receptor 3 1.07
FCN1 ficolin (collagen/fibrinogen domain containing) 1 1.066
KITLG KIT ligand 1.065
NIPAL2 NIPA-like domain containing 2 1.064
NOD1 nucleotide-binding oligomerization domain containing 1 1.062
LILRB1 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 1 1.06
AFP alpha-fetoprotein 1.059
CCL17 chemokine (C-C motif) ligand 17 1.059
NEIL3 nei endonuclease VIII-like 3 (E. coli) 1.057
THBD thrombomodulin 1.056
CCND1 cyclin D1 1.055
CACNA1E calcium channel, voltage-dependent, R type, alpha 1E subunit 1.054
ITGB7 integrin, beta 7 1.053
BIRC3 baculoviral IAP repeat containing 3 1.052
FHL2 four and a half LIM domains 2 1.052
CAV1 caveolin 1, caveolae protein, 22kDa 1.052
NCOR2 nuclear receptor corepressor 2 1.051
SAMHD1 SAM domain and HD domain 1 1.05
MAVS mitochondrial antiviral signaling protein 1.049
CCL11 chemokine (C-C motif) ligand 11 1.048
DSG3 desmoglein 3 1.048
TOP2B topoisomerase (DNA) II beta 180kDa 1.047
CNBP CCHC-type zinc finger, nucleic acid binding protein 1.046
ASPG asparaginase 1.046
IGF1 insulin-like growth factor 1 (somatomedin C) 1.046
CD74 CD74 molecule, major histocompatibility complex, class II invariant chain 1.045
SH2D3C SH2 domain containing 3C 1.044
TREM1 triggering receptor expressed on myeloid cells 1 1.044
LACC1 laccase (multicopper oxidoreductase) domain containing 1 1.042
IDO2 indoleamine 2,3-dioxygenase 2 1.042
RPS6KB2 ribosomal protein S6 kinase, 70kDa, polypeptide 2 1.041
HPRT1 hypoxanthine phosphoribosyltransferase 1 1.04
LIG1 ligase I, DNA, ATP-dependent 1.039
DIAPH1 diaphanous-related formin 1 1.038
FAAP24 FA core complex associated protein 24 1.037
CIB1 calcium and integrin binding 1 (calmyrin) 1.033
CSF1R colony stimulating factor 1 receptor 1.032
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) 1.031
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 1.03
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 1.029
NIPAL1 NIPA-like domain containing 1 1.029
CKM creatine kinase, muscle 1.026
EIF2AK3 eukaryotic translation initiation factor 2-alpha kinase 3 1.026
CX3CR1 chemokine (C-X3-C motif) receptor 1 1.025
USB1 U6 snRNA biogenesis 1 1.025
CCR4 chemokine (C-C motif) receptor 4 1.024
PSMA3 proteasome (prosome, macropain) subunit, alpha type, 3 1.023
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65kDa) 1.023
CKB creatine kinase, brain 1.02
CASP3 caspase 3, apoptosis-related cysteine peptidase 1.02
SHARPIN SHANK-associated RH domain interactor 1.02
HCST hematopoietic cell signal transducer 1.019
CRLF2 cytokine receptor-like factor 2 1.019
KDM6A lysine (K)-specific demethylase 6A 1.018
ADAM17 ADAM metallopeptidase domain 17 1.016
CKMT2 creatine kinase, mitochondrial 2 (sarcomeric) 1.016
GYPA glycophorin A (MNS blood group) 1.016
CKMT1B creatine kinase, mitochondrial 1B 1.015
CTAG1B cancer/testis antigen 1B 1.013
SELP selectin P (granule membrane protein 140kDa, antigen CD62) 1.012
RDX radixin 1.012
ANKRD54 ankyrin repeat domain 54 1.01
CCR3 chemokine (C-C motif) receptor 3 1.009
SIGLEC12 sialic acid binding Ig-like lectin 12 (gene/pseudogene) 1.008
EDA ectodysplasin A 1.007
FCHO1 FCH domain only 1 1.005
PTK2B protein tyrosine kinase 2 beta 1.005
ITGA2 integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) 1.005
EFR3B EFR3 homolog B (S. cerevisiae) 1.004
TLR10 toll-like receptor 10 1.004
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa 1.003
FANCA Fanconi anemia, complementation group A 1.003
IL18BP interleukin 18 binding protein 1.002
CD48 CD48 molecule 1.0